Clinical trials: End of Life Care
Palliative Care
Complex Decisions Regarding Antithrombotic Therapy: the QUIET Study
"Complex decisions regarding antithrombotic therapy: the QUIET study" is a monocentric observational study without drug intervention, conducted through the administration of a questionnaire (survey).The aim of this study is to…
- Trial name
- QUIET (NCT07486154)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Perinatal Death, Third Trimester Modified Biophysical Profile Scan
Third Trimester Modified Biophysical Profile Scan for Predicting Fetal Outcome.
Study topic: Predicting fetal outcome using third trimester modified biophysical profile (BPP) scan compared with standard of care; a randomized clinical trial at St. Francis Hospital, Nsambya.
- Trial name
- NCT03729089
- Testing
- Modified Biophysical Profile scan
- Where
- Uganda
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Dr Andrew Odur
Palliative Care
Implementation of RELIEF for Patients With Palliative Care Needs
For patients with palliative care needs, access to care is constrained by health system resources and a requirement to visit their clinician for assessments.
- Trial name
- NCT05806255
- Testing
- The RELIEF App
- Volunteers
- 600 people
- Sponsor
- William Osler Health System
Brain Injuries, Congenital Heart Disease
Protecting Brains and Saving Futures - the PBSF Protocol
Background: Multiple neonatal disorders are associated with risks of neurological injury. Thus, management of these infants should involve a coordinated approach to permit early diagnosis with improved clinical care.
- Conditions
- Brain Injuries, Congenital Heart Disease, Newborn Morbidity, Intraventricular Hemorrhage
- Trial name
- PBSF (NCT03786497)
- Where
- 2 sites in Brazil
- Volunteers
- 2,268 people
- Sponsor
- Protecting Brains Saving Futures
Pre-Eclampsia, Premature Birth
PREPARE, Prematurity Reduction by Pre-eclampsia Care
Investigators will test a novel system of integrated care, to promote the use of the WORLD HEALTH ORGANIZATION Guidelines for the management of pre-eclampsia and initiate the use of a structured risk assessment strategy to reduce…
- Trial name
- PREPARE (NCT03073317)
- Testing
- FullPIERS and sFlit/PLGF (Soluble fms-Like Tyrosine Kinase-1-to-Placental Growth Factor Ratio)
- Where
- 8 sites in Brazil
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Instituto Fernandes Figueira
Maternal Mortality, Maternal Morbidity
An Implementation Study of Interventions to Promote Safe Motherhood in Jimma Zone Ethiopia
Ethiopia has one of the highest rates of maternal mortality among all countries in Africa and indeed worldwide, with a maternal mortality ratio of 676 per 100,000 live births in 2011 (UNFPA, 2012).
- Trial name
- NCT03299491
- Testing
- MWA intervention, IEC intervention
- Volunteers
- 3,784 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Advanced Cancer, Terminal Malignant Tumors
Nurses' Competence and Role in Survival Prediction and Prognostic Communication
[Background] Nurses' roles in survival prediction and prognostic communication have historically been limited due to role delineation, lack of formal training, and cultural norms.
- Conditions
- Advanced Cancer, Terminal Malignant Tumors, Hospices
- Trial name
- NCT06962553
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Death
Advance Directives and End-of-life Decision Making in Intensive Care Medicine in Germany
Description of the decision making process as well as the practices of end of life care in an ICU of a German university hospital during the period when changes of German legislation occurred.
- Trial name
- NCT01294189
- Where
- Germany
- Volunteers
- 224 people
- Sponsor
- Charite University, Berlin, Germany
Demographics of Intubated Patients Due to an Urgent Call
Assessment of the Patients of Emergency Consultation
The demographic data, mortality rates and clinical diagnoses of the patients who were evaluated, intubated and interned to ICU by the anesthesiology department due to an urgent consultation call from the emergency department in…
- Trial name
- ICU (NCT02216929)
- Where
- Turkey (Türkiye)
- Volunteers
- 287 people
- Sponsor
- Gulsah Karaoren
Maternal Death
Maternal Health Service Utilization Among Women of Reproductive Age in Sidama Region, Ethiopia
Introduction: Maternal health service (MHS) utilization helps to decrease maternal morbidity and mortality. However, the existing evidence is not sufficient to design effective and efficient strategies.
- Trial name
- MHSU (NCT05865873)
- Testing
- Health education
- Where
- Ethiopia
- Volunteers
- 1,126 people, healthy volunteers welcome
- Sponsor
- Hawassa University
Mitochondrial Diseases
EPI-743 for Mitochondrial Respiratory Chain Diseases
This study will evaluate the safety and efficacy of EPI-743 in participants with severe mitochondrial respiratory chain diseases who are considered to be within 90 days of end-of-life care.
- Trial name
- NCT01370447
- Testing
- EPI-743
- Where
- 16 sites in United States
- Sponsor
- PTC Therapeutics
Perinatal Problems, Still Births
Community-based Perinatal and Newborn Care in Gilgit District, Northern Areas, Pakistan: an AKU-AKHSP Collaboration
There is limited evidence from community-based interventions to guide the development of effective maternal, perinatal and newborn care practices and services in developing countries.
- Conditions
- Perinatal Problems, Still Births, Neonatal Deaths
- Trial name
- NCT02412293
- Testing
- Health Education & Promotion, Training of Health Workers, Community Mobilization
- Where
- Pakistan
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Death Occurring in Intensive Care Units
Informed Consents for Withholding/Withdrawing Life Support in Intensive Care Units
End-of- life care is a major issue in medical ethics with life support technology progress. Intensive care may prolong the dying process in patients who have been unresponsive to the treatment already provided.
- Trial name
- NCT02020473
- Where
- South Korea
- Volunteers
- 348 people
- Sponsor
- Yonsei University
Cervical Pregnancy, Maternal Care for Late Fetal Death
Medical Management of Late Intrauterine Death.
The purpose of this study is to assess the therapeutic efficacy and safety of isosorbide dinitrate-oxytocin in combination in the management of late intrauterine foetal death.
- Trial name
- INPer (NCT02488642)
- Testing
- Isosorbide Dinitrate, Misoprostol, Oxytocin
- Volunteers
- 60 people
- Sponsor
- National Institute of Perinatology
Neoplasms (Cancer / Tumors), Palliative Care
Nurse-Led Culturally Adapted Palliative and End-of-Life Training for Oncology Nurses in Oman
This study evaluated a nurse-led, culturally adapted training program in palliative and end-of-life care (N-PELTP) for oncology nurses in Oman.
- Conditions
- Neoplasms (Cancer / Tumors), Palliative Care, Terminal Care
- Trial name
- N-PELTP (NCT07460570)
- Testing
- N-PELTP Palliative and End-of-Life Training Program
- Where
- 2 sites in Oman
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- Sultan Qaboos University
Dementia
Palliative and End-of-life Care in Advanced Dementia: Evaluation of a Program of Organization of Care in Long-term Care
Rationale: In Canada, as in most industrialized countries, Alzheimer's disease and other related dementia are increasingly prevalent in older people.
- Trial name
- NCT01441726
- Where
- Canada
- Volunteers
- 175 people
- Sponsor
- Laval University
Infant Mortality, Under-two Mortality
Integrating Pediatric Care Delivery in Rural Healthcare Systems
Globally, over seven million children under the age of five die each year, although a suite of interventions-safe delivery care, neonatal care and resuscitation, and management of childhood diarrhea, malnutrition, and…
- Trial name
- NCT02331082
- Testing
- Structured Quality Improvement, Chronic Care Model, Integrated Electronic Medical Record
- Where
- 2 sites in Nepal
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Possible
Preterm Infant, Hypothermia, Newborn
Early Kangaroo Mother Care in Gambian Hospitalised Unstable Neonates
The mortality effect of kangaroo mother care in stable newborns <2000g is well established but mortality effect in unstable newborns is not conclusively known.
- Conditions
- Preterm Infant, Hypothermia, Newborn, Death, Kangaroo Mother Care
- Trial name
- eKMC (NCT03555981)
- Testing
- Early Kangaroo Mother Care, Standard care
- Where
- The Gambia
- Volunteers
- 279 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Education, Medical, Education, Medical, Graduate
Discussing Death and Dying: An End of Life Curriculum to Empower Residents
This study will evaluate how the educational intervention utilized affects pediatric resident comfort level with EOL discussions.
- Conditions
- Education, Medical, Education, Medical, Graduate, Care, Palliative, Medicine, Palliative
- Trial name
- NCT03186274
- Testing
- Facilitated Group Session, CELA Session
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Cancer, Patients Living With Stage IV or Recurrent Cancer
Quality of Care for Adolescent and Young Adult (AYA) Patients Living With Serious or Advanced Cancer
Background: Cancer among adolescents and young adults (AYAs) is on the rise, with nearly 90,000 AYAs diagnosed in the US each year.
- Trial name
- NCT07484282
- Testing
- Quality Assessment
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)