Clinical trials: Enamel Demineralization
Dental Caries
Prevention of Enamel Demineralization by Use of K18-smooth Surface Sealant
This study will evaluate effectiveness of a urethane dimethacrylate (UDMA)-quaternary ammonium methacrylate (K18) resin (UDMA-K18) smooth surface sealant to prevent biofilm attachment to tooth surfaces thereby eliminating the…
- Trial name
- K18 (NCT03306433)
- Testing
- UDMA-K18 smooth surface sealant
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Caries,Dental
Fluoridated Milk and Enamel Caries in Adolescents
The goal of this trial is to investigate whether low daily doses of fluoridated milk, in addition to oral hygiene routines with fluoridated toothpaste, can prevent caries development in adolescents' teeth.
- Trial name
- NCT06684405
- Testing
- sodium sodium fluoride solution (0.75 mg for subjects aged 12 and 1.0 mg for subjects aged 13), Subjects in the control group received a daily dose of 0.5 ml sterile water to be added to 200 ml of milk.
- Where
- Sweden
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Malmö University
White Spot Lesions, Proximal Caries
Labial White Spot Lesions and Proximal Caries Development in Orthodontic Patients Using Clear Aligners Versus Traditional Braces.
This randomized clinical trial evaluates the risk of developing early tooth decay in patients undergoing orthodontic treatment with either traditional fixed braces or clear aligners.
- Conditions
- White Spot Lesions, Proximal Caries, Oral Hygiene in Orthodontic Patients, Plaque Removal
- Trial name
- NCT07550179
- Testing
- Fixed pre-adjusted edgewise orthodontic appliance, Clear aligner therapy
- Where
- United Arab Emirates
- Volunteers
- 24 people
- Sponsor
- University of Sharjah
Enamel Hypomineralization, Dental
The Effectiveness of Biomimetic Materials in Preventing Enamel Demineralization During Fixed Orthodontic Treatment
This study will be done to evaluate the impact of Biosmalto Impact Action Mousse™ on the development and healing of WSLs in individuals receiving orthodontic treatment.
- Trial name
- NCT05940701
- Testing
- Curasept Biosmalto Mousse and toothpaste, Colgate toothpaste
- Where
- Iraq
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Dental Caries, Dental Fluorosis
Anticaries Potential and Fluorosis Risk From Different Fluoride Toothpastes
Fluoride toothpaste has been associated not only with declining dental caries prevalence but also with an increase in dental fluorosis.
- Trial name
- NCT01589991
- Testing
- Toothpaste
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Dental Erosion
A New Protocol for the Management of Dental Erosion in Rugby Players
The aim of the present study is to provide a new domiciliary oral care treatment for enamel remineralization in rugby players patients using mouthguards.
- Trial name
- NCT05140538
- Testing
- SRP + toothpaste + mouthwash, SRP + toothpaste
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Pavia
White Spot Lesion
Comparing Fluoride Varnish and Sealant to Prevent White Spots in Orthodontic Patients
The purpose of the study is o compare the efficacy of CPP-ACP MI Varnish and ProSeal sealant in preventing white spot lesion (WSL) formation in orthodontic patients.
- Trial name
- NCT04560478
- Testing
- Pro Seal Sealant, MI Varnish
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Dental Caries, Tooth Demineralization
Kissing as a Protective Factor Against Acidic pH in Saliva
The pH of saliva can be acidic or alkaline; When it is acidic, the tooth enamel is demineralized, that is, weakened. Additionally, bacteria in the mouth can increase and cause infections such as cavities.
- Conditions
- Dental Caries, Tooth Demineralization, Teeth Erosion Limited to the Enamel
- Trial name
- NCT06501729
- Testing
- Kiss
- Where
- Ecuador
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Universidad Catolica Santiago de Guayaquil
Dental Caries in Children, Tooth Erosion
3D Scanning as an Advanced Tool for Identifying Tooth Lesions in Children
This study focuses on assessing dental caries, erosive tooth wear, and fluorosis in primary teeth using a 3D intraoral digital scanner.
- Conditions
- Dental Caries in Children, Tooth Erosion, Fluorosis, Dental, Dental Caries
- Trial name
- NCT06829550
- Testing
- indirect- 3D digital scanning
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Indiana University
Molar Incisor Hypomineralization, Dental Caries
Silver Diamine Fluoride and Papain-Based Gel for Management of MIH-affected Molar in Paediatric Patients
Molar incisor hypomineralization (MIH) is a developmental defect of enamel affecting the first permanent molar and frequently the incisors with a prevalence of 16-16.9% in Malaysia.
- Conditions
- Molar Incisor Hypomineralization, Dental Caries, Hypomineralization of Enamel
- Trial name
- NCT04710927
- Testing
- Silver Diamine Fluoride, Papain-Based Gel, High Viscosity Glass Ionomer Cement (HVGIC)
- Where
- Malaysia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Tooth Erosion
Evaluation of a Test Mouthwash and Dentifrice Regimen in an In-situ Model of Dental Erosion
An in situ model will be used to evaluate and compare enamel remineralization of bovine enamel specimens.
- Trial name
- NCT01128972
- Testing
- Sodium fluoride, Sodium monoflurophosphate, Sterile water
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
White Spot Lesions, Enamel Demineralization
A Novel Remineralizing Self-Etch Primer for Orthodontic Bracket Bonding
This randomized clinical trial aims to evaluate the clinical effectiveness of a remineralizing self-etch primer used for orthodontic bracket bonding.
- Trial name
- NCT07291830
- Testing
- Remineralizing self-etch primer (M-SEP, SEP 1), Standard self-etch primer (P-SEP, SEP 2)
- Where
- Iraq
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Tooth Erosion
An Erosion Study to Investigate the Efficacy of an Experimental Dentifrice to Remineralize Enamel
The purpose of this study is to investigate the ability of an experimental dentifrice containing 1150 parts per million (ppm) fluoride to remineralize acid-softened dental enamel and help prevent further demineralization compared…
- Trial name
- NCT06242444
- Testing
- Experimental Dentifrice, Reference Dentifrice
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- HALEON
Dental Caries
In Situ Remineralisation Response of Different Artificial Caries-like Enamel Lesions to Home-care and Professional Fluoride Treatments
This study mainly compared the response of the artificial carious enamel lesions to remineralisation in situ. The tested in vitro demineralising protocols were: MC gel, PA gel, MHDP and Buffer solutions.
- Trial name
- NCT02637830
- Testing
- Application of fluoride varnish (22600 ppm F, Duraphat) at the begining of the study, Application of fluoride toothpaste (1500 ppm F, Crest) twice a day for 3 days of the study
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Dental Atraumatic Restorative Treatment
Clinical Evaluation of Enamel Microhardness Using Tooth Whitening Agents
The investigator will review the medical history taken by the participants' orthodontist that determined participants eligibility to participate in this study on the first appointment.
- Trial name
- NCT07165366
- Testing
- Carbamide Peroxide 10%, Hydrogen Peroxide
- Where
- Mexico
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ultradent Products, Inc.
Enamel Demineralization
Comparative Assessment of Adhesive PreCoated (APC) Flash-free and Conventional Brackets and the Effects on Enamel Demineralization and Periodontal Health
Adhesive PreCoated (APC) flash-free brackets have been recently introduced, with no need of flash removal step. Evaluation of APC and conventional brackets and their effects on enamel demineralization and periodontal health.
- Trial name
- NCT07752290
- Testing
- Group A, Group B
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Foundation University Islamabad
Orthodontic Appliance Complication, Tooth Demineralization
Fluoride Delivery to Prevent White Spots During Orthodontic Treatment
The aim of this 2-armed, parallel, randomised, controlled trial is to assess the effect of different ways of applying fluoride to teeth on the formation of white spots (enamel demineralisation), during orthodontic treatment with…
- Trial name
- FL4OWS (NCT05005689)
- Testing
- Fluoride mouthwash (0.05%; 225ppm)., Tooth Mousse Plus
- Where
- United Kingdom
- Volunteers
- 130 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Fissure Sealants, Oral Hygiene Orientation
Efficacy of Sealants in Cavitated Enamel Lesions on Occlusal Surfaces in Children
The aim of this study is to evaluate the efficacy of oral hygiene orientation singly, compared to resin-based sealants in controlling occlusal cavitated enamel lesions on primary and permanent molars.
- Trial name
- SLM1661 (NCT02617940)
- Testing
- fissure sealant, oral hygiene orientation
- Where
- Brazil
- Volunteers
- 546 people
- Sponsor
- Faculty Sao Leopoldo Mandic Campinas
Caries, Dental, Fluorosis, Dental
Dental Fluorosis Risk by the Use of Acidulated Fluoride Dentifrice
This research aimed to evaluate the risk of dental fluorosis by using an experimental fluoridated acidulated dentifrice compared to conventional dentifrices in two-to-four-year-old children residing in a non fluoridated area by…
- Trial name
- NCT03761485
- Testing
- Use of Dentifrice Fluoride
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- Federal University of Paraíba
Dental White Spots
Enamel Damages Following De-bracketing From Infiltrated Surfaces
Demineralisation and white-spot caries often occures during MB treatment. While resin infiltration has been proved to stop progression of enamel demineralisation, there is still a paucity of information in the literature…
- Trial name
- NCT02359318
- Testing
- Resin infiltration, Bonding and debonding of brackets.
- Where
- Chile
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- DMG Dental Material Gesellschaft mbH