Clinical trials: GI Disorders
Mucositis
Ketamine and Hydromorphone for Patient Controlled Pain Relief in Children's Mucositis
The treatment of cancer in children may result in an extremely painful condition called oral mucositis when the cells lining the mouth are injured due to the cancer medication.
- Trial name
- NCT00474110
- Testing
- Ketamine & hydromorphone
- Where
- Canada
- Sponsor
- University of British Columbia
Clostridium Difficile Infection
Effect of Acid Suppression Medication on Pediatric Microbiome
The colonic microbiome is essential in health and disease, and is highly dynamic during the first several years of life. Proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) are widely used in children, but…
- Trial name
- NCT02016820
- Testing
- Omeprazole (suspension), Lifestyle Modification
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Columbia University
Rotavirus Infections, Rotavirus Gastroenteritis
Safety and Immunogenicity Study of Recombinant Trivalent Rotavirus Subunit Vaccine in Healthy Infants and Toddlers
The purpose of this study is to assess the immunogenicity, safety and immune persistence of recombinant trivalent rotavirus subunit vaccine in healthy infants aged 6-12 weeks and healthy toddlers aged 7-71 months.
- Trial name
- NCT05621655
- Testing
- Mid dose Recombinant Trivalent Subunit Rotavirus Vaccine, High dose Recombinant Trivalent Subunit Rotavirus Vaccine
- Where
- 2 sites in China
- Volunteers
- 1,512 people, healthy volunteers welcome
- Sponsor
- MAXVAX Biotechnology Limited Liability Company
Hirschsprung Disease, Enterocolitis
Identification Genetic, Immunologic and Microbial Markers of Hirschsprung Associated Enterocolitis in Children With Hirschsprung Disease
To identify demographic, clinical, genetic, immunologic and/or microbial (i.e., fecal stream characterization) risk factors that influence the likelihood of development of the HAEC phenotype in children who carry the diagnosis of…
- Trial name
- HAEC (NCT02193685)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Cedars-Sinai Medical Center
Infant Nutrition Disorders, Gastrointestinal Dysfunction
Management of Infant Digestive Disorders and Quality of Life
The objective of the study is to measure the evolution of the quality of life in infants between 0 and 5 months old, not breastfed and suffering from regurgitation or colic.
- Trial name
- NCT04462640
- Testing
- Management of Infant Digestive Disorders and Quality of Life
- Where
- France
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Gastroesophageal Reflux
Study on the Tolerance and Efficacy of a New Anti Regurgitation Formula
The aim of this study is to evaluate the efficacy of a new thickened formula on regurgitation.
- Trial name
- SONAR (NCT02425423)
- Testing
- New thickened formula
- Where
- 3 sites in Belgium, France
- Volunteers
- 100 people
- Sponsor
- United Pharmaceuticals
Recurrent Colon Cancer, Recurrent Rectal Cancer
Imatinib Mesylate in Treating Patients With Stage IV Colorectal Cancer
Phase II trial to study the effectiveness of imatinib mesylate in treating patients who have stage IV colorectal cancer. Imatinib mesylate may interfere with the growth of tumor cells by blocking certain enzymes necessary for…
- Conditions
- Recurrent Colon Cancer, Recurrent Rectal Cancer, Stage IV Colon Cancer, Stage IV Rectal Cancer
- Trial name
- NCT00041340
- Testing
- imatinib mesylate, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- National Cancer Institute (NCI)
Inflammatory Bowel Disease
A Pharmacokinetic Study to Determine the Oral Bioavailability of Methotrexate in Patients With Inflammatory Bowel Disease
Patients with inflammatory bowel disease (IBD) who require methotrexate (MTX)for treatment currently receive this drug by injection.
- Trial name
- NCT00035074
- Testing
- Methotrexate
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Crohn's Disease
A Comparative Study of Capsule Endoscopy, Magnetic Resonance Imaging and Computer Tomography Scanning of the Small Bowel in Crohn's Disease
The aim of this study is to evaluate three diagnostic methods for assessing small bowel disease in patients with suspected or known Crohn's disease.
- Trial name
- NCT01019460
- Testing
- Magnetic resonance imaging, computed tomography scanning and capsule endoscopy
- Volunteers
- 150 people
- Sponsor
- University of Southern Denmark
Short Bowel Syndrome (SBS)
Retrospective Study on Participants With Short Bowel Syndrome and Chronic Intestinal Failure That Underwent Transplantation in Brazil
The main aim of this study is to capture management and treatment outcome data in participants with short bowel syndrome and chronic intestinal failure (SBS-IF) that underwent intestinal transplantation in Brazil.
- Trial name
- NCT05113082
- Where
- Brazil
- Volunteers
- 7 people
- Sponsor
- Takeda
Inflammatory Bowel Diseases
Comparison of VoLumen and Breeza Oral Contrast Agents in Pediatric Patients
In this research study, two different oral contrast materials that can be used for CT or MR enterography will be studied. This study is designed to compare which oral contrast material (VoLumen or Breeza) is preferred by…
- Trial name
- NCT02946203
- Testing
- Barium Sulfate, Flavored beverage Oral Contrast
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Neoplasms, Adenomatous Polyposis Coli
Clinical Sequencing of Cancer and Tissue Repository: OncoGenomics
Background: Saliva, blood, tissue, and cancer contain DNA. DNA makes the "instruction book" for the cells in the body. Cancer is caused by changes in DNA that affect cell function.
- Conditions
- Neoplasms, Adenomatous Polyposis Coli, Neurofibroma, Plexiform, Myelodysplastic Syndromes
- Trial name
- NCT03027401
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Acute Abdomen, Bowel Obstruction
The Best Care for Abdominal Emergencies Study
This is a single-centre retrospective cohort study utilising electronic hospital records. The aim of this study is to improve care for all patients with an intestinal emergency, irrespective of whether they have surgery or not.
- Conditions
- Acute Abdomen, Bowel Obstruction, Bowel; Ischemic, Acute, Bowel Perforated
- Trial name
- BCAE (NCT04577339)
- Testing
- Laparotomy or laparoscopy
- Where
- United Kingdom
- Volunteers
- 2,500 people
- Sponsor
- Portsmouth Hospitals NHS Trust
Dehydration, Gastroenteritis
Efficacy Study of IV Fluids Only vs Ondansetron to Treat Dehydration
Dehydration due to vomiting is a common complication of acute gastroenteritis in children. Persistent vomiting following rehydration is a problem in outpatient management using oral rehydration therapy.
- Trial name
- NCT00691275
- Testing
- Ondansetron, Saline
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Eosinophilic Esophagitis
A Six Month, Safety Follow-up Study in Eosinophilic Esophagitis Subjects Who Completed Study PR-021
This purpose of this study is the long-term follow-up of glucocorticosteroid-related adverse events and hypothalamic-pituitary-adrenal axis (HPA) suppression in subjects after discontinuation of study drug received in the PR-021…
- Trial name
- NCT01498497
- Testing
- EUR-1100
- Where
- 6 sites in United States
- Volunteers
- 14 people
- Sponsor
- Forest Laboratories
Nutritional and Metabolic Diseases, Oncologic Disorders
Prognostic Performance of the Naples Prognostic Score
To investigate the prognostic performance of the Naples Prognostic Score in gastric cancer patients undergoing surgery
- Trial name
- NPS (NCT03272646)
- Testing
- surgery
- Volunteers
- 477 people
- Sponsor
- University of Campania Luigi Vanvitelli
Deglutition Disorder
Effect of Pre-emptive Transcutaneous Neuro-muscular Electrical Stimulation for Dysphagia in Long Term Intubated Patients
It was well known that long term intubation caused a various kind of abnormal presentations of dysphagia such as the increased aspiration risk, the decreased gag reflex, mucosal pathology, the airway stenosis and so on.
- Trial name
- NCT01202968
- Testing
- Transcutaneous neuro-muscular electrical stimulation
- Where
- South Korea
- Sponsor
- Ulsan University Hospital
Appendicitis, Acute, Appendectomy
Video-Based Grading of Intraoperative Adverse Events in Pediatric Laparoscopic Appendectomy
Acute appendicitis is the most common surgical emergency in children, and laparoscopic appendectomy is its standard treatment. Although intraoperative adverse events (iAEs) are recognized as an important determinant of surgical…
- Conditions
- Appendicitis, Acute, Appendectomy, Intraoperative Complications, Patient Safety
- Trial name
- PedAppy-iAE (NCT07794618)
- Testing
- Laparoscopic appendectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ahmet Burak Doğan, MD
Inflammatory Bowel Disease, Glycogen Storage Disease Type Ia
Study of the Relationship Between Glycogen Storage Disease Type Ia and Inflammatory Bowel Disease
The purpose of this research study is to understand the relationship between inflammatory bowel disease (IBD) and Glycogen storage disease (GSD)type Ia.
- Trial name
- NCT01854242
- Testing
- Glycogen Storage Disease type Ia patients
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Florida
Esophageal Squamous Cell Carcinoma
A Pilot for a Case-Control Study of Esophageal Squamous Cell Carcinoma in Western Kenya
Background: Esophageal cancer is the sixth leading cause of cancer deaths worldwide. Two primary cell types, squamous cell carcinoma and adenocarcinoma, account for most cases.
- Trial name
- NCT00901173
- Where
- Kenya
- Volunteers
- 372 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.