Clinical trials: Enamel Demineralization
Dental Caries, White Spot Lesion
A Randomized Controlled Trial of Vitamin D Supplementation on Salivary Biomarkers and Cariogenic Oral Microbiome
The goal of this clinical trial is to compare the treatment effect of vitamin D supplementation and topical fluorides in the population having vitamin D deficiency and Initial Carious Lesions (ICL) on the progression of ICL in…
- Conditions
- Dental Caries, White Spot Lesion, Initial Caries, Incipient Enamel Caries
- Trial name
- Incipient (NCT06172764)
- Testing
- Vitamin D supplements along with behavioral modification, Topical fluoride application and Vitamin D supplements along with behavioral modification, Topical fluoride application along with behavioral modification
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Primary Ciliary Dyskinesia, Caries,Dental
Assessment of Oral Health Status of Children With Primary Ciliary Dyskinesia
The aim of this study is to compare the oral health findings, salivary parameters and pediatric oral health related quality of life of children with Primary Ciliary Dyskinesia (PCD) with healthy children
- Conditions
- Primary Ciliary Dyskinesia, Caries,Dental, Quality of Life, Saliva Altered
- Trial name
- NCT06618209
- Testing
- physical and chemical methods, biochemical methods, Oral Findings
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Marmara University
Dental White Spots
Enamel Damages Following De-bracketing From Infiltrated Surfaces
Demineralisation and white-spot caries often occures during MB treatment. While resin infiltration has been proved to stop progression of enamel demineralisation, there is still a paucity of information in the literature…
- Trial name
- NCT02359318
- Testing
- Resin infiltration, Bonding and debonding of brackets.
- Where
- Chile
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- DMG Dental Material Gesellschaft mbH
Dental Caries
Diammine Silver Fluoride in Arresting Enamel Caries Lesions on Babies' Occlusal Surfaces
This study aims to verify the actual possibility of using silver diammine fluoride (SDF) in arresting enamel caries lesions on occlusal surfaces of primary molars in babies.
- Trial name
- NCT02789202
- Testing
- Silver diamine fluoride, Fluoride Varnish
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Dental Enamel Hypoplasia
Laser Used in the Treatment of Hypomineralized Occlusal Lesions in Teeth Enamel Affected by MIH
Background: Nowadays an increase in the incidence of teeth affected by molar incisor hypomineralisation (MIH) has been observed.
- Trial name
- NCT03614819
- Testing
- Diode laser group, Glass Ionomer Sealing Group
- Where
- Brazil
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Caries Dentalis
Effect of Lozenges Containing Probiotic Lactobacilli on Enamel Demineralization Assed by QLF
Clinical trials in children and adults have suggested that daily consumption of probiotic lactic acid bacteria can reduce caries risk and caries development in primary teeth in preschool and stop root caries in the elderly.
- Trial name
- NCT01738958
- Testing
- L. retueri
- Where
- Denmark
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Tooth Erosion, Teeth Erosion Due to Vomiting
Clinical Evaluation of Ultrathin Occlusal Veneers for the Treatment of Severe Dental Erosion
Ultra-thin bonded posterior occlusal veneers represent a conservative alternative to traditional onlays and complete coverage crowns for the treatment of severe erosive lesions.
- Conditions
- Tooth Erosion, Teeth Erosion Due to Vomiting, Teeth Erosion Limited to the Enamel, Teeth Erosion Extending Into the Dentine
- Trial name
- UOVTDE (NCT03112278)
- Testing
- Ceramic ultrathin occlusal veneers, Composite resin ultrathin occlusal veneers
- Volunteers
- 10 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Dental Caries, Molar Incisor Hypomineralization
Management of Molar Incisor Hypomineralization With Silver Diamine Fluoride or SMART
The purpose of this study is to evaluate and compare the clinical performance of Silver diamine Fluoride+Potassium Iodide (SDF+KI) and Silver-Modified Atraumatic Restorative Technique (SMART/SDF+KI+GIC) on molars with MIH
- Trial name
- NCT03862014
- Testing
- SDF+KI, SDF+KI+GIC(SMART)
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Enamel Hypomineralization, Dental
The Effectiveness of Biomimetic Materials in Preventing Enamel Demineralization During Fixed Orthodontic Treatment
This study will be done to evaluate the impact of Biosmalto Impact Action Mousse™ on the development and healing of WSLs in individuals receiving orthodontic treatment.
- Trial name
- NCT05940701
- Testing
- Curasept Biosmalto Mousse and toothpaste, Colgate toothpaste
- Where
- Iraq
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Dental Caries Secondary to Polymorphisms, Polymorphisms in Enamel Encoding Genes
Polymorphisms in ENAM, AMBN, and KLK4 Contribute to DCS.
A Cross-Sectional Study aims to shed light on potential genetic determinants influencing dental caries susceptibility within this demographic and significantly understanding of genetic factors associated with dental caries…
- Trial name
- NCT06343766
- Testing
- DNA collation and genotyping
- Where
- Egypt
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Amina Fouad Farag
Dental Caries
Prevention of Enamel Demineralization by Use of K18-smooth Surface Sealant
This study will evaluate effectiveness of a urethane dimethacrylate (UDMA)-quaternary ammonium methacrylate (K18) resin (UDMA-K18) smooth surface sealant to prevent biofilm attachment to tooth surfaces thereby eliminating the…
- Trial name
- K18 (NCT03306433)
- Testing
- UDMA-K18 smooth surface sealant
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Vitamin D Deficiency, Dental Caries
Maternal Vitamin D Levels in Pregnancy and Dental Caries in Children
The main aim of this study is to investigate potential associations between maternal pre- and postnatal vitamin D level and oral health outcomes (caries and developmental defects of enamel) in their children at 7-9 years of age.
- Conditions
- Vitamin D Deficiency, Dental Caries, Dental Enamel Hypoplasia
- Trial name
- NCT03273725
- Testing
- Dental examination including taking a saliva sample.
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Tannhelsetjenestens Kompetansesenter Midt-Norge
Enamel Hypomineralization, Tooth Erosion
Hydroxyapatite Toothpastes and Enamel Remineralization:
This randomized controlled clinical trial aims to evaluate the efficacy of two commercially available toothpastes containing hydroxyapatite in the remineralization of early enamel lesions.
- Trial name
- HEREMI (NCT07069218)
- Testing
- Biorepair® Total Protection Plus Toothpaste, Bioniq® Toothpaste
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
Dental Caries
Study of Factors of Genetic Susceptibility Associated to Severe Caries Phenotype
Alteration of the post- eruptive enamel microstructure due to a mutation of a gene coding for a matrix protein could increase the susceptibility of the enamel to caries after tooth eruption.
- Trial name
- Cariogene (NCT00541060)
- Testing
- mutation
- Where
- France
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Dental Caries, Early Caries Lesions
A Randomized Split-Mouth Clinical Trial Comparing Resin Infiltration and Microabrasion for Early Caries Lesions
This study aims to evaluate and compare the clinical characteristics and treatment outcomes of early caries lesions using resin infiltration (Icon) and microabrasion (Opalustre).
- Conditions
- Dental Caries, Early Caries Lesions, White Spot Lesions[Initial Caries]on Smooth Surface of Tooth
- Trial name
- ICON-CTU (NCT07544849)
- Testing
- Resin Infiltration, Microabrasion
- Where
- Vietnam
- Volunteers
- 30 people
- Sponsor
- Can Tho University of Medicine and Pharmacy
Demineralization
Prevention of Enamel Demineralization Using CPP-ACP-NaF Varnish
Sometimes when people wear braces, the combination of dental plaque and diets high in sugar and acids can lead to white spots on the teeth surrounding the braces.
- Trial name
- CPP-ACP (NCT04002232)
- Testing
- CPP-ACP-NaF varnish
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Dental Enamel Hypoplasia, Dental Caries
Evaluation Direct and Indirect Composite Restoration in Hypomineralization Molars.
The aim of this study is to evaluate the effectiveness of direct and Indirect Composite Restoration in Children With Molar Incisor Hypomineralization Patients (MIH) and following up after 3 , 6 , 12 months (Clinically): Group A …
- Trial name
- NCT05299489
- Testing
- Direct restoration, Indirect restoration
- Where
- Syria
- Volunteers
- 20 people
- Sponsor
- Damascus University
Dental Atraumatic Restorative Treatment
Clinical Evaluation of Enamel Microhardness Using Tooth Whitening Agents
The investigator will review the medical history taken by the participants' orthodontist that determined participants eligibility to participate in this study on the first appointment.
- Trial name
- NCT07165366
- Testing
- Carbamide Peroxide 10%, Hydrogen Peroxide
- Where
- Mexico
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ultradent Products, Inc.
Dental Caries
Validation of Near-infrared Light Transillumination for Interproximal Enamel Caries Detection
The aim of this study is to validate a near-infrared light transillumination device (DIAGNOcam, KaVo, Biberach, Germany) for interproximal enamel caries detection and compare it with the established diagnostic methods (visual…
- Trial name
- NCT02657538
- Testing
- Non invasive caries treatment, Invasive caries treatment, Near-infrared light transillumination device (DIAGNOcam, KaVo, Biberach, Germany)
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Bern
White Spot Lesion
Evaluation of Enamel Demineralization During Clear Aligner Orthodontic Treatment
Development of white spot lesions (enamel demineralization) will be evaluated quantitatively during clear aligner orthodontic treatment compared to conventional fixed appliances using quantitative light induced fluorescence (QLF)
- Trial name
- NCT04107012
- Testing
- Orthodontic treatment with clear aligner
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology