Clinical trials: General Anaesthesia
Opioid Analgesic Adverse Reaction
Cardiovascular Protection Conservative Effects of Esketamine Versus µ-opioid Receptor Agonists in General Anesthesia
Pain is 'a double-edged sword', disturbing daily life of the sufferers and activating the intrinsic protective mechanisms. Transient receptor potential vanilloid 1 (TRPV1), play such role as 'a double agent', transmitting the…
- Trial name
- NCT04553536
- Testing
- Esketamine, Sulfentanil or/and Remifentanil
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Hospital of Shanxi Medical University
Pediatric Dental General Anesthesia, Restoration
Clinical Performance and Failure Rates of Restorations Following Pediatric Dental Rehabilitation Under General Anesthesia
Full-mouth dental rehabilitation under general anesthesia (GA) is frequently required for young children with extensive dental caries, behavioral challenges, or special healthcare needs.
- Conditions
- Pediatric Dental General Anesthesia, Restoration, Clinical Performance, Full Mouth Rehabilitation
- Trial name
- NCT07827833
- Testing
- Routine Restorative Materials and Treatment Methods
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Tanta University
Awareness, Anesthesia
Anesthesia Awareness on YouTube: Content and Quality Analysis
This study aims to evaluate the quality and reliability of YouTube videos related to "anesthesia awareness." Using the search terms "anesthesia awareness" and "waking up during surgery," the first 100 videos from each search…
- Trial name
- NCT07323537
- Volunteers
- 200 people
- Sponsor
- Mentese State Hospital
General Anesthetic, Electroencephalogram
General Anesthetics-related Changes in Prefrontal EEG During Pediatric Surgical Anesthesia
The change profiles of indices derived from pEEG such as phase-amplitude coupling and bicoherence based on individual general anesthetics in children have not been examined in previous literature.
- Trial name
- NCT05210764
- Testing
- propofol, sevoflurane, S-ketamine
- Where
- China
- Volunteers
- 366 people
- Sponsor
- Peking University First Hospital
Anaesthesia, Anesthesia Depth Monitoring
Monitoring the Depth of Anesthesia and Nociception During the Induction of General Anesthesia in Pediatric Patients
Perioperative assessment of adequate depth of anesthesia and analgesia is currently a recommended part of routine anesthesia practice for all surgical procedures.
- Trial name
- ANIGAPP (NCT07245654)
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Brno University Hospital
Anesthesia
A Study to Evaluate the Safety and Efficacy of Ultiva (Remifentanil Hydrochloride) in Pediatric Participants General Anesthetised
The purpose of this study is to evaluate the efficacy and safety of JNJ-268229 (Ultiva /Remifentanil Hydrochloride) in pediatric participants between 1 and 15 years of age during maintenance of general anesthesia.
- Trial name
- NCT01998165
- Testing
- Remifentanil
- Where
- 9 sites in Japan
- Volunteers
- 80 people
- Sponsor
- Janssen Pharmaceutical K.K.
Postoperative Complications
The Effect of Local Anaesthesia Technique on the Recovery After Dental Treatment in General Anaesthesia
Use of local anaesthesia during full mouth dental rehabilitation under general anaesthesia is an everyday practice. It enables better control of the post-extraction bleeding and better control of physiological responses.
- Trial name
- NCT04156334
- Testing
- Extraction of teeth in general anaesthesia using either computer-controlled intraosseous anesthesia device or carpule for local anaesthesia
- Where
- Slovenia
- Volunteers
- 120 people
- Sponsor
- University of Ljubljana
Postoperative Delirium, Postoperative Pain
Effect of Electroencephalography Guided General Anesthesia on Postoperative Delirium in Children
Participants aged 4-10 years (92 patients), who came to the Hospital Operating Room at the University Faculty of Dentistry with an indication for dental treatment under general anesthesia due to lack of cooperation, will be…
- Trial name
- NCT06400706
- Testing
- EEG guided general anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Surgery, Anxiety
Pediatric Preoperative Virtual Reality Program
Does the introduction of a preparatory virtual reality (VR) program that is used in the home environment, have an effect on the anxiety level of children immediately before surgery, prior to administration of preoperative…
- Trial name
- PPVRP (NCT03957525)
- Testing
- Pre-Operative Preparatory Virtual Reality Program
- Where
- Switzerland
- Volunteers
- 11 people
- Sponsor
- Thoralf Liebs
Ophthalmology
Study on the Effect of Eye-covering Pretreatment on Acute Delirium After General Anesthesia in Pre-school Aged Children
Participants (preschool children), because their cognitive ability and anti pressure ability are obviously weaker than adults, most of the children who have this kind of operation and anesthesia stressors will have perioperative…
- Trial name
- NCT04973150
- Testing
- To explore whether pretreatment with eye covering can reduce the incidence of acute delirium and the score of delirium after general anesthesia in ophthalmology pre-age children.
- Where
- China
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Dental Caries
The Use of Pit and Fissure Sealants in Children Requiring Caries Related Dental Extractions
The purpose of thus study is to assess the feasibility and inform the planning of a proposed definitive randomised controlled clinical trial to investigate the efficacy of sealing permanent molars in children requiring caries…
- Trial name
- NCT02443896
- Testing
- Pit and Fissure Sealant of permanent molars, No sealant of permanent molars
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Birmingham
General Anesthesia
The Relationship Between the SPI and the Postop ED
Surgical plethysmography index (SPI) is a device that can noninvasively monitor the balance between the nociception and ant-nociception using pulse photoplethysmographic amplitude (PPGA) and heart rate obtained through an oxygen…
- Trial name
- SPI_ED (NCT03328910)
- Testing
- SPI monitor (GE Healthcare, Helsinki, Finland)
- Where
- South Korea
- Sponsor
- Daegu Catholic University Medical Center
General Anesthetic Drug Adverse Reaction
PKPD of Rocuronium and Sugammadex Profile in Pediatric Patients
The aim of the study is to assess the pharmacokinetic and pharmacodynamic properties of rocuronium and sugammadex and their clinical effect in the terms of both the relaxation of paralysed muscles (rocuronium) and the reversal of…
- Trial name
- NCT04851574
- Testing
- Sugammadex Injection
- Where
- Poland
- Volunteers
- 37 people
- Sponsor
- Poznan University of Medical Sciences
General Anaesthesia
Comparing Between Air-Q Intubating Laryngeal Airway and Ambu® AuraGain™
The aim of this randomized study is conducted is to evaluate the performance and safety of air-Q intubating laryngeal airway as primary airway device in various short surgical procedure in children compared to Ambu® AuraGain™…
- Trial name
- Nira (NCT03130413)
- Testing
- Ambu Aura Gain supraglottic airway, Air-Q supraglottic airway
- Where
- Malaysia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Intubation; Difficult or Failed, Postoperative Pain
The Comparison of Direct Macintosh Laryngoscopy and HugeMed Video Laryngoscope for Nasotracheal Intubation in Children
Forty-four patients aged 4-10 years who applied to Aydın Adnan Menderes University Faculty of Dentistry for dental treatment under general anesthesia will be selected and divided into 2 groups by simple randomization.
- Trial name
- NCT05121597
- Testing
- HugeMed Videolaryngoscope
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Neurosurgical Patients
COMparative Performance of General Purpose Models
To compare the performance of the Eleveld models for propofol and remifentanil on neurosurgery patients admitted to intensive care with their intraoperative performance.
- Trial name
- NCT06584097
- Where
- 2 sites in Italy
- Volunteers
- 42 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Delirium,, Dementia,
Long-term Outcome of General Anesthesia on Dysgnosia
Cognitive disorders in patients underwent general anesthesia are discussed for decades, but whether there were precise relationship between general anesthesia and dysgnosia is yet to be guaranteed.
- Conditions
- Delirium,, Dementia,, Amnestic,, Cognitive Disorders
- Trial name
- LOGAND (NCT01184638)
- Testing
- Sevoflurane, Propofol
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Nanjing Medical University
Central Nervous System Complications of Anesthesia, Impaired Cognition
Exposure to General Anaesthesia in Infancy and Neurocognitive Development
This prospective cohort study aims to determine if apparently healthy children with no significant co-morbidities who undergo general anaesthesia for minor surgery before 15 months of age will develop measurable deficits in…
- Trial name
- EGAIN (NCT02182817)
- Where
- 2 sites in Singapore
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Complication of Anesthesia
Postoperative Complication After G.A
What are the possible postoperative complications that may occur for children following dental treatment under general anaesthesia and is there a correlation between those complications and type of dental treatment done?
- Trial name
- NCT05758974
- Testing
- dental treatment
- Volunteers
- 110 people
- Sponsor
- Cairo University
Anesthesia
A Multicenter, Open, Controlled, Phase III Clinical Study to Evaluate the Efficacy and Safety of Cipepofol Injection for General Anesthesia in Pediatric Patients Undergoing Elective Surgery
A multicenter, open, controlled, Phase III clinical study to evaluate the efficacy and safety of Cipepofol injection for general anesthesia in pediatric patients undergoing elective surgery
- Trial name
- NCT06391931
- Testing
- Cipepofol, Propofol
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.