Clinical trials: Functional Immune Response
Infectious Gastroenteritis
Probiotics for Infectious Diarrhea in Children in South India
The overall goal of this study is to investigate whether the modulatory effects of probiotics, which are used as food supplements (Lactobacillus GG marketed as Culturelle or yoghurt) in the gastrointestinal tract promote…
- Trial name
- NCT01130792
- Testing
- Lactobacillus GG, Inulin
- Where
- India
- Volunteers
- 124 people
- Sponsor
- Christian Medical College, Vellore, India
Inflammation, Psychosocial Functioning
Mindfulness Meditation Neuroimaging Study for Undergraduates
This study is designed to test the effectiveness of mindfulness meditation intervention classes on psychosocial health outcomes.
- Conditions
- Inflammation, Psychosocial Functioning, Depression, Anxiety
- Trial name
- NCT05304052
- Testing
- Mindfulness Meditation classes
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Asthma
Lung Function Changes of Induced Asthma Children Treated With Inhaled MgSO4
As a non-selective bronchodilator, magnesium sulfate (MgSO4) is effective when administered intravenously in the treatment of the patients with acute severe asthma not responding to conventional therapy (oxygen, nebulized…
- Trial name
- NCT01856959
- Testing
- Magnesium Sulfate, magnesium sulfate & albuterol, Albuterol
- Where
- China
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Chongqing Medical University
Hepatitis A, Hepatitis A Virus
Immunity With Acute Hepatits A
Hepatitis A Virus (HAV) is a public health concern in Egypt, especially among children. Historically highly endemic, recent studies suggest a changing epidemiology.
- Trial name
- Hepatitis A (NCT06942962)
- Volunteers
- 50 people
- Sponsor
- Assiut University
Immunologic Deficiency Syndrome, Leukemia
In Vitro Studies of Immunological and Stem Cell Function in Peripheral Blood Mononuclear Cells in Patients
Peripheral blood mononuclear cells (PBMC) will be collected from patients who have leukemia or lymphoma or other medical conditions involving altered lymphohematopoietic stem cell or immunological function.
- Conditions
- Immunologic Deficiency Syndrome, Leukemia, Lymphoma, Neoplasm
- Trial name
- NCT00001336
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Cancer Institute (NCI)
Type 1 Diabetes, Diabetes Mellitus, Type 1
Insulin and Abatacept in Recently-diagnosed Type 1 Diabetes
The goal of this clinical trial is to test whether the combination of two safe immune therapies called abatacept and nasal insulin can preserve pancreas function in recently-diagnosed type 1 diabetes.
- Trial name
- IAA (NCT05742243)
- Testing
- Abatacept (CTLA4-Ig) and nasal insulin (Humulin R®)
- Where
- 6 sites in Australia
- Volunteers
- 68 people
- Sponsor
- Melbourne Health
Lymphoma, Hodgkin
MELT - MRI Evaluation of Lymphoma Treatment
Patients who are newly diagnosed with Hodgkin's lymphoma will undergo disease staging at diagnosis and initial treatment response assessment.
- Trial name
- MELT (NCT01459224)
- Where
- United Kingdom
- Volunteers
- 58 people
- Sponsor
- University College, London
Inflammatory Bowel Disease
Immune Function in Offsprings of Females With Inflammatory Bowel Disease
1. To evaluate the immune response to vaccines in infants of IBD patients treated with anti-TNF medications during pregnancy compared to infants of IBD mother not treated with anti-TNF medications. 2.
- Trial name
- NCT02079441
- Where
- Israel
- Volunteers
- 24 people
- Sponsor
- Sheba Medical Center
Constipation - Functional
Breath Gases, Gut Flora, and Immunity in Children With Constipation
Constipation is a common problem in children that can affect their daily life, school performance, and social activities. Researchers have found that the bacteria living in our intestines (called "gut microbiome") may play an…
- Trial name
- NCT07797491
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Preterm, Surgery
An Exploratory Study of Arginine Supplementation and the Postoperative Immune REsponse
ASPIRE is a nutrition study focusing on the effect of arginine supplementation on immune function in postoperative infants. The investigators will explore the effect of current intravenous feeding (parenteral nutrition (PN))…
- Conditions
- Preterm, Surgery, Nutritional Deficiency, Immune System and Related Disorders
- Trial name
- ASPIRE (NCT05306925)
- Testing
- Arginine
- Where
- 2 sites in United Kingdom
- Volunteers
- 48 people
- Sponsor
- University of Liverpool
Vaginal Infection, Breastmilk Collection
Evaluation of Breastmilk Microbiota as a Function for Immunity
The aim of this study is to evaluate the difference of breast milk microbiota between mothers with and without vaginal infections during pregnancy.
- Trial name
- NCT05005286
- Testing
- Past history of vaginal Infections
- Where
- Malaysia
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
HIV
Reconstitution of HIV-specific Immunity Against HIV
Research Goal: To reconstitute the anti-HIV specific immunity system of the AIDS patients, so the viruses could not massively replicate when HAART was discontinued, then make HIV functional cure possible.
- Trial name
- NCT02563509
- Testing
- HIV-specific CD8 cells
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Guangzhou 8th People's Hospital
Asthma (Diagnosis)
Respiratory Admittance by Oscillometry in Children
Oscillometry is a pulmonary function testing technique suited for children because it does not require specific respiratory maneuvers like spirometry.
- Trial name
- ArsEIB (NCT07771608)
- Volunteers
- 144 people
- Sponsor
- Central Hospital, Nancy, France
Sleep Deprivation, Sleep
Sleep Deprivation's Regulation of Immune System Function and Behavior
The study proposes to investigate whether sleep deprivation will affect a variety of measures, including hormones, immune system functioning, and behaviors related to food intake and hunger.
- Trial name
- SS (NCT01730742)
- Testing
- Neuroeconomics task, Portion Size Task, Blood sample
- Where
- Sweden
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Immune Responses, Post Operative Recovery
Comparative Study Between the Effects of Deep Versus Moderate Neuromuscular Blockade on Postoperative Recovery and Immune Function in Patients Undergoing Total Hip Replacement Surgery.
. The investigators hypothesized that DNMB ( Deep NeuroMuscular Block) would yield superior postoperative recovery quality and attenuate the surgery-induced immune suppression compared to MNMB ( Moderate NeuroMuscular Block)in…
- Trial name
- NCT07870954
- Testing
- ToF ( Train of Four) Scan
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Graft-Versus-Host Disease
Bridging Pediatric and Adult Biomarkers in Graft-Versus-Host Disease
This study is designed to collect longitudinal biological samples from patients after hematopoietic cell transplantation (HCT) cared for at multiple bone marrow transplant centers to validate biomarkers of both acute and chronic…
- Trial name
- NCT02194439
- Where
- United States
- Volunteers
- 415 people
- Sponsor
- Indiana University
Familial Mediterranean Fever, MEFV Gene Mutation
Characterization of a Functional Test for Mediterranean Family Fever Screening - 2
Familial Mediterranean fever (FMF) is the most common auto-inflammatory disease (prevalence: 1-5 / 10,000 inhabitants). It is caused by mutations in the MEFV gene, which encodes variants of the Pyrine inflammasome.
- Trial name
- DEPIST-FMF 2 (NCT04478409)
- Testing
- one additional blood sample during a planned blood test
- Where
- 8 sites in France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Bronchiolitis Obliterans Syndrome (BOS)
Mechanisms and Targeted Therapy of Airway Basal Cell Dysfunction in Bronchiolitis Obliterans Syndrome
This experimental study aims to investigate the pathogenesis of bronchiolitis obliterans syndrome (BOS) and provide a basis for clinical diagnosis and treatment.
- Trial name
- NCT07018804
- Testing
- Bronchoscopic brushing, Single - cell cloning, Cell function identification
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Haikou Affiliated Hospital of Central South University Xiangya School of Medicine
Gut Microbiota, Skin Microbiota
Lactobacillus Rhamnosus GG: Interaction With Human Microbiota and Immunity
Hypothesis: Probiotics have been used as novel adjunct therapeutic approach in atopic dermatitis. In addition to balancing the gut microecology and promoting host immune defences, specific probiotics might further aid in…
- Conditions
- Gut Microbiota, Skin Microbiota, Humoral Immune Responses, Severity of Atopic Dermatitis
- Trial name
- NCT01148667
- Testing
- Casein hydrolysate added with LGG, Infants drink casein hydrolysate without LGG
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- Turku University Hospital
Safety Issues
Tolerability and Modulatory Action of the Butyrate Releaser N-(1-carbamoyl-2-phenyl-ethyl) Butyramide
Accumulating evidence is showing that gut microbiota could play a key role in gastrointestinal tract and immune system development and function. Many beneficial effects elicited by gut microbiota are mediated its metabolites.
- Trial name
- NCT04491266
- Testing
- FBA
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Federico II University