Clinical trials: First Nations
Healthy Children, Elementary School Age
Healthy Buddies Manitoba
School-based interventions are generally ineffective for preventing weight gain in children. In 2007, a group from the University of British Columbia, developed a program called Healthy Buddies, that relied on peer mentors to…
- Conditions
- Healthy Children, Elementary School Age, Rural and Urban, First Nations
- Trial name
- NCT01979978
- Testing
- Healthy Buddies Curriculum
- Where
- Canada
- Volunteers
- 647 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Head Start Participation
American Indian and Alaska Native Head Start Family and Child Experiences Survey (AIAN FACES 2019)
The American Indian and Alaska Native Head Start Family and Child Experiences Survey (AIAN FACES) 2019 builds on AIAN FACES 2015 (NCT03842111), which was the first national study children and families participating in Region XI…
- Trial name
- AIAN FACES (NCT04046965)
- Where
- United States
- Volunteers
- 1,587 people
- Sponsor
- Mathematica Policy Research, Inc.
Smokeless Tobacco Cessation
Testing ANSOS for Efficacy in Multi-Tribal Urban Communities
This is a wait-list control trial to test for efficacy of the All Nations Snuff Out Smokeless (ANSOS) recreational tobacco cessation program in multi-tribal American Indian (AI) communities.
- Trial name
- NCT06566703
- Testing
- All Nations Snuff Out Smokeless, Healthy Living
- Where
- United States
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Lehigh University
Specialist Referral: Neurology, Specialist Referral: Ophthalmology
A Study to Characterize Access to Specialty Care Received by American Indians/Alaska Natives
This is an observational study to define current care pathways for American Indian or Alaska Native patients who require specialty care and potential feasibility of conducting clinical research within the existing framework.
- Conditions
- Specialist Referral: Neurology, Specialist Referral: Ophthalmology, Specialist Referral: Oncology
- Trial name
- CATORI (NCT05624788)
- Testing
- No Intervention
- Where
- 2 sites in United States
- Volunteers
- 84 people
- Sponsor
- Genentech, Inc.
Obesity Prevention, School Wellness Policy
Primary Prevention of Obesity in American Indian Youth in Rural Tribal Schools
The goal of this study is to learn if a culturally relevant health promotion curricula prevents obesity among 4th graders in rural tribal schools.
- Trial name
- NCT06864468
- Testing
- Health promotion curricula
- Where
- 3 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Northern Arizona University
Cancer
A Nutrition & Exercise Prehabilitation Intervention on Inflammatory Biomarkers in AI Cancer Patients
The purpose of this study is to assess the feasibility of a prehab intervention among American Indian (AI) patients diagnosed with cancer and measure inflammatory biomarkers to evaluate the preliminary impact of the trial…
- Trial name
- NCT06644560
- Testing
- Prehabilitation Intervention
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Arizona
Obesity
Engaging Tribal Policy Makers to Improve the Food and Physical Activity Environments in American Indian Communities
The overall objective of the study is to reduce adult obesity in participating American Indian (AI) communities and to improve understanding of the behavioral and environmental factors affecting obesity in these settings.
- Trial name
- OPREVENT2 (NCT02803853)
- Testing
- Intervention
- Where
- United States
- Volunteers
- 876 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Cardiovascular Diseases, Heart Diseases
Preventing American Indian Children From Becoming Overweight
The purpose of this study is to establish an intervention to keep American Indian/Alaskan Native (AI/AN) children from becoming overweight.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Obesity
- Trial name
- NCT00245180
- Testing
- Diet, Exercise
- Volunteers
- 577 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Diabetic Kidney Disease, Diabetes Mellitus Type 2
Empaglifozin in Early Diabetic Kidney Disease
Background: Diabetes is common among American Indian people and diabetic kidney disease is a common complication. Kidney disease caused by diabetes can lead to the need for kidney replacement, by dialysis or kidney transplant…
- Trial name
- NCT03173963
- Testing
- Empagliflozin
- Where
- United States
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Lifestyle, Diet
Study of Diets and Way of Life of Native Americans and Hispanics in New Mexico During the Time of the Trinity Nuclear Test
Background: The National Cancer Institute has been studying health risks to people in New Mexico at the time of the first nuclear bomb test. This was called the Trinity nuclear test. It took place in 1945.
- Conditions
- Lifestyle, Diet, Ionizing Radiation Exposure
- Trial name
- NCT02211781
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- National Cancer Institute (NCI)
Advance Care Planning
Culturally-Adapting a Communication Intervention to Improve Palliative Care Literacy on Two Native American Reservations
This study will evaluate the feasibility, acceptability, and perceived effectiveness of the culturally-adapted COMFORT Communication Curriculum in two Native American reservation communities.
- Trial name
- NCT03569150
- Testing
- Cultural adaptation/implementation COMFORT CC
- Volunteers
- healthy volunteers welcome
- Sponsor
- South Dakota State University
Breast Cancer
Community-led Navigation to Address Disparities in Mammography Among Native American Women
The goal of this study is to evaluate the effectiveness of an intervention to promote breast cancer screening mammography among women in one community on the Navajo Nation.
- Trial name
- NCT06957535
- Testing
- Navigation, TEAM
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Asthma in Children
Factors Influencing Pediatric Asthma
Asthma is a chronic lung disease with serious morbidity and potential mortality. Multiple physiologic, environmental and social conditions impact the prevalence and severity of asthma.
- Trial name
- FIPA (NCT03302962)
- Testing
- Intensive Asthma Education
- Where
- United States
- Volunteers
- 324 people
- Sponsor
- Missouri Breaks Industries Research, Inc.
Cholesterol, Elevated, Diabetes Mellitus
Community Intervention to Improve CVD Risk Factor Control in Young American Indians
American Indians are more likely to die from heart disease compared to other people in the United States. High levels of fat (lipids) and sugar (glucose) in the blood are related to heart disease.
- Trial name
- CIRCLE (NCT06230705)
- Testing
- Guided management, Self management
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- University of Oklahoma
Mental Health Wellness 1, Behavior, Health
Talking Circle for Native American Youth
Native American youth have higher rates of depression and lifetime major depressive episodes, and, by age 11, are more likely to have initiated alcohol and substance use than any other racial/ethnic group.
- Conditions
- Mental Health Wellness 1, Behavior, Health, Emotional Stress
- Trial name
- AYoLi (NCT06781736)
- Testing
- Talking Circle intervention
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Substance Use
Intertribal Talking Circle for the Prevention of Substance Abuse in Native Youth
This project will evaluate an after-school substance abuse prevention intervention, compared to a standard substance abuse education program, targeting 6th grade AI youth in three AI communities: Ojibwe/Chippewa in Minnesota…
- Trial name
- NCT03086434
- Testing
- Culturally Tailored Intervention, Standard Substance Abuse Education
- Volunteers
- 630 people
- Sponsor
- Florida State University
Malignant Neoplasm
Engagement of American Indians of Southwestern Tribal Nations in Cancer Genome Sequencing
This clinical trial studies engagement strategies for recruiting American Indians (AI) of Southwestern Tribal Nations for cancer genome sequencing.
- Trial name
- PE-CGS (NCT06207864)
- Testing
- Biospecimen Collection, Return of Results, Survey Administration
- Where
- United States
- Volunteers
- 1,001 people
- Sponsor
- New Mexico Cancer Research Alliance
Reproductive Behavior, Sexual Behavior
We Are Here Now: a Multi-level, Multicomponent Sexual and Reproductive Health Intervention for American Indian Youth
N/E is a community-based participatory research (CBPR) multi-level, multi-component sexual and reproductive health (SRH) intervention, constructed on Ecological Systems Theory.
- Trial name
- NE (NCT03694418)
- Testing
- We are here now: a multi-level, multi-component sexual and reproductive health intervention for American Indian youth
- Where
- 2 sites in United States
- Volunteers
- 453 people
- Sponsor
- Montana State University
Substance Use
Culturally Grounded Early Substance Use Prevention for American Indian Families
This study involves adaptation, implementation, and rigorous evaluation of a family-based program designed to prevent early initiation of substance use on a Northern Plains Indian reservation.
- Trial name
- NCT02383225
- Testing
- Lakota Language enhancement, Facebook Supplement, Substance Use Resistance Skills
- Where
- United States
- Volunteers
- 449 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Applied Suicide Intervention Skills Training
The Safety and Effectiveness of Gatekeeper Training in First Nations Communities
Gatekeeper training is where people in the community are trained to recognize and identify those who are at risk for suicide and assist them in getting care. Gatekeeper training has been widely implemented around the world.
- Trial name
- NCT02118116
- Testing
- Applied Suicide Intervention Skills Training
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Manitoba