Clinical trials: Extracorporeal Life Support
Acute Respiratory Distress Syndrome (ARDS), Multiple Organ Failure
Intrapleural Methylprednisolone Injection for Multiple Organ Failure With Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) in combination with multi-organ dysfunction syndrome (MODS) is a life-threatening condition, particularly when treatment modalities such as extracorporeal membrane oxygenation (ECMO) and…
- Trial name
- IP steroid (NCT01423864)
- Testing
- conventional ECMO with intravenous steroid, solumedrol
- Where
- Taiwan
- Volunteers
- 29 people
- Sponsor
- National Taiwan University Hospital
Poison;Medicinal, Extracorporeal Membrane Oxygenation
Treatment of Extracorporeal Membrane Oxygenation in Severe Poisoning
This is a prospective, multicentre clinical study to determine the value of the Extracorporeal Membrane Oxygenation in the treatment of critically ill poisoning patients and whether there are significant differences in the…
- Trial name
- NCT05762029
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Affiliated Hospital of Nantong University
Acute Respiratory Failure
Observational Cohort Study of a National Extracorporeal Membrane Oxygenation Service for Adults With Respiratory Failure: the NHS ECMO Study.
This is an observational study of outcomes of the NHS England-commissioned national respiratory ECMO service, which has been active at six centres since December 2011.
- Trial name
- NHS ECMO (NCT03979222)
- Testing
- Extracorporeal Membrane Oxygenation
- Volunteers
- 1,205 people
- Sponsor
- University of Cambridge
Respiratory Distress Syndrome, Adult, Septic Shock
Immunglobulin M Enriched Intra Venous Immunoglobulin (IVIG) Therapy in Adult Respiratory Distress Syndrom (ARDS) Patients
57 patients with Adult Respiratory Distress Syndrome (ARDS) requiring Extracorporeal membrane oxygenation (ECMO) therapy were analyzed retrospectively.
- Trial name
- IVIG (NCT02961166)
- Testing
- IgM enriched Immunoglobulins
- Where
- Germany
- Volunteers
- 57 people
- Sponsor
- University Hospital Tuebingen
Extra Corporeal Membrane Oxygenation, Decanulated Alive
Modeling of Intracerebral Vascularization After Extracorporeal Membrane Oxygenation in Children
Extra corporeal membrane oxygenation (ECMO) is a transient supplementation technique that alleviates hemodynamic and ventilatory failure.
- Trial name
- MoVa-ECMO (NCT05237232)
- Testing
- Magnetic Resonance Angiography (MRA) additional acquisition time, Modeling cerebral vascularization
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Extracorporeal Membrane Oxygenation, Children
Biomarkers of Brain Injury in Critically-Ill Children on Extracorporeal Membrane Oxygenation
The BEAM study is a multicenter, prospective, observational study in children supported on extracorporeal membrane oxygenation (ECMO).
- Conditions
- Extracorporeal Membrane Oxygenation, Children, Neurologic Injury
- Trial name
- BEAM (NCT05041712)
- Where
- 11 sites in United States
- Volunteers
- 455 people
- Sponsor
- Johns Hopkins University
Extracorporeal Membrane Oxygenation Complication, Cardiopulmonary Bypass
Evaluation Of The Pharmacokinetics Of Antithrombin III In Neonates And Infants Undergoing CPB And ECMO Support
The potential role of ATIII in achieving and maintaining adequate anticoagulation in pediatric patients on the heart-lung machine has recently taken on increased importance as caregivers strive to mitigate the risk for clinically…
- Trial name
- NCT02631174
- Testing
- Antithrombin III
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Extracorporeal Circulation; Complications, Extracorporeal Membrane Oxygenation Complication
DIC Markers and Thrombin Generation Parameters in Patients on ECMO Support: a Pilot Study
To study the correlation between novel DIC markers and thrombin generation parameters with thrombotic and hemorrhagic complications of patients on ECMO support.
- Trial name
- DIC-ECMO (NCT06095518)
- Testing
- DIC markers and Thrombin Generation Parameters
- Where
- Hong Kong
- Volunteers
- 49 people
- Sponsor
- Queen Mary Hospital, Hong Kong
Extracorporeal Membrane Oxygenation Complication, Pediatric ALL
Study Comparing Bivalirudin Versus Heparin in Neonatal and Pediatric ECMO
The investigators will prospectively enroll 30 neonatal and pediatric ECMO patients at a single pediatric Level 1 trauma center.
- Conditions
- Extracorporeal Membrane Oxygenation Complication, Pediatric ALL, Anticoagulants
- Trial name
- NCT03318393
- Testing
- Bivalirudin, Unfractionated heparin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Texas Southwestern Medical Center
Acute Hypoxemic Respiratory Failure
Airway Closure During Extracorporeal Membrane Oxygenation: The AiCLOSE Study
About 65,000 Canadians develop acute respiratory failure requiring breathing machines (ventilators) to give oxygen to their lungs. Unfortunately, up to 50% of these individuals will not survive their illness.
- Trial name
- AiCLOSE (NCT05196074)
- Testing
- Acute hypoxemic respiratory failure patients on VV-ECMO
- Where
- Canada
- Volunteers
- 299 people
- Sponsor
- Lorenzo delSorbo
Cardiac Arrest, Extracorporeal Membrane Oxygenation
Predictors for Survival and Good Neurological Outcome in E-CPR and Non CPR Treated Patients
In ECPR, where CPR times often range from 30 to 120 minutes, only patients with good circulation during CPR survive, while non-survivors commonly suffer from anoxic brain injury.
- Conditions
- Cardiac Arrest, Extracorporeal Membrane Oxygenation, Hypoxia-Ischemia, Brain
- Trial name
- NCT04198792
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 700 people
- Sponsor
- Sahlgrenska University Hospital
Extracorporeal Life Support, Extracorporeal Membrane Oxygenation
Quality Improvement to Reduce Mortality or Severe Intracranial Hemorrhage in Neonatal Extracorporeal Life Support
This is a three-year pre- and post- interventional study to assess the effectiveness of collaborative quality improvement interventions on reducing mortality and severe intracranial hemorrhage (ICH) for neonates receiving…
- Conditions
- Extracorporeal Life Support, Extracorporeal Membrane Oxygenation, Quality Improvement, Intracranial Hemorrhage
- Trial name
- NCT05075486
- Testing
- Collaborative quality improvement
- Sponsor
- Children's Hospital of Fudan University
Extracorporeal Life Support, Neonate
Chinese Neonatal Extracorporeal Life Support Registry (Chi-NELS)
Extracorporeal life support (ECLS), also known as extracorporeal membrane oxygenation (ECMO), is an extracorporeal technique which provides respiratory and cardiac support to patients with respiratory and/or heart failure.
- Trial name
- NCT05085080
- Sponsor
- Children's Hospital of Fudan University
Cardiopulmonary Arrest, Fungal Infection
Pharmacokinetics/Pharmacodynamics (PK/PD) of Fluconazole in Children on Extracorporeal Membrane Oxygenation (ECMO)
Extracorporeal membrane oxygenation (ECMO) is a form of heart-lung bypass used to support children who suffer heart or lung failure until whatever illness caused that failure can be treated and reversed.
- Trial name
- NCT01169402
- Testing
- Fluconazole
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Michael Cohen-Wolkowiez
Extracorporeal Membrane Oxygenation
Oxygen Consumption In Critically Ill Children
The investigators propose to examine the relationship between DO2 and VO2 in critically ill patients requiring an Extracorporeal Membrane Oxygenation (ECMO) machine.
- Trial name
- NCT01521195
- Testing
- Extracorporeal blood flow via ECMO machine
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- The Hospital for Sick Children
Shock, Cardiogenic, Cardiac Arrest
ECMO LEft Ventricle UNloading Strategy
The present study is an International multicentric prospective observational cohort study. This will be an international research campaign to prospectively collect and analyze clinical data of all VA ECLS patients admitted to…
- Conditions
- Shock, Cardiogenic, Cardiac Arrest, Extracorporeal Membrane Oxygenation Complication
- Trial name
- ECMOLENS (NCT06766006)
- Testing
- Venoarterial extracorporeal life support (VA ECLS) implant
- Where
- Netherlands
- Volunteers
- 500 people
- Sponsor
- Maastricht University Medical Center
Extracorporeal Membrane Oxygenation, Cardiopulmonary Resuscitation
Cross-sectional Survey of Zhejiang ECMO Application
Extracorporeal lung oxygenation (ECMO) was first used in neonates in the 1970s and is now widely used to treat adult patients with intractable shock and respiratory failure who have failed various types of conventional life…
- Conditions
- Extracorporeal Membrane Oxygenation, Cardiopulmonary Resuscitation, Epidemiology
- Trial name
- NCT04979325
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Extra Corporeal Membrane Oxygenation
Acute Neurological Complications and Neurodevelopmental Outcome in Children Undergoing Extracorporeal Membrane Oxygenation.
The purpose of this retrospective study is to describe the different types of acute neurologic complications in children who underwent extracorporeal membrane oxygenation (ECMO), and their risk factors.
- Trial name
- NeurECMO (NCT04519528)
- Testing
- DENVER scale (under 2 years old) or Pediatric Cerebral Performance Category (PCPC) score (over 2 years old), Pediatric Quality of Life Inventory™ (PedsQL)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Out-of-Hospital Cardiac Arrest
Induced Hypothermia in Cardiac Arrest Patients Rescued by Extracorporeal Cardiopulmonary Resuscitation.
Background： Cardiopulmonary resuscitation (CPR) with closed-chest cardiac massage has been shown that survival to discharge rate is poor.
- Trial name
- NCT00965016
- Testing
- hypothermia
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Min-Sheng General Hospital
Sepsis, Critical Illness
Exploring and Establishment of Combined Extracorporeal Life Support(CELS) in Critically Ill Children
Multiple organ failure (MODS) is still the leading cause of death in children in ICU. The treatment of MODS is mainly organ function monitoring and organ replacement therapy.
- Conditions
- Sepsis, Critical Illness, MODS
- Trial name
- CELS (NCT03654287)
- Testing
- Treatment
- Where
- China
- Sponsor
- Guoping Lu