Clinical trials: Eye Inflammation
Ocular Surface Allergy, Conjunctivitis, Allergic
Treatment of Ocular Surface Inflammations
The goal of this clinical trial is to learn if topical Cyclosporine 1% works to treat severe allergic ocular surface inflammation in pediatric population.
- Conditions
- Ocular Surface Allergy, Conjunctivitis, Allergic, Blepharoconjunctivitis
- Trial name
- NCT07732855
- Testing
- Topical Cyclosporine 1%
- Where
- Hungary
- Volunteers
- 50 people
- Sponsor
- Semmelweis University
Cataract
A Study Assessing the Safety and Efficacy of Dextenza® for the Treatment of Ocular Pain and Inflammation Following Surgery for Pediatric Cataract
To assess the safety of Dextenza compared to an active control, prednisolone acetate suspension, for the treatment of postoperative pain and inflammation following ocular surgery for pediatric cataract.
- Trial name
- NCT04539548
- Testing
- Dextenza Ophthalmic Insert, Prednisolone acetate ophthalmic suspension USP 1%
- Where
- 14 sites in United States
- Volunteers
- 65 people
- Sponsor
- Ocular Therapeutix, Inc.
Cataract
Nepafenac Opthalmic Suspension 0.1% Compared to Acular LS for Treatment of Inflammation After Cataract Surgery
The purpose of this study is to compare the effectiveness of Nepafenac Ophthalmic Suspension, 0.1% eye drops to Acular LS eye drops, used before and after cataract surgery, for treating inflammation in the eye.
- Trial name
- NCT00333255
- Testing
- Nepafenac Ophthalmic Suspension, 0.1%
- Where
- United States
- Volunteers
- 267 people
- Sponsor
- Alcon Research
Sepsis, Bronchopulmonary Dysplasia
Cysteine Supplementation in Critically Ill Neonates
Critically ill babies less than 1 month of age have deficient amounts of the antioxidant glutathione and a high incidence of disease associated with oxidative injury compared to healthy babies.
- Conditions
- Sepsis, Bronchopulmonary Dysplasia, Necrotizing Enterocolitis, Retinopathy of Prematurity
- Trial name
- NCT00254176
- Testing
- Parenteral cysteine-HCl supplementation
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- University of California, Los Angeles
Malnutrition, Diabetes
Efficacy of Zinc Fortified Fermented Wheat Flour
Zinc is a pivotal micronutrient that participates in numerous essential metabolic pathways within the human body. Its multifaceted role makes the manifestations of zinc deficiency remarkably nonspecific and age-dependent.
- Conditions
- Malnutrition, Diabetes, Inflammation, Conjunctivitis
- Trial name
- EZAFFAW (NCT06092515)
- Testing
- Fermented High Zinc Wheat Flour Flatbread, Unfermented High Zinc Wheat Flour Flatbread, Post-Harvest Fortified Whole Wheat Flour Flatbread
- Where
- Pakistan
- Volunteers
- 1,044 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Endophthalmitis, Cataract
Early Vitrectomy for Endophthalmitis After Cataract Surgery
Post-operative infectious endophthalmitis is devastating condition that causes a diffuse intraocular inflammation and may lead to blindness.
- Conditions
- Endophthalmitis, Cataract, Vitreous Detachment, Retinal Detachment
- Trial name
- NCT05249413
- Testing
- Early 23-gauge pars-plana vitrectomy
- Where
- Egypt
- Volunteers
- 11 people
- Sponsor
- Benha University
Chlamydia Infections, Ophthalmia Neonatorum
Clinical Trial of Eye Prophylaxis in the Newborn
To compare the effectiveness of silver nitrate drops, erythromycin ointment, or no medication in preventing neonatal conjunctivitis caused by Chlamydia trachomatis and other eye infections.
- Trial name
- NCT00000120
- Testing
- Erythromycin Ointment, Silver Nitrate Drops
- Sponsor
- National Eye Institute (NEI)
Arthritis, Juvenile Rheumatoid, Uveitis
The Safety and Efficacy of Chicken Type II Collagen on Uveitis Associated With Juvenile Rheumatoid Arthritis
Current treatment modalities for uveitis associated with juvenile rheumatoid arthritis have not been beneficial in the juvenile population.
- Trial name
- NCT00001614
- Testing
- Chicken type II collagen
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- National Eye Institute (NEI)
Cataract Surgery
Omidria and Dexycu, or Omidria and Dextenza Compared to Topical Prednisolone Acetate 1% Following Cataract Surgery
This research will evaluate the efficacy of Omidria and Dexycu, Omidria and Dextenza, and Omidria and prednisolone acetate 1% in the resolution of post-operative inflammation and pain following cataract surgery.
- Trial name
- NCT04316936
- Testing
- Omidria, Dextenza (dexamethasone ophthalmic insert) 0.4mg, Dexycu, 9% Intraocular Suspension
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Silverstein Eye Centers
Endophthalmitis, Prophylaxy of Post Traumatic Endophthalmitis
Prophylaxis of Acute Post-Traumatic Bacterial Endophthalmitis
Purpose: To evaluate the efficacy of combined intraocular injection of gentamycin and clindamycin in prevention of acute posttraumatic bacterial endophthalmitis (APBE) following penetrating eye injuries.
- Conditions
- Endophthalmitis, Prophylaxy of Post Traumatic Endophthalmitis, Bacterial Endophthalmitis
- Trial name
- NCT00398658
- Testing
- gentamycin and clindamycin
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Eye Manifestations
Ocular Surface Changes in Patients With Cystic Fibrosis
Cystic fibrosis(CF) is an inherited disease affecting children, adolescents and young adults with dysfunction of secretory glands.It is caused by mutations in the protein-coding gene which function as the cystic fibrosis…
- Trial name
- NCT00345280
- Testing
- impression cytology, obtain the tear fluid
- Where
- Poland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Bialystok
Corneal Infiltrates
A Phase II Study of Moxidex Ophthalmic Solution for Treatment of Marginal Corneal Infiltrates
The purpose of the study is to determine whether Moxidex ophthalmic solution is safe and effective in treating marginal corneal infiltrates.
- Trial name
- NCT00579020
- Testing
- Moxifloxacin/dexamethasone phosphate ophthalmic solution, Moxifloxacin ophthalmic solution 0.5%, Dexamethasone phosphate solution, 0.1%
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Alcon Research
Uveitis, Aqueous Humor
Metagenomics for Ocular Inflammation
The aim of this study is to apply a diagnostic test called 'metagenomic sequencing' to identify the involvement of potential infections in patients with ocular inflammation, where this hasn't been detected by currently available…
- Conditions
- Uveitis, Aqueous Humor, Infection
- Trial name
- NCT06974162
- Testing
- Metagenomic sequencing of aqueous humor, Ocular Imaging
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Cataracts Infantile
Clobetasol Propionate Ophthalmic Nanoemulsion, 0.05% in the Treatment of Inflammation After Cataract Surgery in Pediatric Population
Multicenter, randomized, evaluator-blinded clinical trial compared to Prednisolone acetate, 1% in the treatment of inflammation and pain after cataract surgery in pediatric population.
- Trial name
- CLOSE-3 (NCT05724446)
- Testing
- Clobetasol Propionate, Prednisolone acetate ophthalmic suspension, 1%
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Salvat
Inflammation
Intravitreal Celecoxib for Chronic Uveitis
Intraocular delivery of celecoxib will be an effective means to treat inflammation and macular edema and prevent structural complications and vision loss in patients with chronic inflammation or macular edema who are unable to…
- Trial name
- Celecoxib (NCT02131012)
- Testing
- Intravitreal Celecoxib
- Volunteers
- 4 people
- Sponsor
- Vanderbilt University
Conjunctivitis, Allergic
OJO-miR: microRNA Expression in Allergic Conjunctivitis.
Allergic conjunctivitis (AC) causes inflammation of the conjunctiva in response to environmental allergens, affecting a significant percentage of the world population and reducing quality of life.
- Trial name
- OJO-miR (NCT07385495)
- Where
- Mexico
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Inflammation
Study of Difluprednate Ophthalmic Emulsion in the Treatment of Postoperative Inflammation
The purpose of this phase 2 study is to determine if difluprednate ophthalmic emulsion is effective in the treatment of postoperative inflammation.
- Trial name
- NCT00407225
- Testing
- Difluprednate Ophthalmic Emulsion
- Volunteers
- 24 people
- Sponsor
- Sirion Therapeutics, Inc.
Dry Eye Syndromes
Lipiflow Treatment Alone vs. Lipiflow + Dextenza Treatment for Dry Eye Disease
To evaluate the benefit of treatment with a physician administered intracanalicular dexamethasone insert in evaporative dry eye disease (DED) patients with meibomian gland disfunction (MGD) and underlying inflammation undergoing…
- Trial name
- NCT04413279
- Testing
- LipiFlow Thermal Pulsation, Dexamethasone Intracanalicular Insert, 0.4mg with LipiFlow Thermal Pulsation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Eye Surgeons of Indiana
Choroiditis, Iridocyclitis
Evaluation and Treatment of Patients With Inflammatory Eye Diseases
This study offers evaluation and treatment for patients with inflammatory eye diseases, such as uveitis. The protocol is not designed to test new treatments; rather, patients will receive current standard of care treatments.
- Conditions
- Choroiditis, Iridocyclitis, Iritis, Retinal Disease
- Trial name
- NCT00006188
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Eye Institute (NEI)
Ocular Surface Disease, Inflammatory Disease
Establishment of a Multimodal Standard Database for Inflammation-related Ophthalmopathy
Through a systematic observational study, the intrinsic connections and patterns between the occurrence and development of common blinding retinal diseases such as diabetic retinopathy, pathological myopia, and age-related…
- Conditions
- Ocular Surface Disease, Inflammatory Disease, Retinal Disease, Choroid Diseases
- Trial name
- NCT07628946
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Dan Chen