Clinical trials: Drug Use Disorder, open to volunteers
Microbiome Analysis, Drug Abuse in Pregnancy
Alcohol and Cannabis Use Among Pregnant Slovenian Women
The aim of the study is to determine the prevalence of alcohol and drug use among Slovenian pregnant women. Alcohol and drug use during pregnancy has significant effects on the foetus and has short- and long-term health…
- Conditions
- Microbiome Analysis, Drug Abuse in Pregnancy, Alcohol Abuse in Pregnancy, Health Behavior, Risky
- Trial name
- NCT07456579
- Where
- Slovenia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Endodontic Disease
Postoperative Pain and Incidence of Extrusion Following the Use of Two Intra-canal Medications in Retreatment of Single Rooted Teeth
This study aims to compare the postoperative pain and incidence of extrusion of two intracanal medications in the retreatment of single-rooted teeth.
- Trial name
- NCT06913673
- Testing
- Bio-c Temp, Metapex
- Volunteers
- 30 people
- Sponsor
- Minia University
Opiate-Related Disorders, Opiate Use Disorder
MedSMA℞T Mobile ED
The goal of this clinical trial is to learn if a new smartphone-based intervention can help with factors related to opioid misuse in parents and adolescent/early adult children.
- Conditions
- Opiate-Related Disorders, Opiate Use Disorder, Opioid
- Trial name
- NCT06848504
- Testing
- MedSMA℞T Mobile
- Where
- 3 sites in United States
- Volunteers
- 244 people
- Sponsor
- Olufunmilola Abraham
Autistic Disorder, Autism Spectrum Disorder
SQUED™ Series 28.1 Home-use and Treatment of Autowave Reverberator of Autism
Locomotor, transport and information functions in human body systems are carried out by active media in autowave regimes! Any living organism is a (micro-macro-mega) hierarchy of autowave subsystems-an ensemble of loosely coupled…
- Conditions
- Autistic Disorder, Autism Spectrum Disorder, Child Development Disorders, Pervasive, Neurodevelopmental Disorders
- Trial name
- SQUED™ (NCT03222375)
- Testing
- SQUED™ series 28.1 home-use
- Where
- 2 sites in United States, Ukraine
- Volunteers
- 80 people
- Sponsor
- American Federation of Medical Synergetics
Aplastic Anemia
Revolade Tablets Specified Drug-use Survey
This is a multicenter, single-arm, non-interventional study (NIS) to confirm the safety and efficacy of eltrombopag in Anti-Thymocyte Globulin (ATG) treatment naive pediatric patients with aplastic anemia (AA).
- Trial name
- NCT06287268
- Testing
- eltrombopag
- Where
- 17 sites in Japan
- Volunteers
- 10 people
- Sponsor
- Novartis Pharmaceuticals
Pompe Disease
Pompe Disease RWE Long-term Monitoring Program
Evaluate short- and long-term biomarker, motor function, respiratory function and safety with avalglucosidase alfa in IOPD and LOPD patients who switched from other ERT.
- Trial name
- NCT07834320
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Persistent Pulmonary Hypertension of Newborn
Treprostinil in Newborns With Pulmonary Hypertension; a Non-Interventional Study to Collect Data on Drug Utilization, Safety, and Effectiveness
This observational study will seek to describe the uses and safety and efficacy outcomes of treprostinil in clinical practice in patients with persistent pulmonary hypertension (PPHN).
- Trial name
- NEPHY (NCT06499363)
- Where
- 4 sites in France
- Volunteers
- 60 people
- Sponsor
- Ferrer Internacional S.A.
Myocarditis, Cardiomyopathies
JOint Use of Database to Identify Risk Factors of CARDio-vascular Toxicity Induced by Immune Checkpoint Inhibitors
Immune checkpoint inhibitors (ICIs) might induce high grade immune-related adverse events (irAEs) involving the cardio-vascular system.
- Conditions
- Myocarditis, Cardiomyopathies, Heart Diseases, Cardiovascular Diseases
- Trial name
- JOCARDITE (NCT04294771)
- Testing
- ICI
- Where
- France
- Volunteers
- 500,000 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Alcohol Abuse, Substance Use
Adaptation and Evaluation of Bright Horizons
This study will test if a program called 'Bright Horizons' is effective at reducing binge substance use among adolescents. Bright Horizons is a culturally adapted intervention developed and tested through a partnership between…
- Trial name
- NCT05743699
- Testing
- Bright Horizons, Case Management
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Medication Abuse, Harm Reduction
Evaluation of Clinical Decision Support in Opioid Tapering
The 2022 Center for Disease Control and Prevention (CDC) clinical practice guideline for prescribing opioids for pain recommends that when tapering a patient's opioid dose, doses should be decreased at a slow rate to reduce the…
- Conditions
- Medication Abuse, Harm Reduction, Opioid Use Disorder, Opioid Prescribing
- Trial name
- NCT06527079
- Testing
- Observational study without a prospective intervention
- Volunteers
- 200,000 people
- Sponsor
- University of Colorado, Denver
Apnea of Prematurity
MICropsampling for CAffeine in PREMature Newborns
Caffeine is one of the top five most prescribed drugs in neonatology. Caffeine has many beneficial impacts on preterm infants (cardiac, neurologic and pulmonary). One of these beneficial impacts is to prevent apnea.
- Trial name
- MICCAPREM (NCT07779915)
- Testing
- collection of an extra drop of capillary blood
- Where
- 2 sites in France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Limoges
Substance Use (Drugs, Alcohol)
Adaptation of the Family Check-Up Online
Latinx people are the largest and fastest growing minority population in the U.S., yet most lack access to community responsive preventative interventions to reduce substance use among youth.
- Trial name
- NCT07025083
- Testing
- Adapted Family Check-Up Online, Original Family Check-Up Online
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Adolescent Alcohol Use, Mental Health Issue
Centralized Virtual SBIRT for Pediatric Primary Care
Adolescent alcohol and other drug (AOD) use is a significant public health problem which contributes to high levels of mortality, morbidity and healthcare costs in young people, and identification and early intervention for these…
- Conditions
- Adolescent Alcohol Use, Mental Health Issue, Alcohol Related Disorders, Adolescents
- Trial name
- NCT06486688
- Testing
- Centralized Virtual SBIRT
- Where
- United States
- Volunteers
- 22,320 people
- Sponsor
- Kaiser Permanente
Abdominal Injuries, Alcohol Intoxication
Alcohol, Psychoactive Drugs, Analgesics and Evaluation in Penetrating Abdominal Trauma
This prospective observational study aims to evaluate whether alcohol consumption, psychoactive drug use, or prior administration of analgesics affects the clinical evaluation and surgical decision-making process in patients with…
- Conditions
- Abdominal Injuries, Alcohol Intoxication, Substance-related Disorders, Penetrating Abdominal Trauma
- Trial name
- DIRECT (NCT07330349)
- Testing
- Alcohol consumption, Psychoactive substance use, Analgesic administration
- Where
- 2 sites in Colombia
- Volunteers
- 363 people
- Sponsor
- Fundacion Clinica Valle del Lili
Venous Thromboembolism, Children Under 2 Years
A Study to Observe the Pattern of Use and Safety of Rivaroxaban in Children Under 2 Years Old With Venous Thromboembolism (VTE)
This is an observational study in which only data are collected from participants receiving their usual treatment. The study is done in children under 2 years old with venous thromboembolism (VTE).
- Trial name
- XAPAEDUS (NCT05900388)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), Standard of care (SOC)
- Where
- 4 sites in Denmark, France and 2 more
- Volunteers
- 850 people
- Sponsor
- Bayer
Community Acquired Pneumonia in Children, Antibiotic Stewardship
Antibiotic Prescription in Children Hospitalized for Community-acquired Pneumonia
A study to observe how often antibiotics are prescribed in children hospitalized for pneumonia and how doctors decide if a child needs antibiotics or not. Parent satisfaction will also be recorded.
- Trial name
- NCT04681339
- Testing
- Antibiotic treatment, No antibiotic treatment
- Where
- 2 sites in Germany
- Volunteers
- 200 people
- Sponsor
- ARCIM Institute Academic Research in Complementary and Integrative Medicine
Leigh Syndrome (Maternally Inherited, MILS), Leigh Syndrome (AR, AD, XR)
Drug Repurposing for Mitochondrial Disorders Using iPSCs Derived Neural Cells
In this project, the investigators are using iPSC lines derived from patients with Leigh syndrome that carry mutations in the mitochondrial (mtDNA) and in the nuclear DNA (nDNA) to reprogram them into neural progenitor cells and…
- Trial name
- cureMILS (NCT06967831)
- Testing
- skin biopsy, generation of iPSCs, blood drawing
- Where
- 2 sites in Germany
- Volunteers
- 80 people
- Sponsor
- Charite University, Berlin, Germany
Acute Renal Failure (ARF), Acute Tubular Necrosis
Use of QRX3 for Acute Tubular Necrosis Type of Renal Failure in Hospitalized Patients ( QRX-3 in ARF)
Use of QRX-3 in hospitalized patients with pediatric and adult patients with acute tubular necrosis renal failure
- Trial name
- QRX3 in ARF (NCT07161843)
- Testing
- QRX-3
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Ebima Clifford Okundaye
Opioid-use Disorder, Opioid Dependence
Young Houston Emergency Opioid Engagement System
The Houston Emergency Response Opioid Engagement System for Youths and Adolescents (Young HEROES) is a community-based research program integrating assertive outreach, medication for opioid use disorder (MOUD), behavioral…
- Conditions
- Opioid-use Disorder, Opioid Dependence, Opioid Overdose, Opioid Use
- Trial name
- YHEROES (NCT04811014)
- Testing
- Buprenorphine, Naloxone Drug Combination, Individual Counseling, Peer Recovery Support Services
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- The University of Texas Health Science Center, Houston