Clinical trials: Endocrine System Disorder
Hypothyroidism, Hashimoto Disease
Gluten Free Diet in Hashimoto's Hypothyroidism
Hashimoto's thyroiditis is an autoimmune condition that reduces functioning of the thyroid gland and can lead to a substantial decline in quality of life for patients, with impacted patients often describing unremitting brain…
- Trial name
- NCT07060118
- Testing
- Gluten Free Diet in Hashimoto's Hypothyroidism
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The Cleveland Clinic
Type 2 Diabetes Mellitus
Continuous Glucose Monitoring (CGM) in Subjects With Type 2 Diabetes Taking Twice-Daily Exenatide or Once-Weekly Exenatide
The purpose of this substudy is to obtain CGM data from individuals taking exenatide. The CGM measurements gathered before starting and during treatment with exenatide IR and/or exenatide LAR will help determine the…
- Trial name
- NCT00803920
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- HealthPartners Institute
Type 1 Diabetes (Juvenile Onset), Continuous Glucose Monitoring System
Mediterranean Diet and Oxidative Stress in Type 1 Diabetes (MEDOX-T1D)
Achieving optimal glycemic control in type 1 diabetes requires a holistic approach that includes individualized medical nutrition therapy in addition to appropriate insulin therapy.
- Conditions
- Type 1 Diabetes (Juvenile Onset), Continuous Glucose Monitoring System, Oxidative Stress
- Trial name
- MEDOX-T1D (NCT07544368)
- Testing
- Mediterranean Diet Intervention
- Volunteers
- 54 people
- Sponsor
- Istanbul University
Obesity, Type 2 Diabetes
Activity and Metformin Intervention in Obese Adolescents
The purpose of this study is to assess the sustainability of a two-year intervention aimed at improving body mass index (BMI) and metabolic and vascular health in obese youth.
- Trial name
- REACH (NCT00934570)
- Testing
- Metformin and standard exercise, Metformin Intensive exercise, Intensive exercise
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Diabetes Type 1
French Version of the Scales of Fear of Hypoglycaemia in Children With Type 1 Diabetes and Their Parents
Type 1 diabetes usually appears brutally in children or young adults. While many factors of poor glycemic balance have been identified in the literature (age, socio-cultural and socio-economic level, family structure, adherence…
- Trial name
- FHS (NCT03529188)
- Where
- 3 sites in France
- Volunteers
- 194 people
- Sponsor
- University Hospital, Brest
Inguinal or Ovarian Hernia, Hydrocele
Transversus Abdominis Plane Block in Pediatrics: Volume or Concentration ?
The transversus abdominis plane (TAP) block provide a local anesthesia drug diffusion between the transverse abdominis muscle and the internal oblique muscle.
- Conditions
- Inguinal or Ovarian Hernia, Hydrocele, Cord Kyst, Local Analgesia Block
- Trial name
- TAP Bloc (NCT02064088)
- Testing
- Injection of 0,2 ml/kg of 0,2% levobupivacaine for small volume group, Injection of 0,4 ml/kg of 0,1% lévobupivacaine for high volume group
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Montpellier
Mediastinal Cancer, Metastatic Cancer
Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
- Conditions
- Mediastinal Cancer, Metastatic Cancer, Testicular Germ Cell Tumor
- Trial name
- NCT00003941
- Testing
- bleomycin sulfate, filgrastim, cisplatin
- Where
- 37 sites in Austria, Belgium and 10 more
- Volunteers
- 222 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Diabetes
Investigating Ultrasound Debridement in Wound Care
The initial step of wound management, debridement, is thought to be critical in promoting wound healing. Of the numerous debridement modalities, ultrasound seems to hold promising results in accelerate healing in our own clinical…
- Trial name
- NCT03516422
- Testing
- ULTRASOUND DEBRIDEMENT, STANDARD CARE GROUP
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor
High-Dose Thiotepa Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Conditions
- Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Ovarian Cancer
- Trial name
- NCT00003173
- Testing
- filgrastim, thiotepa, autologous bone marrow transplantation
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Turner Syndrome, Ovarian Insufficiency
Cryopreservation of Ovarian Cortex in Girls With Turner Syndrome
Ovarian insufficiency is common in Turner syndrome related to premature and rapid follicular apoptosis and spontaneous pregnancies are rare in this population.
- Trial name
- CRYO-X0 (NCT01410045)
- Testing
- Ovariectomy
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
PreDiabetes, Obesity
Clinical Trial of Crocus Kozanis Administration in Obese Children and Adolescents
The study aims to investigate possible effects of per os Crocus Kozanis administration in children and adolescents with obesity
- Conditions
- PreDiabetes, Obesity, Dyslipidemias
- Trial name
- NCT05572749
- Testing
- Crocus Kozanis, Metformin
- Where
- Greece
- Volunteers
- 75 people
- Sponsor
- Aristotle University Of Thessaloniki
Type 1 Diabetes Mellitus
Shared Medical Decision Making in Pediatric Diabetes
This work is testing a shared medical decision making intervention for adolescents with type 1 diabetes and their parents who are candidates for adding either an insulin pump or continuous glucose monitor to their treatment plan.
- Trial name
- NCT02496156
- Testing
- Usual Clinical Practice, Shared Medical Decision Making
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- Nemours Children's Clinic
Type 1 Diabetes Mellitus
Frexalimab in Preservation of Endogenous Insulin Secretion Compared to Placebo in Adults and Adolescents on Top of Insulin Therapy (FABULINUS)
This is a randomized, parallel group, double-blind Phase 2 study with a blinded extension evaluating the safety and efficacy of 3 dose levels of frexalimab in comparison with placebo in participants with newly diagnosed T1D on…
- Trial name
- FABULINUS (NCT06111586)
- Testing
- Frexalimab, Insulin
- Where
- 79 sites in United States, Austria and 14 more
- Volunteers
- 197 people
- Sponsor
- Sanofi
Pancreatic Neoplasm
Endoscopic Ultrasound Radiofrequency Ablation, Database Repository
The purpose of having this database is to collect data related to endoscopic ultrasound RFA procedures performed by Indiana University EUS physicians for the treatment of tumors or adenopathy.
- Trial name
- EUS-RFA (NCT04693754)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Indiana University
Diabetes Mellitus, Type 1
A Pilot Study of Biomarkers of Stress in Youth Who Use Teens.Connect
This feasibility/pilot study has three purposes. First, the investigators will determine the feasibility of collecting saliva to measure stress biomarkers over three days at home in youth.
- Trial name
- NCT02970656
- Testing
- Teens.Connect
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Yale University
Type I Diabetes
Management of Type 1 Diabetes Among Adolescents
This 1-year study will explore the influences of family and peers on how diabetic adolescents manage their disease, focusing on adolescent developmental transitions.
- Trial name
- NCT00340639
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Diabetes Mellitus
Continuous Glucose Monitor Use in School
The purpose of this study is to find the impact of continuous blood glucose sensors use in the classroom/school environment. We will be asking the subject,subject's parent and subject's teachers to complete a short…
- Trial name
- NCT01364766
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Stanford University
Pancreatic Cancer, Neoadjuvant
An Exploration of Candidates for Neoadjuvant Treatment in Resectable Pancreatic Cancer
An Exploration of Candidates for Neoadjuvant Treatment in Resectable Pancreatic Cancer
- Trial name
- NCT06129812
- Testing
- Neoadjuvant treatment
- Volunteers
- 1,132 people
- Sponsor
- Seoul National University Hospital
Advanced Solid Tumor
A Phase I/IIa Study of JAB-23E73 in Patients With Advanced Solid Tumors Harboring KRAS Gene Alteration
This is a multicenter, open-label, phase I/IIa to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of pan-KRAS inhibitor JAB-23E73 in patients with advanced solid…
- Trial name
- NCT06959615
- Testing
- JAB-23E73
- Where
- 32 sites in China
- Volunteers
- 334 people
- Sponsor
- Jacobio Pharmaceuticals Co., Ltd.
Carcinoma, Endometrioid, Fertility Preservation
Fertility Sparing Therapy for Patients With Stage IA G2 Endometrial Cancer
Endometrial cancer (EC) is a prevalent gynecological cancer with an escalating global incidence and a decreasing age of onset. In the era of precision medicine, there is an increasing emphasis on tailoring treatments to different…
- Trial name
- NCT06468215
- Testing
- Treatment Option 1 is a single-drug regimen, with oral medroxyprogesterone acetate (MPA) 500mg/d or MA 320mg/d.
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Peking University People's Hospital
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