Clinical trials: Functional Disturbance
Type 1 Diabetes Mellitus, Endothelial Dysfunction
High-Intensity Exercise and Endothelial Function in Type 1 Diabetes(HIIT-T1D)
To study the effect of 8 week high-intensity interval training (HIIT) compared with moderate intensity (MCT) interval training and sedentary patients(CON) with type 1 diabetes.
- Trial name
- HIIT-T1D (NCT03451201)
- Testing
- High Intensity Interval Training, Moderate Continuous Exercise Training, Non-exercise
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Opioid Induced Constipation (OIC)
A Phase 2, Double-Blind, Multiple-Dose Escalation Study to Evaluate NKTR-118 (Oral PEG-Naloxol) in Patients With Opioid-Induced Constipation (OIC)
Study (07-IN-NX003) is a Phase 2, multi-center, placebo-controlled, double-blind, randomized, dose-escalation trial. It is designed to investigate the safety, efficacy and tolerability of NKTR-118 (PEG-naloxol) in patients with…
- Trial name
- NCT00600119
- Testing
- NKTR-118
- Where
- 33 sites in United States
- Volunteers
- 207 people
- Sponsor
- AstraZeneca
Obesity (Disorder), Systemic Inflammation Markers
Understanding How Gut and Brain Barriers Are Linked to Inflammation in Obesity
The goal of this observational study is to understand how obesity affects the function of the gut and blood-brain barriers in adults.
- Conditions
- Obesity (Disorder), Systemic Inflammation Markers, Intestinal Barrier Dysfunction, Blood Brain Barrier
- Trial name
- GUTBBB (NCT06787001)
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Insomnia, Cognitive Impairment
The Effect of Aromatherapy on Sleep and Cognitive Level in the Elderly
This research aims to investigate the effect of aromatherapy on sleep duration, sleep quality, falling asleep time and cognitive functions of elderly individuals in the short term and to improve the general health status and…
- Conditions
- Insomnia, Cognitive Impairment, Elderly
- Trial name
- NCT06208800
- Testing
- Blend Aromatherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medipol University
Temporomandibular Joint Dysfunction Syndrome
Immediate Effect of Ultrasound Therapy on Bilateral Masseter Myalgia: Randomized Single Blinded Investigational Trial
Introduction. Temporomandibular disorders (TMD) are a group of conditions that are multifactorial in nature, and it primarily presents with symptoms of pain and decreased functional capacity.
- Trial name
- NCT02295644
- Testing
- Ultrasound Sonicator 740
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- State University of New York at Buffalo
Alzheimer Disease, Mild Cognitive Impairment
BioFINDER-Brown: Examination of Alzheimer's Disease Biomarkers
This research study aims to examine biomarkers of Alzheimer's disease as early as possible which could potentially be a screening tool for the general population.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Dementia
- Trial name
- NCT05457998
- Testing
- Flutemetamol F18 Injection, [18F]-RO6958948 Injection, [18F]-MK-6240 Injection
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Butler Hospital
Myofacial Pain, Pelvic Pain
Measuring Pelvic Floor Muscle Fitness Before and After Treatment
This study is being done to better understand and improve treatment for myofascial pelvic pain, a common cause of long-lasting pelvic pain in women.
- Conditions
- Myofacial Pain, Pelvic Pain, Myofascial Pelvic Pain, Chronic Pelvic Pain
- Trial name
- NCT07605598
- Testing
- Near Infrared Imaging
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, Los Angeles
Cognitive Impairment
Putative Cognitive Enhancer VU319
This is a safety study of the molecule VU319 to ascertain pharmacokinetic and pharmacodynamic data and test cognitive enhancement in healthy volunteers.
- Trial name
- NCT03220295
- Testing
- Single Dose of VU319, Fed State, Fasted State
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Mild Cognitive Impairment (MCI), Depressive Symptoms
rTMS Combined With Aerobic Exercise for Older Adults With Mild Cognitive Impairment and Comorbid Depression
This study aims to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) and aerobic exercise on cognitive function and mental health in older adults with mild cognitive impairment (MCI) and comorbid…
- Trial name
- NCT07652775
- Testing
- Repetitive Transcranial Magnetic Stimulation, Aerobic Exercise
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Cheng-Hsin General Hospital
Overactive Bladder, Detrusor Instability
Botulin-A Toxin Instillations and Overactive Bladder
The primary objective of this pilot study is to evaluate the safety and efficacy of direct instillations of Botulinum-A toxin/DMSO into the bladder via a catheter system as a means of treating women with symptoms of overactive…
- Conditions
- Overactive Bladder, Detrusor Instability, Detrusor Hyperreflexia
- Trial name
- NCT00583219
- Testing
- Botulinum-A toxin, Dimethyl sulfoxide (DMSO)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Mayo Clinic
Cancer, Fatigue
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy
Background: Fatigue is a very common early and late side effect of cancer treatment, including radiation therapy. The cause of fatigue is poorly understood, making it hard to diagnose and treat.
- Trial name
- NCT01143467
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- National Institute of Nursing Research (NINR)
Mild Cognitive Impairment
Effectiveness of Tai Chi to Improve Cognitive Function in Older Adults With Mild Cognitive Impairment
Mild cognitive impairment (MCI) is a transitional state between normal cognitive decline and dementia. Individuals with MCI are having an impairment in cognitive function compared with normal age-matched counterparts, while their…
- Trial name
- NCT04248400
- Testing
- Tai Chi training, Conventional exercise
- Where
- Hong Kong
- Volunteers
- 37 people
- Sponsor
- The University of Hong Kong
Erectile Dysfunction
Penile Rehabilitation in Patients With Erectile Dysfunction After Pelvic Fracture Urethral Injury Using Low-intensity Shock Wave.
the efficacy and safety of low intensity shock wave therapy (LiSWT) as an ED treatment. Olsen et al. demonstrated that LiSWT might be a possible solution in some ED patients of organic origin .
- Trial name
- NCT07460167
- Testing
- ELvation® Piezowave² linear focused piezoelectric shock wave device (Richard Wolf, Vernon Hills, IL, USA) effect of itsshockwaves on Erectile dysfunction
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- South Valley University
Head and Neck Cancer, Taste Dysfunction
Addressing Taste Dysfunction With Miraculin in Head and Neck Cancer Patients Receiving Radiation Therapy
Patients diagnosed with head and neck cancer who receive radiation therapy with and without chemotherapy develop altered sense of taste due to treatment effect, which typically arises in the second week of radiation therapy and…
- Trial name
- NCT05273307
- Testing
- Miraculin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
Amnestic Mild Cognitive Impairment, Alzheimer's Disease
The Study of Nasal Insulin in the Fight Against Forgetfulness (SNIFF)
An urgent need exists to find effective treatments for Alzheimer's disease (AD) that can arrest or reverse the disease at its earliest stages.
- Trial name
- NCT01767909
- Testing
- Insulin (Humulin® R U-100)
- Where
- 25 sites in United States
- Volunteers
- 240 people
- Sponsor
- University of Southern California
Major Injury
Perioperative Research Into Memory: Cognitive Outcome Following Major Burns
The long term survival of patients who require admission to critical care (CC) following a major burn injury (MBI) continues to improve with advanced clinical management.
- Trial name
- PRiMe (NCT03470844)
- Testing
- Face-to-face neurocognitive tests, Psychological screening, fMRI
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Epilepsy
Levetiracetam for Benign Rolandic Epilepsy
This study is designed to test if the language problems commonly seen in children with benign rolandic epilepsy would improve by switching anticonvulsants to levetiracetam.
- Trial name
- NCT00181116
- Testing
- Levetiracetam
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Johns Hopkins University
Alzheimer's Disease
A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease
The purpose of this study is to evaluate the efficacy and safety of KarXT + KarX-EC for cognitive impairment in Alzheimer's Disease
- Trial name
- MINDSET 1 (NCT06976216)
- Testing
- KarXT, KarX-EC
- Where
- 119 sites in United States, Argentina and 17 more
- Volunteers
- 586 people
- Sponsor
- Bristol-Myers Squibb
Heart Failure, Congestive
Efficacy and Safety of Relaxin for the Treatment of Acute Heart Failure
Different doses of relaxin will be compared to placebo to determine efficacy and safety for the treatment of patients hospitalized with acute heart failure
- Trial name
- RELAX-AHF (NCT00520806)
- Testing
- Relaxin
- Where
- 3 sites in United States, Israel
- Volunteers
- 1,161 people
- Sponsor
- Corthera, Inc.(formerly BAS Medical, Inc.), a member of the Novartis group of companies
Heart Failure With Preserved Ejection Fraction (HFpEF)
Exercise Capacity According to Coronary Microvascular Dysfunction and Body Composition
The correlation of coronary microvascular function and body composition with cardiopulmonary exercise capacity will be assessed in patients with heart failure with preserved ejection fraction.
- Trial name
- NCT04822649
- Testing
- Adenosine stress echocardiography with the evaluation of coronary artery blood flow
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Korea University Anam Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.