Clinical trials: GI Disorders
Esophageal Cancer
The Role of PET/MRI in Predicting the Outcome of Definitive Chemoradiotherapy for Esophageal Cancer Patients
PET/MRI has the advantage to assess the metabolism, diffusion, and perfusion parameters of the tumor simultaneously and has been investigated in some cancers with promising results.
- Trial name
- NCT05855278
- Testing
- PET/MRI
- Where
- Taiwan
- Volunteers
- 22 people
- Sponsor
- Chang Gung Memorial Hospital
Gastroenteritis
A Study to Evaluate the Safety and Efficacy of Domperidone in Pediatric Participants With Nausea and Vomiting Due to Acute Gastroenteritis
The purpose of this study is to demonstrate that domperidone suspension plus oral rehydration therapy (ORT) is more effective than placebo plus ORT at reducing the symptoms of vomiting associated with acute gastroenteritis (AG)…
- Trial name
- NCT02699385
- Testing
- Oral Rehydration Therapy, Domperidone
- Where
- 29 sites in Austria, Belgium and 4 more
- Volunteers
- 10 people
- Sponsor
- Janssen-Cilag International NV
Inflammatory Bowel Diseases, Crohn Disease
Pilot and Feasibility Study of 2'-FL as a Dietary Supplement in IBD Patients Receiving Stable Maintenance Anti-TNF Therapy
Randomized, placebo-controlled dose-ranging study of 2'-FL in IBD, Crohn's Disease (CD) and ulcerative colitis (UC). The overarching hypothesis is that 2'-FL supplementation in IBD will be safe and well tolerated, while…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- PRIME (NCT03847467)
- Testing
- 2'-Fucosyllactose
- Where
- 3 sites in United States
- Volunteers
- 128 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Celiac Disease, Celiac Disease in Children
Supporting Children and Young People to Live Well with Coeliac Disease
Managing a strict gluten-free diet is crucial for children and young people with coeliac disease. However, this can have adverse effects on psychological well-being and quality of life.
- Trial name
- NCT06007898
- Testing
- Parent self-help psychological resource
- Where
- 3 sites in United Kingdom
- Volunteers
- 95 people
- Sponsor
- University of Surrey
Colorectal Neoplasms, Peritoneal Neoplasms
PIPAC for Peritoneal Metastases of Colorectal Cancer
This is multicentre, open-label, single-arm phase II study that investigates the feasibility, safety, tolerability, preliminary efficacy, costs, and pharmacokinetics or repetitive electrostatic pressurised intraperitoneal aerosol…
- Conditions
- Colorectal Neoplasms, Peritoneal Neoplasms, Appendiceal Neoplasms, Peritoneal Carcinomatosis
- Trial name
- CRC-PIPAC (NCT03246321)
- Testing
- repetitive ePIPAC-OX
- Where
- 2 sites in Netherlands
- Volunteers
- 20 people
- Sponsor
- Koen Rovers
Gastric Cancer
Expression of S100A2 and Trefoil Factor Family Members in Epstein-Barr Virus Related Gastric Cancer
The investigators hypothesize that aberrant hypermethylation of tumour suppressor genes is an important mechanism for Epstein-Barr Virus (EBV) - related gastric carcinogenesis, the promoter hypermethylation status and the…
- Trial name
- NCT01100814
- Where
- Singapore
- Sponsor
- National University Hospital, Singapore
Short Bowel Syndrome, Vitamin E Deficiency
Use of Tocofersolan (Vedrop®) to Prevent or Treat Refractive Vitamin E Deficiency in Infants and Children
Patients with short bowel syndrome or other forms of intestinal failure/fat malabsorption are unable to tolerate adequate oral or enteral feedings.
- Trial name
- NCT03582384
- Testing
- Tocofersolan
- Sponsor
- Boston Children's Hospital
Hirschsprung Disease
Translation and Validation of a Disease-specific Questionnaire for Hirschsprung's Disease in Danish Patients
The Hirschsprung and anorectal malformation quality of life (HAQL) questionnaire is a disease-specific quality of life questionnaire with 5 different elements (3 questionnaires for patients (categories: age 8-11, 12-16, and >17…
- Trial name
- NCT04730128
- Where
- Denmark
- Volunteers
- 173 people
- Sponsor
- University of Southern Denmark
Inflammatory Bowel Diseases, Functional Gastrointestinal Disorders
Functional Gastrointestinal Disorders in Pediatric IBD
Background: Persistent gastrointestinal symptoms have been described in patients who are considered in remission of their inflammatory bowel disease (IBD).
- Conditions
- Inflammatory Bowel Diseases, Functional Gastrointestinal Disorders, Pediatric Disorder, Anxiety Depression
- Trial name
- TFI-MICI (NCT03565263)
- Where
- France
- Volunteers
- 350 people
- Sponsor
- University Hospital, Caen
Ulcerative Colitis
A Study of the Safety and Efficacy of Infliximab(REMICADE ) in Pediatric Patients With Moderately to SeverelyActive Ulcerative Colitis
The purpose of the study is to evaluate the effectiveness and safety of infliximab (Remicade) in children with moderately to severely active ulcerative colitis.
- Trial name
- NCT00336492
- Testing
- infliximab
- Where
- 27 sites in United States, Belgium and 3 more
- Volunteers
- 60 people
- Sponsor
- Centocor, Inc.
Dehydration, Acute Gastroenteritis
Assessment of Volume Status by Bedside Ultrasound in Children With Acute Gastroenteritis
The purpose of the study is assessment of volume status by bedside ultrasound in children with acute gastroenteritis
- Trial name
- NCT03021109
- Testing
- Measurement of inferior vena cava diameters with ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 190 people
- Sponsor
- Derince Training and Research Hospital
Perforated Peptic Ulcer
Open Versus Laparoscopic Repair of Perforated Peptic Ulcer
The aim of this clinical trial is to compare the outcomes of open versus laparoscopic repair for perforated peptic ulcer and provide evidence-based guidance to the selection of the most appropriate operative technique at Sohag…
- Trial name
- NCT06484699
- Testing
- open repair of perforated peptic ulcer, laparoscopic repair of perforated peptic ulcer
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Barrett's Esophagus
Optical Coherence Tomography (OCT) Based Screening of Esophagus and Gastroesophageal Junction
The specific aim of this study is to determine the accuracy of Optical Coherence Tomography (OCT) imaging for screening and diagnosis of the distal esophagus in patients undergoing a clinical esophagogastroduodenoscopy (EGD)…
- Trial name
- NCT01401699
- Testing
- Optical Frequency Domain Imaging (OFDI)
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Massachusetts General Hospital
Esophageal Neoplasms, Esophagectomy
Metachronic Brain Metastases After Esophagectomy for Esophageal Cancer (METABREC)
Esophagectomy is the cornerstone of the curative treatment of esophageal carcinoma. Despite this treatment, patients can suffer from locoregional or distant metastatic disease and only a very selected group of patients can be…
- Conditions
- Esophageal Neoplasms, Esophagectomy, Brain Metastases
- Trial name
- METABREC (NCT04654975)
- Testing
- Esophagectomy for esophageal cancer
- Where
- 8 sites in United States, Belgium and 4 more
- Volunteers
- 10,000 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Adenomatous Polyposis Coli
Trial In Pediatric Patients With Familial Adenomatous Polyposis (FAP)
To test whether celecoxib can be used to prevent colon polyp formation in children with familial adenomatous polyposis (FAP).
- Trial name
- CHIP (NCT00585312)
- Testing
- Celecoxib
- Where
- 42 sites in United States, Belgium and 12 more
- Volunteers
- 106 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Rotavirus Infections, Gastroenteritis
Vaccine Effectiveness of RV1 in a Naïve Population
Rotavirus (RV) is the leading cause of severe gastroenteritis (GE) in young children. The cumulative risk of GE hospitalizations and hospital stays of < 24 hours is 1/25, which would amount to 13,600 Canadian children < 5 years.
- Conditions
- Rotavirus Infections, Gastroenteritis, Diarrhea
- Trial name
- NCT01467037
- Testing
- No intervention done
- Where
- 3 sites in Canada
- Volunteers
- 374 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Stage I Esophageal Adenocarcinoma, Stage II Esophageal Adenocarcinoma
Clinical Study of Time Optimizing of Endoscopic Photodynamic Therapy on Esophageal and/or Gastric Cardiac Cancer
The therapy of photofrin PDT was effective in improving life quality of patients with advanced esophageal and/or gastric cardiac cancer and the time optimizing for employing laser irradiation was of great importance.The purpose…
- Conditions
- Stage I Esophageal Adenocarcinoma, Stage II Esophageal Adenocarcinoma, Stage III Esophageal Adenocarcinoma, Stage I Esophageal Squamous Cell Carcinoma
- Trial name
- NCT02628665
- Testing
- photosensitizer(photofrin), 630 nm laser irradiation (DIOMED)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The First Affiliated Hospital of Henan University of Science and Technology
Inflammatory Bowel Diseases, Ulcerative Colitis
Evaluate Established Anti-DEFA5 mAbs Diagnostic Efficacy and Safety in IBD
Investigators propose to validate efficacy and safety of the detection of DEFA5 in the diagnosis of the colonic IBD using longitudinal vs.
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Colitis, Indeterminate Colitis
- Trial name
- NCT05663671
- Testing
- Diagnostic Test
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Meharry Medical College
Early Gastric Cancer
Endoscopic Submucosal Dissection Combine With Laparoscopic Regional Lymph Node Dissection for Early Gastric Cancer
The purpose of this study is to determine whether Endoscopic Submucosal Dissection combine with Laparoscopic Regional Lymph node Dissection for early gastric cancer can improve Disease-free survival ？
- Trial name
- NCT02325999
- Testing
- ESD AND LRLD
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Friendship Hospital
Cushing's Syndrome, Pituitary Adenoma
Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney Complex
Lentiginosis refers to groups of diseases marked by the presence of pigmented spots on the skin. These conditions are most commonly associated with multiple tumors and changes in hormone producing glands.
- Conditions
- Cushing's Syndrome, Pituitary Adenoma, Carney Complex, Primary Pigmented Nodular Adrenocortical Disease
- Trial name
- NCT00001452
- Testing
- oCRH
- Where
- United States
- Volunteers
- 1,387 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
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