Clinical trials: Frailty
Frailty
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Intravenous Infusion for Aging Frailty
This trial will study the safety and efficacy of intravenous infusion of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells for the treatment of Aging Frailty
- Trial name
- NCT05018767
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells
- Where
- 2 sites in United States, Greece
- Volunteers
- 86 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Myocardial Infarction, Frailty
Management and Outcomes of Patients Admitted to Coronary Care Units, Depending on Degree of Frailty and Comorbidities
Background Patients less than 80 years of age, who suffer a myocardial infarction (MI) are usually (>90%) offered an early invasive strategy including coronary angiography possibly followed by intervention, preferably…
- Trial name
- NCT04488536
- Testing
- Clinical Frailty Scale
- Where
- 2 sites in Sweden
- Volunteers
- 10,000 people
- Sponsor
- Linkoeping University
Advanced Lung Disease, COPD
Effects of Inpatient Pulmonary Rehabilitation on Frailty in Patients After Lung-Transplantation
Frailty is closely linked to the success of lung transplantations (LTx) (1,2). Studies have shown that frailty causes a diminished physical performance in candidates for LTx and an increased 30 day rate of re-hospitalization…
- Conditions
- Advanced Lung Disease, COPD, Interstitial Lung Disease
- Trial name
- NCT04184180
- Where
- Germany
- Volunteers
- 33 people
- Sponsor
- Klaus Kenn
Parkinson Disease
Frailty and Cognitive Function in Parkinson's Disease.
Introduction: Parkinson's disease (PD) is the association of tremor, rigidity, akinesia-bradykinesia and loss of postural reflexes. Non-motor symptoms such as cognitive impairment may also develop.
- Trial name
- NCT05388526
- Testing
- No intervention
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- University of Oviedo
Quality of Life, Aortic Valve Stenosis
Frailty and Cognitive Function Assessment of TAVI Patients
Aortic stenosis (AS) is the most common valve disease among the adult population, in the majority of the cases it only requires treatment in advanced age.
- Conditions
- Quality of Life, Aortic Valve Stenosis, Heart Valve Disease
- Trial name
- NCT02650388
- Testing
- Cognitive fuction, quality of life
- Where
- Hungary
- Volunteers
- 100 people
- Sponsor
- Hungarian Institute of Cardiology
Pulmonary Hypertension, Heart Failure
Frailty in Children With Cardiac Disease
Frailty is a complex biologic syndrome of diminished physiologic reserve that leads to decreased resistance to stressors and is associated with adverse health outcomes.
- Conditions
- Pulmonary Hypertension, Heart Failure, Single Ventricle
- Trial name
- NCT02999438
- Testing
- Actigraph to check activity levels at home
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Frailty
Implementation Study of the ICOPE Program for the Detection of Frailty in the Elderly Within the Territorial Health Professional Communities (CPTS) of Brest Region
Frailty is a geriatric syndrome resulting from a decrease in physiological reserve capacities altering the mechanisms of adaptation to stress with, in the absence of diagnosis and management, a short-term risk of falls…
- Trial name
- ICOPE 29 (NCT05541731)
- Where
- 2 sites in France
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Sedentary Lifestyle
The Breaking "Bad Rest" Study: Interrupting Sedentary Time to Reverse Frailty Levels in Acute Care
This study will determine whether an intervention aimed at reducing sedentary time in patients admitted to acute care will result in decreased frailty levels at hospital discharge, compared to the current standard of care.
- Trial name
- NCT03682523
- Testing
- Sedentary behavior reduction intervention
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Olga Theou
Idiopathic Normal Pressure Hydrocephalus (INPH)
Change in Cognition and Frailty After Shunt Surgery in Idiopathic Normal Pressure Hydrocephalus (iNPH)
The goal of this observational study is to describe changes in cognitive profile and frailty from pre shunt to one year after the shunt surgery and to identify clinical predictors of an improvement in terms of cognition and…
- Trial name
- NCT07642726
- Testing
- Ventriculoperitoneal shunt
- Where
- Norway
- Volunteers
- 276 people
- Sponsor
- Oslo University Hospital
Cancer, Anesthesia
Cancer Anesthesia and Frailty
Subjects undergoing cancer related surgery at the Fondazione IRCCS Istituto Nazionale dei Tumori - Milano will be consecutively recruited.
- Conditions
- Cancer, Anesthesia, Fragility
- Trial name
- NCT03575416
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Central Nervous System Neoplasm, Hodgkin Lymphoma
Mobility and Physical Activity in Adolescent and Young Adult Cancer Patients or Survivors at Risk for Cardiovascular Morbidity and Frailty, The MOBILE AYA Study
This study attempts to learn more about the activity levels of adolescent and young adult (AYA) cancer patients or survivors at risk for cardiovascular morbidity and frailty by using a smartphone application called Beiwe.
- Conditions
- Central Nervous System Neoplasm, Hodgkin Lymphoma, Malignant Solid Neoplasm, Non-Hodgkin Lymphoma
- Trial name
- NCT05169151
- Testing
- Smartphone Application
- Where
- United States
- Sponsor
- M.D. Anderson Cancer Center
CGA, Comprehensive Geriatric Assessment
Exploring the User Experience of CGA-Q
As people become older they may start to have more than one health issue at one time. Geriatricians are doctors who specialise in looking after older people.
- Conditions
- CGA, Comprehensive Geriatric Assessment, Person Centred Care, Frailty
- Trial name
- NCT06646575
- Testing
- Qualitative data, no intervention
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Small Bowel Obstruction, Frailty
The Utility of Treatment With Nasogastric Tube Placement for Small Bowel Obstruction
Small bowel obstruction (SBO) occurs when the normal movements of the small bowel is obstructed, most commonly due to adhesion related to previous abdominal surgery.
- Conditions
- Small Bowel Obstruction, Frailty, Nasogastric Tube
- Trial name
- NGTUBE-OBS (NCT06262815)
- Testing
- Nasogastric tube placement, Clinical Frailty Scale
- Where
- 8 sites in Sweden
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Daniel Wilhelms
Frailty, Caregiver Burnout
Mindfulness-Based Intervention for Caregivers of Frail Older Chinese Adults
This is study to investigate the effects of a brief mindfulness-based program for frail older adults caregivers.
- Trial name
- NCT04861610
- Testing
- Brief mindfulness based program, Psychoeducation
- Where
- Hong Kong
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Malnutrition
Effect of Early Nutritional Therapy on Frailty, Functional Outcomes and Recovery of Undernourished Medical Inpatients Trial
The aims of the randomized-controlled, multicenter EFFORT trial are to assess the effects of early nutritional therapy in regard to effectiveness, safety and costs when applied to the heterogenous, polymorbid medical inpatient…
- Trial name
- EFFORT (NCT02517476)
- Testing
- Nutritional therapy
- Where
- Switzerland
- Volunteers
- 2,088 people
- Sponsor
- University Hospital, Basel, Switzerland
Congenital Heart Disease, Frailty
Frailty and Non-Fragile Congenital Heart Disease
Congenital heart disease (CHD) is defined as congenital functional or anatomical abnormalities of the heart and intrathoracic great vessels.
- Trial name
- NCT05824650
- Testing
- Observational
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Hacettepe University
Esophageal Atresia, Healthy Children
Symptoms, Pulmonary Function, Muscle Strength, Exercise Capacity, and Frailty in Esophageal Atresia vs. Healthy Peers
Esophageal atresia is the most common congenital anomaly of the esophagus and is caused by abnormal development of the esophagus during intrauterine life.
- Trial name
- NCT06975982
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Surgery, Aging
Preparing Older Adults for Major Surgery With Preoperative Comprehensive Geriatric Assessments
The researchers will conduct observations, interviews, and focus groups with clinicians, staff and patients of the Perioperative Optimization of Senior Health (POSH) clinic, which conducts preoperative comprehensive geriatric…
- Conditions
- Surgery, Aging, Health Care Utilization, Frailty
- Trial name
- NCT06184919
- Testing
- Process Mapping: Observations, Process Mapping: Interviews, Process Mapping: Focus Group
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Wisconsin, Madison
Frail Elderly, Frailty
Frailty Training for Emergency Nurses: A Cluster RCT in Morocco
This study tests whether a training program helps nurses better recognize and care for older adults with frailty in hospital emergency departments.
- Trial name
- NCT07892612
- Testing
- Structured Educational Program on Geriatric Frailty
- Where
- Morocco
- Volunteers
- 144 people
- Sponsor
- Cadi Ayyad University
Burden, Dependency, Mortality
Burden, Mortality and Supply Costs in Intensive Care Unit Patients
This study systematically observes in a pragmatic trail under real world conditions the association between strategies of therapy (maximal therapy, withhold, withdraw) and treatment success in three endpoint related initial risk…
- Conditions
- Burden, Dependency, Mortality, End-of-life Care, Intensive Care Unit
- Trial name
- PLV_Ulm (NCT04094428)
- Where
- Germany
- Volunteers
- 700 people
- Sponsor
- University of Ulm