Clinical trials: Drug Reaction
Medication Errors
Electronic Prescribing and Electronic Transmission of Discharge Medication Lists
The purpose of this study is twofold: 1. to measure the effects of transitioning from one electronic prescribing system to another in the ambulatory setting on medication errors and human-computer interactions 2.
- Trial name
- NCT00603070
- Testing
- E-prescribing system, Electronic transmission of medication discharge lists
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Weill Medical College of Cornell University
Adverse Drug Event
Improving Wisely - Polypharmacy
This is a randomized controlled trial that uses an audit and feedback intervention to alert primary care physicians who are outliers in one or more metrics related to high risk prescribing of participants' outlier status.
- Trial name
- NCT03857100
- Testing
- Audit and feedback - letter and report
- Where
- United States
- Volunteers
- 11,000 people
- Sponsor
- Johns Hopkins University
Oncolytic Virus, Diffuse Intrinsic Pontine Glioma
Oncolytic Virus Ad-TD-nsIL12 for Progressive Pediatric Diffuse Intrinsic Pontine Glioma
This is a single-arm, single-center, drug safety assessment clinical trial with a 3+3 dose escalation design, to observe the safety, tolerability and toxicity of a novel oncolytic virus Ad-TD-nsIL12 intratumoral injection in…
- Conditions
- Oncolytic Virus, Diffuse Intrinsic Pontine Glioma, Adverse Drug Event
- Trial name
- NCT05717699
- Testing
- Ad-TD-nsIL12
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Capital Medical University
Clinical Efficacy, Treatment Efficacy
Lubiprostone for Functional Constipation in the Under 18 Years Patients
The investigators will enroll subjects 8 - < 18 years of age, fulfilling Rome IV criteria for functional constipation. Participants will be randomly assigned to either Lubiprostone treatment (study group), or the control group…
- Conditions
- Clinical Efficacy, Treatment Efficacy, Drug Side Effect
- Trial name
- NCT05144295
- Testing
- Lubiprostone Pill, Lactulose Oral Liquid Product, Bisacodyl 5 MG
- Where
- 2 sites in Egypt
- Volunteers
- 274 people
- Sponsor
- Alexandria University
Covid19, Ivermectin Poisoning
Adverse Effects of Ivermectin Used in Egypt During COVID-19
retrograde study of common and rare adverse effects of multiple doses of ivermectin used during the coivd 19 pandemic in egypt
- Conditions
- Covid19, Ivermectin Poisoning, Drug Toxicity, Drug Side Effect
- Trial name
- NCT04747678
- Testing
- Ivermectin
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Menoufia University
Electrode Site Reaction, Therapy
Functional Electrostimulation on the Upper Lip in Multiple Sclerosis
Multiple sclerosis (MS) is an autoimmune disease where immune cells attack the body, triggering an inflammatory response. A study comparing multifield FES and conventional FES on upper extremity motor skills and functional…
- Conditions
- Electrode Site Reaction, Therapy, Directly Observed Therapy
- Trial name
- EM/2024 (NCT06638775)
- Testing
- Fesia Grasp, GLOBUS ELITE
- Volunteers
- 30 people
- Sponsor
- Universidad de Burgos
Adverse Drug Event
Effectiveness of an ADE-related Hospitalization Risk Prediction Tool for Patients (ADE-RED)
The rationale for this study is to evaluate the effectiveness of a risk prediction tool for patients who are at high risk for ADEs resulting in hospitalization or ED revisit.
- Trial name
- NCT04181775
- Testing
- ADE-RED scoring tool
- Where
- United States
- Volunteers
- 471 people
- Sponsor
- Methodist Health System
Upper Respiratory Tract Infection;, Acute Tracheobronchitis
A Registry Study on Reduning（a Chinese Medicine Injection）Used in Hospitals in China
This study was advocated by Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences in January 2013.
- Trial name
- NCT01824719
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- China Academy of Chinese Medical Sciences
Drug Hypersensitivity Reaction
Prediction of Rituximab Hypersensitivity and Desensitization Treatment
This is a single-center prospective single arm study. The purpose of this study is to assess the usefulness of skin test as a diagnostic tool to predict the hypersensitivity to rituximab in Chinese population, evaluate the rate…
- Trial name
- NCT04610242
- Testing
- skin test
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking Union Medical College Hospital
Cytochrome P450 2D6 Ultra-rapid Metabolism
CYP2D6 Screening for Adverse Drug Reactions to Codeine in Breast Milk
The purpose of this study is to determine if non-invasive salivary genetic screening of breastfeeding mothers taking codeine will allow for the successful identification of mother-infant pairs susceptible to adverse events and to…
- Trial name
- NCT01050400
- Testing
- Cytochrome P450 2D6 (CYP2D6) genetic screening.
- Where
- Canada
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Adverse Effects, Adverse Drug Event
How Safe Are Our Pediatric Emergency Departments?
Patient safety is an internationally recognized health care priority. Canadian data suggests that about 8% of adults admitted to hospital experience unintended harm (or 'adverse events') from the health care provided during their…
- Trial name
- NCT02162147
- Where
- 10 sites in Canada
- Volunteers
- 6,385 people
- Sponsor
- Children's Hospital of Eastern Ontario
Adverse Drug Reaction, Cinepazide
Post-Marketing Surveillance of the Cinepazide Maleate Injection: a Real World Study
Cinepazide Maleate Injection is widely used in cerebrovascular disease in china. The safety of the cinepazide, especially the blood system, has not been fully evaluated in Chinese population.
- Conditions
- Adverse Drug Reaction, Cinepazide, Stroke
- Trial name
- PACER (NCT01946919)
- Where
- 61 sites in China
- Volunteers
- 18,260 people
- Sponsor
- Peking University Third Hospital
Drug-induced Disorder of Liver, Adverse Reaction to Drug
Cells of Monocytic Origin as Surrogate Markers for Individual Drug Effects and Hepatotoxicity
Drug metabolism in the liver is subject to large fluctuations (differences between women and men, people of different ethnic backgrounds, children and adults).
- Trial name
- NCT02353455
- Testing
- Blood sampling
- Where
- 5 sites in Australia, Germany and 3 more
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Andreas Benesic, MD
COVID-19 Vaccine Adverse Reaction
Safety Study About the mRNA Vaccines Against COVID-19 in Children (PEDIVACOV-HCSC)
Drugs side effects in children need to be evaluated in a different way because of their constant growth and body changes. The use of COVID-19 vaccines (mRNA vaccines) is worldwide spread as a safety measure against the pandemic.
- Trial name
- PEDIVACOV-HCSC (NCT06646744)
- Testing
- mRNA COVID-19 vaccine
- Where
- Spain
- Volunteers
- 2,100 people, healthy volunteers welcome
- Sponsor
- Ana Belen Rivas Paterna
Steven-Johnson Syndrome, Toxic Epidermal Necrolysis
Severe Cutaneous Adverse Reactions in Thailand
The multicenter registry of patients with severe cutaneous adverse reactions among tertiary medical institutes in Thailand to study clinical characteristics, etiologies, therapeutic outcomes, quality of life, and the values of in…
- Conditions
- Steven-Johnson Syndrome, Toxic Epidermal Necrolysis, Drug Reaction With Eosinophilia and Systemic Symptoms, Acute Generalized Exanthematous Pustulosis
- Trial name
- ThaiSCAR (NCT02574988)
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Chulalongkorn University
Medication Safety
Pharmacist and Data Driven Quality Improvement in Primary Care
P-DQIP is an intervention to improve prescribing safety in primary care. The 'intervention' is a health board quality improvement programme that will be implemented across all practices in one National Health Service (NHS) board…
- Trial name
- P-DQIP (NCT03747107)
- Testing
- P-DQIP
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- University of Dundee
Perioperative Complication, Perioperative/Postoperative Complications
Registry of Anesthesia and Perioperative Medicine
To assess mortality and morbidity associated to anesthesia interventions
- Conditions
- Perioperative Complication, Perioperative/Postoperative Complications, Anesthesia Morbidity, Anesthesia; Adverse Effect
- Trial name
- RAMP (NCT05869578)
- Testing
- Anesthesia Intervention
- Where
- Chile
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Clinica Alemana de Santiago
Lymphoma, T-cell, Peripheral, Lymphoma, T-cell, Cutaneous
A Study of Remitoro in Participants With Recurrent or Refractory Peripheral T Cell Lymphoma and Cutaneous T Cell Lymphoma (All Case Study)
The primary purpose of the study is to investigate the incidence of adverse drug reactions (ADRs) (ADR of special interest: capillary leak syndrome, infusion reaction, rhabdomyolysis, myelosuppression, infection, hepatic…
- Trial name
- NCT05137847
- Testing
- Remitoro
- Where
- 3 sites in Japan
- Volunteers
- 118 people
- Sponsor
- Eisai Inc.
Adverse Drug Reaction, Drug Allergy
Post-Marketing Surveillance of the Tanreqing Injection: a Real World Study
Tanreqing Injection is widely used in respiratory disease with Chinese medicine syndrome of retention of phlegm and heat in Fei.
- Trial name
- NCT02094638
- Where
- 90 sites in China
- Volunteers
- 30,400 people
- Sponsor
- Suodi ZHAI
Injection Reactions Site, Systemic Reactions
Can Epinephrine Coated Syringe for Subcutaneous Immunotherapy (SCIT) Reduce Large Local Reaction?
Allergen immunotherapy is effective in the management of allergic asthma, allergic rhinitis/conjunctivitis, and stinging insect hypersensitivity.
- Trial name
- NCT03963115
- Testing
- Epinephrine or normal saline
- Where
- Thailand
- Volunteers
- 17 people
- Sponsor
- Mahidol University