Clinical trials: Dyskinesia
Ataxia
Special Drug Use Investigation for Arixtra® (Fondaparinux) Venous Thromboembolism Treatment
The purpose of this post-marketing surveillance study is to collect and assess information on safety and efficacy of fondaparinux injection in patients with venous thromboembolism (VTE).
- Trial name
- NCT01428531
- Testing
- Fondaparinux Sodium
- Volunteers
- 200 people
- Sponsor
- GlaxoSmithKline
Essential Tremor
1-Octanol to Treat Essential Tremor
This study will determine the optimal dose of 1-octanol that will safely reduce tremors in patients with essential tremor-a disorder in which the hands, and sometimes the head, shake involuntarily.
- Trial name
- NCT00016679
- Testing
- 1-Octanol
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Tourette Syndrome, Tic Disorder, Chronic Motor or Vocal
Open-label MNS for Tourette Syndrome
A recent report (Morera Maiquez et al 2020) described reduced tic severity in people with Tourette syndrome during 1-minute epochs of median nerve stimulation (MNS) at 10 Hz.
- Trial name
- NCT05016765
- Testing
- Active, self-directed electrical stimulation of the median nerve
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Washington University School of Medicine
Ataxia, Chorea
Amantadine for Improving Neurologic Symptoms in Ataxia-Telangiectasia
Ataxia-Telangiectasia A-T is a neurodegenerative disorder of the cerebellum, manifesting with ataxia, as well as extrapyramidal features.
- Conditions
- Ataxia, Chorea, Dystonia, Parkinsonism
- Trial name
- NCT00950196
- Testing
- amantadine sulphate
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Idiopathic Parkinson Disease, Dyskinesias
Reliability and Validity Study of the Turkish Version of the Parkinson's Disease Dyskinesia Scale (PDYS-26)
The aim of this methodological study was to investigate the Turkish validity and reliability of the Parkinson's Disease Dyskinesia Scale (PDYS-26).The scale evaluates choreic dyskinesia.Measures the impact of dyskinesia on…
- Conditions
- Idiopathic Parkinson Disease, Dyskinesias, Quality of Life
- Trial name
- NCT07023224
- Testing
- Turkish version of the Parkinson's Disease Dyskinesia Scale (PDYS-26)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 130 people
- Sponsor
- Izmir Bakircay University
Ataxia-Telangiectasia (A-T)
Cell-Based Approaches For Modeling and Treating Ataxia-Telangiectasia
This research is being done to better understand the causes of the disease Ataxia-Telangiectasia and, in the longer-term, develop new therapies for the disease using stem cells.
- Trial name
- NCT02246491
- Testing
- A-T iPS cell line, Carrier patients iPS cell line
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Johns Hopkins University
Dystonia, Drug Induced Dystonia
Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia
This research involves retrospective and prospective studies for clinical validation of a DystoniaNet deep learning platform for the diagnosis of isolated dystonia.
- Conditions
- Dystonia, Drug Induced Dystonia, Parkinson Disease, Essential Tremor
- Trial name
- NCT05317390
- Testing
- DystoniaNet-based diagnosis of isolated dystonia
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Delayed Emergence From Anesthesia, Delirium, Cause Unknown
Inadequate Emergence After Laparoscopic Surgery in Trendelemburg Position
The purpose of this study is to determinate if the patients submitted to laparoscopic surgery in trendelemburg position develope more inadequate anaesthesic emergence than patients submitted to laparoscopic surgery in other…
- Conditions
- Delayed Emergence From Anesthesia, Delirium, Cause Unknown, Confusion, Disorientation on Emergence
- Trial name
- NCT02101671
- Where
- Spain
- Volunteers
- 140 people
- Sponsor
- Corporacion Parc Tauli
Acute Pain, Pain, Procedural
Premature Enhanced Automated Capture of Comfort Knowledge
The goal of this observational study is to develop methods that could provide continual monitoring of comfort levels for preterm neonates in hospitals.
- Conditions
- Acute Pain, Pain, Procedural, Agitation, Discomfort
- Trial name
- PEACOCK (NCT06037629)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Newcastle University
Parkinson Disease, PD
Genetic Characterization of Parkinson's Disease
This study will explore the risks and causes of Parkinson's disease, a chronic progressive nervous system disorder. Patients typically have tremors, muscle weakness and a shuffling gait.
- Conditions
- Parkinson Disease, PD, Movement Disorder, Healthy Volunteer
- Trial name
- NCT00105131
- Where
- United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Leukaemia (Acute Lymphoblastic), Leukaemia (Acute Myeloid)
Phase I Clinical Trial of ThINKK Adoptive Immunotherapy After Allogeneic Hematopoietic Transplantation in Children With Leukemia or Neuroblastoma
A first-in-class adoptive immunotherapy we called ThINKK, for Therapeutic Inducers of Natural Killer (NK) cell Killing, have been designed for use after hematopoietic stem cell transplantation (HSCT), where the proper stimulation…
- Conditions
- Leukaemia (Acute Lymphoblastic), Leukaemia (Acute Myeloid), Neuroblastoma, Neuroblastoma, Metastatic
- Trial name
- ThINKK-01 (NCT07518654)
- Testing
- Therapeutic Inducers of Natural Killer Killing (ThINKK)
- Where
- 2 sites in Canada
- Volunteers
- 12 people
- Sponsor
- Michel Duval
Primary Ciliary Dyskinesia, Healthy
Examining Bronchial Hyperresponsiveness in Primary Ciliary Dyskinesia
The purpose of this study is to look at children with PCD and see if they have another condition called "bronchial hyperresponsiveness".
- Trial name
- BHR (NCT07288827)
- Testing
- Lung Function Testing, Phlebotomy, Allergy skin prick testing
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Indiana University
Ataxia Telangiectasia, Growth Failure
Status of Growth Hormone/ Insulin-like Growth Factor-1 (GH/IGF-1) Axis and Growth Failure in Ataxia Telangiectasia (AT)
This study will evaluate the status of the growth hormone/ insulin-like growth factor-1 (GH/IGF-1) axis in relation to growth failure, body weight and composition and neuroprotection in children with Ataxia telangiectasia (AT).
- Trial name
- GHAT (NCT01052623)
- Testing
- Somatropin, Clonidine, L-Arginin-Hydrochloride, Estradiol valerate
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Autism Spectrum Disorder, Movement Disorders
Database Of Clinical Data For Individuals With Variants In The IRF2BPL Gene
This protocol serves as a data collection tool for individuals with variants (missense, nonsense, frameshifts) in the IRF2BPL gene (MIM 611720), which causes Neurodevelopmental Regression, Seizures, Autism and Developmental Delay…
- Conditions
- Autism Spectrum Disorder, Movement Disorders, Seizures, Dystonia
- Trial name
- IRF2BPL (NCT03892798)
- Testing
- No interventions are planned
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Spastic Dysphonia, Healthy
Study of Air Stream in Voice Production
This study will investigate and compare the air stream during voice production in patients with abductor spasmodic dysphonia and in normal volunteers.
- Trial name
- NCT00015795
- Testing
- airway interruption test
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cerebellar Ataxia
A Registered Cohort Study on Cerebellar Ataxia in the Organization in South-East China for Cerebellar Ataxia Research (OSCCAR)
Cerebellar ataxia is a form of ataxia originating in the cerebellum. Cerebellar ataxia can occur as a result of many diseases and may present with symptoms of an inability to coordinate balance, gait, extremity and eye movements.
- Trial name
- NCT04010214
- Testing
- No intervention
- Where
- China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Ning Wang, MD., PhD.
Rheumatic Fever, Sydenham Chorea
TREAT-SC: Early, Short Course Oral Dexamethasone for the Treatment of Sydenham Chorea in Children
The purpose of this study is to find out whether an early three-day course of an oral steroid medication (dexamethasone) can improve the physical and mental recovery and wellbeing for children with Sydenham's chorea.
- Trial name
- TREAT-SC (NCT06259006)
- Testing
- Dexamethasone Oral
- Where
- 17 sites in Australia, New Zealand
- Volunteers
- 80 people
- Sponsor
- Starship Child Health, Te Toka Tumai Auckland
Neurodegenerative Diseases, Behavioral Symptoms
Impact of Harp Therapy on Behavioral Disorders in Nursing Home Residents With Neurodegenerative Disease (ARPE)
The ARPE study looked at whether weekly harp therapy sessions could reduce behavioral problems in older adults living in memory care units of a nursing home (EHPAD).
- Conditions
- Neurodegenerative Diseases, Behavioral Symptoms, Dementia, Agitation
- Trial name
- ARPE (NCT07748013)
- Testing
- Harp therapy (receptive music therapy)
- Where
- France
- Volunteers
- 25 people
- Sponsor
- LNA SANTE
Dementia, Agitation
Person- Centred Care Among Nursing Home Patients With Dementia
Dementia is a common and devastating disease in the elderly. No cure exist and there is an increasing need for care. To improve knowledge on how to provide better care for the patients with dementia in nursing homes, the…
- Trial name
- NCT01280890
- Testing
- Staff training using VIPS, Staff training using DCM, Control group
- Volunteers
- 624 people
- Sponsor
- Norwegian Centre for Ageing and Health
Primary Ciliary Dyskinesia, Primary Immune Deficiency
Defining the Genetic Etiology of Suppurative Lung Disease in Children and Adults
The investigators will utilize a systematic approach for the diagnostic evaluation of patients to identify characteristics which may distinguish between Primary Immunodeficiency (PID) disorders versus Primary Ciliary Dyskinesia…
- Conditions
- Primary Ciliary Dyskinesia, Primary Immune Deficiency, Kartagener Syndrome
- Trial name
- NCT04702243
- Testing
- Genetic Testing for PCD or PID, Unaffected Family Member Genetic Testing
- Where
- 8 sites in United States, Canada
- Volunteers
- 436 people
- Sponsor
- University of North Carolina, Chapel Hill