Clinical trials: EOS
Eosinophilic Asthma, Chronic Sinusitis
Eosinophils Endotypes in Chronic Airway Inflammatory Diseases
Asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) are frequently described as unified airway inflammatory diseases. Both heavily impacts quality of life with substantial productivity loss.
- Conditions
- Eosinophilic Asthma, Chronic Sinusitis, Eosinophilic Rhinitis
- Trial name
- PLEIAD (NCT04187976)
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Lille
Asthma, Eosinophilic Asthma
Effect of Mepolizumab on Severe Eosinophilic Asthma
Two parts: A:Case-control study including 15 healthy adult donors and 15 severe adult eosinophilic asthmatics selected for treatment with mepolizumab.
- Trial name
- EMESEA (NCT04641741)
- Testing
- Mepolizumab 100 MG
- Where
- 5 sites in Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospital Clinico Universitario de Santiago
Asthma, Asthma in Children
Diagnostic and Translational Values of Point-of-care Blood Eosinophils and Exhaled Nitric Oxide (FeNO) in People Referred by Primary Care for Suspected Asthma
Asthma is characterised by episodic symptoms (attacks) caused by airway inflammation and decreased airflow to the lungs. It affects 10% of the Canadian population and is the most common chronic disease in childhood.
- Conditions
- Asthma, Asthma in Children, Diagnosis, Inflammation
- Trial name
- DIVE (NCT05992519)
- Testing
- ¸FeNO
- Where
- Canada
- Volunteers
- 123 people
- Sponsor
- Université de Sherbrooke
Hand Injuries
3D Personalized Modelization of the Hand Using EOS Imaging System
This study aims to compare the quality of 3D hand modelization with EOS imaging with gold-standard computed tomography
- Trial name
- M3DME (NCT04895891)
- Testing
- EOS hand imaging
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Asthma
Phenotyping Responses to Systemic Corticosteroids in the Management of Asthma Attacks
This observational study compares the phenotypic variability (clinical and biological) in treatment response to systemic corticosteroids according to the blood eosinophil count and FeNO in physician-diagnosed ≥12-year-old…
- Trial name
- PRISMA (NCT05870215)
- Testing
- Visit 1: Clinical exam and questionnaires, Visit 1: Respiratory physiology, Visit 1: Inflammometry
- Where
- Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Systemic Sclerosis, Systemic Scleroderma
Role of Eosinophil in Fibrogenesis of Systemic Sclerosis
Eosinophils are involved in tissue remodeling and fibrosis in many inflammatory diseases. Systemic sclerosis (SSc) is an autoimmune disease with fibrotic skin and lung complications.
- Trial name
- EOFIB-SSC (NCT03816189)
- Testing
- Blood test, Skin biopsies
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Acute Heart Failure, Reduced Systolic Function
Eosinophil Indices in Patients With Acute Heart Failure
All consecutive patients admitted to the intensive care unit (ICU) with ADHF between January 2017 and December 2021 were enrolled in this retrospective study.
- Trial name
- NCT05410990
- Testing
- eosinophil and other hematological parameters
- Volunteers
- 395 people
- Sponsor
- Giresun University
Hypereosinophilic Syndrome
Anti-Interleukin-5 Antibody to Treat Hypereosinophilic Syndrome
This study will examine the safety and effectiveness of a single dose of anti-interleukin-5 antibody (SCH 55700) in reducing the number of eosinophils (a type of white blood cell) in patients with hypereosinophilic syndrome.
- Trial name
- NCT00017862
- Testing
- SCH55700
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Neonatal SEPSIS
Prognostic Value of Red Cell Distribution Width (RDW) in Neonatal Sepsis
1. Evaluate the relationship of RDW and severity and mortality in patients with neonatal sepsis . 2. Using RDW as a simple, inexpensive, applicable and rapid test to detect prognosis of neonatal sepsis .
- Trial name
- NCT03403062
- Volunteers
- 100 people
- Sponsor
- Assiut University
Asthma
Airway Inflammation and Disease Burden in Asthmatic Smokers
Aim : To compare, among patients with an uncontrolled moderate to severe asthma, the blood eosinophil levels of smokers and non-smokers.
- Trial name
- NCT02833727
- Testing
- Smoking
- Where
- Canada
- Volunteers
- 160 people
- Sponsor
- Université de Montréal
Pemphigoid, Bullous
Cytokines in Blister Fluids of Bullous Pemphigoid (BP)
This study investigates the differences of Eosinophil Cationic Protein, Tumor Necrosis Factor-alpha and Anti-BP180-NC16A IgG levels of blister fluids in Bullous Pemphigoid patients which appeared before and under treatment…
- Trial name
- BP (NCT03856840)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 21 people
- Sponsor
- Mahmut Can Koska
Healthy Volunteers
Spine Reference Parameters on EOS Imaging
The lumbar pain caring consists from a 3D reconstruction of the spine obtained to scan or radiography, determining the lumbar pain cause and gravity, to propose a conservative treatment in first intention or a adapted spine…
- Trial name
- EOS-SPINE (NCT01406743)
- Testing
- EOS™ Acquisition
- Where
- France
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Asthma, Asthma, Bronchial
Mechanistic Study of Anti-inflammatory Effects of Fevipiprant in Patients With Eosinophilic Asthma.
This is an exploratory, randomized, subject- and investigator-blinded, placebo-controlled mode-of-action study to demonstrate the anti-inflammatory effects of fevipiprant compared to placebo after 12 weeks of treatment in 48…
- Conditions
- Asthma, Asthma, Bronchial, Bronchial Asthma, Eosinophilia
- Trial name
- NCT03989635
- Testing
- QAW039
- Sponsor
- Novartis Pharmaceuticals
Asthma, Type 2 Asthma
Quantifying the Burden of Type 2 (T2) Inflammation in Asthma
This study is designed to support the assessment of Type 2 (T2) biomarkers in asthma in primary care and community specialty practices.
- Trial name
- QUANTAS (NCT07675044)
- Testing
- FeNO Breath Test
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Asthma With Eosinophilic Phenotype
A Study to Evaluate the Pharmacodynamic, Efficacy and Safety of SHR-1703 in Asthma Patients With Eosinophil Phenotype
The purpose of this study is to evaluate the Pharmacodynamic, Efficacy and Safety of SHR-1703 in Asthma Patients with Eosinophil Phenotype.
- Trial name
- NCT05522439
- Testing
- SHR-1703
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Femoral Shaft Fracture
Contribution of Stereography (EOS Imaging System) in the Quantification of Femoral Shaft Fractures.
This observational study is a collection of clinical and imaging data of patients with a femoral shaft fracture treated by nails.
- Trial name
- FEOS (NCT03251534)
- Testing
- Centromedullary nailing
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Grenoble
Postural Balance
Postural Balance of the Adult
Description of the geometrical configuration of the skeleton with regard to gravity line by patients suffering from spinal disorders that may induce postural troubles
- Trial name
- POSTURADULT (NCT00926432)
- Testing
- EOS™ Acquisition
- Where
- France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Eosinophilic Gastritis, Eosinophilic Gastroenteritis
A Study of AK002 in Patients With Eosinophilic Gastritis and/or Eosinophilic Gastroenteritis
This is a Phase 2, double-blind, randomized, placebo-controlled study to assess the effects of AK002, given monthly for 4 doses.
- Trial name
- ENIGMA (NCT03496571)
- Testing
- AK002
- Where
- 21 sites in United States
- Volunteers
- 65 people
- Sponsor
- Allakos Inc.
Asthma
Efficacy of Dupilumab Added to Medium Dose Inhaled Corticosteroid/Long-acting Beta-agonist (ICS/LABA) in Comparison to ICS Dose Escalation to High Dose ICS/LABA in Adolescent and Adult Patients With Uncontrolled Asthma
This study is researching a drug called dupilumab. The study is focused on patients who have uncontrolled asthma. Asthma is a condition where the airways narrow and swell, making it difficult to breathe.
- Trial name
- AIM4:Next Step (NCT06572228)
- Testing
- dupilumab, ICS/LABA
- Where
- 77 sites in United States, Canada and 4 more
- Volunteers
- 120 people
- Sponsor
- Regeneron Pharmaceuticals
Copd
The Association Between Blood Eosinophilsp in Thai COPD Patients: A Prospective Study
The association of blood eosinophil as a biomarker for eosinophilic Thai COPD patients, such as COPD exacerbation, hospital admission, lung functions and mortlity.
- Trial name
- NCT04123028
- Testing
- observatory
- Where
- Thailand
- Volunteers
- 145 people
- Sponsor
- Prince of Songkla University