Clinical trials: Fungal Diseases
Pneumocystis Infection, Infection
New Techniques for Using a Saline Wash as a Diagnostic Tool for Pneumocystis Pneumonia
This study will examine the effectiveness of a new laboratory method for detecting pneumocystis organisms in a salt-water (saline) oral wash.
- Conditions
- Pneumocystis Infection, Infection, Pneumonia, Pneumocystis, Lung Disease, Fungal
- Trial name
- NCT00342589
- Where
- United States
- Volunteers
- 1,015 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Post-COVID-19 Condition, Ulcerative Colitis
Emerging Indications for Hyperbaric Oxygen Treatment
This study will evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) on treating emerging indications (i.e., conditions that have shown to potentially benefit from HBOT) using the Multicenter Registry for Hyperbaric…
- Conditions
- Post-COVID-19 Condition, Ulcerative Colitis, Crohn Disease, Calciphylaxis
- Trial name
- NCT07240649
- Testing
- Hyperbaric oxygen treatment (HBOT), 100% Oxygen
- Volunteers
- 100 people
- Sponsor
- Jay C. Buckey Jr.
Thalassemia, Hematopoietic Stem Cell Transplantation
Low-Dose Liposomal Amphotericin B for Invasive Fungal Infection Prophylaxis in Neutropenic Children
This is a single-center, single-arm, observational clinical study evaluating the efficacy and safety of low-dose liposomal amphotericin B (1 mg/kg/day, intravenous, once daily) for the prevention of invasive fungal infections in…
- Conditions
- Thalassemia, Hematopoietic Stem Cell Transplantation, Neutropenia, Invasive Fungal Infections
- Trial name
- NCT07725263
- Testing
- Liposomal Amphotericin B (LAmB)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Haikou Affiliated Hospital of Central South University Xiangya School of Medicine
Invasive Fungal Disease, Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)
Longitudinal Cohort Study on Invasive Fungal Disease After Allogeneic Hematopoietic Stem Cell Transplantation
Invasive fungal disease (IFD) is one of the serious complications after hematopoietic stem cell transplantation (HSCT), characterized by high incidence and high mortality.
- Trial name
- NCT07569055
- Where
- China
- Volunteers
- 6,000 people
- Sponsor
- Peking University People's Hospital
Meningitis, Bacterial Infections
Prospective Clinical Registry of Acute Treatment and Long-term Assessment of Children Meningitis
Prospective, multicenter, observational clinical registry of pediatric patients with acute infectious meningitis across approximately 20 public and private hospitals in Brazil.
- Conditions
- Meningitis, Bacterial Infections, Viral Meningitis, Fungal Meningitis
- Trial name
- ATLAS-II (NCT07062445)
- Where
- Brazil
- Volunteers
- 600 people
- Sponsor
- Hospital Israelita Albert Einstein
Fungal Infection, Haematological Malignancy
Pharmacogenomics for Better Treatment of Fungal Infections Clinical Trial
This project aims to address invasive fungal infections in patients, by precision dosing of voriconazole based on CYP2C19 genotype testing with Bayesian dose-forecasting dosing software to develop patient-centric and maximally…
- Conditions
- Fungal Infection, Haematological Malignancy, Blood Cancer, Infectious Disease
- Trial name
- PRAGMATIC (NCT06510699)
- Testing
- genotype-directed dosing with dosing software based on therapeutic drug monitoring
- Where
- 7 sites in United States, Australia
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- The University of Queensland
Invasive Pulmonary Fungal Disease
Blood mNGS for Diagnosing Invasive Pulmonary Fungal Disease in Hematologic Patients
The goal of this clinical trial is to learn whether a blood test called metagenomic next-generation sequencing (mNGS) can help diagnose invasive pulmonary fungal disease in patients with blood disorders.
- Trial name
- NCT07511595
- Testing
- Blood microbial metagenomic next-generation sequencing (mNGS)
- Volunteers
- 1,000 people
- Sponsor
- Peking University People's Hospital
Pulmonary Fungal Infection
Posaconazole for Pulmonary Fungal Infection Prophylaxis in Hematopoietic Stem Cell Transplantation Patients
This open, prospective, observational multicenter cohort study aims to evaluate the efficacy, safety as well as the effective serum concentration of Posaconazole for prevention of pulmonary fungal infections in patients with…
- Trial name
- NCT04725942
- Testing
- Oral Posaconazole tablets
- Where
- 4 sites in China
- Volunteers
- 360 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Fungal Disease
A Real-world Prospective Observational Study on the Efficacy and Safety of L-AmB(Liposomal Amphotericin B) for br- IFD(Breakthrough Invasive Fungal Disease) in Children and Adolescent Patients With Hematological Malignancies Receiving Triazoles or Echinocandins Prophylaxis
The goal of this observational study is to evaluate the efficacy the favorable response rate and safety of L-AmB(liposomal amphotericin B) for the treatment of br-IFD(breakthrough invasive fungal disease) in Chinese children and…
- Trial name
- NCT07357038
- Testing
- Patients received the Drug: liposomal amphotericin B（AmBisome） for treatment
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Enterobacterial Infections, Oncologic Disease
Biodistribution and Pathophysiology Study of 18F-Fluorodeoxysorbitol (18F-FDS) in Diseased Patients
In this study, the investigators will assess the hypothesis that this new positron emission tomography (PET) radiopharmaceutical, 18F-Fluorodeoxysorbitol (18F-FDS), will specifically localize at sites of Gram-negative bacterial…
- Conditions
- Enterobacterial Infections, Oncologic Disease, Inflammatory Disease, Invasive Fungal Infections
- Trial name
- NCT05611892
- Testing
- 18F-FDS PET/CT
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Johns Hopkins University
Fungal Disease
Azole Susceptibility and Resistance Mechanisms Surveys in Pathogenic Fungi by the CARST-fungi (2023-2024)
The China Antifungal Resistance Surveillance Trial (CARST-fungi) study, which has been starting in July 2019, is a multi-center, prospective, observational, and laboratory-based study of pathogenic fungal isolates causing IFDs.
- Trial name
- NCT06969703
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University First Hospital
Invasive Fungal Infections, Prophylaxis
L-AmB_ Retrospective mUlticenter Study on Mycosis prOphylaxis
Invasive fungal disease (IFD) still represents an important cause of morbidity and mortality in immunocompromised patients, particularly in patients undergoing antineoplastic chemotherapy or allogeneic hemopoietic stem cell…
- Conditions
- Invasive Fungal Infections, Prophylaxis, Invasive Fungal Disease
- Trial name
- L-AmB_RUSCO (NCT06640296)
- Testing
- Liposomal Amphotericin B (LAmB)
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Istituto Giannina Gaslini
Invasive Fungal Disease
Efficacy and Safety of Amphotericin B and Azoles in the Treatment of Invasive Fungal Disease
Efficacy and safety of amphotericin B and azoles in the treatment of invasive fungal disease
- Trial name
- NCT06819410
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Sichuan Provincial People's Hospital
Invasive Fungal Disease
FungiScope - A Global Emerging Fungal Infection Registry
The objective of this registry is to broaden the knowledge on epidemiology, diagnostic procedures and clinical course of emerging invasive fungal infections.
- Trial name
- FungiScope (NCT01731353)
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- University of Cologne
Rhinosinusitis, Intracranial Extension
Role of Imaging in Complications of Sinusitis
This study aims to assess the diagnostic performance of CT and MRI in the diagnosis of complications of rhinosinusitis in comparison to clinical and operative findings.
- Conditions
- Rhinosinusitis, Intracranial Extension, Rhinosinusitis Chronic, Rhinosinusitis Acute
- Trial name
- NCT05836935
- Testing
- Multislice CT scan of the paranasal sinuses., MRI examination of the paranasal sinuses
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sohag University
Invasive Pulmonary Aspergillosis, Invasive Fungal Disease
LFD of Aspergillus Antigen in Paediatrics
Many children and young people are at risk of invasive fungal disease (IFD), such as those who have had a haematopoietic stem cell transplants, those with an immune deficiency or those who are prescribed immunosuppressive drugs…
- Trial name
- LFD-AsPaeds (NCT05569824)
- Testing
- Lateral-flow Device
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- St George's University Hospitals NHS Foundation Trust
Invasive Fungal Disease, Fever and Neutropenia
Evaluation of NGS for Detection and Follow-up of Fungal Pathogens in Immunocompromised Pediatric Patients
The Sponsor hypothesize that Next-generation Sequencing (NGS) can identify fungal pathogens, is more accurate than other noninvasive options and can report fungal genomic load.
- Conditions
- Invasive Fungal Disease, Fever and Neutropenia, Invasive Fungal Infections, Immunocompromised
- Trial name
- NCT03262584
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Karius, Inc.
Corneal Ulcer, Eye Infections, Fungal
The Mycotic Ulcer Treatment Trial II: A Randomized Trial Comparing Oral Voriconazole vs Placebo
The purpose of this study is to determine if the addition of oral voriconazole to topical treatment regimens results in lower rates of perforation in severe fungal corneal ulcers.
- Trial name
- MUTTII (NCT00997035)
- Testing
- Voriconazole
- Where
- 7 sites in United States, India and 1 more
- Volunteers
- 240 people
- Sponsor
- University of California, San Francisco
Corneal Ulcer, Eye Infections, Fungal
Mycotic Ulcer Treatment Trial I
The purpose of this study is to determine if natamycin or voriconazole results in better visual outcomes in fungal corneal ulcers, especially visual acuity.
- Trial name
- MUTT I (NCT00996736)
- Testing
- Natamycin, Voriconazole
- Where
- 3 sites in United States, India
- Volunteers
- 323 people
- Sponsor
- University of California, San Francisco
Neutropenia, Fungal Disease
Micafungin Prevention Study for Invasive Fungal Disease in Pediatric & Adolescent Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation
This study is to evaluate safety and prophylaxis effect of micafungin after hematopoietic stem cell transplantation. Micafungin is administered until confirmation of neutrophil engraftment or treatment failure.
- Trial name
- NCT01417169
- Testing
- micafungin
- Where
- South Korea
- Volunteers
- 112 people
- Sponsor
- Seoul National University Hospital