Clinical trials: Gas Exchange
COPD
Effects of Bevespi on Ventilation and Gas Exchange Abnormalities in COPD Assessed by 129Xe MRI
The purpose of this study is to determine whether the new inhaler, Bevespi improves lung function. Magnetic resonance imaging (MRI) using inhaled hyperpolarized 129Xe gas, that can provide useful images of the functioning of the…
- Trial name
- COPD (NCT03324607)
- Testing
- hyperpolarized 129Xe gas MRI, Bevespi Aerosphere
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Bastiaan Driehuys
HSCT, Respiratory
Assessing Pulmonary Changes in HSCT
This will be an un-blinded, open-label study of children and adults, including those who are being evaluated for or who have undergone HSCT, those with existing respiratory conditions and/or diagnosed gas-exchange impairment, and…
- Conditions
- HSCT, Respiratory, Gas Exchange Impairment
- Trial name
- NCT07823036
- Testing
- Hyperpolarized 129 Xenon
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Pneumonia, Viral
Characterization of Persistent Pulmonary Abnormalities Following COVID-19 Pneumonia
Severe Acute Respiratory Syndrome (SARS) SARS-CoV-2, name of the Coronavirus Group of international Committee on taxonomy of viruses, is an emerging virus from the family of coronaviridae, responsible for the COVID-19 pandemic.
- Trial name
- PULCO-19 (NCT04422613)
- Testing
- pulmonary anomalies 4 months after documented COVID-19 pneumonia
- Where
- France
- Volunteers
- 73 people
- Sponsor
- University Hospital, Toulouse
Resp Gas Exchange Disorder Nos
Effect of Parallel Oxygen Delivery Through a Tracheal Gas Insufflation (TGI) and a T-piece, on Blood Gases and Respiratory Rate, in ICU Tracheostomized Patients
The study investigates if there are benefits (better oxygenation, minimized work of breath) from the parallel oxygenation with Tracheal Gas Insufflation and T-piece, in order to provide respiratory support in tracheostomized…
- Trial name
- NCT03040297
- Testing
- Tracheal gas insufflation 6 L/min, Tracheal gas insufflation 11 L/min, Tracheal gas insufflation catheter, without gas flow
- Where
- Greece
- Volunteers
- 11 people
- Sponsor
- Attikon Hospital
COPD (Chronic Obstructive Pulmonary Disease)
HFNC Versus NIV in Hypercapneic COPD Patients
Aim: To compare gas exchange trends, clinical outcomes, and tolerability between HFNC and NIV in COPD patients with mild-to-moderate hypercapnic respiratory failure.
- Trial name
- NCT07854210
- Testing
- high flow nasal cannula, non invasive ventilation
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Mohammed Shehta
Pulmonary Atelectasis, Patient Comfort
HFNC During Awake Craniotomy - Impact on Patient Comfort
Background: Patients undergoing awake brain surgery are exposed to non-humidified, non-warmed oxygen/air mix flow through a face mask for a prolonged duration.
- Trial name
- NCT03763461
- Testing
- HFNC, Oxygen Mask
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Western University, Canada
Chronic Obstructive Pulmonary Disease
Effects of Temazepam in Patients With Chronic Pulmonary Obstructive Disease
The purpose of this study is to evaluate the effects of temazepam during sleep and in daytime on dyspnea, gas exchange and sleep quality in patients with chronic obstructive pulmonary disease.
- Trial name
- NCT00245661
- Testing
- Temazepam
- Where
- Netherlands
- Volunteers
- 14 people
- Sponsor
- Rijnstate Hospital
Pulmonary Gas Exchange, Carbon Dioxide
Influence of Inspiratory Flow Pattern on Exchange of Carbon Dioxide in Humans Without Primary Lung Disease
The purpose of this study is to investigate how inspiratory flow pattern influences CO2 elimination in people without primary lung disease.
- Trial name
- NCT01686984
- Testing
- Altered breath
- Where
- Sweden
- Volunteers
- 8 people
- Sponsor
- Region Skane
One-lung Ventilation (OLV), Low-flow Anesthesia
Effects of Low-Flow Sevoflurane Anesthesia on Pulmonary Function During One-Lung Ventilation
This prospective observational study aims to evaluate the effects of low-flow sevoflurane anesthesia on respiratory mechanics, gas exchange, and postoperative pulmonary function in patients undergoing one-lung ventilation (OLV)…
- Conditions
- One-lung Ventilation (OLV), Low-flow Anesthesia, Thoracic Surgery, Respiratory Mechanics
- Trial name
- OLV-LOWSEVO (NCT07085546)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Adrenal Tumors
Anesthesia Management of Retroperitoneal Adrenalectomies
This study is a prospective, perioperative evaluation of hemodynamic and respiratory parameters in patients undergoing retroperitoneoscopic adrenalectomies.
- Trial name
- NCT00894335
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Kliniken Essen-Mitte
Hypertension, Pulmonary, Altitude Sickness
Efficacy Study of Riociguat and Its Effects on Exercise Performance and Pulmonary Artery Pressure at High Altitude
During ascent to high altitude there is a physiologic response to hypoxia that results in an elevated pulmonary arterial pressure associated with decreased exercise performance, altitude-induced pulmonary hypertension, and high…
- Trial name
- NCT02024386
- Testing
- Riociguat
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Richard Moon
COPD
Evaluation Inhaled Corticosteroids on Exhaled Nitric Oxide Gas Exchange
To evaluate the role of inhaled corticosteroids to suppress nitric oxide gas exchange in stable patients with moderate-to-severe COPD who are current non-smokers and not on oral corticosteroids.
- Trial name
- NCT00568347
- Testing
- fluticasone 100mcg/ salmeterol 50mcg, fluticasone 250/salmeterol 50, salmeterol
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Arthur F Gelb MD
Positive End Expiratory Pressure
Titration of Intraoperative PEEP in Patients Undergoing Robotic Assisted Laparoscopic Prostatectomy
Optimal intraoperative positive end expiratory pressure (PEEP) improves the outcome. Optimal PEEP is not only very different among individuals, but each individual's optimal PEEP is affected by positioning, muscle paralysis, and…
- Trial name
- TIPPR (NCT05155371)
- Testing
- Titration of Optimal Positive End-expiratory Pressure
- Where
- 2 sites in China
- Volunteers
- 95 people
- Sponsor
- Fudan University
Trauma ICU Patients, Endothelial Injury
Inflammation Severity and miRNA-126 in Trauma
Trauma triggers a complex immune response intended to eliminate danger signals and restore physiological balance. Early post-traumatic inflammation is primarily initiated by damage-associated molecular patterns (DAMPs) and…
- Trial name
- NCT07291908
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Melike Cengiz
Chronic Obstructive Pulmonary Disease
QVA Mechanistic Efficacy Study (Receptor Effects, Etc)
The purpose of this study was to assess global ventilated lung volume in moderate to severe COPD patients using MRI lung imaging after treatment with QVA149 compared to placebo.
- Trial name
- NCT02634983
- Testing
- QVA149
- Where
- 3 sites in United Kingdom
- Volunteers
- 31 people
- Sponsor
- Novartis Pharmaceuticals
Idiopathic Pulmonary Fibrosis
Inhaled Nitric Oxide (iNO) in Idiopathic Pulmonary Fibrosis (IPF).
Idiopathic Pulmonary Fibrosis (IPF) is a progressive lung disease marked by reduced exercise capacity and activity-related breathlessness (commonly termed dyspnea).
- Trial name
- NCT05052229
- Testing
- Nitric Oxide, Medical air
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dr. Denis O'Donnell
Respiratory Distress Syndrome, Adult, Critical Illness
Measuring Heart and Lung Function in Critical Care
This is a feasibility study of the use of a novel technique called 'Inspiwave' to measure heart and lung function in adult patients in critical care.
- Conditions
- Respiratory Distress Syndrome, Adult, Critical Illness, Mechanical Ventilation Complication, Haemodynamic Instability
- Trial name
- NCT03424798
- Testing
- Inspiwave
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Oxford
Acute Lung Injury, Acute Respiratory Distress Syndrome
Safety Study of Nebulized Sodium Nitroprusside in Adult Acute Lung Injury
Acute lung injury (ALI) is caused by a wide variety of conditions, but always characterized by hypoxia and non-cardiogenic pulmonary edema. Current treatment of ALI is supportive and treatment of the underlying cause.
- Conditions
- Acute Lung Injury, Acute Respiratory Distress Syndrome, Sodium Nitroprusside, Hypoxia
- Trial name
- NCT01619280
- Testing
- Sodium Nitroprusside
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Mount Sinai Hospital, Canada
One-lung Ventilation (OLV), Thoracic Surgery
Comparison of FCV and VCV in One-Lung Ventilation
One-lung ventilation (OLV) is commonly used during thoracic surgery but may negatively affect lung mechanics and gas exchange. Different ventilation strategies are used during OLV, and their effects on respiratory parameters…
- Conditions
- One-lung Ventilation (OLV), Thoracic Surgery, Respiratory Mechanics
- Trial name
- FCVOLVent (NCT07392086)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Respiration, Artificial, Pleural Effusion
Impact of Draining Significant Effusion on Gas Exchange and Lung Mechanics in Patient Under Mechanical Ventilation
Patients with acute respiratory failure (ARF) who were receiving mechanical ventilator support, had significant pleural effusion (both transudates and exudates) and drainage plan were evaluated.
- Conditions
- Respiration, Artificial, Pleural Effusion, Ultrasonography
- Trial name
- NCT03394872
- Testing
- Drainage of the pleural effusion
- Volunteers
- 27 people
- Sponsor
- Dokuz Eylul University