Clinical trials: Folate
Vitamin A Deficiency, Iron-deficiency
Effect of Household Use of Multiple Micronutrient-fortified Bouillon on Micronutrient Status Among Women and Children in Two Districts in the Northern Region of Ghana
Background: Micronutrient (MN) deficiencies are severe and widespread in West Africa, particularly among young children and women of reproductive age.
- Conditions
- Vitamin A Deficiency, Iron-deficiency, Folate Deficiency, Vitamin B 12 Deficiency
- Trial name
- NCT05178407
- Testing
- Multiple micronutrient-fortified bouillon cube, Control bouillon cube (iodine-only)
- Where
- Ghana
- Volunteers
- 2,372 people
- Sponsor
- University of California, Davis
Autism
Folate Rechallenge
New evidence suggests that autistic disorder (AD) may be associated with abnormalities in folate metabolism, which is a process that affects genetic expression by facilitating the formation of methyl donors for DNA methylation.
- Trial name
- NCT00672360
- Testing
- Folic acid
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Baylor College of Medicine
Maternal Dietary Diversity, Iron-Folic Acid Supplementation
A Feasibility Study of Integrating Maternal Nutrition Interventions Into Antenatal Care Services in Ethiopia
Alive \& Thrive (A\&T) is an initiative that supports the scaling up of nutrition interventions to save lives, prevent illnesses, and contribute to healthy growth and development through improved maternal nutrition, breastfeeding…
- Conditions
- Maternal Dietary Diversity, Iron-Folic Acid Supplementation, Early Initiation of Breastfeeding
- Trial name
- NCT04125368
- Testing
- Health Facility Interventions, Community Interventions, Health System Interventions
- Where
- United States
- Volunteers
- 4,256 people, healthy volunteers welcome
- Sponsor
- International Food Policy Research Institute
Anemia
School-Based Assessment of Micronutrient Interventions in Adolescents in Burkina Faso
This purpose of this study is to assess effects of iron and folic acid supplementation and multiple micronutrient supplementation on anemia status, school performance/attendance and development outcomes among adolescents in…
- Trial name
- SAMIA (NCT04657640)
- Testing
- Iron and folic acid (IFA), Multiple Micronutrient Supplements (MMS) and loading dose of Iron and Folic Acid (IFA)
- Where
- Burkina Faso
- Volunteers
- 3,123 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Sevoflurane, Propofol
Effects of Propofol and Sevoflurane on Blood Folic Acid and Homocysteine Concentrations in Children
To investigate the effect of sevoflurane and propofol on the concentrations of serum homocysteine and folic acid in children who received cochlear implant surgery.
- Conditions
- Sevoflurane, Propofol, Homocysteine, Cochlear Hearing Loss
- Trial name
- NCT03595163
- Testing
- Sevoflurane, Propofol
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Extreme Prematurity, Anemia of Prematurity
Folic Acid Supplementation to Reduce Anemia in Extremely Preterm Infants
Anemia of Prematurity (AOP) is very common in extremely preterm infants and often leads to blood transfusions. Folic acid, essential for growth and DNA synthesis, is deficient in premature infants.
- Trial name
- FASCINATE (NCT06220461)
- Testing
- Folic acid
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- University of Calgary
Mild Hyperhomocysteinemia
Does B Vitamin Supplementation Decrease Homocysteine Concentrations in Newborns
The purpose of this study is to determine whether supplementation with folinic acid, a B vitamin, lowers the concentrations of total homocysteine in newborns.
- Trial name
- NCT00877227
- Testing
- 5-formyltetrahydrofolate (10 mg/ml) (Pharmachemie bv)
- Where
- Netherlands
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Anesthetic Toxicity
The Effects of Different General Anesthetics on Serum Folic Acid and Homocysteine Concentrations in Children
The concentration of folic acid and homocysteine in the blood can be used as independent risk factors for a variety of diseases.
- Trial name
- NCT03746340
- Testing
- Propofol, Sevoflurane
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Neural Tube Defects
Efficacy of Weekly Versus Daily Folic Acid Supplementation
Investigate the efficacy of weekly versus daily of folic acid supplementation on improving folate, vitamin B12,
- Trial name
- NCT00394862
- Testing
- multivitamin
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Emory University
Down Syndrome
Efficacy Assessment of Systematic Treatment With Folinic Acid and Thyroid Hormone on Psychomotor Development of Down Syndrome Young Children
Evaluation of the following in very young children with Down syndrome: the efficacy of systematic treatment with L-thyroxine at controlled doses (clinically and by ultrasensitive thyreostimulating hormone (TSH) assay), the…
- Trial name
- ACTHYF (NCT01576705)
- Testing
- thyroid hormone and folinic acid
- Where
- France
- Volunteers
- 175 people
- Sponsor
- Institut Jerome Lejeune
Neural Tube Defects (NTDs), Facial Cleft Defect
Genetic Analysis of Neural Tube and Orofacial Cleft Defects in the Irish Population
In a collaborative effort with the Health Research Board, the national organization for medical research in the Republic of Ireland, individuals with neural tube defects (NTDs) or facial cleft defects and their parents will be…
- Conditions
- Neural Tube Defects (NTDs), Facial Cleft Defect, Hereditary Oral Clefts
- Trial name
- NCT00341068
- Where
- United States
- Volunteers
- 7,451 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Autism Spectrum Disorder
Folinic Acid in Children With Autism Spectrum Disorders
The investigator planned to study the efficiency of folinic acid treatment on autistic symptoms in children suffering from autism spectrum disorder.
- Trial name
- EFFET (NCT02551380)
- Testing
- FOLINORAL
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Central Hospital, Nancy, France
Iron Deficiency Anemia, Infectious Diseases
Efficacy Trial to Examine Efficacy of Multimicronutrient Home Supplementation in Infants
The objective of the program is to examine the efficacy of 6 month home micronutrient supplementation in Bedouin and Jewish children on improvements in nutritional status including measures of iron, ferritin, zinc and folic acid…
- Conditions
- Iron Deficiency Anemia, Infectious Diseases, Undernutrition
- Trial name
- NCT00276198
- Testing
- Sprinkles, Ferripel-3, Vitamins A&D drops
- Where
- Israel
- Volunteers
- 771 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Anemia
Treatment and Prevention of Anemia With Ferrous Sulfate Plus Folic Acid in Children in Goiania - Goias, Brazil
Iron deficiency anemia is the most common nutritional problem in the world. The objectives of this study are: to evaluate the prevalence of anemia in children from 6 to 24 months of age and the therapeutic and prophylactic…
- Trial name
- NCT00701246
- Testing
- ferrous sulfate, folic acid
- Where
- Brazil
- Volunteers
- 196 people
- Sponsor
- Universidade Federal de Goias
Autism Spectrum Disorder, Asthma
Folic Acid Clinical Trial: Follow up of Children (FACT 4 Child)
FACT 4 Child is a follow up study of mothers who participated in the Folic Acid Clinical Trial (NCT01355159) and their children at 4-6 years of age to determine the effect of high dose folic acid supplementation on social…
- Conditions
- Autism Spectrum Disorder, Asthma, Executive Dysfunction, Emotional Problem
- Trial name
- NCT03269110
- Testing
- SRS 2, CBCL, BRIEF-P
- Where
- 58 sites in Australia, Canada and 2 more
- Volunteers
- 664 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Osteosarcoma
A Retrospective Non-intervention Study to Characterize FOlate Rescue Treatment in Osteosarcoma Patients Treated With HDMTX
The purpose of this study is to investigate to which extend osteosarcoma patients do NOT meet the criteria for successfully advancement to next planned chemotherapy course.
- Trial name
- FORTO (NCT02383901)
- Testing
- Methotrexate
- Where
- 5 sites in Hungary, Norway and 2 more
- Volunteers
- 116 people
- Sponsor
- Isofol Medical AB
Cleft Lip, Cleft Palate
Oral Cleft Prevention Trial in Brazil
Cleft lip and palate are a significant component of morbid human birth defects in the developing world. By supplementing a high-risk group of women with folic acid (4.0 mg versus 0.4 mg) from preconception and continuing…
- Trial name
- NCT00098319
- Testing
- Folic acid (0.4mg vs. 4.0mg)
- Where
- 3 sites in Brazil
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Diarrhea, Pneumonia
Folic Acid and Vitamin B12 in Young Indian Children
Hypothesis: Supplementation of two recommended daily allowances (RDA) of folic acid with or without simultaneous administration of vitamin B12 reduces the rates of acute lower respiratory tract infections (ALRI), clinical…
- Trial name
- NCT00717730
- Testing
- Folic Acid, Vitamin B12, Folic acid and vitamin B12
- Where
- India
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Tor A. Strand
Folic Acid Deficiency
Serum Folic Acid Status, Genotyping MTHFR 677C-->T, Plasma Homocysteine, DNA Methylation of IGF2 Gene and Microbiota of the Children: Mother-Children Cohort Study
This study is part of the East Jakarta Cohort Study to assess the current micronutrient status of the mothers and their children.
- Trial name
- NCT04096521
- Where
- Indonesia
- Volunteers
- 254 people
- Sponsor
- Universitas Indonesia
Adenoma of Large Intestine
Folic Acid in Preventing Colorectal Polyps in Patients With Previous Colorectal Polyps
RATIONALE: Chemoprevention is the use of certain substances to keep cancer from forming. The use of folic acid may prevent colorectal cancer.
- Trial name
- NCT00512850
- Testing
- Folic acid
- Volunteers
- 672 people
- Sponsor
- Brigham and Women's Hospital