Clinical trials: Fear Extinction
Specific Phobia
Enhancing Exposure Therapy for Snake and Spider Phobias
This study tests whether exposure therapy for fear of snakes or spiders is enhanced by the addition of a brief fear retrieval trial prior to treatment, and the use of compound extinction during treatment.
- Trial name
- Snake/Spider (NCT02160470)
- Testing
- Exposure Therapy with Retrieval, Exposure Therapy with Compound Extinction, Exposure Therapy with Retrieval and Compound Extinction
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Posttraumatic Stress Disorder
Effects of Delta9-tetrahydrocannabinol (THC) on Retention of Memory for Fear Extinction Learning in PTSD: R33 Study
The goal of this study is to look at how a type of drug called cannabinoids are related to the processing of fear signals, the experience of emotions and fear, and the pattern of activity in the brain that is involved in these…
- Trial name
- NCT04080427
- Testing
- Dronabinol 7.5 milligram oral capsule
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Wayne State University
Stress Disorders, Posttraumatic
Veteran Stress and Learning Study
This is a research study examining the use of two medications, Hydrocortisone and D-Cycloserine, compared to an inactive substance (placebo), on their ability to reduce fear responses and memory of fear in Veterans with symptoms…
- Trial name
- VSL (NCT00674570)
- Testing
- Hydrocortisone, D-Cycloserine
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
PTSD, Exercise Intensity
Using Exercise to Enhance Fear Extinction Learning
The goal of the current project is to establish the efficacy and mechanisms of exercise-enhanced fear extinction retrieval and generalization in posttraumatic stress disorder (PTSD).
- Conditions
- PTSD, Exercise Intensity, Fear Extinction, Fear Conditioning
- Trial name
- NCT07548125
- Testing
- Exercise
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Josh Cisler
Healthy Adults
Does Transcutaneous Vagal Nerve Stimulation Improves Fear Extinction in Humans
A recent study with rats showed that electrical stimulation of the vagus nerve (VNS) facilitates extinction of fear (Pena, Engineer, \& McIntyre, Biological Psychiatry, 2013).
- Trial name
- t-VNSext (NCT02113306)
- Testing
- t-VNS
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Posttraumatic Stress Disorder
Enhancing Week-long Psychological Treatment for PTSD With Ketamine
The purpose of this study is to test if the combination of ketamine, vs midazolam, with an intensive trauma-focused psychotherapy will be more effective in relieving post-traumatic stress disorder (PTSD).
- Trial name
- NCT05737693
- Testing
- Ketamine, Midazolam
- Where
- 2 sites in United States, Israel
- Volunteers
- 350 people
- Sponsor
- Yale University
Public Speaking Anxiety, Public Speaking Fear
Enhancing Generalization of Virtual Reality Exposure for Public Speaking Anxiety
This randomized controlled trial examines whether imagery-based extinction memory updating following a standardized virtual reality (VR) exposure session improves the generalization of exposure effects to novel public speaking…
- Trial name
- VREX2 (NCT07323498)
- Testing
- VR Exposure, Standard Mental Rehearsal, Mental Rehearsal With Extinction Memory Updating
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- Philipps University Marburg
Posttraumatic Stress Disorder (PTSD)
Inflammatory Challenge and Fear
The goal of this study is to learn if short-term changes in the immune system alter how we process information and experience fear.
- Trial name
- LIFE (NCT06630884)
- Testing
- Typhoid VI Polysaccharide Vaccine Injectable Solution
- Where
- United States
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
PTSD
Effects of Methylphenidate (Ritalin®) on the Neural Basis of Anxiety
In the present study, investigator will investigate the effects of methylphenidate (40 mg) on mPFC activity in healthy male volunteers during fear extinction using functional magnetic resonance imaging (fMRI).
- Trial name
- NCT02021214
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Fear
Effect of D-cycloserine on Extinction of Fear Conditioning
This study will evaluate whether the drug D-cycloserine (DCS) can improve a type of learning called classical conditioning, in which the brain learns to associate neutral stimuli with stimuli that elicit emotional or…
- Trial name
- NCT00352586
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Posttraumatic Stress Disorder
Extinction of Fear Memories With Glucocorticoids in Veterans With PTSD
The purpose of this study is to examine the effects of glucocorticoid administration following traumatic memory reactivation on psychiatric symptoms in veterans with combat-related PTSD, in addition to examining the effects of…
- Trial name
- VA CORT (NCT01090180)
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- VA Office of Research and Development
Anxiety Disorders, Panic Disorder
Efficacy of Expectancy Focused Exposure Therapy for Anxiety Disorders
This clinical trial evaluates whether an optimized exposure-based treatment improves long-term outcomes for adults with anxiety disorders.
- Conditions
- Anxiety Disorders, Panic Disorder, Social Anxiety Disorder (SAD), Generalised Anxiety Disorder
- Trial name
- EFE-AD (NCT07753330)
- Testing
- Expectancy Focused Exposure, Anxiety Focused Exposure
- Where
- Chile
- Volunteers
- 203 people
- Sponsor
- University of Chile
Post-traumatic Stress Disorder
Effects of Treatment of PTSD on Reduced Recall for Fear Extinction
This preliminary study will examine the differential effects of rTMS on the recall of extinction of conditioned fear in patients suffering from PTSD (post-traumatic stress disorder ) compared with subjects without PTSD but with…
- Trial name
- NCT01228253
- Testing
- rTMS: repetitive transcranial magnetic stimulation
- Where
- France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Anxiety, Fear Extinction
Uncovering Neurocognitive Mechanisms and Enhancement of Exposure-based Fear Learning With Cognitive Training
Anxiety disorders remain are among the most prevalent psychiatric conditions and are associated with negative outcomes spanning poor health to increased suicide risk.
- Trial name
- NCT07805070
- Testing
- Cognitive training
- Volunteers
- 120 people
- Sponsor
- University of California, San Diego
Chronic Posttraumatic Stress Disorder
Enhancing Exposure Therapy for Post-traumatic Stress Disorder
This study is investigating a new brief psychotherapy for post-traumatic stress disorder (PTSD) which, modifies an already proven psychotherapy for PTSD by adding two new components and modifying several others.
- Trial name
- NCT01574118
- Testing
- Revisiting the Trauma memories, Processing the trauma memories, Psychoeducation
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Healthy
Losartan and Emotion Processing
The aim of the study is to investigate the effect of losartan (50mg, single dose) on the extinction of conditioned fear
- Trial name
- NCT03396523
- Testing
- Losartan
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Obsessive Compulsive Disorder (OCD)
Transcranial Direct Current Stimulation and Extinction in Obsessive Compulsive Disorder
Obsessive-compulsive disorder (OCD) is associated with substantial impairments in quality of life and is among the most disabling psychiatric disorders.
- Trial name
- NCT06834217
- Testing
- Active transcranial direct current stimulation
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Yale University
Post Traumatic Stress Disorder
Fear and Avoidance in PTSD Patients
The purpose of this research study is to study how the brain learns to avoid certain stimuli or situations using an experimental paradigm.
- Trial name
- NCT04770584
- Testing
- Fear Conditioning, Avoidance conditioning, Pavlovian fear extinction learning
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Healthy
Effect of Methylenedioxymethamphetamine (MDMA) (Serotonin Release) on Fear Extinction
Serotonin and oxytocin play a role in fear conditioning and fear extinction learning, psychological processes that are critically involved in psychiatric disorders such as posttraumatic stress disorder (PTSD).
- Trial name
- MFE (NCT03527316)
- Testing
- MDMA
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Stress Related Disorder, Anxiety
Modulation of Fear Extinction Processes Using Transcranial Electrical Stimulation
The aim of this study is to examine the effects of transcranial electrical stimulation on processes associated with fear extinction in healthy humans.
- Trial name
- NCT02723188
- Testing
- DC stimulation (1.5 milliampere, 20 minutes), AC stimulation (1.5 milliampere,1.5 Hertz frequency)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University