Clinical trials: Disabilities
Prader-Willi Syndrome
Register of Patients With Prader-Willi Syndrome
Prader-Willi Syndrome (PWS) is a rare syndrome with a prevalence of 15 to 20 000 at birth. PWS represents a large fraction of mental retardation syndromes due to a genetic cause and the most frequent cause of genetic obesity.
- Trial name
- NCT02829684
- Testing
- Data collection
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Toulouse
Child Development Disorder
Craniosacral Therapy Improves Infant Neurodevelopment
Craniosacral exploration and therapy is one of the innovative palpation and treatment techniques in specialized physiotherapy, which can contribute in an efficient, subtle and sudden way to the detection of dysfunctions in the…
- Trial name
- NCT05340049
- Testing
- Academic behavioral intervention of teachers, Therapy sessions
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Clinica Gema Leon
Epilepsy, Intellectual Disabilities
Effect of the EpiSchool-M App on Teachers' Epilepsy Knowledge, Attitudes, and Self-Management
The aim of this study was to determine the effects of the training given to the teachers of children with intellectual disabilities with the "Epilepsy Management at School Mobile Health Application" and the "Digital Epilepsy…
- Conditions
- Epilepsy, Intellectual Disabilities, Teacher Training, Mobile Applications
- Trial name
- EpiSchool-M (NCT06807047)
- Testing
- Epilepsy Management at School Mobile Health Application, Digital Epilepsy Education Guide
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kafkas University
Mucopolysaccharidosis II
A Study of Tividenofusp Alfa (DNL310) in Pediatric Participants With Hunter Syndrome
This is a multicenter, multiregional, open-label study to assess the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of tividenofusp alfa (DNL310), an investigational central nervous system (CNS)-penetrant enzyme…
- Trial name
- NCT04251026
- Testing
- tividenofusp alfa
- Where
- 7 sites in United States, Canada and 2 more
- Volunteers
- 47 people
- Sponsor
- Denali Therapeutics Inc.
Child Development Disorder, Development Delay
Implementation of Electronic Shared Decision-Making Support for Early Intervention
Family-centered care is a best practice approach to delivering high quality early intervention (EI) services for children 0-3 years old with developmental needs.
- Trial name
- NCT04562038
- Testing
- Young Children's Participation and Environment Measure (YC-PEM) electronic patient-reported outcome (e-PRO)
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- University of Illinois Chicago
Epilepsy, Mental Retardation
Use of Sustained Release Antiepileptic Medication (Depakote® ER) for Pediatric Epilepsy in a Mental Retardation/Developmental Disorder Population
This study is being done to see if children with learning problems can learn how to swallow pills without chewing them. The reason this is important is that if a person has seizures, medications must be taken every day.
- Conditions
- Epilepsy, Mental Retardation, Developmental Disabilities
- Trial name
- NCT00207935
- Testing
- Swallow instruction
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's National Research Institute
B Acute Lymphoblastic Leukemia, B Lymphoblastic Lymphoma
A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia
This phase III trial studies how well blinatumomab works in combination with chemotherapy in treating patients with newly diagnosed, standard risk B-lymphoblastic leukemia or B-lymphoblastic lymphoma with or without Down…
- Conditions
- B Acute Lymphoblastic Leukemia, B Lymphoblastic Lymphoma, Down Syndrome
- Trial name
- NCT03914625
- Testing
- Asparaginase Erwinia chrysanthemi, Blinatumomab, Cyclophosphamide
- Where
- 228 sites in United States, Australia and 3 more
- Volunteers
- 6,720 people
- Sponsor
- National Cancer Institute (NCI)
Autism Spectrum Disorder, Intellectual Disability
Facing Your Fears: Adolescents With ASD and Intellectual Disability
Adolescents with ASD and intellectual disability (ID) are a complex and underserved population. Approximately 50% of individuals with ASD/ID experience significant anxiety.
- Conditions
- Autism Spectrum Disorder, Intellectual Disability, Anxiety, Emotion Regulation
- Trial name
- FYF:ASD/ID (NCT05131425)
- Testing
- Facing Your Fears: ASD/ID, Treatment as Usual
- Where
- 2 sites in United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Rett Syndrome
Creatine Metabolism in Rett Syndrome
Rett syndrome (RTT) is an X-linked severe neurodevelopmental disorder. Despite their good appetite, many females with RTT meet the criteria for moderate to severe malnutrition. The pathological mechanism is barely understood.
- Trial name
- NCT01198015
- Where
- Netherlands
- Volunteers
- 13 people
- Sponsor
- Maastricht University Medical Center
Psychological Stress, Depression
Conventional vs Mindfulness Intervention in Parents of Children With Disabilities
This application compares the effectiveness of a conventional Parent Group intervention to Mindfulness- Based Stress Reduction (MBSR) in parents of children with autism spectrum disorders (ASD) and other disabilities.
- Conditions
- Psychological Stress, Depression, Anxiety
- Trial name
- PSIP (NCT01110343)
- Testing
- mindfulness intervention, Conventional parent Support Group
- Where
- United States
- Volunteers
- 243 people
- Sponsor
- Vanderbilt University
Intellectual Disability
Equine Therapy Programme on Stress, Autonomy and Balance in School-age Children With Intellectual Disabilities
The aim of this study is to determine the impact of an equine therapy programme on the emotional state and autonomy of school-aged individuals with intellectual disabilities.
- Trial name
- NCT07497035
- Testing
- EQUINE THERAPY
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Universidad Pontificia Comillas
Multiple Sclerosis
A Retrospective Study to Understand the Clinical Management of Subjects With Multiple Sclerosis at a Site in Taiwan Over the Last 10 Years
This is an observational, non comparative, non-randomised, open-label, retrospective, single centre study planned to collect the data of subjects diagnosed with multiple sclerosis (MS) as per Poser or McDonald criteria between…
- Trial name
- NCT01084798
- Where
- Taiwan
- Volunteers
- 123 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Developmental Dysgraphia
Effectiveness of a Handwriting Intervention
The purpose of the study was to examine the effectiveness of an occupational therapy led handwriting intervention for special education and at-risk kindergarten students.
- Trial name
- NCT02620098
- Testing
- Size Matters Handwriting Program
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Temple University
Fragile X Syndrome
An Open-Label Trial of Donepezil in Fragile X Syndrome
Fragile X syndrome is the most common known inherited cause of neurodevelopmental disability. Functional magnetic resonance imaging (fMRI) studies from our laboratory indicate that specific brain regions using the neurochemical…
- Trial name
- NCT00220584
- Testing
- donepezil
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Stanford University
Language Disorders in Children, Learning; Developmental Disorder
Impact of Teacher Training and the Introduction of Early Adjustments on the Developmental Trajectory of Children at Risk of SLLD in Pre-school.
The high incidence of neurodevelopmental disorders, including specific language and learning disorders, and their profund impact on the schooling of the children concerned remains a major public health concern.
- Trial name
- PRISME-TSLA (NCT06062147)
- Testing
- Teacher training
- Where
- Reunion
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Preterm, Extreme Prematurity
Effectiveness of Home Based Early Intervention of Extremely Premature Infant by Parent
This study is to prove the effectiveness of home based early intervention of extremely premature infant by Parent.
- Conditions
- Preterm, Extreme Prematurity, Early Intervention, Developmental Delay
- Trial name
- NCT05334550
- Testing
- Home Based Early Intervention by Parent
- Volunteers
- 110 people
- Sponsor
- Samsung Medical Center
Cerebral Palsy, Child, Preschool
Effect of Power Wheelchairs on the Development and Function of Young Children With Severe Physical Disabilities
Self-produced locomotion often is limited in children with cerebral palsy and other conditions that cause severe motor impairments.
- Trial name
- NCT01115998
- Testing
- Power wheelchair, No power wheelchairs
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Oklahoma
Down Syndrome
Immune Profile and Respiratory Parameters in Down Syndrome Children With Acute Pneumonia: Pre-Intervention Analysis
Baseline serum IgG, IgA, IgM (nephelometry), total WBC count (automated analyzer), RR (manual count), and SaO2 (pulse oximetry) were measured.
- Trial name
- NCT07366593
- Testing
- Pearson or Spearman correlations were used to assess relationships between immune and respiratory variables, and with age
- Where
- 2 sites in Egypt
- Volunteers
- 40 people
- Sponsor
- Badr University
Hypotonia, Muscle, Obstructive Sleep Apnea
Long-term Evaluation of Nasopharyngeal Airway in Hypotonia
This research is studying the long term use of a nasal airway device (self-supporting nasopharyngeal airway; "ssNPA") in children with hypotonic upper airway obstruction to learn about its effectiveness and tolerability as a…
- Conditions
- Hypotonia, Muscle, Obstructive Sleep Apnea, Nasal Airway Obstruction
- Trial name
- NCT06614582
- Testing
- Self-Supporting Nasopharyngeal Airway (ssNPA)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Cerebral Palsy Children, Motor Disabilities
Implementing Powered Mobility in Early Childhood Settings for Children With Cerebral Palsy
The goal of this clinical trial is to learn if a therapist training program can help providers in Part C Early Childhood Settings use powered mobility (PM) with young children who have cerebral palsy (Gross Motor Function…
- Conditions
- Cerebral Palsy Children, Motor Disabilities, Developmental Disability, Rehabilitation
- Trial name
- NCT07220590
- Testing
- Therapist Training on Powered Mobility Implementation, Powered Mobility Intervention for Child-Caregiver Dyads
- Where
- 3 sites in United States
- Volunteers
- 70 people
- Sponsor
- Oregon Health and Science University
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