Clinical trials: Fluorescence
Dental Caries, Streptococcus Mutans
Effect of MI Paste Plus™ on Streptococcus Mutans and White Spot Lesions in Fixed Orthodontics
Background This study is part of a doctoral research project at Universidad Cardenal Herrera CEU (Spain), directed by Prof. Santiago Arias de Luxán and conducted by doctoral candidate Shirli Kelmendi within the PhD program in…
- Conditions
- Dental Caries, Streptococcus Mutans, Tooth Demineralization, Orthodontic Appliances, Fixed
- Trial name
- MIPASTEORTHO (NCT07244991)
- Testing
- MI Paste Plus (CPP-ACP with Sodium Fluoride)
- Where
- 2 sites in Albania
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cardenal Herrera University
Acute Cholestatic Hepatitis
Emergent Laparoscopic Cholecystectomy With ICG Cholangiography
A consecutive case series report to share our experience in surgical outcome of patients who underwent emergency laparoscopic cholecystectomy guided by indocyanine green (ICG) fluorescence.
- Trial name
- ELG-ICGC (NCT06549881)
- Testing
- emergency laparoscopic cholecystectomy guided by indocyanine green (ICG) fluorescence
- Where
- China
- Volunteers
- 97 people
- Sponsor
- Peking Union Medical College Hospital
Basal Cell Carcinoma
Investigation of Standard Excision Surgical Margins Using Two Photon Fluorescence Microscopy
The goal of this clinical trial is to compare the use of two photon fluorescence microscopy for detecting residual basal cell carcinoma during standard local excision.
- Trial name
- NCT06473103
- Testing
- Two photon fluorescence microscopy imaging
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Rochester
Molar Incisor Hypomineralisation
Hydroxyapatite vs Fluoride Toothpaste for MIH Remineralization
Molar Incisor Hypomineralization (MIH) is a common developmental enamel defect affecting children, particularly in Dubai, where it contributes to hypersensitivity, esthetic concerns, plaque accumulation, and increased caries…
- Trial name
- MIH-CARE (NCT07177053)
- Testing
- non fluoridated hydroxyapatite tooth paste (KAREX KINDER tooth paste), fluoridated toothpaste (Colgate Total PROTECTION ACTIVE)
- Volunteers
- 160 people
- Sponsor
- Dubai Health
Ureter Injury
IS-001 Injection in Patients Undergoing Robotic-Assisted Colorectal Surgery
This study evaluates the safety and efficacy of intravenous injection of IS-001 to aid in intraoperative ureter structure delineation
- Trial name
- NCT07346066
- Testing
- filricianine
- Where
- 9 sites in United States
- Volunteers
- 146 people
- Sponsor
- Intuitive Surgical
Intraoperative Ureter Visualization, Abdominolpelvic Surgery
A Study to Find Out if ASP5354 Can Clearly Help Show the Ureter During Surgery
The ureter was the tube that carries urine from the kidneys to the bladder. It was difficult for surgeons to see the ureter during abdominal surgery. This could lead to injuring the ureter which, although rare, could be serious.
- Trial name
- NCT05754333
- Testing
- pudexacianinium chloride
- Where
- 6 sites in United States
- Volunteers
- 107 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Neuroblastoma
An Imaging Study of Anti-GD2-800CW in Patients With Neuroblastoma
This is a non-randomized, open label phase Ib/II dose-escalation and expansion study designed to define the recommended dose of anti-GD2-800CW in pediatric neuroblastoma patients.
- Trial name
- GLOW-FISH (NCT07399821)
- Testing
- anti-GD2-800CW
- Where
- Netherlands
- Volunteers
- 22 people
- Sponsor
- Princess Maxima Center for Pediatric Oncology
Bone Tumor
Utility of ICG in Benign Bone Tumors
Patients with a biopsy-proven benign bone tumor for which standard of care is intralesional operative management will receive a weight-appropriate IV dose of indocyanine green (ICG, FDA-approved) the day prior to surgery during…
- Trial name
- NCT05075889
- Testing
- Indocyanine Green
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Gastric Cancer, Sentinel Lymph Node
Fluorescence Image-Guided Lymphadenectomy in Robotic Gastrectomy
Gastric cancer is a worldwide challenge due to its spread, even epidemic in some areas, and the high mortality rates. Lymphadenectomy is considered the fundamental step during radical gastrectomy.
- Trial name
- IG-MIG (NCT03931044)
- Testing
- Image-Guided Robotic Gastrectomy
- Where
- 2 sites in Italy
- Volunteers
- 40 people
- Sponsor
- International Study Group on Minimally Invasive Surgery for Gastric Cancer
To Assess the Feasibility, Visualization Capability, and Optimal Dosing of ICG Fluorescence Imaging for Intraoperative Assessment of Knee Tissue Perfusion
ICG Fluorescence in Knee Arthroscopy Study
The purpose of this study is to first evaluate whether ICG fluorescence angiography can be used to evaluate blood flow of the anterior cruciate ligament (ACL), tendons, and knee structures during an arthroscopic surgery.
- Trial name
- NCT07793266
- Testing
- Intravenous administration of indocyanine green (SPY Agent Green) 2 mL of SPY Agent Green (5.0 mg dose), Intravenous administration of indocyanine green (SPY Agent Green) 3 mL of SPY Agent Green (7.5 mg dose), Intravenous administration of indocyanine green (SPY Agent Green) 4 mL of SPY Agent Green (10 mg dose)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Henry Ford Health System
Surgical Education and Anatomical Identification in Laparoscopic Cholecystectomy
Using AI and Fluorescence Guidance to Enhance Extrahepatic Bile Duct Identification Among Junior Surgeons During Laparoscopic Cholecystectomy
The present study evaluates whether PGY trainees and surgical residents, with or without AI assistance, could accurately identify the presence and anatomical location of the CBD, as well as delineate intraoperative danger zones…
- Trial name
- NCT07188181
- Where
- Taiwan
- Volunteers
- 8 people
- Sponsor
- Chang Gung Memorial Hospital
White Spot Lesion
The Effect of Fluoride Varnish on White Spot Lesion in Clear Aligner Orthodontic Patients
Fluoride varnish is being applied on the teeth surfaces of patients undergoing orthodontic treatment just before receiving their clear aligners.
- Trial name
- NCT06403371
- Testing
- Fluoride varnsh, Normal saline
- Where
- Jordan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Composite Resins, Clear Aligner Therapy
Color Stability and Fluorescence Properties of Two Aligner Attachment Composites
This split mouth study aims to evaluate whether 2 different composite materials used for making clear aligner attachments change color over time and do they have different fluorescent characteristics when illuminated with…
- Trial name
- NCT07806214
- Testing
- GC Aligner Connect, VOCO AlignerFlow LC
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Marmara University
Chronic Calculous Cholecystitis, Laparoscopic Cholecystectomy
Using Indocyanine Green (ICG) to Outline Biliary Tree During Laparoscopic Cholecystectomy
The current study shows that Indocyanine green (ICG)-fluorescence cholangiography can be useful in identifying the extrahepatic biliary anatomy during Calot's triangle dissection.
- Trial name
- ICG (NCT06629415)
- Testing
- Indocyanine Green, Indocyanine Green Drug
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Theodor Bilharz Research Institute
Pediatric Renal Tumor, Metastatic Osteosarcoma
Indo-cyanine Green (ICG) in Paediatric Oncology MIS
Indo-cyanine green (ICG) is a dye that has been used for a variety of adult and paediatric uses since 1956. Over the past few years, near infrared (NIRF) technology has been developed which allow is use as a fluorescence agent…
- Conditions
- Pediatric Renal Tumor, Metastatic Osteosarcoma, Metastatic Ewing Sarcoma, Pulmonary Metastasis
- Trial name
- NCT04854018
- Testing
- Indocyanine green
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Birmingham Women's and Children's NHS Foundation Trust
Pediatric Central Nervous System Tumor
Study of Tozuleristide and the Canvas Imaging System in Pediatric Subjects With CNS Tumors Undergoing Surgery
Many types of cancer are primarily treated with surgery and patient survival is directly related to the extent to which the tumor is able to be removed.
- Trial name
- NCT03579602
- Testing
- tozuleristide, Canvas System
- Where
- 9 sites in United States
- Volunteers
- 118 people
- Sponsor
- Blaze Bioscience Inc.
Dental Caries, Non-cavitated Occlusal Caries
Detection of Non-cavitated Occlusal Caries Lesions by Visual Inspection, LF, QLF and NILT
This study aims to evaluate and compare the diagnostic accuracy of visual examination using ICDAS-II and three adjunctive optical methods-laser fluorescence (LF), near-infrared light transillumination (NILT), and quantitative…
- Trial name
- NCT07532291
- Testing
- Diagnostic assessment of occlusal caries
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Neslihan Atmaca
Perfusion, Fluorescence Imaging
Micro-dosing Indocyanine Green (ICG) in Children
The goal of this cohort study is to identify the lowest dose of Indocyanine Green (ICG) that achieves satisfactory intra-operative fluorescence for the assessment of gastrointestinal or genitourinary tract perfusion in children.
- Conditions
- Perfusion, Fluorescence Imaging, Gastrointestinal Tract Disorders, Genitourinary Disease
- Trial name
- NCT06421103
- Testing
- Indocyanine Green (ICG)
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Hepatocellular Carcinoma (HCC)
Hepatocellular Carcinoma 3 Gene Methylation Combination Detection Kit (PCR Fluorescent Probe Method) Multicenter Clinical Trial
This clinical trial aims to systematically evaluate the clinical performance and accuracy of the HepaAiQ test kit, a multi-gene methylation assay based on PCR with fluorescent probe detection.
- Trial name
- NCT06842563
- Where
- China
- Volunteers
- 900 people
- Sponsor
- Singlera Genomics Inc.
White Spot Lesion
White Spot Lesions Treatment in Orthodontic
The study aims to investigate the effectiveness of a new treatment for demineralized white spot lesions (WSLs) after fixed appliance therapy.
- Trial name
- WSL (NCT06051981)
- Testing
- 5% sodium fluoride, Intensive 5% sodium fluoride, Casein Phosphopeptide-Amorphous Calcium Phosphate
- Volunteers
- 88 people
- Sponsor
- Riyadh Elm University