Clinical trials: Dystonia, Focal
Dystonia, Focal
Oral Zinc Supplementation to Enhance Botulinum Neurotoxin Response
Botulinum neurotoxin (BoNT) is injected into muscles for treatment of dystonia. BoNTs are zinc proteases, and their enzymatic effect is reduced in the setting of low zinc.
- Trial name
- NCT05095493
- Testing
- Zinc Acetate
- Volunteers
- 54 people
- Sponsor
- University of Texas Southwestern Medical Center
Cerebral Palsy, Dyskinetic, Secondary Dystonia
Focused Ultrasound Pallidotomy for Dyskinetic Cerebral Palsy in Pediatric and Young Adult Subjects
The primary objective of the proposed study is to evaluate the safety of ExAblate Transcranial MRgFUS as a tool for creating bilateral or unilateral lesions in the globus pallidus (GPi) in patients with treatment-refractory…
- Trial name
- NCT06036199
- Testing
- Focused Ultrasound Pallidotomy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's National Research Institute
Writer's Cramp, Dystonias
VTS Sensorimotor Neuromodulation in WC
Writer's cramps (WC) is a focal task-specific upper limb dystonia that significantly impairs handwriting and other manual skills, affecting functionality.
- Trial name
- VTS in WC (NCT07894198)
- Testing
- Vibro-tactile stimulation
- Volunteers
- 10 people
- Sponsor
- Ottawa Hospital Research Institute
Dystonic Disorder
Sensory Training to Treat Focal Dystonia
This study will examine the effectiveness of Braille reading as a sensory training program for improving symptoms of focal (localized) dystonia, a movement disorder caused by sustained muscle contractions.
- Trial name
- NCT00006336
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Dystonic Disorders, Healthy
Surround Inhibition in Patients With Dystonia
This study will use transcranial magnetic stimulation (TMS) to examine how the brain controls muscle movement in dystonia. Dystonia is a movement disorder in which involuntary muscle contractions cause uncontrolled twisting and…
- Trial name
- NCT00029601
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Dystonia, Dystonia; Idiopathic
Dystonia Genotype-Phenotype Correlation
The purpose of this study is to (1) investigate the effect of known dystonia-causing mutations on brain structure and function, to (2) identify structural brain changes that differ between clinical phenotypes of dystonia, and to…
- Conditions
- Dystonia, Dystonia; Idiopathic, Dystonia, Primary, Dystonia, Secondary
- Trial name
- NCT03428009
- Testing
- Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Focal Dystonia
Motor Training to Treat Hand Dystonia
This study will evaluate the effect of motor training on focal hand dystonia in people with writer's cramp and will examine whether this training affects excitability of the motor cortex of the brain.
- Trial name
- NCT00021853
- Testing
- constraint-induced movement therapy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Focal Dystonia
Survey of Sensory and Motor Tricks in Focal Dystonia
This study will collect information on (tricks) patients with focal dystonia use to relieve their symptoms. Dystonia is a movement disorder caused by sustained muscle contractions often causing twisting and abnormal posturing.
- Trial name
- NCT00054652
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Dystonic Disorder, Healthy
Transcranial Magnetic Stimulation (TMS) Studies of Dystonia
This study will use transcranial magnetic stimulation to examine how the brain controls muscle movement in focal and generalized types of dystonia.
- Trial name
- NCT00017875
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Blepharospasm, Dystonia
Mexiletine for the Treatment of Focal Dystonia
Dystonia refers to a condition characterized by involuntary muscle contractions that may cause pain, abnormal posture, or abnormal movements.
- Conditions
- Blepharospasm, Dystonia, Spasm
- Trial name
- NCT00001784
- Testing
- Mexiletine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)