Clinical trials: Disabilities, Intellectual
Mental Retardation
Effect of Valproate on Propofol
The aim of this study is to evaluate the effect of valproate on the required dose of propofol for sedation in patients with mental retardation.
- Trial name
- NCT01170377
- Where
- Japan
- Volunteers
- 50 people
- Sponsor
- Okayama University
Down Syndrome
Parent Supported Weight Reduction in Down Syndrome
The purpose of this study is to determine whether a nutrition and physical activity education program for families of overweight or obese adolescents with Down syndrome is more effective when behavioral lifestyle change…
- Trial name
- NCT01256112
- Testing
- Parent Supported Behavioral Intervention, Nutrition/Activity Education (NAE)
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obstructive Sleep Apnea
Optimizing the Management of OSA in Children With Down Syndrome
The objective of this retrospective descriptive study is to assess current practices for the screening and surgical treatment of OSA in children with Down syndrome at the Strasbourg University Hospital and to disseminate a…
- Trial name
- SAOS-21 (NCT07334444)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Hematologic Malignancies, Inborn Errors of Metabolism Disorders
Expanded Access to T-cell Depleted Haplo-Identical Stem Cells for Patients Receiving Haplo-Identical and Unrelated Cord Blood Transplants
The objective of this study is to make T-cell depleted stem cells from a family member who is a half match (haplo-identical) available on an expanded access basis to patients receiving one or two unrelated cord blood transplants…
- Conditions
- Hematologic Malignancies, Inborn Errors of Metabolism Disorders, Immune Deficiencies
- Trial name
- NCT01881334
- Testing
- CliniMACS CD34 Reagent System
- Where
- United States
- Sponsor
- Joanne Kurtzberg, MD
Anxiety Disorders, Child Developmental Disorders, Pervasive
Examining Social, Emotional, and Cognitive Functioning in People With Fragile X and Down Syndromes
By testing physiological responses to anxiety in people with nervous system developmental disorders, this study will identify specific physiological characteristics associated with response to anxiety treatments.
- Trial name
- NCT00879515
- Where
- United States
- Volunteers
- 511 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Children With Down Syndrome
Interaction Effects of Vitamin D Supplementation and Aerobic Exercises on Balance and Physical Performance in Children With Down Syndrome
Objective: To investigate the interaction effects of vitamin D supplementation and aerobic exercises on balance control and physical performance in children with Down syndrome (DS).
- Trial name
- NCT03783338
- Testing
- Aerobic exercises and Vitamin D supplementation
- Where
- Egypt
- Volunteers
- 59 people
- Sponsor
- Cairo University
Rett Syndrome
A Safety Study of NNZ-2566 in Patients With Rett Syndrome
The purpose of this study is to determine whether NNZ-2566 is safe and well tolerated in the treatment of Rett Syndrome in adolescent and adult females.
- Trial name
- NCT01703533
- Testing
- NNZ-2566
- Where
- 3 sites in United States
- Volunteers
- 67 people
- Sponsor
- Neuren Pharmaceuticals Limited
Fragile X Syndrome, Fragile X Mental Retardation Syndrome
A Trial of Metformin in Individuals With Fragile X Syndrome
This study is a controlled trial of metformin in individuals with fragile X syndrome between the ages of 6 and 25 years. Participants will be randomized in a double-blind design to either drug or placebo and will attend three…
- Conditions
- Fragile X Syndrome, Fragile X Mental Retardation Syndrome, Mental Retardation, X Linked, Genetic Diseases, X-Linked
- Trial name
- Met (NCT03479476)
- Testing
- Metformin
- Where
- 3 sites in United States, Canada
- Volunteers
- 120 people
- Sponsor
- University of California, Davis
Down Syndrome
Efficacy of Rivastigmine in Patients With Down Syndrome
This study is to understand the efficacy on language and cognitive function in Down syndrome patients who take Rivastigmine.
- Trial name
- NCT00748007
- Testing
- Rivastigmine
- Where
- Taiwan
- Volunteers
- 14 people
- Sponsor
- National Taiwan University Hospital
Down Syndrome
Relationship Between BMI, Physical Fitness and Motor Skills in Children With Down's Syndrome
Down syndrome is a congenital condition which includes physical mental, and functional abnormalities. It arises from defect involving chromosome 21, usually an extra copy (trisomy 21).
- Trial name
- NCT05904821
- Where
- Pakistan
- Volunteers
- 169 people
- Sponsor
- Riphah International University
Obesity, Over-weight
An Efficacy, Safety, and Pharmacokinetics Study of Beloranib in Obese Subjects With Prader-Willi Syndrome
The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics for certain doses of beloranib in obese subjects with Prader-Willi Syndrome.
- Conditions
- Obesity, Over-weight, Prader-Willi Syndrome
- Trial name
- NCT01818921
- Testing
- ZGN-440 sterile diluent, 1.2 mg ZGN-440 for injectable suspension, 1.8 mg ZGN-440 for injectable suspension
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Zafgen, Inc.
Mucopolysaccharidosis II
A Study of JR-141 in Patients With Mucopolysaccharidosis Type II
The purpose of this study in patients with mucopolysaccharidosis type II (MPS II) is below, to collect the safety information of JR-141 to evaluate the plasma pharmacokinetics of JR-141 to explore the efficacy of JR-141 on MPS…
- Trial name
- NCT03128593
- Testing
- JR-141
- Where
- 8 sites in Japan
- Volunteers
- 14 people
- Sponsor
- JCR Pharmaceuticals Co., Ltd.
Mild Intellectual Disability
Comparison of Sensory-Adapted and Regular Dental Environments in Patients With Mild Intellectual Disability and Moderate Dental Anxiety
This study compared a sensory-adapted dental environment (SADE) with a regular dental environment (RDE) in 6-7-year-old children with mild intellectual disability and moderate dental anxiety.
- Trial name
- SADE vs RDE (NCT07413016)
- Testing
- SADE, RDE
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Oasi Research Institute-IRCCS
Self-Injurious Behavior, Problem Behavior
Expanding Interventions for Automatically Maintained SIB
The goal of this clinical trial is to demonstrate feasibility of procedures and compare the outcomes of intervention arrangements to reduce sensory based self-injurious behavior exhibited by individuals with intellectual and…
- Conditions
- Self-Injurious Behavior, Problem Behavior, Intellectual Disability, Autism Spectrum Disorder
- Trial name
- NCT06739616
- Testing
- AUTOSIB across time, AUTOSIB diminished reinforcement
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Georgia
Rett Syndrome, MECP2 Duplication Disorder
Genetic and Physical Characteristics of Rett Syndrome
Rett Syndrome (RTT) is a genetic brain disorder that occurs almost exclusively in females and is usually caused by a change (mutation) in the gene MECP2.
- Conditions
- Rett Syndrome, MECP2 Duplication Disorder, Rett-related Disorder
- Trial name
- NCT00299312
- Where
- 11 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Alabama at Birmingham
Mucopolysaccharidosis Type II (MPS II)
RGX-121 Gene Therapy in Children 5 Years of Age and Over With MPS II (Hunter Syndrome)
RGX-121 is a gene therapy which is designed to deliver a functional copy of the iduronate-2-sulfatase (IDS) gene to the central nervous system.
- Trial name
- NCT04571970
- Testing
- RGX-121
- Where
- 2 sites in United States, Canada
- Volunteers
- 6 people
- Sponsor
- REGENXBIO Inc.
Autism Spectrum Disorder (ASD), Intellectual Disability
A Cognitive Behavioral Therapy Approach to Addressing Anxiety in Children With ASD and Intellectual Disability
Anxiety can be a debilitating and common concomitant diagnosis in autism spectrum disorders (ASD). Dependent on age and subtype of anxiety, the prevalence of anxiety in individuals with autism ranges between 1.7-84%.
- Trial name
- FYF (NCT07245160)
- Testing
- Facing your Fears, Baseline Treatment
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Down Syndrome With and Without Auto Immune Abnormalities
Pilot Study of Auto-immune Abnormalities Associated With Down Syndrome
The purpose of the study is to identify biological data linked to auto immune abnormalities associated with Down Syndrome.
- Trial name
- IMMUTRI (NCT01041469)
- Where
- 2 sites in France
- Volunteers
- 72 people
- Sponsor
- Institut Jerome Lejeune
Conduct Disorder, Oppositional Defiant Disorder
A Study of the Safety and Effectiveness of Risperidone for the Treatment of Conduct Disorder and Other Disruptive Behavior Disorders in Children Ages 5 to 12 With Mild, Moderate, or Borderline Mental Retardation
The purpose of the study is to assess the safety and effectiveness of oral risperidone (an antipsychotic medication) in the treatment of conduct disorder and other disruptive behavior disorders in children ages 5 to 12 with mild…
- Conditions
- Conduct Disorder, Oppositional Defiant Disorder, Disruptive Behavior Disorder
- Trial name
- NCT00250354
- Testing
- Risperidone oral solution
- Volunteers
- 110 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium