Clinical trials: Disease Spread
Melanoma, Clear-Cell Renal-Cell Carcinoma (ccRCC)
A First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their Body
This study is researching an experimental drug called REGN10597 alone or in combination with another drug called cemiplimab (called "study drug(s)").
- Conditions
- Melanoma, Clear-Cell Renal-Cell Carcinoma (ccRCC), Advanced Solid Tumors
- Trial name
- BrILliance (NCT06413680)
- Testing
- REGN10597, Cemiplimab
- Where
- 11 sites in United States
- Volunteers
- 240 people
- Sponsor
- Regeneron Pharmaceuticals
COVID-19
Characterizing the Perioperative Epidemiology of SARS-CoV-2 (COVID-19) Spread for Quality Improvement of Perioperative Infection Control Program
In a case-series analysis, up to 20 patients undergoing elective or urgent/emergent surgery that are COVID-19 positive will be approached for patient consent.
- Trial name
- NCT04443803
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Randy Loftus
Subarachnoid Hemorrhage, Intracerebral Hemorrhage
Multimodal Neuromonitoring
Theoretical Framework \& Background Cortical spreading depressions (CSD) and seizures, are crucial in the development of delayed cerebral ischemia and poor functional outcome in patients suffering from acute brain injuries such…
- Conditions
- Subarachnoid Hemorrhage, Intracerebral Hemorrhage, Traumatic Brain Injury, Cortical Spreading Depolarization and Depression
- Trial name
- MMNM (NCT04737369)
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna
Nurse's Role, Pain Management
Effect of Virtual Reality on Pain and Anxiety During Pap Smear Testing
This randomized controlled pretest-posttest experimental study aims to evaluate the effect of virtual reality (VR) on pain and anxiety levels experienced during Pap smear sampling.
- Conditions
- Nurse's Role, Pain Management, Cervical Cancer Screening, Anxiety
- Trial name
- NCT07462039
- Testing
- Virtual Reality
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
Bacterial Vaginosis (BV)
LUXSOL(TM) Topical Cream for the Treatment of Symptomatic Bacterial Vaginosis; A Proof of Concept Study
LUXSOL Cream may be useful for the treatment of bacterial Vaginosis. In this study, LUXSOL Cream is compared to a control arm group using metronidazole cream.
- Trial name
- NCT02197182
- Testing
- LUXSOL copper containing cream, Metronidazole gel
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- CDA Research Group, Inc.
Covid19
Cluster-Randomized Trial of Air Filtration and Ventilation to Reduce Covid19 Spread in Homes
Investigators are evaluating whether an intervention consisting of box-fans with MERV 16 filters ("filtration fans") and recommendations for improving ventilation in the home can reduce secondary spread of Covid19 from an index…
- Trial name
- NCT05777720
- Testing
- Filtration Fan, Safe-home pamphlet, Mid-week phone call
- Where
- 2 sites in United States
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Stanford University
Metastatic Renal Cell Carcinoma, Brain Metastases
A Study of Cabozantinib and Nivolumab With Radiation Therapy for People With Renal Cell Carcinoma That Has Spread to the Brain
The purpose of this study is to find out whether the combination of cabozantinib, nivolumab, and radiation therapy is a safe and effective treatment that causes few or mild side effects in people with renal cell cancer that has…
- Trial name
- NCT06132945
- Testing
- Cabozantinib, Nivolumab, Stereotactic Radiosurgery (SRS)
- Where
- 7 sites in United States
- Volunteers
- 2 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cervical Cancer, Pathological Screening Smear
Comparison of 2 Types of Cervical Specimens in Patients With a Pathological Screening Smear
The recommendations on the method and the realization of the cervico-uterine smears are clear. With regard to performing endocervical curettage, several methods are possible without precise consensus.
- Trial name
- ENDOCOL (NCT04000477)
- Testing
- Cytobrush, Kevorkian curette
- Where
- France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Lille
Total Knee Anthroplasty, Postoperative Pain
Proximal Spread in Adductor Canal Block(ACB)
This prospective, randomized clinical study is designed to evaluate the effects of two different injection levels of adductor canal block (ACB) on the proximal spread of local anesthetic and clinical outcomes in patients…
- Trial name
- ACB (NCT07595471)
- Testing
- Comparison of Proximal Adductor Canal Block, Comparison True Distal Adductor Canal Block.
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Ankara Etlik City Hospital
Traumatic Brain Injury
Observational Study of Cortical Spreading Depression in Human Brain Trauma
Since the primary damage from traumatic brain injury (TBI) is irreversible, the focus of medical management of TBI is preventing secondary injury that can be life-threatening and worsen patient outcome.
- Trial name
- COSBID-TBI (NCT00803036)
- Where
- 5 sites in United States, United Kingdom
- Volunteers
- 165 people
- Sponsor
- University of Cincinnati
Tuberculosis, Pulmonary
A Study to Validate and Improve an Automated Image Analysis Algorithm to Detect Tuberculosis in Sputum Smear Slides
A Study to Validate and Improve an Automated Image Analysis Algorithm to Detect Tuberculosis in Sputum Smear Slides
- Trial name
- NCT05899400
- Testing
- Diascopic iON Image Analysis System
- Where
- Uganda
- Volunteers
- 400 people
- Sponsor
- Diascopic, LLC
Prostate Cancer, Metastatic (Spread to Other Areas of the Body)
BKM120 in Metastatic Castration-resistant Prostate Cancer
The purpose of this study is to evaluate the effects of the study drug, BKM120. The study drug, BKM120, is an inhibitor of a protein called phosphatidyl inositol-3-kinase (PI3K).
- Trial name
- NCT01385293
- Testing
- BKM120
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Andrew J. Armstrong, MD
Rectal Cancer
DETECT: Target Volume for Rectal Endoluminal Radiation Boosting
The aim of the study is to provide prospective data regarding microscopic tumor spread in all directions from the macroscopic tumor in pathology specimens, as seen by eye, and on imaging to define the target volume for…
- Trial name
- DETECT (NCT04927897)
- Testing
- Ultrasound, Rectoscopy, Scan, e.g. CT (resection specimen)
- Where
- 3 sites in Netherlands
- Volunteers
- 50 people
- Sponsor
- Maastricht Radiation Oncology
Subarachnoid Hemorrhage, Aneurysmal
Pilot Study of Ketamine Sedation for Aneurysmal Subarachnoid Hemorrhage
Aneurysmal subarachnoid hemorrhage (aSAH) is bleeding into the space between the brain and the tissues that surround the brain as a result of a ruptured aneurysm and is a type of stroke associated with high morbidity and…
- Trial name
- PENDULUM (NCT05032118)
- Testing
- Ketamine Hydrochloride, Propofol
- Sponsor
- Jenna L Leclerc MD, PhD
Cystic Fibrosis
Contraceptive Practices and Cervical Screening in Women With Cystic Fibrosis
Little is known about gynaecological follow-up and cervical screening in Cystic Fibrosis (CF). Only few studies have described contraceptive practices in cohorts of CF women.
- Trial name
- NCT02847208
- Testing
- self-report written questionnaire
- Where
- France
- Volunteers
- 155 people
- Sponsor
- Hospices Civils de Lyon
Breast Cancer
Combination Chemotherapy in Treating Women With Stage II or Stage IIIA Breast Cancer That Has Spread to the Lymph Nodes
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known which regimen of chemotherapy is more effective for breast cancer.
- Trial name
- NCT00004125
- Testing
- cyclophosphamide, docetaxel, doxorubicin hydrochloride
- Where
- 48 sites in United States
- Sponsor
- Eastern Cooperative Oncology Group
Malaria
Preventing the Spread of Malaria in Mali
A vaccine which interrupts malaria transmission is a critical tool to achieve the ultimate goal of eradication of this disease. Transmission blocking vaccines work by inducing antibody in vaccinated individuals that inhibits the…
- Trial name
- NCT01360112
- Where
- Mali
- Volunteers
- 816 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Adenoma Colon, Colon Adenoma
Conventional Endoscopic Mucosal Resection Versus Cold Snare Endoscopic Mucosal Resection of Colonic Lateral Spreading Lesions - A Randomised Controlled Trial
Comparing the complete resection rate and subsequent adenoma recurrence rate at surveillance colonoscopy of 15-40mm laterally spreading adenomas for conventional EMR vs. cold snare EMR.
- Conditions
- Adenoma Colon, Colon Adenoma, Colon Cancer
- Trial name
- NCT04138030
- Testing
- Conventional Endoscopic Mucosal Resection, Cold Snare Endoscopic Mucosal Resection
- Where
- Australia
- Volunteers
- 182 people
- Sponsor
- Western Sydney Local Health District
SARS-CoV-2 Acute Respiratory Disease
Povidone Iodine Nasal Application to Prevent Intraoperative Spread of SARS-CoV-2
The primary aim is to test whether preoperative asepsis with 5% nasal povidone iodine versus no preoperative asepsis with 5% nasal povidone iodine reduces proximal and distal SARS-CoV-2 transmission in operating rooms among…
- Trial name
- NCT05745467
- Testing
- Povidone Iodine 5% Soln,Top,Kit
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Iowa
Cancer Cervix
Vaginal Self-sampling and Human Papillomavirus Testing in Unscreened Women
Despite the existence of an effective screening test (pap smear), cervical cancer is, every year in France, the cause of more than 3,000 new cases and 1,100 deaths.
- Trial name
- APACHE-3 (NCT02255084)
- Testing
- Group 1 remove self sample kit at gp consulting room or perform pap smear, Group 2 perform self sample at home or pap smear
- Where
- France
- Volunteers
- 3,612 people
- Sponsor
- University Hospital, Tours