Clinical trials: Gas Exchange
HSCT, Respiratory
Assessing Pulmonary Changes in HSCT
This will be an un-blinded, open-label study of children and adults, including those who are being evaluated for or who have undergone HSCT, those with existing respiratory conditions and/or diagnosed gas-exchange impairment, and…
- Conditions
- HSCT, Respiratory, Gas Exchange Impairment
- Trial name
- NCT07823036
- Testing
- Hyperpolarized 129 Xenon
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Methods of Exercise in Children
Gas Exchange Kinetics and Work Load During Exercise
The purpose of this research study is to understand how different kinds of exercise affect the human body and the health of the heart and lungs.Participants will exercise in different protocols on a bicycle ergometer or…
- Trial name
- NCT03770507
- Testing
- Exercise Training
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Cystic Fibrosis
Pre-flight Evaluation of Adult Patients With Cystic Fibrosis
The purpose of the study is to investigate the relationship between hypoxemia achieved during Hypoxia Altitude Simulation test and sea level values of pulmonary function, arterial blood gases, pulse oximetry and cardiopulmonary…
- Trial name
- NCT01569880
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Oslo University Hospital
Acute Respiratory Distress Syndrome
PEEP Test and Gas Exchange in ALI/ARDS Patients
The investigators aim to study the effect of different levels of PEEP in ALI/ARDS patients on gas exchange.
- Trial name
- NCT00284102
- Testing
- Mechanical ventilation
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Policlinico Hospital
Long COVID, Breathlessness
Long COVID and Post-exertional Pulmonary Diffusion
Aim of investigators was to study whether abnormalities of lung diffusing capacity for nitric oxide (DLNO) and carbon monoxide (DLCO) in long COVID may have a clinical impact in relation to exercise intolerance.
- Conditions
- Long COVID, Breathlessness, Exercise Intolerance, Alveolar Lung Disease
- Trial name
- Long_COVID_Ex (NCT05430503)
- Testing
- Lung volumes, spirometry and standard single-breath DLCO were measured at rest while combined DLNO and DLCO were measured at rest and post-exercise
- Where
- Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Gastroscopy
High Flow Nasal Cannula in Patients Undergoing Gastroscopy
During gastroscopy, the insertion of the fiberscope and gastric distension required to perform the examination may induce modifications to respiratory mechanics, respiratory effort and breathing pattern.
- Trial name
- NCT05693298
- Testing
- High Flow Nasal Cannula, Conventional Oxygen Therapy
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- University Magna Graecia
Normal Middle Ears., Otitis Media Ears.
Observation of Gas Exchange in the Middle Ear
Observation of fluid behavior over a perforated eardrum. A comparison of the behavior of the gas in normal vs. different kinds of otitis media ears.
- Trial name
- NCT00794105
- Where
- Israel
- Sponsor
- Shaare Zedek Medical Center
Mechanical Ventilation Complication, Congenital Heart Disease
Application of Neurally Adjusted Ventilatory Assist to Children After Congenital Cardiac Surgery
Neurally adjusted ventilatory assist (NAVA) is a new mode of mechanical ventilation that delivers ventilatory assist in proportion to neural effort.
- Trial name
- NCT01662011
- Testing
- mode of neurally adjusted ventilatory assist, Mode of pressure support ventilation
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Apnea
Different Flow Rates on Gas Exchange in Children During Apnea
Background: Children desaturate rapidly during apnea following anesthetic induction. The optimal apneic oxygenation flow rate and its effect on CO2 accumulation remain unclear.
- Trial name
- NCT06659887
- Testing
- nasal cannula
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Yasser S Mostafa, MD
Diffusion Limitation of Pulmonary Gas Exchange in Systemic Sclerosis
Mechanisms of Pulmonary Diffusion Limitation in Systemic Sclerosis
This study was designed to test the hypothesis that, irrespective of the degree of interstiaI lung disease and/or pulmonary arterial hypertension, the combined measurement of lung diffusing capacity for nitric oxide and carbon…
- Trial name
- DL-SSc (NCT03601520)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Organ Preservation
Ex Vivo Lung Perfusion : Effect of Cellular Perfusate on Mechanical Properties and Gas Exchange Function of Donor Lungs
The lungs retrieved from the brain dead multi organ donor will be placed in a lab . They will be connected to a ventilator and preservative solution will be circulated through it .
- Trial name
- NCT02953483
- Testing
- Red blood cells
- Where
- India
- Volunteers
- 6 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Respiratory Distress Syndrome, Preterm Birth
nHFOV vs nCPAP: Effects on Gas Exchange for the Treatment of Neonates Recovering From RDS
The purpose of this study is to compare the effects of two different techniques of non-invasive ventilation (nCPAP and nHFOV) on gas exchange in preterm infants recovering from respiratory distress syndrome.
- Trial name
- NCT02772835
- Testing
- Medin-cno
- Where
- 8 sites in Italy, Lithuania
- Volunteers
- 30 people
- Sponsor
- Fondazione Poliambulanza Istituto Ospedaliero
Otitis Media With Effusion
Middle Ear Pressure Disregulation After Tympanostomy Tube Insertion
This study will determine if the investigators can use certain tests (eustachian tube function tests and gas exchange tests) to predict whether or not a child who had tubes surgically placed in their eardrum because of middle-ear…
- Trial name
- NCT00393900
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- University of Pittsburgh
Mechanical Ventilation Complication
Assessing Gas Exchange in Intensive Care Patients on a Ventilator
In an attempt to standardise the degree of impairment of gas exchange in the lungs of ICU patients a number of indices of oxygen exchange have been developed.
- Trial name
- NCT02599350
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Aberdeen
Acute Lung Injury, ARDS
The Specific Elastance in Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) Patients
The investigators aim to study the specific elastance in ALI/ARDS patients during invasive mechanical ventilation.
- Trial name
- NCT00143468
- Testing
- mechanical ventilation
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Policlinico Hospital
Chronic Obstructive Pulmonary Disease
The Effect of Cycling Off Criteria During Pressure Support Ventilation in Chronic Obstructive Pulmonary Disease (COPD) Patients
The investigators' aim is to study the effect of cycling off criteria during pressure support ventilation in COPD patients at two levels of PEEP and PSV.
- Trial name
- NCT00141440
- Testing
- mechanical ventilation
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Policlinico Hospital
Respiratory Failure
Comparison of Gas Exchange Between Two Invasive Mechanical Ventilation Modes in Children
This study assesses the feasibility of digital data collection for a randomized controlled trial in a quaternary pediatric intensive care unit and the effect of two commonly used mechanical ventilation modes on gas exchange (CO2)…
- Trial name
- CoCO2 (NCT05843123)
- Testing
- Respiratory support a, Respiratory support b
- Where
- Switzerland
- Volunteers
- 59 people
- Sponsor
- University Children's Hospital, Zurich
Hypoxia
Effects of Dihydropyridine Calcium Channel Inhibitors on Respiratory Gas Exchanges in the Intensive Care Unit: a Pharmacovigilance Study in VigiBase® and a Comparison With Urapidil
Due to their effects on hypoxic pulmonary vasoconstriction (HPV), dihydropyridine calcium channel inhibitors (CCI) could lead to hypoxia in patients with a pulmonary shunt.
- Trial name
- NCT05537194
- Testing
- dihydropyridine calcium channel inhibitors use
- Where
- France
- Volunteers
- 32,000,000 people
- Sponsor
- University Hospital, Caen
Respiratory Support
Effects of Nasal High Flow Therapy on Ventilation and Gas Exchange in Healthy Newborns
Nasal High Flow (NHF) and CPAP are established forms of respiratory support in neonates and often produce similar clinical outcomes.
- Trial name
- NCT02632825
- Testing
- Nasal High Flow
- Where
- Armenia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Research Center of Maternal and Child Health Protection, Armenia