Clinical trials: Ex Vivo Lung Perfusion
Organ Preservation
Ex Vivo Lung Perfusion : Effect of Cellular Perfusate on Mechanical Properties and Gas Exchange Function of Donor Lungs
The lungs retrieved from the brain dead multi organ donor will be placed in a lab . They will be connected to a ventilator and preservative solution will be circulated through it .
- Trial name
- NCT02953483
- Testing
- Red blood cells
- Where
- India
- Volunteers
- 6 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Ex Vivo Lung Perfusion, Lung Transplantation
Ex Vivo Lung Perfusion in Bergamo Lung Transplant Program
Ex Vivo Lung Perfusion (EVLP) appears to be an effective strategy to expand the lung donor pool by better evaluation and reconditioning of non standard grafts.
- Trial name
- NCT03053349
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Papa Giovanni XXIII Hospital
Emphysema, Chronic Obstructive Pulmonary Disease (COPD)
Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability
The purpose of this research study is to learn about the safety of transplanting lungs obtained from non-heart-beating donors (NHBDs) that have been ventilated (attached to a breathing machine or ventilator to deliver oxygen) and…
- Conditions
- Emphysema, Chronic Obstructive Pulmonary Disease (COPD), Cystic Fibrosis, Pulmonary Fibrosis
- Trial name
- NCT01615484
- Testing
- Transplantation of lungs obtained from Non-Heart-Beating Donors (NHBDs) after ex-vivo perfusion w/ STEEN Solution™, STEEN Solution™
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- University of North Carolina, Chapel Hill
Respiratory Tract Diseases
Evaluation and Reconditioning of Marginal Lung Donors to Transplantation by ex Vivo Lung Perfusion
Only about 15% of the potential candidates for lung donation are considered suitable for transplantation. A new method for ex vivo lung perfusion (EVLP) has been developed and can be used for evaluation and reconditioning of…
- Trial name
- NCT01353105
- Testing
- Ex vivo lung transplantation
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- InCor Heart Institute
Neurogenic Lung Edema
Rule of Carbone Monoxyde in the Ex Vivo Lung Perfusion Reconditionning
Ex vivo lung perfusion (EVLP) is not a new concept and has been widely used to study lung function in small animals. It also has been shown to be a useful technique to evaluate lungs from donation after cardiac death (DCD)…
- Trial name
- NCT02032082
- Testing
- Carbone monoxide
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- University Hospital of Mont-Godinne
Lung Transplantation
Pharmacokinetics of Imipenem During Ex Vivo Lung Perfusion (EVLP)
Ex vivo lung perfusion (EVLP) is an established strategy to evaluate and optimize high-risk donor lungs that would otherwise be rejected for transplantation mainly due to the presence of edema or infection.
- Trial name
- NCT02670239
- Testing
- normothermic ex vivo lung perfusion
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Turin, Italy
Lung Diseases
Evaluating the Addition of Hemodiafiltration to EVLP - Impact on the Regeneration of Marginal Donor Lungs
The primary objective of the study is the evaluation of the effect of hemodiafiltration during ex vivo lung perfusion in marginal donor lungs, and its feasibility.
- Trial name
- NCT06082401
- Testing
- hemodiafiltration (HDF), Ex vivo lung perfusion (EVLP)
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna