Clinical trials: Disease Spread
Covid19
Cluster-Randomized Trial of Air Filtration and Ventilation to Reduce Covid19 Spread in Homes
Investigators are evaluating whether an intervention consisting of box-fans with MERV 16 filters ("filtration fans") and recommendations for improving ventilation in the home can reduce secondary spread of Covid19 from an index…
- Trial name
- NCT05777720
- Testing
- Filtration Fan, Safe-home pamphlet, Mid-week phone call
- Where
- 2 sites in United States
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Stanford University
Tuberculosis, Pulmonary
A Study to Validate and Improve an Automated Image Analysis Algorithm to Detect Tuberculosis in Sputum Smear Slides
A Study to Validate and Improve an Automated Image Analysis Algorithm to Detect Tuberculosis in Sputum Smear Slides
- Trial name
- NCT05899400
- Testing
- Diascopic iON Image Analysis System
- Where
- Uganda
- Volunteers
- 400 people
- Sponsor
- Diascopic, LLC
Malaria
Preventing the Spread of Malaria in Mali
A vaccine which interrupts malaria transmission is a critical tool to achieve the ultimate goal of eradication of this disease. Transmission blocking vaccines work by inducing antibody in vaccinated individuals that inhibits the…
- Trial name
- NCT01360112
- Where
- Mali
- Volunteers
- 816 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis
Xpert MTB/Rif, a New Tool for the Diagnosis of Pulmonary Tuberculosis in Two Municipalities in Brazil
Diagnosis of tuberculosis (TB) is a challenge because sputum smear, the most rapid and inexpensive test, often fails to detect the disease, in around 20 to 30% of cases.
- Trial name
- NCT01363765
- Testing
- Xpert MTB/Rif, Smear microscopy
- Where
- Brazil
- Volunteers
- 34,758 people
- Sponsor
- Ataulpho de Paiva Foundation
COVID-19, Urologic Diseases
The Utility of Enhanced Pre and Post-surgical Work-out to Prevent the Spread of COVID-19 in a Large Urology Department
Since the outbreak of COVID-19 hit Spain in March 2020, most of the elective surgeries have been canceled everywhere. As soon as the epidemiology phase of the pandemic changed and the restrictions have been eased, different…
- Conditions
- COVID-19, Urologic Diseases, Surgery--Complications, Epidemic Disease
- Trial name
- UroCovid (NCT04409899)
- Testing
- Blood tests
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Fundacio Puigvert
First Episode Psychosis, Schizophrenia, Childhood
Early Psychosis Intervention - Spreading Evidence-based Treatment
Implementation of 'NAVIGATE' in Ontario aims to help youth and emerging adults suffering from a first episode of psychosis. Although Ontario already has early psychosis intervention programs, the team's recent work has identified…
- Conditions
- First Episode Psychosis, Schizophrenia, Childhood, Psychosis, Schizophrenia
- Trial name
- EPI-SET (NCT03919760)
- Testing
- NAVIGATE, Treatment as Usual
- Where
- 6 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Centre for Addiction and Mental Health
Colo-rectal Cancer
EMVI as a Determinant of Metastasis in Colorectal Cancer
Bowel cancer is the fourth most commonly occurring cancer and the second highest cause of cancer deaths in the UK. Despite advances in treatment, over 40% of patients will die within 5 years.
- Trial name
- EVIDENCE (NCT06646341)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Imperial College London
Venous Thromboembolism, Delivery of Health Care
Improving Venous Thromboembolism Prophylaxis
Preventing the formation of blood clots in the veins so they do not injure leg veins or travel to the lungs, also called venous thromboembolism prophylaxis (VTE-P) is an essential component of safe in-patient care, yet it is…
- Conditions
- Venous Thromboembolism, Delivery of Health Care, Quality Improvement
- Trial name
- NCT01304108
- Testing
- VTE-P Tollgate, BLAZE Pop up, Usual Care
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Falciparum; Malaria
The Transmission of Artemisinin Resistant Parasites Before and After Conventional Artemisinin-combination Therapy
A prospective study will be carried out in an area where parasites with reduced sensitivity to malaria drugs (artemisinins) have recently emerged.
- Trial name
- SPARTAN (NCT06347471)
- Testing
- Artemether-lumefantrine, Dihydroartemisinin-Piperaquine
- Where
- 2 sites in Uganda
- Volunteers
- 160 people
- Sponsor
- Infectious Diseases Research Collaboration, Uganda
Carcinoma, Basal Cell, Porokeratosis, Disseminated Superficial Actinic
Cytodiagnosis of Basal Cell Carcinoma and Actinic Keratosis Using Papanicolaou and May-grunwald-giemsa Stained Tissue Smear
The purpose of this study is to compare and evaluate the diagnostic performance of scrape cytology using two different cytological staining techniques, and to evaluate additional touch imprint cytology with that of histopathology…
- Trial name
- NCT00218868
- Testing
- Skin scrape
- Where
- Norway
- Volunteers
- 66 people
- Sponsor
- Norwegian University of Science and Technology
Dengue, Chikungunya
Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective
RACSMEI addresses the high burden of infectious diseases in low- and middle-income countries, including Cambodia, where limited surveillance and laboratory capacity often obscure etiologies and transmission dynamics.
- Conditions
- Dengue, Chikungunya, Zika Virus Infection, Japanese Encephalitis
- Trial name
- RACSMEI (NCT07358910)
- Where
- Cambodia
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur du Cambodge
Malaria, Falciparum
A Study by the Tracking Resistance to Artemisinin Collaboration (TRAC)
This study is an open-label randomised trial comparing standard ACT treatment with matching triple artemisinin-based combination therapies (TACTs), evaluating efficacy in safety and tolerability.
- Trial name
- TRACII (NCT02453308)
- Testing
- ACT, TACT
- Where
- 20 sites in Bangladesh, Burma and 6 more
- Volunteers
- 1,110 people
- Sponsor
- University of Oxford
Malnutrition
Effectiveness Trial on Alleviation of Infant Malnutrition With Fortified Spread or Maize-Soy Flour Food Supplements
This study tests the hypothesis that moderately underweight but not severely wasted 6-17-month old infants receiving fortified spread or maize-spy flour as a food supplement for 12 weeks grow better during the supplementation…
- Trial name
- NCT00420758
- Testing
- Food supplement: fortified spread, Food supplement: maize-soy flour
- Where
- Malawi
- Volunteers
- 299 people
- Sponsor
- Tampere University
Leprosy, Leprosy Neuropathy
Accuracy of the Polymerase Chain Reaction of Ulnar Perineural Subcutaneous Aspirate Guided by Ultrasound for the Diagnosis and Monitoring of Leprosy Cure
Brief Summary Leprosy is a chronic granulomatous infectious disease caused by *Mycobacterium leprae* or *Mycobacterium lepromatosis*, characterized by peripheral nerve involvement that may lead to progressive neurological damage…
- Conditions
- Leprosy, Leprosy Neuropathy, Leprosy, Multibacillary, Leprosy--Patients
- Trial name
- Does not exist (NCT07515989)
- Testing
- Ultrasound-Guided Ulnar Perineural Subcutaneous Aspirate
- Where
- Brazil
- Volunteers
- 108 people
- Sponsor
- University of Brasilia
Blood Disease, Cytomegalovirus Infections
Cytomegalovirus Spread and Reactivation in Blood Cells
To investigate the relationship between HCMV and bone marrow progenitor cells to understand whether HCMV is latent in CD34 + bone marrow progenitors and the mechanism by which the virus remains in a latent state.
- Trial name
- NCT00006314
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cerebral Palsy and Botulinum Toxin
Spread And Effectiveness Of Botulinum Neurotoxin A In Spastic Equinus In Cerebral Palsy
Objectives. To study the short-term neurophysiological and clinical outcome of botulinum toxin type A(BoNT-A), injected at standard doses, and assess toxin spread to neighboring uninjected muscles in children with cerebral palsy.
- Trial name
- NCT01276015
- Testing
- Botulinum Toxin Type A
- Volunteers
- 18 people
- Sponsor
- Universita di Verona
Malaria
Malaria Prevalence Around Maferinyah, Guinea
Background: Many women in Sub-Saharan Africa get malaria while they are pregnant. Plasmodium falciparum is a parasite that can cause malaria. Placental malaria (PM) caused by P.
- Trial name
- NCT04105855
- Where
- Guinea
- Volunteers
- 3,392 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Onychomycosis, Tinea Pedis
Spread of Dermatophytes Among Families
The objective is to demonstrate person-to-person spread of dermatophytes of the skin and nails among family members, as measured by fungal culture and DNA typing of the dermatophytes isolated.
- Trial name
- NCT00233493
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Pancreatic Cancer
Comparison Between Base and Cover Slide From Endoscopic Ultrasound Guided Fine Needle Aspiration for Pancreatic Cancer
The purpose of this study is to determine whether there is a difference of diagnostic accuracy between cover slides and base slides from EUS-FNA cytopathologic sample in patients who were previously suspected of pancreatic cancer…
- Trial name
- EUS-FNA (NCT02190071)
- Where
- South Korea
- Volunteers
- 73 people
- Sponsor
- Seoul National University Hospital
Cervical Cancer, Cancer
The Association Between Cervical Cancer Screening and Cancer Occurrence
To investigate the protective effect of cervical cancer incidence and mortality by screening attending frequency or screening pattern, and to evaluate the possible risk of developing malignancies among women with cervical…
- Trial name
- NCT01015079
- Where
- Taiwan
- Volunteers
- 6,000,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital