Clinical trials: Eye Change
Circumscribed Choroidal Haemangioma, Optical Coherence Tomography Angiography
Quantitative Evaluation of Parafoveal Microvasculature Changes in Eyes With Exudative Circumscribed Choroidal Haemangioma: An Optical Coherence Tomography Angiography Study
The study aims to quantitative evaluation of parafoveal microvasculature changes in eyes with exudative circumscribed choroidal haemangioma using optical coherence tomography angiography.
- Conditions
- Circumscribed Choroidal Haemangioma, Optical Coherence Tomography Angiography, Macular
- Trial name
- NCT04449900
- Testing
- This is observational study with the examination of OCTA
- Where
- China
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
High Myopia
Development and Pathological Changes of High Myopia Among Children and Adolescents in China
The study aims to observe the relationship between the changes of ocular structure parameters and pathological changes among children and adolescents with high myopia.
- Trial name
- NCT03533647
- Testing
- Observational
- Where
- China
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Induced Defocus to the Retina
Defocus Induced Changes on Choroidal Thickness
The goals of this study are to assess the short-term (10-60 minutes) effects of different magnitudes of myopic and hyperopic optical defocus on the transient thickness of the choroid in children and adults, as well as to assess…
- Trial name
- NCT03954886
- Testing
- Plus powered optical lens
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Houston
Myopia
Investigation of the Regulation of Retinal and Choroidal Blood Vessels in Various AL Based on WF SS-OCTA Detection With Changes in Body Position
This prospective observational study aims to understand the effects of different subaxial body positions on choroidal and retinal blood vessel density.
- Trial name
- NCT06587776
- Volunteers
- 60 people
- Sponsor
- Science and Technology Department of Sichuan Province
Cataract
Modified Surgical Techniques for Pediatric Cataract Treatment
Pediatric cataract is totally different from adult cataract. There is traditionally no difference in technique between pediatric and adult cataract surgery.
- Trial name
- NCT01844258
- Testing
- Modified technique, Traditional technique
- Where
- China
- Volunteers
- 37 people
- Sponsor
- Sun Yat-sen University
Myopia
Performance of Somofilcon A Over One Week in Wearers Adapted to Omafilcon A
The objective of the study is to determine if habitual or adapted contact lens wearers of Omafilcon A can be confidently refit into Somofilcon A lenses and be successful after one week of daily wear.
- Trial name
- NCT03226353
- Testing
- somofilcon A, omafilcon A
- Where
- Canada
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
Open Angle Glaucoma (OAG)
Conventional Non-Penetrating Deep Sclerectomy Versus Modified Subflap Mattress Suture in OAG
The goal of this clinical trial is to learn if modified non-penetrating deep sclerectomy (NPDS) with a sub-flap mattress suture works to treat open-angle glaucoma (OAG).
- Trial name
- NCT07425743
- Testing
- Modified Deep Sclerectomy with Ahmed's sub-flap mattress suture (modified NPDS), Conventional Nonpenetrating Deep Sclerectomy (NPDS)
- Where
- 2 sites in Egypt
- Volunteers
- 26 people
- Sponsor
- Beni-Suef University
Cataract, Healthy
Dynamic Light Scattering Device (DLS) Study of Age-Related Changes in the Lens and Cataracts
This study will use a newly developed instrument called dynamic light scattering device (DLS) to examine age-related changes in the human lens and to study the causes and development of cataracts.
- Trial name
- NCT00007215
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Optic Glioma, Pediatric Brain Tumor, Optic Nerve Glioma
Modified CV Regimen in Optic Pathway Glioma
Optic pathway glioma (OPG) can result in visual deterioration. Symptomatic patients often report deficits in visual acuity (VA), visual field, visual-evoked potentials (VEPs), strabismus, proptosis, disc swelling, and other…
- Trial name
- NCT05278715
- Testing
- Carboplatin, Vincristine, Recombinant human endostatin
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Beijing Sanbo Brain Hospital
The Lamina Cribrosa and Optic Nerve Head Changes
The Lamina Cribrosa (LC) Changes in the Eyes After Laser-Assisted in Situ Keratomileusis (LASIK)
The burden of LASIK surgery on optic nerve head (ONH) has been controversial. Until now, the change of retinal nerve fiber layer (RNFL) thickness was used as the indicator of the study.
- Trial name
- NCT02676557
- Testing
- Exposed to the high pressure during the surgery
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
Myopia
Choroidal Changes Post Short Term Exposure To Virtual Reality Devices
This is a prospective, randomized, controlled, contralateral eye, clinical study. The objective of the study is to determine the impact of Virtual Reality (VR) usage on choroidal thickness when viewed through a test display…
- Trial name
- MIRABILE (NCT04140877)
- Testing
- Visu
- Volunteers
- healthy volunteers welcome
- Sponsor
- Visu, Inc.
Acupressure
0.01% and 0.025% Atropine Eye Drops Combined Auricular Acupoint Stimulation on Myopia Control and Corneal Endothelium Change
This randomized, double-blind, placebo-controlled pilot trial evaluates the efficacy and safety of low-dose atropine (0.01%, 0.025%) combined with auricular acupoint stimulation for myopia control in children.
- Trial name
- NCT07537166
- Testing
- Auricular acupoint stimulation, 0.01% concentration atropine drops, 0.025% atropine eye drops
- Where
- Taiwan
- Volunteers
- 420 people
- Sponsor
- China Medical University Hospital
Eye Manifestations
Ocular Surface Changes in Patients With Cystic Fibrosis
Cystic fibrosis(CF) is an inherited disease affecting children, adolescents and young adults with dysfunction of secretory glands.It is caused by mutations in the protein-coding gene which function as the cystic fibrosis…
- Trial name
- NCT00345280
- Testing
- impression cytology, obtain the tear fluid
- Where
- Poland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Bialystok
Cataract
Dynamic Light Scattering for Studying Lens Aging and Cataract Formation
This study will use dynamic light scattering (DLS) technology to study normal lens aging and early cataract formation. Cataract is a clouding of the lens that interferes with the passage of light to the retina, impairing visual…
- Trial name
- NCT00081991
- Where
- United States
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Non-arteritic Ischemic Optic Neuropathy
Peripapillary and Macular Vascular Changes of Unilateral Anterior Ischemic Optic Neuropathy: An Optical Coherence Tomography Angiography Study
This series aims at studying the peripapillary and macular vascular changes in subjects with unilateral anterior ischemic optic neuropathy via Optical Coherence Tomography Angiography (OCTA).
- Trial name
- NCT06031350
- Testing
- Optical Coherence Tomography Angiography
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Omar Said
Familial Mediterranean Fever (FMF), Autoinflammation
Familial Mediterranean Fever and Related Disorders: Genetics and Disease Characteristics
This study is designed to explore the genetics and pathophysiology of diseases presenting with intermittent fever, including familial Mediterranean fever, TRAPS, hyper-IgD syndrome, and related diseases.
- Conditions
- Familial Mediterranean Fever (FMF), Autoinflammation, Periodic Fever, Fever
- Trial name
- NCT00001373
- Where
- 5 sites in United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Allergic Conjunctivitis
Efficacy of AC-150 for the Treatment of Allergic Conjunctivitis in the Enviro-CAC™ Model
The purpose of this study is to evaluate the efficacy of AC-150 compared to vehicle and its components in the prevention of the signs and symptoms of allergic conjunctivitis in Enviro-CAC™ Model.
- Trial name
- NCT01134328
- Testing
- AC-150 Combo, AC-150A 0.1%, AC-150B 0.005%
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Aciex Therapeutics, Inc.
Cataracts
Modified Intraocular Lens to Reduce Eye Inflammation After Cataract Surgery in Uveitis Patients
This study will test the effectiveness of an intraocular lens treated with heparin in reducing or preventing inflammation after cataract surgery in patients with uveitis.
- Trial name
- NCT00001311
- Testing
- heparin-surface modified intraocular lens
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Eye Institute (NEI)
Myopia, High Myopia
The Monitoring and Intervention of Refractive Changes in Children and Teenagers in Tianjin
The study aimed to collect multi-factor information on school-age children with pre-clinical myopia, and to identify the initial factors and warning signs of myopia.
- Trial name
- NCT05691296
- Testing
- Home training, School training
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Tianjin Eye Hospital
Visual Snow Syndrome, Trailing Phenomenon
Mindfulness Based Cognitive Therapy Modified for Visual Symptoms (MBCT-vision)
This is a research study on Mindfulness-Based Cognitive Therapy for visual symptoms (MBCT-vision), to treat patients with debilitating symptoms of visual snow (VS) and is associated visual symptoms, severe light sensitivity (i.e.
- Conditions
- Visual Snow Syndrome, Trailing Phenomenon, Photophobia, Visual Aura
- Trial name
- MBCT-vision (NCT04184726)
- Testing
- Mindfulness Based Cognitive Therapy
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust