Clinical trials: Extremity
Diplegic Cerebral Palsy
"Immediate Effect of DAFO on Gross Motor Function and Balance in Diplegic Cerebral Palsy
" Study will investigate the immediate effect of DAFO usage on balance and gross motor functions in individuals with spastic diplegic cerebral palsy.
- Trial name
- NCT06343688
- Testing
- "Assessment of Balance and Lower Extremity Gross Motor Function with and without DAFO"
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Diparesis, Cerebral Palsy
Lower Extremity Evaluation in Children With Diparetic Cerebral Palsy According to ICF Perspective
Cerebral palsy (CP); is the most common neurodevelopmental disorder seen in childhood, characterized by permanent motor dysfunctions that develop due to brain damage occurring before birth, during birth, or in early childhood.
- Conditions
- Diparesis, Cerebral Palsy, Diplegic Cerebral Palsy, Lower Extremity Paresis
- Trial name
- NCT06583746
- Testing
- Group1
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Acıbadem Atunizade Hospital
Neuromuscular Disorders
Upper Limb Evaluation in Non Ambulatory Patients With Neuromuscular Disorder
The aim of this study is to evaluate different devices to quantify upper limb function (Motriplate) and strength (Myogrip, Myopinch) in non-ambulatory patients with neuromuscular disorder.
- Trial name
- ULENAP (NCT00993161)
- Testing
- Motriplate
- Where
- 4 sites in France
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Institut de Myologie, France
Surgical Pain
Erector Spinae Plane Block Versus Caudal Epidural Analgesia
The goal of this clinical trial is to compare the analgesic effect and safety of erector spinae plane block vs caudal epidural block in paediatric population undergoing lower limb cancer surgery.
- Trial name
- NCT06815094
- Testing
- Regional analgesia either CEA or ESP
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- National Cancer Institute, Egypt
Adolescent, Foot Posture Index Score
Relationship Between Foot Posture, Toe Flexor Strength, and Balance in Adolescents
The foot plays a critical role in movement and postural control, with toe flexor strength linked to gait, performance, and stability. While these relationships are well studied in adults, evidence in adolescents is limited.
- Conditions
- Adolescent, Foot Posture Index Score, Toe Flexor Strength, Flat Foot Acquired Bilateral (Pes Planus)
- Trial name
- NCT07132424
- Testing
- Assesment
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul Kültür University
Postural Orthostatic Tachycardia Syndrome (POTS), Syncope
Abdominal and Lower Extremity Compression During Tilt Table Testing in Adolescent POTS Patients
Postural orthostatic tachycardia syndrome (POTS) is a common cause of orthostatic intolerance in adolescents and adults. Compression stockings are commonly recommended as a treatment modality for POTS, but the effects of…
- Trial name
- NCT01795469
- Testing
- Zoex compression garment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Nationwide Children's Hospital
Soft Tissue Sarcoma of the Extremities
Predicting Radiotherapy Response and Toxicities in Soft Tissue Sarcoma of the Extremities - Cohort B
This is a multicentre prospective cohort study, primarily aimed at reporting the frequency and intensity of radiotherapy side-effects of patients with soft tissues sarcoma of the extremities (STSE).
- Trial name
- PredicT-B (NCT05978024)
- Where
- 3 sites in United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Ultrasonography, Upper Extremity
The Relationship Between Upper Extremity Explosive Power and Trunk Muscles in Volleyball Players
Volleyball is an interval sport involving consecutive aerobic and anaerobic loads. Strength training based on explosive movements can improve performance in the upper extremities.
- Conditions
- Ultrasonography, Upper Extremity, Physical Endurance
- Trial name
- NCT06001242
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Pediatrics, Muscle Spasticity
BOTOX® Open-Label Treatment in Pediatric Lower Limb Spasticity
This study will evaluate the long-term safety of BOTOX® (botulinum toxin Type A) for the treatment of pediatric lower limb spasticity.
- Conditions
- Pediatrics, Muscle Spasticity, Cerebral Palsy
- Trial name
- NCT01603641
- Testing
- Botulinum Toxin Type A
- Where
- 56 sites in United States, Hungary and 7 more
- Volunteers
- 370 people
- Sponsor
- Allergan
Limb-Girdle Muscular Dystrophy, Type 2E
Gene Delivery Clinical Trial of SRP-9003 (Bidridistrogene Xeboparvovec) for Participants With Limb-Girdle Muscular Dystrophy, Type 2E (LGMD2E) (Beta-Sarcoglycan Deficiency)
The proposed clinical trial is the first-in-human, single-center, open-label, gene delivery study of SRP-9003 (bidridistrogene xeboparvovec) in participants with LGMD2E.
- Trial name
- NCT03652259
- Testing
- SRP-9003
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Sarepta Therapeutics, Inc.
Peripheral Arterial Disease
Novel Therapy of PAD by Combined Transplantation of BMCs
We analyze the effects of combined intramuscular and intraarterial transplantation of BMCs in patients with PAD. BMCs were transplanted into the ischemic limb.
- Trial name
- NCT00411840
- Testing
- intraarterial and intramuscular injection of BMCs
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Limb-Girdle Muscular Dystrophy Type 2I (LGMD2I)
Study to Evaluate the Efficacy and Safety of BBP-418 (Ribitol) in Patients With Limb Girdle Muscular Dystrophy 2I (LGMD2I)
This study will evaluate the safety and efficacy of long-term administration of BBP-418 in patients with LGMD2I/R9. The study will include patients ages 12 to 60, consistent with the existing preclinical toxicology profile.
- Trial name
- Fortify (NCT05775848)
- Testing
- BBP-418 (ribitol)
- Where
- 21 sites in United States, Australia and 6 more
- Volunteers
- 112 people
- Sponsor
- ML Bio Solutions, Inc.
Duchenne Muscular Dystrophy, Becker Muscular Dystrophy
Clinical Trial of Coenzyme Q10 and Lisinopril in Muscular Dystrophies
The study will include 120 participants aged 8 and up with Duchenne, Becker, or autosomal recessive limb-girdle (specifically: LGMD 2C-2F and 2I) muscular dystrophies that have no clinical cardiac symptoms.
- Conditions
- Duchenne Muscular Dystrophy, Becker Muscular Dystrophy, Limb Girdle Muscular Dystrophy
- Trial name
- NCT01126697
- Testing
- Coenzyme Q10 and Lisinopril
- Where
- 7 sites in United States, Canada and 1 more
- Volunteers
- 63 people
- Sponsor
- Cooperative International Neuromuscular Research Group
CLIFAHDD, Congenital Contractures of the Limbs and Face, Hypotonia, and Developmental Delay
Aprepitant for the Treatment of CLIFAHDD
There are no drug treatments for individuals with Congenital Contractures of the Limb and Face, Hypotonia, and Developmental Delay (CLIFAHDD), an ultra-rare and severe neurodevelopmental disease.
- Conditions
- CLIFAHDD, Congenital Contractures of the Limbs and Face, Hypotonia, and Developmental Delay, NALCN Channelopathy, Ataxia - Other
- Trial name
- NCT07845825
- Testing
- Aprepitant Powder for Oral Suspension
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Image, Athletic Injuries
The Effect of Competition Season on Physical Characteristic and Shoulder Periarticular Structures in Swimmers
The aim of this study is to investigate the effect of a competition season on shoulder periarticular structures, muscle strength, muscle endurance, joint range of motion and upper extremity performance in young swimmers.
- Conditions
- Image, Athletic Injuries, Upper Extremity
- Trial name
- NCT05426876
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Burn Contracture of Skin
Serial Casting for Upper Extremity Burn Contractures
The use of a splint, serial casting and passive stretching have been described in the literature as conservative interventions to manage joint contractures after burn injury.
- Trial name
- NCT05425433
- Testing
- Tailored serial casting intercention
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Cerebral Palsy, Muscle Spasticity
Dysport® Pediatric Lower Limb Spasticity Study
The purpose of this research study is to determine whether Dysport® is effective in the treatment of increased stiffness of the calf muscles and to evaluate the safety of this treatment in children with Cerebral Palsy.
- Conditions
- Cerebral Palsy, Muscle Spasticity, Children
- Trial name
- NCT01249417
- Testing
- Botulinum toxin type A
- Where
- 29 sites in United States, Chile and 4 more
- Volunteers
- 241 people
- Sponsor
- Ipsen
Sports Physical Therapy
Effect of Plyometric Exercises on Upper Extremity Function in Children With Unilateral Cerebral Palsy
Plyometric training includes muscle contraction that moves rapidly from the eccentric to the concentric phase of movement while using proper biomechanics.
- Trial name
- NCT05313607
- Testing
- Designed physical therapy, Occupational therapy, Conventional Therapy
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Stroke
Localized Muscle Vibration Post Stroke
Background and objectives: Lower extremity functional impairments are common consequences of stroke. Thus, continuous examination of effective treatment interventions for lower extremity functions after stroke is a necessity.
- Trial name
- NCT04700553
- Testing
- Localized muscle vibration, Conventional physiotherapy intervention
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- Giuseppe Annino
Congenital Muscular Dystrophy With ITGA7 (Integrin Alpha-7) Deficiency, Alpha-Dystroglycanopathy (Congenital Muscular Dystrophy and Abnormal Glycosylation of Dystroglycan With Severe Epilepsy)
Congenital Muscle Disease Study of Patient and Family Reported Medical Information
The Congenital Muscle Disease Patient and Proxy Reported Outcome Study (CMDPROS) is a longitudinal 10 year study to identify and trend care parameters, adverse events in the congenital muscle diseases using the Congenital Muscle…
- Conditions
- Congenital Muscular Dystrophy With ITGA7 (Integrin Alpha-7) Deficiency, Alpha-Dystroglycanopathy (Congenital Muscular Dystrophy and Abnormal Glycosylation of Dystroglycan With Severe Epilepsy), Alpha-Dystroglycanopathy (Congenital Muscular Dystrophy With Fatty Liver and Infantile-onset Cataract Caused by TRAPPC11 Mutations), Alpha-Dystroglycanopathy (Congenital Muscular Dystrophy With Hypoglycosylation of Dystroglycan)
- Trial name
- CMDPROS (NCT01403402)
- Where
- United States
- Volunteers
- 4,000 people
- Sponsor
- Cure CMD
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