Clinical trials: Functional Disturbance
Pierre Robin Sequence, Brainstem Dysfunction
Brainstem Dysfunction Involvement in the Pathogenesis of Pierre Robin Sequence
Introduction Pierre Robin Sequence, PRS, incidence is about one hundred births per year in France. The main neonatal clinical manifestations are secondary to airway obstruction and food difficulties related to swallowing…
- Trial name
- DYSROBIN (NCT03423017)
- Testing
- Recording of data
- Where
- 2 sites in France
- Volunteers
- 113 people
- Sponsor
- Hospices Civils de Lyon
Patients With Frontal and Parietal Lobe Dysfunction
Study of Brain Anatomo-functional Substrates Related to the Use of Human Tool by Means of Simultaneous Acquisition of Magnetic Resonance Imaging and Electroencephalogram
This is an observational study, conducted on subjects with neurological disorders primarily involving the frontal and parietal lobes of the brain.
- Trial name
- NCT05767489
- Testing
- electroencephalogram (EEG) and magnetic resonance (MR)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS SYNLAB SDN
Flatfoot, Flexible, Sports Physical Therapy
Neurophysiology-based Intervention of Foot Dysfunction in Sportive Children
The goal of the clinical trial study is to test the effect of the individual complex physiotherapy intervention program in the children actively playing soccer with flatfoot or valgus foot. The aims are: 1.
- Conditions
- Flatfoot, Flexible, Sports Physical Therapy, Child Development
- Trial name
- NCT05902091
- Testing
- Neurophysiology-based intervention
- Where
- Czechia
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Cerebral Palsy
Non-Invasive Measurement of Pulmonary Dysfunction in Children With Cerebral Palsy
This proposal addresses pulmonary dysfunction in severe cerebral palsy by using a novel non-invasive respiratory sensor. The two aims of the project are to 1) provide a screening tool to detect respiratory distress and 2) Find a…
- Trial name
- NCT05791877
- Testing
- pneuRIP
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Nemours Children's Clinic
Parkinson's Disease, Somatosensory Disorders
Somatosensory Dysfunction as the Underlying Mechanism of Upper Limbs Motor Blocks in People With Parkinson's Disease
Motor blocks during gait and upper limb movements (FOULs) are a disabling and common motor impairment in mild to severe stages of Parkinson's disease (PD).
- Trial name
- NCT02610257
- Testing
- Mechanical stimulus (vibration) applied on the forearm
- Where
- Belgium
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Neurogenic Urinary Bladder
Alfuzosin Treatment in Children and Adolescents With Neurogenic Urinary Bladder Dysfunction
The primary objective of the study was to evaluate the efficacy of Alfuzosin in comparison to Placebo on the detrusor Leak Point Pressure (LPP) in children and adolescents 2-16 years of age with elevated detrusor LPP of…
- Trial name
- ALFACHIN (NCT00549939)
- Testing
- Alfuzosin
- Where
- 18 sites in United States, Bulgaria and 16 more
- Volunteers
- 172 people
- Sponsor
- Sanofi
Severe Isolated Left Ventricular Dysfunction, Severe Biventricular Dysfunction
Berlin Heart EXCOR Pediatric Post Approval Study
The purpose of this post-approval study of the EXCOR® Pediatric VAD is to evaluate whether safety and outcomes of the device use in the commercial setting are comparable to the safety and outcomes of the device use in the IDE…
- Trial name
- NCT01674699
- Testing
- EXCOR Pediatric
- Volunteers
- 49 people
- Sponsor
- Berlin Heart, Inc
Kidney Transplant Failure and Rejection, Transplantation, Kidney
To Explore the Application Value of Magnetic Resonance Imaging in Noninvasive Quantitative Evaluation of Graft Function and Systemic Metabolism After Renal Transplantation
At present, renal biopsy is the gold standard for evaluating the pathology of renal transplants, but it is invasive and has the risk of serious complications; and the sampled tissue is only a small part of the kidney, which is…
- Conditions
- Kidney Transplant Failure and Rejection, Transplantation, Kidney, Kidney Transplant Dysfunction
- Trial name
- NCT07145944
- Volunteers
- 500 people
- Sponsor
- Tongji Hospital
Individual Psychiatric Disorder, Couple Dysfunction
Assessing Psychotherapy Outcome With Feedback
This study is a comparison of client outcomes in two different types of psychotherapy treatment. In one condition clients will receive treatment-as-usual (TAU); the therapy that they would normally receive.
- Conditions
- Individual Psychiatric Disorder, Couple Dysfunction, Family Dysfunction
- Trial name
- NCT02023736
- Testing
- Systemic Therapy Inventory of Change (STIC), Treatment as Usual
- Where
- 4 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- The Family Institute at Northwestern University
Healthy Volunteers
Early Environmental and Maternal Determinants of Airway Inflammation in Wheezing Disorders in Infants
This study collects data on microbiological, genetic and environmental factors, as well as lung function parameters (e.g. spirometry, body plethysmography, lung-MRI) to assess the complex interaction of predisposing risk factors…
- Trial name
- NCT04286464
- Testing
- No intervention
- Where
- Switzerland
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Anterior Cruciate Ligament Injury, Quadriceps Dysfunction
Exercise Loading Biology Post-Traumatic OsteoArthritis Study - a Pilot and Feasibility Study
FROM RISK FACTORS TO THE PREVENTION OF LONG-TERM CONSEQUENCES AFTER CRUCIATE LIGAMENT INJURY (ACL injury) - This is a research project where we seek new knowledge about why some people have a high risk and others a low risk of…
- Conditions
- Anterior Cruciate Ligament Injury, Quadriceps Dysfunction, Knee Joint Loading, Anterior Cruciate Ligament Reconstruction
- Trial name
- ExeLoadBioPTOA (NCT06892899)
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- May Arna Risberg
Velopharyngeal Insufficiency, Articulation Disorders
Efficacy of an Arabic Articulatory Error Remediation Software Program in Patients With Velopharyngeal Valve Dysfunction:
To develop a remediation software program that is specific for correcting speech errors in patients with velopharyngeal dysfunction in the Arabic language and test its efficacy, on one group comparing pre and post results
- Conditions
- Velopharyngeal Insufficiency, Articulation Disorders, Hypernasality Syndrome Due to Velopharyngeal Weakness
- Trial name
- NCT04392817
- Testing
- Arabic Articulatory Error Remediation software program
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Alaa Mamdouh
Arthrogryposis Multiplex Congenita, Piezo2 Mutation Gain of Function
Piezo2-related Arthrogryposis & physiopathOLOgy 3
Study type: Observational, non-interventional, single-center, descriptive study. Goal of the study: The goal of this observational study is to characterize the intensity, variability, and qualitative features of pain in patients…
- Trial name
- PAOLO3 (NCT07360574)
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Grenoble
Immunosuppression, Periodontal Disease
Oral Bacteria and Immune System Problems Involved in Gum Disease (Periodontitis)
Background: Gum disease is a condition in which the tissue around the tooth root becomes swollen and infected. This condition can cause tooth loss if it is not treated.
- Conditions
- Immunosuppression, Periodontal Disease, Healthy Subjects, Healthy Volunteer
- Trial name
- NCT01568697
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Primary Immune Deficiency Disorder
Pathophysiology of Inborn Immunodeficiencies
The pathophysiology of primary immunodeficiencies (PID), which encompass a broad range of different diseases with susceptibility to infection and/or a deregulated inflammatory response, is poorly understood.
- Trial name
- NCT03422614
- Testing
- Diagnostic Test
- Where
- Switzerland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Myocardial Infarction, Cardiogenic Shock
Aortic Balloon Counterpulastion in Myocardial Infarction Related Shock
The role of intra aortic balloon counterpulsation in patients experiencing acute myocardial infarction with shock is not established. We hypothesised that use of such a device would lead to improved outcomes in these patients.
- Trial name
- IABPSHOCK (NCT00469248)
- Testing
- Intra-aortic balloon pump counterpulsation
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Diastolic Dysfunction
A Cross-sectional Study on the Impact of Shift Work on Diastolic Dysfunction in Healthcare Workers
The goal of this observational cross-sectional study is to assess the prevalence of left ventricular diastolic dysfunction and identify associated risk factors in health-care workers of various ages and both sexes.
- Trial name
- NCT07331233
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Pediatric Obesity, Insulin Resistance
Intensive Exercise to Improve Mitochondrial Dysfunction in Pediatric Obesity
Obesity and type 2 diabetes are occurring at epidemic rates in the United States and worldwide. The global burden of diabetes is estimated to double over the next 25 years.
- Conditions
- Pediatric Obesity, Insulin Resistance, Mitochondrial Dysfunction
- Trial name
- NCT00962806
- Testing
- Exercise, Lifestyle counseling
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Food Insecurity
Implementing Food Referrals for Equity and Sustained Health
Food insecurity (FI) disproportionately affects those who have been historically marginalized and significantly contributes to poor health outcomes.
- Trial name
- I-FRESH (NCT06661538)
- Testing
- Food Security Screening & Referral Program
- Where
- 2 sites in United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Liver Disease
Oxaliplatin to Treat Advanced Cancers With Liver Dysfunction
This is a phase I study of the experimental anticancer drug oxaliplatin. It is designed to establish the maximum dose of the drug that can be given safely to patients with cancer who have impaired liver function and to determine…
- Trial name
- NCT00006062
- Testing
- oxaliplatin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute (NCI)
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