Clinical trials: Dyslipidemia
Insulin Resistance, Obesity
Developing an Adaptive Lifestyle Intervention Program in Family Medicine Clinics
The purpose of this study is to investigate the feasibility of conducting a multicomponent lifestyle intervention research study within the UAB Family Medicine Clinic at Highlands and to obtain preliminary data on the…
- Conditions
- Insulin Resistance, Obesity, Diabetes, Hypertension
- Trial name
- NCT04392284
- Testing
- Diet Counseling, Exercise Counseling
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Hypercholesterolemia, Dyslipidemias
A Study to Evaluate the Effectiveness and Safety of Fixed-Dose Combination of Pitavastatin/ Ezetimibe
The objective of this study is to evaluate the effectiveness and safety of Pitavastatin/Ezetimibe FDC in patients with hypercholesterolemia.
- Trial name
- PIVOTAL (NCT07083206)
- Where
- South Korea
- Volunteers
- 4,500 people
- Sponsor
- Ahn-Gook Pharmaceuticals Co.,Ltd
Homozygous Familial Hypercholesterolemia
Study of Zodasiran in Adolescent Participants With Homozygous Familial Hypercholesterolemia
This study will evaluate the efficacy and safety of zodasiran subcutaneous (sc) injection in participants 12 to <18 years of age with genetically or clinically diagnosed homozygous familial hypercholesterolemia (HoFH) and…
- Trial name
- SPRUCE (NCT07473843)
- Testing
- Zodasiran
- Where
- 3 sites in United States, Denmark and 1 more
- Volunteers
- 10 people
- Sponsor
- Arrowhead Pharmaceuticals
Heterozygous Familial Hypercholesterolemia (HeFH)
EDIT-401 in Adults Who Require Additional Lowering of Low-Density Lipoprotein Cholesterol (LDL-C)
A phase 1/2, two-part trial consisting of an open label dose-escalation part and a randomized, double blind, placebo-controlled part to investigate safety, tolerability, pharmacokinetics, and efficacy with EDIT-401 gene editing…
- Trial name
- NCT07894887
- Testing
- Drug: EDIT-401
- Where
- 2 sites in Australia
- Volunteers
- 56 people
- Sponsor
- Editas Medicine, Inc.
Dyslipidaemia
Evaluation of Food Supplementation in Subjects With Suboptimal Levels of LDL Cholesterol
This randomized, double-blind, placebo-controlled, parallel-group clinical study aims to evaluate the effect of a dietary supplement on LDL-cholesterol levels in healthy adults with suboptimal LDL-C values.
- Trial name
- NCT07492264
- Testing
- NUT2
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Cooper Consumer Health
Acute Myocardial Infarction, Dyslipidemias
Ezetimibe Utilization Early After Acute Myocardial Infarction, "EzAMI Trial"
Rationale: Patients with acute coronary syndromes are at an increased risk for recurrent adverse coronary events, particularly during the early period following their initial presentation.
- Trial name
- EzAMI (NCT04701242)
- Testing
- Ezetimibe 10mg
- Where
- Egypt
- Volunteers
- 500 people
- Sponsor
- Cairo University
Coronary Artery Disease, Arterial Stiffness, Blood Pressure
Expanded Studies on the SCAPIS Stockholm Reexamination Cohort
The Swedish CArdioPulmonary bioImage Study (SCAPIS) is a unique, large-scale national research initiative involving 30,000 randomly selected individuals aged 50-64, recruited between 2014 and 2018.
- Conditions
- Coronary Artery Disease, Arterial Stiffness, Blood Pressure, AORTIC VALVE DISEASES, Mitral Valve Stenosis and/or Insufficiency
- Trial name
- SCAPIS-ReEx (NCT07476703)
- Testing
- Coronary computer tomography (CCTA), Echocardiograhy and aortic ultrasound, Liver elastography
- Where
- Sweden
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Danderyd Hospital
Obesity & Overweight, Diabetes Mellitus, Type 2
Chinese Overweight/Obesity Cohort: Metabolic & Comorbidity Risks
This is a nationwide, multi-center, long-term follow-up study of overweight and obese adults in China. The study aims to recruit approximately 26,000 participants across 39 hospitals to better understand how body weight affects…
- Conditions
- Obesity & Overweight, Diabetes Mellitus, Type 2, Hypertension, Non-alcoholic Fatty Liver Disease (MASLD)
- Trial name
- NCT07884903
- Testing
- No intervention; observational assessment only
- Where
- China
- Volunteers
- 25,974 people
- Sponsor
- Shanxi Bethune Hospital
Type 2 Diabetes Mellitus, Hypercholesterolemia / Elevated LDL Cholesterol
Dual vs Triple Lipid-Lowering Therapy in Type 2 Diabetes Mellitus Patients With Elevated LDL Cholesterol
This Open-label, randomized clinical trial evaluates the comparative efficacy and safety of dual versus triple lipid-lowering therapy using rosuvastatin, ezetimibe, and bempedoic acid in patients with type 2 diabetes mellitus and…
- Trial name
- NCT07255820
- Testing
- Rosuvastatin + Ezetimibe, Bempedoic Acid + Ezetimibe, Rosuvastatin + Ezetimibe + Bempedoic Acid
- Where
- Pakistan
- Volunteers
- 126 people
- Sponsor
- Bahria University
Epilepsy, Dyslipidemia
Improving Cardiovascular Health Risks in Adults With Epilepsy on a Modified Atkins Diet
Ketogenic diet therapies (KDTs) emphasize high fat and very low carbohydrate intake and help to control seizures in adults who fail to respond to medications.
- Trial name
- NCT06369571
- Testing
- Atorvastatin 10mg, Modification of dietary fat composition
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Johns Hopkins University
Primary Hypercholesterolaemia, Mixed Dyslipidemia
A Study of Bempedoic Acid or Its Single-pill Combination Therapy With Ezetimibe in Patients With Primary Hypercholesterolaemia or Mixed Dyslipidaemia
There is limited efficacy and safety data of bempedoic acid or its fixed dose combination (FDC) with ezetimibe in Asian and Latin American patients.
- Trial name
- Musashi (NCT07206472)
- Testing
- Combination of bempedoic acid and ezetimibe
- Where
- 38 sites in Brazil, Hong Kong and 1 more
- Volunteers
- 2,120 people
- Sponsor
- Daiichi Sankyo
Diabete Mellitus, Dyslipidaemia
Prevalence and Associated Factors of High BMI and Periodontitis in Thai Adults Aged Under 60 Years
Overweight and obesity, as well as periodontitis, are common public health problems with increasing prevalence. Both conditions may be linked through shared mechanisms involving chronic low-grade systemic inflammation.
- Conditions
- Diabete Mellitus, Dyslipidaemia, Chronic Kidney Disease, Psychiatric Disorder
- Trial name
- NCT07880717
- Testing
- Periodontal Examination, Questionnaire interview, Anthropometric measurements
- Where
- Thailand
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Hypolipoproteinemia, Hypercholesterolemia
Lipoprotein Metabolism in Normal Volunteers and Patients With High Levels of Lipoproteins
Researchers plan to study the fat-rich particles, called lipoproteins, which circulate in the blood. This study is designed to improve understanding of normal, as well as abnormal, lipoprotein metabolism and the role it plays in…
- Conditions
- Hypolipoproteinemia, Hypercholesterolemia, Dyslipidemia, Hyperlipidemia
- Trial name
- NCT00001154
- Where
- United States
- Volunteers
- 759 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Homozygous Familial Hypercholesterolemic
Cardiovascular Evaluation of Patients With High Cholesterol and Normal Volunteers
Homozygous familial hypercholesterolemia is a rare inherited disease of metabolism. It occurs in less than 1 in 1 million people within the United States.
- Trial name
- NCT00001204
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Dyslipidemias, Lipid Testing
Lipid Testing After Myocardial Infarction at the Montreal Heart Institute
Because treatment decisions are usually based on a single measurement of the lipid panel at the time of an admission for an MI, the overarching objective of this project is to evaluate whether the measurement of LDL, non-HDL, and…
- Conditions
- Dyslipidemias, Lipid Testing, Myocardial Infarction
- Trial name
- NCT06388668
- Testing
- Lipid panel
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Montreal Heart Institute
Hypertension, Dyslipidemia
A Novel Digital Tool Clinicians Can Use to Prescribe Exercise to Patients With Cardiovascular Disease Risk Factors
The investigators will conduct a feasibility and pilot efficacy randomized controlled trial to test the usability and user satisfaction of an evidence-based digital health tool the investigators developed for clinicians to use to…
- Conditions
- Hypertension, Dyslipidemia, Diabetes Mellitus, Obesity
- Trial name
- P3-EX (NCT07238556)
- Testing
- Experimental - 12 Week P3-EX Unsupervised Exercise Program with Virtual Weekly Oversight from Graduate Research Assistants, Active Control - 12 Week ACSM-PAVS Unsupervised Exercise Program with Virtual Weekly Oversight from Graduate Research Assistants
- Where
- 3 sites in United States
- Volunteers
- 72 people
- Sponsor
- University of Connecticut
Hypertension (HTN), Diabetes
Evaluation of a New Virtual Care Pathway for Older Adults With Noncommunicable Diseases
The purpose of this study is to evaluate a newly developed virtual care program for older adults with chronic diseases (hypertension, diabetes and lipid disorders) whether it is feasible and economical to implement in the…
- Conditions
- Hypertension (HTN), Diabetes, Dyslipidaemia
- Trial name
- TeleCOOP-NCD (NCT07843238)
- Testing
- Teleconsultation care pathway for older adults with NCDs (TeleCOOP-NCD©)
- Where
- Malaysia
- Volunteers
- 160 people
- Sponsor
- National University of Malaysia
Cardiovascular Diseases, Cardiovascular Risk Factor
Digital Nudges to Improve Heart Health Actions After Community Screening in Malaysia (NADI-MyHeartRisk)
This is a pragmatic, risk-stratified, individually randomized controlled trial testing whether personalised WhatsApp-based digital behavioural nudges can improve completion of cardiovascular preventive actions after community…
- Trial name
- NADI-MHR (NCT07879144)
- Testing
- Personalised Digital Behavioural Nudges (NADI-MyHeartRisk Enhanced Pathway)
- Where
- 2 sites in Malaysia
- Volunteers
- 6,588 people, healthy volunteers welcome
- Sponsor
- Cardiovascular Advancement and Research Excellence Institute
Dyslipidaemia
A Study to Investigate the Effect of AZD0780 Tablets in Combination With Rosuvastatin Tablets on Low Density Lipoprotein Cholesterol Levels (LDL-C) in Adult Participants With Dyslipidaemia
This is a study to investigate the effect of AZD0780 tablets on low density lipoprotein cholesterol levels (LDL-C) compared with placebo tablets administered in combination with rosuvastatin tablets in adult Russian participants…
- Trial name
- LAZURE (NCT07218900)
- Testing
- AZD0780, Rosuvastatin
- Where
- 8 sites in Russia
- Volunteers
- 76 people
- Sponsor
- AstraZeneca
Dyslipidemia, Obesity & Overweight
Time-Restricted Eating With or Without Energy Restriction in Dyslipidemic Women With Owerweight or Obesity
Background/Objectives: It is unclear whether the effects of time-restricted eating (TRE) on body composition and blood lipids are independent of energy restriction (ER), and whether combining the two confers additional benefit.
- Trial name
- NCT07871565
- Testing
- TRE, ER, TRE+ER
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Acibadem University