Clinical trials: Fear Extinction
Pediatric Anxiety Disorders
Fear Conditioning, Extinction and Its Recall in Anxious Youth
The proposed research aims to isolate brain-based information-processing mechanisms implicated in perturbed fear learning and extinction characteristic of pediatric anxiety.
- Trial name
- FCPA (NCT02631785)
- Testing
- Cognitive Behavioral Therapy
- Where
- 2 sites in Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Haifa
Anxiety Disorder of Childhood
A Pilot Study of Fear Extinction Learning in Anxious Youth
The goal of this proposed study is to identify a potential biobehavioral marker of CBT outcome in the most common child and adolescent anxiety disorders, including separation anxiety disorder (SAD), social phobia (SoP), and…
- Trial name
- NCT03032926
- Testing
- Open Trial
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Hyperalgesia, Chronic Pain Syndrome
Pain-related Fear as a Facilitator of Nocebo Hyperalgesia
Nocebo hyperalgesia is characterized by adverse pain outcomes, induced by patients' expectations. In the lab, nocebo effects are commonly studied via classical conditioning, a method that employs pairings of neutral…
- Conditions
- Hyperalgesia, Chronic Pain Syndrome, Chronic Pain, Psychogenic, Fear of Pain
- Trial name
- LFS (NCT04197154)
- Testing
- Threat manipulation (control, no threat), Threat manipulation, Conditioning of moderate pain
- Where
- Netherlands
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Healthy Adults
Does Transcutaneous Vagal Nerve Stimulation Improves Fear Extinction in Humans
A recent study with rats showed that electrical stimulation of the vagus nerve (VNS) facilitates extinction of fear (Pena, Engineer, \& McIntyre, Biological Psychiatry, 2013).
- Trial name
- t-VNSext (NCT02113306)
- Testing
- t-VNS
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Adolescence
Exercise Facilitation of Adolescent Fear Extinction, Frontolimbic Circuitry, and Endocannabinoids
Anxiety disorders commonly begin during adolescence, and are characterized by deficits in the ability to inhibit or extinguish pathological fear.
- Trial name
- BRAINS (NCT06297278)
- Testing
- Moderate Intensity Exercise
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Wayne State University