Clinical trials: Eye Inflammation
Cataracts
Nepafenac 0.1% Eye Drops, Suspension Compared to Ketorolac Trometamol 0.5% Eye Drops, Solution and Placebo
To evaluate the safety and efficacy of Nepafenac 1 mg/ml Eye Drops, Suspension, compared to Placebo and Ketorolac Trometamol 5 mg/ml Eye Drops, Solution for the prevention and treatment of ocular inflammation and ocular pain…
- Trial name
- NCT00405730
- Testing
- Nepafenac 1mg/ml eye drops, suspension, Ketorolac Trometamol 5 mg/ml eye drops, solution, Nepafenac vehicle eye drops
- Where
- France
- Volunteers
- 227 people
- Sponsor
- Alcon Research
Corneal Neovascularization
Corneal Crosslinking for Treatment of Corneal Neovascularization
The study objective is to assess safety and efficacy of photo-activation of riboflavin for treatment of corneal neovascularization with or without concomitant inflammation and/or infection.
- Trial name
- NCT04787471
- Testing
- 30 minute photoactivation of riboflavin 0.1%, 10 minute photoactivation of riboflavin 0.1%
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- Price Vision Group
Sepsis
Optic Nerve Sheath Diameter for Prediction of Sepsis Associated Encephalopathy
Sepsis-associated brain dysfunction (SABD)with increased intracranial pressure is a complex pathology that can lead to unfavourable outcome.
- Trial name
- NCT05849831
- Testing
- Ultrasound measurement of Optic nerve sheath diameter
- Where
- 2 sites in Egypt
- Volunteers
- 89 people
- Sponsor
- Zagazig University
Multiple Sclerosis, Optic Neuritis, Demyelinating Disease
Visual (Path)Ways in Multiple Sclerosis - Part II
Multiple sclerosis (MS) is an inflammatory demyelinating and degenerative disease of the central nervous system. The mechanisms of neuro-axonal loss remain incompletely elucidated.
- Trial name
- VWIMS - II (NCT06776224)
- Testing
- Measurement of retinal vascular density and visual cognition
- Where
- France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Lille
Conjunctiva, Cornea
MicroPulse Transscleral Laser Therapy and Its Short-term Impact on Ocular Surface
MicroPulse transscleral laser therapy (TLT) is proven to be effective in reducing intraocular pressure with minimal complications in either primary or secondary glaucoma.
- Trial name
- NCT06353776
- Testing
- conjunctival biopsy after micropulse transscleral laser therapy
- Where
- Tunisia
- Volunteers
- 15 people
- Sponsor
- University Tunis El Manar
Pterygium, Ocular Pain
Efficacy and Safety of PRO-155 on Inflammation of the Conjunctival Surface in Subjects With Grade I-III Pterygium vs Placebo.
Title of the study Efficacy and safety of PRO-155 (Zebesten ofteno®) on inflammation of the conjunctival surface in subjects with grade I-III pterygium vs placebo. Hypothesis H0.
- Conditions
- Pterygium, Ocular Pain, Ocular Inflammation, Post-surgical Inflammation
- Trial name
- PRO-155/IV (NCT03521791)
- Testing
- PRO-155
- Where
- 3 sites in Mexico
- Volunteers
- 166 people
- Sponsor
- Laboratorios Sophia S.A de C.V.
Inflammation and Pain Associated With Cataract Surgery
Study to Evaluate ISV-305 Compared to Vehicle for Treatment of Inflammation and Pain Associated With Cataract Surgery
The purpose of this study is to evaluate the ocular safety, tolerability, and efficacy of ISV-305 (dexamethasone in DuraSite® 2) compared with Vehicle in the treatment of inflammation and pain associated with cataract surgery.
- Trial name
- ISV-305 (NCT03192137)
- Testing
- ISV-305, Vehicle
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- Sun Pharmaceutical Industries Limited
Endophthalmitis Postoperative
The Clinical Safety of Levofloxacin 1.5% vs Topical Moxifloxacin 0.5%
Endophthalmitis is defined as intraocular inflammatory disorder affecting the vitreous cavity that can result from exogenous or endogenous spread of infecting organisms into the eye.
- Trial name
- NCT04212429
- Testing
- Levofloxacin Ophthalmic Product, Moxifloxacin Ophthalmic Solution
- Where
- Malaysia
- Volunteers
- 128 people
- Sponsor
- National University of Malaysia
Pharmacological Action
Intravitreal Triamcinolone and Moxifloxacin Injection After Cataract Surgery
This study aims to evaluate the short-term effects and safety of prophylactic intra-vitreal injection of triamcinolone-moxifloxacin combination after cataract surgery.
- Trial name
- NCT05428683
- Testing
- intra-vitreal triamcinolone-moxifloxacin injection after cataract surgery as a prophylactic measures against post-operative endophthalmitis
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Emad Abdel Aal Saliem
Endophthalmitis
Evaluation and Risk Factors of Post-traumatic Endophthalmitis
1. identify the incidence of post-traumatic endophthalmitis and the related risk factors influencing its development. 2. study the clinical- microbiological profile and evaluate the functional and anatomical outcomes of…
- Trial name
- NCT06673784
- Testing
- ophthalmic saline eye drops, Saline
- Volunteers
- 41 people
- Sponsor
- Assiut University
Dry Eye Disease (DED)
Anti-inflammatory Effects and Clinical Efficacy of Topical Thealoz Total Eye Drops in Patients With Chronic Dry Eye Disease
The goal of this prospective, open, monocentric study is to evaluate the clinical efficacy of a new preservative-free combination of trehalose, sodium hyaluronate and NAAGA in 30 patients with chronic dry eye disease and…
- Trial name
- NCT07007702
- Testing
- T2769
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Laboratoires Thea
Allergic Conjunctivitis
AL-38583 Ophthalmic Solution for Allergic Conjunctivitis Associated Inflammation
The purpose of this study is to assess the safety and efficacy of AL-38583 in the treatment of the signs of inflammation associated with allergic conjunctivitis.
- Trial name
- NCT01001091
- Testing
- AL-38583 ophthalmic solution, AL-38583 ophthalmic solution vehicle, Dexamethasone ophthalmic suspension, 0.1%
- Volunteers
- 312 people
- Sponsor
- Alcon Research
Dry Eye Syndrome (DES)
Dietary Supplementation on Tear Secretion and Inflammation in DES
The goal of this clinical trial is to explore the effect of supplementation of fish oil, lutein and zeaxanthin on the symptoms of dry eye syndrome, antioxidant capacity, oxidative stress and anti-inflammatory capacity in DES…
- Trial name
- DES (NCT06738446)
- Testing
- Multicomponent dietary supplement group
- Where
- Taiwan
- Volunteers
- 52 people
- Sponsor
- Shih Chien Huang
Dry Eye Syndromes
Lipiflow Treatment Alone vs. Lipiflow + Dextenza Treatment for Dry Eye Disease
To evaluate the benefit of treatment with a physician administered intracanalicular dexamethasone insert in evaporative dry eye disease (DED) patients with meibomian gland disfunction (MGD) and underlying inflammation undergoing…
- Trial name
- NCT04413279
- Testing
- LipiFlow Thermal Pulsation, Dexamethasone Intracanalicular Insert, 0.4mg with LipiFlow Thermal Pulsation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Eye Surgeons of Indiana
Endophthalmitis Following Cataract Surgery
Conjunctival Flora Before Cataract Surgery: a Microbiological Evaluation
The purpose of the present study is to elucidate the qualitative and quantitative variation of ocular flora after treatment with eyedrops containing 0.6% povidone-iodine in the eye of patients undergoing routine cataract surgery.
- Trial name
- NCT03958292
- Testing
- IODIM
- Where
- 6 sites in Italy
- Volunteers
- 140 people
- Sponsor
- Ospedale Sacra Famiglia - Fatebenefratelli Erba
Vitrectomy, Macular Pucker
Assessing the Efficacy and Safety fo DEXTENZA, Sustained Release Dexamethasone 0.4 mg Insert(s) for the Treatment of Pain, Inflammation, and Cystoid Macular Edema Following 27 Gauge Vitrectomy With Internal Limiting Membrane Peel for the Treatment of Retinal Edema Associated With Macular Pucker.
Assessing the efficacy and safety of DEXTENZA, sustained release dexamethasone 0.4 mg inserts following 27 gauge vitrectomy with internal limiting membrane peel
- Conditions
- Vitrectomy, Macular Pucker, Retinal Edema
- Trial name
- NCT04501367
- Testing
- Dexamethasone Intracanalicular Insert, 0.4 mg, Prednisone acetate 1%
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Kovach Eye Institute
Cataract, Myopia
Measurement of Antioxidant Activity on Postoperative Inflammation in Patients Undergoing Ophthalmic Surgery
This trial hypothesized that novel laser refractive surgery techniques (PRK, LASIK, SMILE) or laser-assisted cataract surgery (FLACAS) could suppress postoperative inflammation and improve recovery in patients by reducing…
- Trial name
- NCT05905237
- Testing
- Cataract surgery, Femtosecond-LASIK, SMILE
- Where
- 2 sites in Taiwan
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Early-Onset Sepses, Neonatal, Periventricular Haemorrhage Neonatal
Zinc Supplementation on Very Low Birth Weight Infant
Premature birth is a major cause of neonatal death in addition to neonatal asphyxia and infections. Early in life, premature babies must get aggressive nutrition so that there is no extrauterine growth restriction (EUGR) in the…
- Conditions
- Early-Onset Sepses, Neonatal, Periventricular Haemorrhage Neonatal, Bronchopulmonary Dysplasia, Retinopathy of Prematurity
- Trial name
- NCT04050488
- Testing
- Zinc Sulfate
- Volunteers
- 364 people, healthy volunteers welcome
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Refractive Surgery
The RESTORE Study, A Randomized, Controlled, Masked (Reading Center) Prospective Study
To determine patient preference and treatment outcomes with an intracanalicular dexamethasone (0.4mg) insert compared to standard steroid drop regimen in the contralateral eye following bilateral PRK surgery.
- Trial name
- NCT04396990
- Testing
- Dextenza 0.4Mg Ophthalmic Insert, Topical Prednisolone
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vance Thompson Vision
Giant Cell Arteritis (GCA), Ischemic Optic Neuropathy
Orbital Vascular Inflammation in Ischemic Optic Neuropathy and Giant Cell Arteritis
Giant cell arteritis (GCA) is an inflammation of the blood vessels. A dangerous complication is sudden vision loss due to insufficient blood supply to the optic nerve.
- Conditions
- Giant Cell Arteritis (GCA), Ischemic Optic Neuropathy, NAION - Non-Arteritic Ischemic Optic Neuropathy
- Trial name
- VISION-GCA (NCT07206238)
- Testing
- Positron Emission Tomography / Magnetic Resonance Imaging
- Where
- Denmark
- Volunteers
- 122 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet