Clinical trials: Dyslipidemia
Tumors of the Central Nervous System, Childhood Cancer Survivors
Cardiovascular Disorders and Risk Factors in Childhood Cranial and Craniospinal Tumors Survivors
The purpose of research is to study to adverse cardiovascular disorder and risks factors in childhood cranial and craniospinal tumors survivors.
- Trial name
- NCT05641636
- Testing
- 12-lead ECG, hormone and lipid blood tests, echocardiography (Echo-CG), cardiopulmonary exercise testing (CPET) and pulse wave analysis
- Where
- Russia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Lipodystrophy, Diabetes
Compassionate Use of Metreleptin in Previously Treated People With Generalized Lipodystrophy
Background: Generalized lipodystrophy can cause high blood fat levels and resistance to insulin. This can lead to health problems including diabetes.
- Conditions
- Lipodystrophy, Diabetes, Hyperlipidemia
- Trial name
- NCT02262832
- Testing
- Metreleptin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity, Insulin Resistance
Vitamin K to Slow Progression of Dyslipidemia and Diabetes Risk (Vita-K 'n' Kids Study II)
Animal studies have found that vitamin K-dependent proteins matrix Gla protein and osteocalcin beneficially influence lipid and glucose metabolism, respectively.
- Conditions
- Obesity, Insulin Resistance, Obesity in Diabetes, Nutritional and Metabolic Diseases
- Trial name
- NCT02959762
- Testing
- Low-Dose Vitamin K2 (menaquinone-7; 45-mcg/d), High-Dose Vitamin K2 (menaquinone-7; 90 mcg/d)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Augusta University
Familial Hypercholesterolemia, Adherence, Medication
The Use of Mobile Health Technology and Behavioral Economics to Encourage Adherence in Adolescents
Familial hypercholesterolemia (FH) affects over one million Americans and increases the risk of cardiovascular disease (CVD) by as much as 20-fold.
- Trial name
- NCT04458766
- Testing
- Monetary incentives
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Boston Children's Hospital
Cardiovascular Disease, Essential Hypertension
The Northwest Coalition for Primary Care Practice Support
The purpose of this project is to build capacity for quality improvement (QI) in small primary care practices across Washington, Oregon and Idaho by improving risk factors for heart attacks such as blood pressure, cholesterol and…
- Conditions
- Cardiovascular Disease, Essential Hypertension, Nicotine Dependence, Hyperlipidemia
- Trial name
- H2N (NCT02839382)
- Testing
- Coaching, Educational Outreach, Site Visits
- Where
- United States
- Volunteers
- 209 people
- Sponsor
- Kaiser Permanente
Metabolic Syndrome X
Study of Chronic Degenerative Diseases
The prevalence of obesity and type 2 diabetes mellitus (DM) in children have been increasing in parallel at an alarming rate. In particular, the increasing prevalence of type 2 DM is attributable to genetic factors, clinical…
- Trial name
- NCT02495961
- Where
- Mexico
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Asociación Científica Latina A.C.
Hypercholesterolemia
Effect of Ezetimibe Treatment on Low-density Lipoprotein Cholesterol (LDL-C) Levels in Participants With Coronary Heart Disease (CHD) Already Treated With a Statin (MK-0653A-205 AM1)
This non-interventional longitudinal study is a follow-up of the Austrian Cholesterol Screening and Treatment project (ACT I), which assessed the cholesterol status, including achievement of the target levels applicable at that…
- Trial name
- ACT II (NCT01381679)
- Testing
- Ezetimibe
- Volunteers
- 1,682 people
- Sponsor
- Organon and Co
Hypertriglyceridemia
Implitapide in Patients With Hypertriglyceridemia (HTG) on Maximal, Concurrent Triglyceride-Lowering Therapy
The purpose of this study is to determine if implitapide is effective in lowering triglyceride (TG) levels in patients with Fredrickson Type I or V hypertriglyceridemia where the maximum tolerable medication and diet were not…
- Trial name
- NCT00080132
- Testing
- implitapide
- Where
- 9 sites in United States, Netherlands and 1 more
- Volunteers
- 50 people
- Sponsor
- Medical Research Laboratories International
Hereditary Breast and Ovarian Cancer Syndrome, Lynch Syndrome
Pediatric Reporting of Adult-Onset Genomic Results
The Investigators will conduct a longitudinal, mixed-methods cohort study to assess primary and secondary psychosocial outcomes among MyCode adolescent participants and their parents, and health behaviors of children who received…
- Conditions
- Hereditary Breast and Ovarian Cancer Syndrome, Lynch Syndrome, Familial Hypercholesterolemia
- Trial name
- NCT03832985
- Testing
- Child(ren) receive an adult-onset result, Child(ren) received a pediatric-onset result, Control - Negative Result
- Where
- United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic
Familial Hypercholesterolemia
Genetic Causes of Hypercholesterolaemia in the Emirati Population
The scientific aims of the project are to understand the genetic basis of Familial Hypercholesterolaemia (FH) in the Emirati population and estimate the overall prevalence of the disease.
- Trial name
- NCT03597958
- Testing
- Next generation sequencing (NGS)
- Where
- United Arab Emirates
- Volunteers
- 1,000 people
- Sponsor
- Imperial College London Diabetes Centre
Familial Hypercholesterolemia, Polygenic Hypercholesterolaemia
Universal Familial Hypercholesterolemia Screening in Children
30 million individuals globally with undiagnosed familial hypercholesterolemia (FH) are at a substantial cardiovascular disease (CVD) risk, which could be normalized by early diagnosis and treatment.
- Trial name
- NCT04507984
- Testing
- Genetic analysis, Lipid levels measurement
- Where
- 2 sites in Germany, Slovenia
- Volunteers
- 17,000 people
- Sponsor
- University of Ljubljana, Faculty of Medicine
Oxidative Stress, Dyslipidemias
Effects of Octacosanol During Taekwondo Training
Taekwondo players undergo rapid reductions of body weight prior to their competition in order to gain a size advantage over the opponent.
- Trial name
- NCT03557476
- Testing
- Octacosanol
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Kosin University
Hypertension, Hyperlipidemia
The Effect of Providing Free Samples of Generic Cardiovascular Medications to Physicians
In this randomized controlled trial, we will provide primary care physicians with free samples of highly effective generic cardiovascular medications.
- Trial name
- SAMPLES (NCT00761904)
- Testing
- Free Generic Samples (hydrochlorothiazide, simvastatin)
- Where
- United States
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Hypertension, Cardiovascular Disease
Meta-analyses of the Effect of Legumes on Blood Pressure
Legumes are generally recognized as healthy dietary components, and although beans and legumes are recommended in food guidelines in North America, guidelines vary in regards to how much and how often these foods should be…
- Conditions
- Hypertension, Cardiovascular Disease, Dyslipidemia, Diabetes
- Trial name
- NCT02600338
- Testing
- Legumes
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- John Sievenpiper
Hypercholesteremia
Efficacy and Safety of Gemcabene in Patients With Homozygous Familial Hypercholesterolemia on Stable, Lipid-Lowering Therapy (COBALT-1)
The purpose of this study was to assess the efficacy, safety, and tolerability of multiple doses of Gemcabene in patients with HoFH on stable, lipid-lowering therapy.
- Trial name
- NCT02722408
- Testing
- Gemcabene
- Where
- 7 sites in United States, Canada and 1 more
- Volunteers
- 8 people
- Sponsor
- NeuroBo Pharmaceuticals Inc.
Familial Hypercholesterolemia
Cascade Genetic Testing of Familial Hypercholesterolemia
Familial hypercholesterolemia (FH) is a frequent genetic disorder (1/200) associated with an increased risk of early-onset myocardial infarction.
- Trial name
- CATCH (NCT04419090)
- Testing
- web-based centralized service and message
- Where
- Switzerland
- Volunteers
- 379 people
- Sponsor
- Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland
Hyperlipidemia
The Effects of a Mediterranean Diet in Pediatric Hyperlipidemia
Children with high cholesterol levels are especially vulnerable and are at high risk for early onset coronary heart disease (CHD).
- Trial name
- EARLYMedit (NCT01308710)
- Testing
- Omega-3 fatty acid (Eicosapentaenoic acid)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, San Francisco
Cardiovascular Diseases, Heart Diseases
Evaluation of Cholesterol Education for At-Risk Children
To evaluate two educational programs that promoted the role of pediatric practices in lowering LDL cholesterol levels in 4-10 year old hypercholesterolemic children through dietary modification.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypercholesterolemia, Coronary Heart Disease Risk Reduction
- Trial name
- NCT00005718
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypercholesteremia
Observational to Investigate the Efficacy of CRESTOR 5mg in Reaching LDL-C Target Goals in Patients Who Are at High Risk for a Cardiovascular Event
Observational study to investigate the use and efficacy of CRESTOR 5 mg in reaching LDL-C target goals in both statin naïve and statin treated primary and secondary prevention patients at high risk for a cardiovascular event.
- Trial name
- NCT00347217
- Where
- 215 sites in Netherlands
- Volunteers
- 3,840 people
- Sponsor
- AstraZeneca
Lipodystrophy
Short-term Effects of Leptin in People With Lipodystrophy
Background: Lipodystrophy is a condition where people do not have enough fat in the body. People with lipodystrophy can have problems such as diabetes or an enlarged liver.
- Trial name
- NCT01778556
- Testing
- Metreleptin
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)