Clinical trials: EOS
Eosinophilic Esophagitis
A Study to Evaluate the Efficacy and Safety of CC-93538 in Adult and Adolescent Participants With Eosinophilic Esophagitis
Study CC-93538-EE-001 is a Phase 3, multicenter, multinational, randomized, double-blind, placebo-controlled induction and maintenance study to evaluate the efficacy and safety of CC- 93538 in adult and adolescent participants…
- Trial name
- NCT04753697
- Testing
- CC-93538
- Where
- 212 sites in United States, Argentina and 13 more
- Volunteers
- 430 people
- Sponsor
- Celgene
Eosinophilic Esophagitis
Use of Topical Budesonide in the Treatment of Eosinophilic Esophagitis
This study is designed to evaluate whether or not oral viscous budesonide is effective in treating children with Eosinophilic Esophagitis.
- Trial name
- NCT00638456
- Testing
- Budesonide plus Prevacid
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Ranjan Dohil
Scoliosis
Bracing During Infantile Scoliosis: Airways Study
Idiopathic juvenile thoracic scoliosis is a tridimensional deformation of the spine which may impact on the intrathoracic organs. Bracing is one of the oldest treatments of spinal deformities.
- Trial name
- MASI (NCT01087034)
- Testing
- Acoustic reflection method evaluation, EOS™, Non invasive respiratory muscle assessment
- Where
- 2 sites in France
- Volunteers
- 15 people
- Sponsor
- Club d'Anesthésie-Réanimation Pédiatrique Armand Trousseau
Allergic Rhinitis
Effect of Hypertonic Solutions on Allergic Rhinitis Patients
The purpose of this study is to assess the effectivity of using hypertonic nasal solutions alone on the symptom scores and nasal eosinophil levels of allergic rhinitis patients, retrospectively.
- Trial name
- hypertonic (NCT02233426)
- Where
- Turkey (Türkiye)
- Volunteers
- 1,000 people
- Sponsor
- Namik Kemal University
Asthma
A Phase 3a, Repeat Dose, Open-label, Long-term Safety Study of Mepolizumab in Asthmatic Subjects
This is a multi-center, open-label, long-term study of subcutaneously (SC) administered mepolizumab 100mg in addition to standard of care (SOC), in subjects with severe eosinophilic asthma.
- Trial name
- NCT02135692
- Testing
- Mepolizumab, SOC
- Where
- 114 sites in United States, Argentina and 16 more
- Volunteers
- 339 people
- Sponsor
- GlaxoSmithKline
COPD (Chronic Obstructive Pulmonary Disease), COPD
Dupilumab in Type 2-Inflamed COPD Across the Full Spectrum of Airflow Limitation: An Italian Multicentre Retrospective Cohort Study
This multicentre retrospective cohort study describes lung function and patient-reported outcomes in adults with chronic obstructive pulmonary disease (COPD) and type 2 inflammation who received add-on dupilumab in routine…
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), COPD, Eosinophilia
- Trial name
- DUPICENTRO (NCT07788092)
- Testing
- Dupilumab
- Where
- 6 sites in Italy
- Volunteers
- 40 people
- Sponsor
- Azienda Ospedaliera di Perugia
Eosinophilic Esophagitis
Safety Study of CC-93538 in Adult and Adolescent Participants With Eosinophilic Esophagitis
This study is an open-label, uncontrolled study design to evaluate the long-term safety and tolerability of treatment with CC-93538.
- Trial name
- NCT04991935
- Testing
- CC-93538
- Where
- 167 sites in United States, Argentina and 13 more
- Volunteers
- 367 people
- Sponsor
- Celgene
Leukopheresis, Plasmapheresis
Apheresis to Obtain Plasma or White Blood Cells for Laboratory Studies
This study will collect blood plasma and white blood cells for laboratory research using a procedure called apheresis. Apheresis is a method of collecting larger quantities of certain blood components than can safely be collected…
- Trial name
- NCT00001349
- Where
- United States
- Volunteers
- 205 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Eosinophils, Asthma
A Study of Reslizumab in Patients 12 Years of Age and Older With Severe Eosinophilic Asthma
This is a multicenter, open-label (OL) extension study to obtain additional long-term safety data for subcutaneous (sc) administration of reslizumab treatment administered at a fixed dose of 110 mg in patients 12 years of age and…
- Trial name
- NCT03052725
- Testing
- reslizumab
- Where
- 134 sites in United States, Belgium and 11 more
- Volunteers
- 391 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Eosinophilic Esophagitis, Gastroesophageal Reflux Disease
Morphological Markers of Gastroesophageal Reflux Disease (GERD)
The purpose of this project is to learn more about a new and promising way to diagnose acid reflux disease using a very high-powered microscope.
- Trial name
- NCT01921686
- Testing
- Sample collection and Questionnaire
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Immune System Diseases, Eosinophilia
Activation and Function of Eosinophils in Conditions With Blood or Tissue Eosinophilia
This study will investigate how, why and under what conditions eosinophils (a type of white blood cell) become activated and will examine their function in immune reactions.
- Conditions
- Immune System Diseases, Eosinophilia, Helminthiasis, Hypersensitivity
- Trial name
- NCT00001406
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Idiopathic Scoliosis
Prediction of 3D Effect of Brace in Idiopathic Scoliosis Treatment Using EOS Imaging System and "Anatomic Transfer".
In this study, the accuracy of a new numerical method is evaluated for predicting the 3D effect of brace on idiopathic scoliosis.
- Trial name
- EOSTransfert (NCT03209752)
- Where
- France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Grenoble
Schizophrenia
Cognitive Remediation Therapy (CRT) in Adolescents With EOS
Cognitive Remediation Therapy (CRT) can enhance cognitive performance in schizophrenia improving functional outcome. But most of the studies have involved participants who are in average in their mid 30s, and little is known…
- Trial name
- NCT01701609
- Testing
- Cognitive Remediation Therapy
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital Clinic of Barcelona
Eosinophilic Gastrointestinal Disorders (EGID), Eosinophilic Esophagitis
Registry for Eosinophilic Gastrointestinal Disorders (REGID)
Develop Registry tool
- Conditions
- Eosinophilic Gastrointestinal Disorders (EGID), Eosinophilic Esophagitis, Eosinophilic Disorder
- Trial name
- EoE (NCT01382563)
- Where
- 8 sites in United States
- Volunteers
- 34 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Lower Limb Length Discrepancy (LLD) in Children
Analysis of the Biomechanical Impact of Lower Limb Length Inequality in PEDiatrics
Lower limb length discrepancy (LLD) is a frequent condition in pediatric orthopedics. Even moderate discrepancies can induce pelvic obliquity and compensatory scoliosis, modifying the distribution of joint loads at the hips and…
- Trial name
- ABILMI-PED (NCT07254351)
- Testing
- EOS Imaging System, Force Platform (Bertec®, integrated into EOS cabin)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Eosinophilic Esophagitis
EDN and Eosinophilic Esophagitis
Eosinophilic esophagitis is a recent and emerging chronic disease, secondary to eosinophilic infiltration of the esophageal mucosa leading to esophageal dysfunction.
- Trial name
- OesEDN (NCT06387030)
- Testing
- Blood sampling, Esophageal biopsies, Unstimulated saliva sampling
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asthma
A Study to Determine Long-term Safety of Mepolizumab in Asthmatic Subjects
This is a multi-centre, open-label long-term safety study of 100 milligram (mg) mepolizumab administered subcutaneously (SC) every 4 weeks for 12 months in addition to standard of care in subjects who have severe, refractory…
- Trial name
- NCT01842607
- Testing
- Mepolizumab
- Where
- 137 sites in United States, Argentina and 17 more
- Volunteers
- 651 people
- Sponsor
- GlaxoSmithKline
Neonatal SEPSIS
Prognostic Value of Red Cell Distribution Width (RDW) in Neonatal Sepsis
1. Evaluate the relationship of RDW and severity and mortality in patients with neonatal sepsis . 2. Using RDW as a simple, inexpensive, applicable and rapid test to detect prognosis of neonatal sepsis .
- Trial name
- NCT03403062
- Volunteers
- 100 people
- Sponsor
- Assiut University
Allergic Rhinitis
Efficacy Of Bacterial Lysate In Children With Allergic Rhinitis
This study evaluate the efficacy of Polyvalent Mechanical Bacterial Lysate (PMBL - Ismigen) to improve the clinical course of grass pollen-induced allergic rhinitis (using: TNSS, TOSS, VAS, PNIF) in children aged 5 to 17.
- Trial name
- NCT04270552
- Testing
- Ismigen
- Where
- Poland
- Volunteers
- 76 people
- Sponsor
- Medical University of Lublin
Asthma
Mepolizumab Steroid-Sparing Study in Subjects With Severe Refractory Asthma
This is a randomised, double-blind, placebo-controlled, parallel-group, multicenter study of mepolizumab in comparison with placebo in reducing Oral Corticosteroid (OCS) use in subjects with severe refractory asthma.
- Trial name
- NCT01691508
- Testing
- Mepolizumab, OCS (prednisone/prednisolone)
- Where
- 47 sites in United States, Australia and 8 more
- Volunteers
- 135 people
- Sponsor
- GlaxoSmithKline