Clinical trials: First Nations
Lead Poisoning
Social Network Based Intervention to Reduce Lead Exposure Among Native American Children
The purpose of this study is to examine whether adding an inter-generational component to an existing social network-based lay health advisor intervention increases its effectiveness in mobilizing a Native American community to…
- Trial name
- NCT00011661
- Testing
- Education on behaviors to reduce lead exposure
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
HIV Prevention, PTSD and Substance Use Disorder
Preventing HIV Among Native Americans Through the Treatment PTSD & Substance Use
Investigators will conduct a two-arm, comparative effectiveness randomized controlled trial of two culturally adapted, empirically based programs (EBP) - Narrative Exposure Therapy (NET) vs.
- Trial name
- NCT03112369
- Testing
- Narrative Exposure Therapy (NET), Motivational Interviewing w/Skills Training (MIST)
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Washington
Fitness Testing
Exercise Effects in Native American Adolscents
This longitudinal study will investigate effects of exercise participation in Southwest Native American adolescents, ages 11-17, from the Gila River Indian Community.
- Trial name
- NCT06758310
- Testing
- Individualized Exercise
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Midwestern University
Alcohol Drinking, Tobacco Use
Developing a Positive Approach to Substance Use Prevention in North American Indian Adolescents
The overall objective of this project is to develop and obtain preliminary data on acceptability, feasibility, and initial efficacy of Native PATHS.
- Conditions
- Alcohol Drinking, Tobacco Use, Drug Use
- Trial name
- NCT05380765
- Testing
- Native PATHS
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Rhode Island
Type 2 Diabetes
Point of Care HbA1c as a Screening Test for Type 2 Diabetes in First Nations
1. Purpose to estimate the prevalence of undiagnosed diabetes mellitus and pre-diabetes in a BC First Nation community to determine the utility of community based screening by examining how many positively screened people follow…
- Trial name
- NCT01333176
- Testing
- Point-of-care "finger-poke" HbA1c determination., HbA1c blood test, HbA1c finger poke test
- Where
- Canada
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Type 2 Diabetes, Gestational Diabetes Mellitus (GDM)
Co-designing Enhanced Models of Care for First Nations Children at Risk for Childhood-onset Type 2 Diabetes
The overall objective: to co-design and implement targeted and timely community led strategies to improve the health of the Next Generation and end the intergenerational impact of T2D in this population.
- Trial name
- NCT07692321
- Testing
- Breastfeeding and perinatal education and support, Purchasing HbA1c machines for communities, Continuous Glucose Monitoring
- Where
- Canada
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Chronic Graft Versus Host Disease
Safety and Efficacy of Oral Belumosudil in Black or African American, American Indian or Alaska Native, and Native Hawaiian or Other Pacific Islander Male and Female Participants Aged 12 Years and Above With Chronic Graft Versus Host Disease (cGVHD) After At Least 2 Prior Lines of Systemic Therapy
The purpose of this study is to measure safety and efficacy of oral belumosudil in Black or African American, American Indian or Alaska Native, and Native Hawaiian or Other Pacific Islander male and female participants with cGVHD…
- Trial name
- NCT05567406
- Testing
- Belumosudil
- Sponsor
- Kadmon, a Sanofi Company
Type 2 Diabetes
Together Overcoming Diabetes
Together Overcoming Diabetes (TOD) is a culturally tailored, family-based type 2 diabetes management and preventive intervention.
- Trial name
- TOD (NCT04734015)
- Testing
- Together Overcoming Diabetes (TOD)
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Obesity, Adolescent, Healthy Nutrition
Wakaya: Rising Up for Choctaw Youth Health
Investigators will conduct a two-group randomized waitlist-control trial to assess the efficacy of the Wakaya: Rising Up for Choctaw Youth Health program on improving physical activity, reducing sedentary behaviors and improving…
- Conditions
- Obesity, Adolescent, Healthy Nutrition, Sedentary Behavior, Drug Abuse
- Trial name
- Wakaya (NCT05818384)
- Testing
- Wakaya: Rising Up for Choctaw Youth Curriculum
- Where
- 2 sites in United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- University of Washington
Sexual Behavior, Unprotected Sex
Protecting Our Future Generation: Promotion of Protective Sexual Health Practices Among Native American Youth and Young Adults Through an Assets-based Self-care Intervention
The aim of this research protocol is to test the efficacy of a self-care intervention through a randomized controlled trial (RCT), for increasing protective sexual health behaviors among youth in the participating Native American…
- Conditions
- Sexual Behavior, Unprotected Sex, Gonorrhea, Chlamydia
- Trial name
- NCT03895320
- Testing
- Sexual Health Risk Assessment, Sexual Health Score, Sexual Health Messaging
- Where
- United States
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Parenting, Mental Health Wellness 1
Parenting in 2 Worlds Multisite Trial
This research study will test the effectiveness of a culturally grounded parenting intervention called Parenting in 2 Worlds (P2W).
- Conditions
- Parenting, Mental Health Wellness 1, Substance Use, Risky Health Behavior
- Trial name
- (P2W) (NCT06324318)
- Testing
- Parenting in 2 Worlds (P2W), Healthy Families in 2 Worlds (HF2W)
- Where
- 4 sites in United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Sex, Unprotected Sex
Evaluation of Respecting the Circle of Life on Pregnancy Prevention Outcomes Among American Indian Adolescents
The objective of this research study is to evaluate a culturally tailored sexual and reproductive health intervention among American Indian (AI) youth.
- Conditions
- Sex, Unprotected Sex, Contraception, Alcohol Use
- Trial name
- TPP (NCT02904629)
- Testing
- Respecting the Circle of Life (RCL), Control Program
- Where
- United States
- Volunteers
- 1,072 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Chronic Hepatitis C
Prospective Anti-Hepatitis C Virus (Anti-HCV) Trial of Peg-Interferon and Ribavirin in Subjects of First Nations, Metis and Caucasian Ethnicity
Background: According to recent estimates, the prevalence of Chronic Hepatitis C (CHC) in Canada is three times more common in First Nations (FN)and Metis compared to non-FN populations.
- Trial name
- Praire (NCT00957866)
- Testing
- Pegylated Interferons (Peg-IFN) and Ribavirin
- Where
- 3 sites in Canada
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Fluoride Varnish and Oral Health Promotion, Usual Care
Preventing Caries in Preschoolers: Testing a Unique Service Delivery Model in American Indian Head Start Programs
An intensive intervention of specially trained paraprofessionals, called community oral health specialists (COHS), administering on a quarterly basis for 2 years fluoride varnish and oral health promotion education, compared to…
- Trial name
- NCT01116739
- Testing
- Fluoride varnish, Oral health education, Dental services delivered by the Indian Health Service.
- Where
- United States
- Volunteers
- 2,060 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Breastfeeding
Motivational Interviewing to Promote Sustained Breastfeeding
1. Evaluate the cultural appropriateness of an intervention protocol related to: a) motivational interviewing technique; b) stool, urine, and breast milk sample collection; and c) infant breastfeeding test weight procedure. 2.
- Trial name
- NCT00579605
- Testing
- Motivational Interviewing
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Cardiovascular Diseases, Heart Diseases
School- and Home-Based Program to Prevent Obesity in American Indian Children
The purpose of this study is to prevent excessive weight gain among kindergarten and first grade American Indian children using improved diet and increased physical activity at home and at school.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Obesity
- Trial name
- NCT00123032
- Testing
- Diet, Exercise
- Where
- 2 sites in United States
- Sponsor
- University of Minnesota
Healthy, Condom Use
Nen ŨnkUmbi/EdaHiYedo Plus (We Are Here Now Plus): a Multi-level Intervention to Reduce Health Disparities Among American Indian Youth
We Are Here Now - Plus (NE+) is a holistic, culturally centered, and multilevel intervention for American Indian youth to improve sexual health, mental health, and substance use outcomes.
- Conditions
- Healthy, Condom Use, Mental Health, Substance Use (Drugs, Alcohol)
- Trial name
- NE+ (NCT07460973)
- Testing
- NE+, Control
- Where
- United States
- Volunteers
- 843 people, healthy volunteers welcome
- Sponsor
- Montana State University
Pneumococcal Nasopharyngeal Colonization, Invasive Pneumococcal Disease
Impact of PCV on Disease and Colonization Among Native American Communities
The purpose of this study is to determine the impact of pneumococcal conjugate vaccine on carriage of pneumococcus in the nasopharynx and on the incidence of invasive pneumococcal disease in the community.
- Trial name
- NCT01083459
- Where
- 2 sites in United States
- Volunteers
- 6,628 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Suicide
Circle of Life. Improving Capacity of Swampy Cree Community Members to Recognize People at Risk for Suicide
Primary Hypothesis: Participants in the Applied Suicide Intervention Skills Training (ASIST) gatekeeper training will be significantly more likely to have increased knowledge and preparedness to help people with suicidal ideation…
- Trial name
- NCT01287416
- Testing
- Applied Suicide Intervention Skills Training, Resilience Retreat
- Where
- Canada
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Depression, Pregnancy
Depression Prevention Program for American Indian Adolescents During and After Pregnancy
This study will determine the effectiveness of the "Living in Harmony" depression prevention program in preventing depressive symptoms among pregnant American Indian adolescents during pregnancy and after giving birth.
- Trial name
- NCT00183547
- Testing
- "Living in Harmony" depression prevention program, Depression-prevention education and support
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University