Clinical trials: Gastro-Intestinal Disorders
Eosinophilic Esophagitis, Eosinophilic Gastritis
Characteristics of Eosinophilic Gastritis, Enteritis, and Colitis in a Multi-Site Cohort
The purpose of this study is to investigate features of patients with Eosinophilic Gastrointestinal Disorders (EGIDs) other than Eosinophilic Esophagitis (EoE) alone, including Eosinophilic Gastritis (EG), Eosinophilic…
- Conditions
- Eosinophilic Esophagitis, Eosinophilic Gastritis, Eosinophilic Gastroenteritis, Eosinophilic Colitis
- Trial name
- NCT02897271
- Where
- 6 sites in United States
- Volunteers
- 381 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Autism Spectrum Disorder
Eating Behaviours, Diet and Gastrointestinal Symptoms in Children With Autism Spectrum Disorders
This case-control study aims to compare the differences in eating behaviours, nutritional status, diet quality and gastrointestinal (GI) health between Chinese children aged 3-6 years with autism spectrum disorders (ASD) (n=65)…
- Trial name
- NCT03270306
- Where
- China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Enterocolitis, Necrotizing, Bacteremia
Antibiotic "Dysbiosis" in Preterm Infants
Prolonged antibiotic use in preterm neonates has significant consequences on the developing intestinal microbiome, metabolome and host response, predisposing the neonate to various major morbidities, including necrotizing…
- Conditions
- Enterocolitis, Necrotizing, Bacteremia, Bronchopulmonary Dysplasia, Intraventricular Hemorrhage
- Trial name
- NCT02784821
- Testing
- Antibiotic, Gastric fluid, Breast milk
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- University of Florida
Eosinophilic Esophagitis
Non-endoscopic Tracking of Disease Activity in Eosinophilic Esophagitis
To prospectively determine the natural history of inflammation resolution following initiation of diet treatment and to optimize the diet treatment of patients with EoE through the use of a non-endoscopic tracking device, the…
- Trial name
- NCT03834298
- Testing
- Four Food Elimination Diet
- Sponsor
- University of Colorado, Denver
Eosinophilic Esophagitis
A Study Comparing Swallowed Flovent and Placebo in Patients With Eosinophilic Disorders
The purpose of this study is assessing the efficacy of swallowed Flovent® vs. placebo for the treatment of eosinophilic esophagitis (EE).
- Trial name
- NCT00266578
- Testing
- Fluticasone Propionate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Marc Rothenberg
Diabetes
Prebiotics and Metformin Improve Gut and Hormones in Type 2 Diabetes in Youth (MIGHTY-fiber)
Background: Metformin is a pill youth with type 2 diabetes take. It can cause side effects like diarrhea and upset stomach. Researchers want to see if a fiber supplement can help decrease these side effects.
- Trial name
- NCT04209075
- Testing
- Biomebliss, Metformin
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 1 Diabetes, Celiac Disease
Accessing Care, Clinical Trials and Screening for Underserved Children and Adults With Type 1 Diabetes (ACCESS-T1D)
The purpose of this study is to identify people with T1D or celiac disease (CD) early in the course of their disease and to improve the methods of screening for these diseases.
- Trial name
- ACCESS-T1D (NCT06908057)
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Erosive Gastroesophageal Reflux Disease, Non-Erosive Reflux Disease
Efficacy of Pantoprazole in Patients Older Than 12 Years With Reflux Associated Sleep Disorders (PULS)
The aim of the study was to evaluate the effect of Pantoprazole 20 mg/40 mg for 14 days on symptoms in patients with NERD (non-erosive reflux disease) or eGERD (erosive gastroesophageal reflux disease) with special focus on the…
- Trial name
- PULS (NCT00562094)
- Testing
- Pantoprazole
- Where
- 1,153 sites in Germany
- Volunteers
- 8,616 people
- Sponsor
- Nycomed
Eosinophilic Esophagitis, Dysphagia
EoE(Eosinophilic Esophagitis)
To evaluate quantitative magnetic resonance imaging(MRI) as a potential non-invasive, radiation-free diagnostic tool for evaluating esophageal wall remodeling (thickness and stiffness) and response to treatment in children and…
- Trial name
- NCT01999439
- Testing
- Eosinophilic Esophagitis with Dysphagia
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Michigan
Pain, Neuropathic, Epilepsy
Cancer in Patients With Gabapentin (GPRD)
High doses of gabapentin are associated with pancreatic acinar cell tumors in rats, but there has been no post marketing pancreatic carcinogenicity signal with gabapentin as reported by spontaneous reports in AERS or in the…
- Conditions
- Pain, Neuropathic, Epilepsy, Renal Pelvis Cancer, Pancreatic Cancer
- Trial name
- NCT01236053
- Testing
- Gabapentin prescriptions
- Volunteers
- 2,323,608 people
- Sponsor
- GlaxoSmithKline
Rumination
Mechanisms and Predictors of Change in App-Based Mindfulness Training for Adolescents
A growing body of research implicates rumination as being a transdiagnostic risk factor involved in the development of depression and anxiety in youth.
- Trial name
- NCT04697966
- Testing
- Mindfulness (Headspace) App, Active Control Condition ("Recharge" condition delivered in Headspace app)
- Where
- United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Dysphagia, Aspiration
Effect of Afferent Oropharyngeal Pharmacological and Electrical Stimulation on Swallow Response and on Activation of Human Cortex in Stroke Patients With Oropharyngeal Dysphagia
Oropharyngeal dysphagia (OD) is a major complaint among many patients with stroke and causes severe complications. There is no specific treatment for these patients.
- Conditions
- Dysphagia, Aspiration, Stroke
- Trial name
- NCT01777672
- Testing
- Dietary and oral hygiene recommendations, oral TRPV1 agonist, pharyngeal electrical stimulation
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Hospital de Mataró
GERD
Gatekeeper European 005
Evaluation of the Gatekeeper System in the treatment of patients with Gastroesophageal Reflux Disease (GERD) who already have been treated under study protocols Endo 2000-03 and Endo 2000-04
- Trial name
- NCT00229086
- Testing
- Gatekeeper Reflux Repari System (Device)
- Where
- 2 sites in United States, Switzerland
- Volunteers
- 55 people
- Sponsor
- MedtronicNeuro
Type 1 Diabetes Mellitus
Gastrointestinal Symptoms in Children With Type 1 Diabetes
This cross-sectional study aims to assess the frequency and types of gastrointestinal symptoms in children with type 1 diabetes mellitus compared with age- and sex-matched healthy controls.
- Trial name
- NCT07845175
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Assiut University
Peptic Ulcer, Helicobacter Pylori Infection
The Prevalence of Helicobacter Pylori in Shanghai, 2013 to 2019
The study was a cross-sectional single-center study, conducted at Renji Hospital, Shanghai Jiaotong university school of medicine.
- Trial name
- NCT04636866
- Testing
- NO intervention
- Where
- China
- Volunteers
- 400,000 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Depression in Adolescence, Rumination
Mindfulness-Based fMRI Neurofeedback for Depression
In the United States, adolescents experience alarmingly high rates of major depression, and gold-standard treatments are only effective for approximately half of patients.
- Trial name
- mbNF (NCT05617495)
- Testing
- Mindfulness + fMRI Neurofeedback
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Columbia University
Eosinophilic Esophagitis
A Study of Flovent in Patients With Eosinophilic Esophagitis
The purpose of this study is to test the effects (both good and bad) of high dose swallowed fluticasone propionate (Flovent) in subjects with eosinophilic esophagitis (EoE).
- Trial name
- NCT00426283
- Testing
- Flovent
- Where
- 4 sites in United States
- Volunteers
- 42 people
- Sponsor
- Marc Rothenberg, MD
Gastrointestinal Dysfunction, Critical Illness
Effect of Different Feeding Method on Gastrointestinal Function of Critical Patients
The intestine is the most vulnerable target organ in septic patients and is the first to be damaged organ in multiple organ dysfunction syndrome(MODS).Therefore, improving intestinal motility and mucosal barrier function is…
- Conditions
- Gastrointestinal Dysfunction, Critical Illness, Nutrition Disorders
- Trial name
- DFM-GFC (NCT04224883)
- Testing
- Continuously feeding, 16-hours feeding, intermittent feeding
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Inflammatory Bowel Diseases, Ulcerative Colitis
Gut Microbiome in Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a chronic inflammatory condition for gastrointestinal tract. There have been numerous studies to reveal dysbiosis of fecal/mucosal microbiome composition in IBD patients but actual trend of…
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease
- Trial name
- NCT03589183
- Where
- South Korea
- Volunteers
- 1,500 people
- Sponsor
- Kyunghee University Medical Center
Functional Gastrointestinal Disorders (FGIDs), Cyclic Vomiting Syndrome
Autonomic Reactivity and Personalized Neurostimulation
Disorders of gut-brain interaction (DGBI) affect up to 25% of U.S. children. Patients often suffer from disabling, multisystem comorbidities that suggest a common root (sleep disturbances, fatigue, anxiety, etc).
- Conditions
- Functional Gastrointestinal Disorders (FGIDs), Cyclic Vomiting Syndrome, Functional Dyspepsia, Dysautonomia
- Trial name
- NCT06863207
- Testing
- Percutaneous electrical nerve field stimulation, Hypnotherapy
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
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