Clinical trials: Fluoride
Dental Caries
Sequential PVP-I and FV
This prospective cohort study in children will determine if: topical povidone iodine 10% followed by topical fluoride varnish is superior to placebo iodine followed two different varnishes alone to prevent tooth decay (dental…
- Trial name
- NCT07683910
- Testing
- fluoride varnish, 2.5%, topical fluoride, 2.1%, Povidone Iodine Topical
- Volunteers
- 393 people, healthy volunteers welcome
- Sponsor
- Advantage Silver Dental Arrest, LLC
Prevention of White Spot Lesions
the Remineralizing Self-Assembling Peptide P11-4, 2% Arginine Enriched Sodium Fluoride and Functionalized Tri Calcium Phosphate Fluoride White Spot Lesions
The aim of the current study is to compare the remineralizing ability of Self-assembling peptide P11-4, 2% Arginine Enriched Sodium Fluoride and Functionalized Tri Calcium Phosphate Fluoride varnishes in treatment of white spot…
- Trial name
- NCT05127889
- Testing
- curodont
- Volunteers
- 39 people
- Sponsor
- Ain Shams University
Child Behavior
Motivational Effect of Choosing Taste of te Fluoride Varnish on Behavior During Dental Visit in Children - RCT
To assess the influence of the choice of fluoride varnish flavor on the acceptance and cooperation in schoolchildren between (5-10) years during the dental visit, in which an application of fluoride varnish is indicated.
- Trial name
- NCT05285228
- Testing
- effect of choice on cooperation (pseudoalternative), given fluoride varnish (control)
- Where
- Germany
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Hypomineralization Molar Incisor
Laser Therapy and Flouride Therapy in Desensibilization Hypomineralized Teeth
To investigate the efficacy of laser therapy associated with fluorotherapy in the desensibitization of hypomineralized teeth in children 8 to 12 years of age. A randomized blinded clinical trial will be conducted.
- Trial name
- LTAFTIDHT (NCT03823170)
- Testing
- Laser therapy, Fluorotherapy, Laser therapy and Fluorotherapy
- Where
- Brazil
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Universidade Ceuma
Early Childhood Caries
Silver Diamine Fluoride(SDF) Versus SDF Combined With Sodium Fluoride Varnish in the Arrest of Early Childhood Caries
Early childhood caries (ECC) is the most common chronic childhood disease worldwide. Early restorative intervention may treat the disease but this is often difficult especially with uncooperative children so it may be left…
- Trial name
- NCT05642494
- Testing
- SDF, NaF
- Where
- Egypt
- Volunteers
- 220 people
- Sponsor
- Alexandria University
White Spot Lesions
Effect of BG Versus RI on the Depth of WSL
The aim of this in vitro study is to assess the mean lesion depth improvement and hardness of artificial white spot lesions by comparing the effects of bioactive glass toothpaste and resin infiltration (ICON).
- Trial name
- NCT07770724
- Testing
- Bioactive Glass (NovaMin), Resin Infiltration (ICON), Fluoride Toothpaste
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Dental Caries in Children
Cost-effectiveness of Topical Fluoride in Preventing Deciduous Dental Caries in Preschool Children
Fluoride foam and fluoride varnish are effectiveness in prevention deciduous dental caries. However, the relative clinical efficacy and cost-effectiveness of these two interventions are uncertain.
- Trial name
- NCT05025163
- Testing
- 1.23% fluoride foam application, 2.26% fluoride varnish application
- Volunteers
- 1,083 people
- Sponsor
- National Center for Chronic and Noncommunicable Disease Control and Prevention, China CDC
White Spot Lesion
Evaluation of Two Varnishes on the Improvement of White Spot Lesions in Children
A randomized control trial evaluating the effect of the Giomer varnish versus fluoride varnish on the color improvement of the white spot lesion in permanent anterior teeth of children aged between 8-14 years by using a…
- Trial name
- NCT05775250
- Testing
- giomer varnish
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- October University for Modern Sciences and Arts
Dental Caries
Efficacy of Two Protocols for Applying Fluorine Varnish to Deciduous Teeth
Evidence that the data flow analysis tests, there are still no studies that show the clarity of the protocols of its application, including the interval and execution factors of applications, concentration of fluoridation and…
- Trial name
- CEPECO3 (NCT03827889)
- Testing
- WMP of fluoride varnish, TWLP of fluoride varnish, DHP (educational intervention)
- Where
- Brazil
- Volunteers
- 168 people
- Sponsor
- Universidade Ibirapuera
Pit and Fissure Caries
Investigation of the Incidence of Caries in Pits and Fissures Sealed With Bioactive Sealant Compared to Fluoride Releasing Resin Based Pit and Fissure Sealant
This study will be conducted to investigate the incidence of caries in pits and fissures sealed with a bioactive sealant compared to a fluoride releasing resin based pits and fissures sealant in preventive treatment procedures in…
- Trial name
- NCT03628729
- Testing
- Embrace™ WetBond™ Pit & Fissure Sealant, Seal-Rite™ Pit & Fissure Sealant, Pulpdent Corportation, USA
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cairo University
Paget's Disease of Bone
18F-Fluoride Positron Emission Tomography (PET) in Paget's Disease of Bone
18 F-fluoride Positron emission tomography (PET) is able to demonstrate and quantify the metabolic activity locally in the skeleton (1).
- Trial name
- NCT00306046
- Testing
- Bisphosphonate treatment
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Université Catholique de Louvain
Tertiary Dentine, Indirect Pulp Capping
Silver Diamine Fluoride/ Potassium Iodide in Indirect Pulp Capping of Young Permanent Molars
The aim of this study is to evaluate and compare the clinical effectiveness of 38% silver diamine fluoride with and without potassium iodide with that of resin modified glass ionomer cement in indirect pulp capping of young…
- Trial name
- NCT04236830
- Testing
- Silver diamine fluoride/ potassium iodide, Silver diamine fluoride, Resin modified glass ionomer cement
- Where
- Egypt
- Volunteers
- 108 people
- Sponsor
- Nourhan M.Aly
Dental Caries, Dental Fluorosis
Anticaries Potential and Fluorosis Risk From Different Fluoride Toothpastes
Fluoride toothpaste has been associated not only with declining dental caries prevalence but also with an increase in dental fluorosis.
- Trial name
- NCT01589991
- Testing
- Toothpaste
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Dental Caries
Comparative Evaluation of Hydrophilic and Hydrophobic Sealants in Partially Erupted First Molars
This randomized controlled clinical trial aims to evaluate and compare the retention, caries prevention, microleakage, and fluoride release of three types of pit and fissure sealants-hydrophilic, nanofilled hydrophobic, and…
- Trial name
- NCT07052526
- Testing
- Prevention, Prevention of caries, Prevention therapy
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Dental Caries
Stopping Cavities Study: Diammine Silver Fluoride
This study is being conducted to test whether the use of diammine silver fluoride (also called silver diamine fluoride) hardens the cavity sufficiently so that it arrests.
- Trial name
- NCT02536040
- Testing
- 38% diammine silver fluoride, Water
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Advantage Dental Services, LLC
Dental Caries
Comparing Two Brands of Silver Diamine Fluoride for Stopping Cavities in Children
this study aims to evaluate two different materials used to stop dental caries in children. both materials are available at the market. both materials leave black stain after application.
- Trial name
- SDF (NCT07708883)
- Testing
- SDF, ToothMate®, Egypt, SDF, Advantage Arrest USA
- Where
- Egypt
- Volunteers
- 134 people
- Sponsor
- National Research Centre, Egypt
White Spot Lesion
Effect of Casein Phosphopeptide Amorphous Calcium Phosphate Fluoride Varnish on Remineralization of White Spot Lesion in Primary Teeth
The aim of this study is to evaluate the effectiveness of Casein phosphopeptide-amorphous calcium phosphate fluoride varnish (CPP-ACP FV) in comparison to fluoride varnish (FV) as a remineralizing agent for white spot lesions in…
- Trial name
- NCT03865680
- Testing
- CPP-ACP, Duraphat
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Nourhan M.Aly
Dental Caries, Fluor
Efficacy of Fluor Protector S in the Prevention in Adolescents
Purpose of the study is to evaluate the effectiveness of Fluor Protector S in preventing tooth decay in adolescents and to isolate factors that reduce its effectiveness.
- Trial name
- NCT03720379
- Testing
- Fluor Protector S
- Where
- Poland
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Dental Caries, Child Behavior
Fluoride vs Probiotic Toothpaste for Caries Prevention
This clinical trial had two objectives. The first was to compare the effectiveness of 950 ppm fluoride toothpaste versus probiotic toothpaste in preventing dental caries in 4- to 5-year-old children.
- Trial name
- NCT07579403
- Testing
- Fluoride toothpaste, Probiotic Toothpaste, Control Toothpaste
- Where
- China
- Volunteers
- 508 people, healthy volunteers welcome
- Sponsor
- The Affiliated Hospital of Qingdao University
White Spot Lesion
Comparing Fluoride Varnish and Sealant to Prevent White Spots in Orthodontic Patients
The purpose of the study is o compare the efficacy of CPP-ACP MI Varnish and ProSeal sealant in preventing white spot lesion (WSL) formation in orthodontic patients.
- Trial name
- NCT04560478
- Testing
- Pro Seal Sealant, MI Varnish
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Texas A&M University