Clinical trials: Gastrointestinal Motility
Gastroparesis
Idiopathic Gastroparesis Registry Using a Predominant-Symptom Classification
The diagnosis of "gastroparesis" suggests that delayed gastric emptying is the underlying cause of symptoms, but this description fails to explain the variable presentation.
- Trial name
- NCT01173484
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Louisville
Functional Gastrointestinal Disorders
The Effect of Amoxicillin Versus Placebo on Gastrointestinal Motility in Children
The goal of this study is to determine whether amoxicillin (AMX) alone has an appreciable effect on upper gastrointestinal motility compared to placebo.
- Trial name
- NCT01530009
- Testing
- Amoxicillin
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Nationwide Children's Hospital
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Feeding; Difficult, Newborn, Growth Failure
Prophylactic Probiotics to Extremely Low Birth Weight Prematures
Mortality and incidence of severe complications is still high among extremely premature infants. Common causes of severe complications in this population are poor nutrition, necrotizing enterocolitis, and severe infections.
- Conditions
- Feeding; Difficult, Newborn, Growth Failure, Necrotizing Enterocolitis, Sepsis
- Trial name
- PROPEL (NCT01603368)
- Testing
- Lactobacillus reuteri
- Where
- 2 sites in Sweden
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Ostergotland County Council, Sweden
Gastro Esophageal Reflux
Esophageal pH-MII Duration: 12 or 24 Hours?
To check whether the first 12 hours of MII-pH recording are sufficient to diagnose gastroesophageal reflux disease (GERD) among newborns/infants, with a diagnostic accuracy similar to 24 hours of recording as currently advised.
- Trial name
- NCT05760274
- Testing
- multichannel intraluminal impedance and pH monitoring (MII/pH)
- Where
- Italy
- Volunteers
- 127 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Voice Disorders, Gastroesophageal Reflux
Quantifying Effects of Treatment of Pediatric Dysphonia
The diagnosis and management of childhood dysphonia is a significant clinical problem; however, there have been few studies aimed at defining standard assessment methods for pediatric dysphonia.
- Trial name
- NCT00237679
- Testing
- Neuromuscular Electrical Stimulation, Unstimulated
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Wisconsin, Madison
Reflux Disease, Gastro-Esophageal, Hiatal Hernia
Treatment of Reflux With Sleeve Gastrectomy
In 2008, the World Health Organization (WHO) report found that 0.5-1.5 billion people aged 20 years and above suffer from overweight (body mass index (BMI) ≥ 25) and obesity (BMI ≥ 30 kg / m2) stated.
- Conditions
- Reflux Disease, Gastro-Esophageal, Hiatal Hernia, Reflux Esophagitis
- Trial name
- NCT06170060
- Testing
- Laparoscopic Sleeve Gastrectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Yusuf Emre ALTUNDAL
Colorectal Cancer, Bowel Ileus
Efficacy of Mosapride on Recovery of Intestinal Motility After Elective Colorectal Cancer Surgery
Postoperative ileus (POI) is one of the most common causes of prolonged hospital stays after abdominal surgery. The pathophysiology of POI is multifactorial and complex.It is known to be associated with sympathetic neural…
- Trial name
- NCT04905147
- Testing
- Mosapride
- Where
- Thailand
- Volunteers
- 44 people
- Sponsor
- Mahidol University
Bone Turnover Rate Disorder, Calcium Metabolism Disorders
Effects of Lansoprazole on Bone Turnover Markers
Use of proton pump inhibitors (PPI) has increased in recent years. There are concerns that PPIs have possible negative effects on bone metabolism.
- Trial name
- NCT04814316
- Testing
- Blood and urine specimens
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Gastro-Oesophageal Reflux
Laparoscopy in Children: Does it Decrease the Metabolic, Endocrine and Inflammatory Stress Response to Surgery
The aim of this trial was to characterise the intra and post operative metabolic, endocrine and inflammatory response to laparoscopic fundoplication in children.
- Trial name
- NCT00231543
- Testing
- Laparoscopic fundoplication, open Nissen fundoplication
- Where
- United Kingdom
- Sponsor
- Institute of Child Health
Gastroesophageal Reflux Disease (GERD)
A Study of the Safety and Effectiveness of Rabeprazole for the Treatment of Gastroesophageal Reflux Disease (GERD) in Pediatric Patients
The purpose of the study is to access the effectiveness and safety of oral rabeprazole in the treatment of acid-related disorders in pediatric patients, focusing specifically on the manifestation of GERD (symptomatic and erosive…
- Trial name
- NCT00787891
- Testing
- rabeprazole
- Volunteers
- 127 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Bronchopulmonary Dysplasia, Gastroesophageal Reflux
Transpyloric Versus Gastric Feeding in Bronchopulmonary Dysplasia
The goal of this clinical trial is to learn if transpyloric tube feeding (feeding directly into the small intestine) versus gastric tube feeding tolerably and effectively reduces gastroesophageal reflux in infants born premature…
- Trial name
- NCT06534359
- Testing
- Transpyloric tube feeding, Gastric tube feeding
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- Children's Hospital of Philadelphia
Gastroesophageal Reflux Disease (GERD), Peptic Ulcers
Long-term Pantoprazole Trial in Patients With Symptoms of Chronic Acid Peptic Complaints (BY1023/VMG-708)
Gastroesophageal reflux disease (GERD) is a medical condition affecting the stomach and esophagus. GERD might occur when the lower esophageal sphincter does not close properly and stomach contents leaks back (refluxes) into the…
- Trial name
- NCT00261300
- Testing
- Pantoprazole
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Takeda
GERD
Effect of Helicobacter Pylori Eradication on Gastroesophageal RefIux Disease (GERD)
Evaluate the effect of H.pylori eradication on Gastroesophageal-reflux disease and symptoms improvement
- Trial name
- NCT06457334
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Functional Gastrointestinal Disorders, Infant Conditions
Prevalence of FGIDs and Probiotics Study
This is a study to evaluate the prevalence of FGIDs in infants using the Thai version of Rome IV diagnostic questionnaire for functional gastrointestinal disorders in infants and evaluate the efficacy of Limosilactobacillus…
- Trial name
- PROOF (NCT06309199)
- Testing
- Biogaia
- Where
- Thailand
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Refractory Gastroesophageal Reflux Disease
Anti-reflux Mucosectomy (ARMS) is a Useful Therapy for Refractory Gastroesophageal Reflux Disease (RGERD)
Anti-reflux mucosectomy (ARMS) may be a new therapy for refractory gastroesophageal reflux disease (RGERD). The aim of the present study is to explore the safety and efficacy of ARMS.
- Trial name
- NCT03259191
- Testing
- anti-reflux mucosectomy
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Ruihua Shi
Gastroesophageal Reflux (GER), Infants
Polaprezinc (Zinc L-carnosine) in Infants With Gastroesophageal Reflux
The goal of this clinical trial is to evaluate efficacy and safety of Zinc-L carnosine/Polaprezinc in infants with GER. Researchers will compare Zinc-L carnosine/Polaprezinc to a placebo (a look-alike substance that contains no…
- Trial name
- GER (NCT06678997)
- Testing
- Zinc-L carnosine/Polaprezinc, Thickened formula
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Roma La Sapienza
Premature Infants, Gastroesophageal Reflux
Lansoprazole in Preterm Infants With Gastroesophageal Reflux (GER)
This study is crossover study to evaluate safety and efficacy of lansoprazole in preterm infants with gastroesophageal reflux.
- Trial name
- NCT01946971
- Testing
- Lansoprazole
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- Seoul National University Hospital
Reflux, Gastroesophageal Reflux Disease (GERD)
RESULT (REflux Surgery in Lung Transplantation) Preliminary Study Protocol
The purpose of the prospective study is to collect information surrounding lung transplant in order to develop a randomized study to determine if prevention of gastroesophageal reflux disease (GERD) related aspiration (stomach…
- Trial name
- RESULT (NCT01406210)
- Where
- 4 sites in United States, Canada
- Volunteers
- 647 people
- Sponsor
- Duke University
Gastro Esophageal Reflux
Prevalence of Symptomatic Gastroesophageal Reflux Disease in Czech Children (Czech GERDKids)
This study aims to determine the prevalence of symptomatic gastroesophageal reflux disease (GERD) in children aged 8-9 years and 12-13 years in the Czech Republic.
- Trial name
- Czech GERDKids (NCT07482969)
- Where
- Czechia
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Motol