Clinical trials: Generations
Dysfunctional Voiding, Children
New Generation Rehabilitation Approach in Children With Dysfunctional Voiding
The investigators hypothesize that Dynamic Neuromuscular Stabilization training, a next-generation exercise approach, and transabdominal ultrasound-guided pelvic floor muscle training (PFMT) will be more effective than PFMT…
- Conditions
- Dysfunctional Voiding, Children, Pelvic Floor Muscle Training, Ultrasound
- Trial name
- NCT06743165
- Testing
- Pelvic floor muscle training with ultrasound biofeedback, Dynamic neuromuscular stabilization exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Izmir University of Economics
Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness
Assessment of Safety and Feasibility of FUS Next Generation Dome Helmet (NGDH) to Perform Neuromodulation in Patients With Disorders of Consciousness
The main questions this study aims to answer are: Can low-intensity FUS neuromodulation be safely and feasibly administered to the bilateral central thalamus in patients with disorders of consciousness (DoC)? Does FUS…
- Trial name
- NCT07694258
- Testing
- Next Generation Dome Helmet (NGDH)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Sunnybrook Health Sciences Centre
Pregnancy Early, Outcome, Adverse Birth
Generation R Next - Optimaal Opgroeien
The aim of this randomized controlled trial is to improve birth outcomes and long-term outcomes in mother and child by optimizing lifestyle,nutrition and stress experience in the preconception period and early pregnancy in women…
- Conditions
- Pregnancy Early, Outcome, Adverse Birth, Lifestyle Factors, Preconception Care
- Trial name
- NCT05870878
- Testing
- Standard care, Lifestyle program
- Where
- Netherlands
- Volunteers
- 1,750 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Prostate Cancer, Stereotactic Body Radiation Therapy
START-MET HS Prostate Cancer. : SbrT & Androgen Receptor Therapy METastatic HSPC
Phase III study of stereotactic body radiation therapy (SBRT) plus standard of care in castration sensitive oligometastatic prostate cancer patients, defined as androgen deprivation therapy plus radiotherapy to the primary tumor…
- Trial name
- START-MET (NCT05209243)
- Testing
- SBRT, STANDARD OF CARE
- Where
- 2 sites in Spain
- Volunteers
- 266 people
- Sponsor
- Instituto de Investigación en Oncología Radioterápica - Fundación Española de Oncología Radioterápic
Paediatric B Cell-related Autoimmune Diseases, Autoimmune Diseases
Exploratory Clinical Study of Second-generation CD19/BCMA Chimeric Antigen Receptor NK Cell Injection in Treating Paediatric B Cell-related Autoimmune Diseases
Evaluating the efficacy and safety of anti-CD19/BCMA CAR-NK Cells in Paediatric B cell-related autoimmune diseases
- Conditions
- Paediatric B Cell-related Autoimmune Diseases, Autoimmune Diseases, CAR
- Trial name
- NCT07283315
- Testing
- anti-CD19/BCMA CAR NK cells (KN5601-K)
- Where
- China
- Volunteers
- 12 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Hereditary Angioedema
Open-Label C1 Esterase Inhibitor (C1INH-nf) for the Prevention of Acute Hereditary Angioedema (HAE) Attacks
The study objective was to evaluate the safety and efficacy of prophylactic use of C1INH-nf for the prevention of acute HAE attacks.
- Trial name
- CHANGE 3 (NCT00462709)
- Testing
- C1 esterase inhibitor [human] (C1INH-nf)
- Where
- 48 sites in United States
- Volunteers
- 146 people
- Sponsor
- Shire
Adolescence, Adolescent
Screen Culture's Impact on Generation Z Adolescents' Physical Activity, Posture and Well-being in Egypt
Ubiquitous adoption of screen-based technologies has transformed the behavioral and physiological environment of Generation Z youth.
- Conditions
- Adolescence, Adolescent, Well Being, Posture
- Trial name
- NCT07247305
- Testing
- BMI Measurement, Screen Time Questionnaire (QUEST), Insomnia Severity Index (ISI)
- Where
- Egypt
- Volunteers
- 532 people, healthy volunteers welcome
- Sponsor
- Sinai University
HIV (Human Immunodeficiency Virus)
Safe Generations Plus: Swaziland PMTCT LTF Study
This study is to understand how to improve retention in care and treatment services to HIV positive pregnant women and their babies in Swaziland.
- Trial name
- SG+ (NCT02969161)
- Where
- 10 sites in Eswatini
- Volunteers
- 616 people
- Sponsor
- Columbia University
Acute Lymphoblastic Leukemia, Pediatric
MRD Detection by NGS in Pediatric B-ALL
This retrospective analysis aims to investigate pediatric patients with B-cell acute lymphoblastic leukemia who were detected for minimal residual disease (MRD) using next-generation sequencing (NGS).
- Trial name
- NCT05973032
- Testing
- MRD
- Where
- China
- Volunteers
- 430 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Myocardial Infarction
Novel Biomarkers of Thrombotic Risk
Treatment of patients who have had a heart attack with drugs that prevent formation of blood clots has been shown to reduce the patient's risk of subsequent cardiovascular events such as heart attack, stroke, and death.
- Trial name
- NCT02505217
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Vermont
T-cell Acute Lymphoblastic Lymphoma, T-non-Hodgkin Lymphoma
Autologous T-Cells Expressing a Second Generation CAR for Treatment of T-Cell Malignancies Expressing CD5 Antigen
Patients eligible for this study have a type of blood cancer called T-cell leukemia or lymphoma (lymph gland cancer). The body has different ways of fighting infection and disease. No one way seems perfect for fighting cancers.
- Conditions
- T-cell Acute Lymphoblastic Lymphoma, T-non-Hodgkin Lymphoma, T-cell Acute Lymphoblastic Leukemia
- Trial name
- MAGENTA (NCT03081910)
- Testing
- Autologous CD5.CAR/28zeta CAR T cells, Allogeneic CD5.CAR/28zeta CAR T cells
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- Baylor College of Medicine
Fever
Tympanic Thermometers Accuracy
The aim of the present study is to evaluate the measurement precision and accuracy of the third-generation tympanic thermometer in relation to the measurement modalities considered gold standard.
- Trial name
- NCT06103604
- Testing
- latest generation tympanic thermometer
- Where
- 7 sites in Italy
- Volunteers
- 1,100 people
- Sponsor
- Istituto Ortopedico Rizzoli
Cancer, NGS
Performance Indicators and Impact on the Care Pathway of Sequencing on the SeqOIA and AURAGEN (Seqogen) Platforms for Oncology Patients
As part of the French Genomic Medicine Plan 2025 (FGM), the SeqOIA and AURAGEN platforms were selected to perform high-throughput genomic sequencing.
- Conditions
- Cancer, NGS, Tumor, RARE DISEASE
- Trial name
- SONCO (NCT07147465)
- Where
- 3 sites in France
- Volunteers
- 3,149 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Autism Spectrum Disorder
Weight Management Intervention for Youth and Young Adults With Autism Spectrum Disorder
Psychotropic medications are the first-line treatment across several diagnostic categories encompassing severe mood disturbances and behavioral problems.
- Trial name
- ACORN-ASD (NCT03865719)
- Testing
- Healthy Habits for Life
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pittsburgh
Spina Bifida
Improving Genetic Counseling for Patients With Spina Bifida Using Next Generation Sequencing
The main objective is to improve genetic counseling in patients with Spina Bifida, by the characterization of variants in new genes using high throughput sequencing either on a panel of targeted genes or on exome in families.
- Trial name
- EXOSPINA (NCT02854150)
- Testing
- characterization of variants in new genes using high throughput sequencing either on a panel of targeted genes or on exome in families.
- Where
- France
- Volunteers
- 106 people
- Sponsor
- Rennes University Hospital
Child Maltreatment, Trauma
PRESERVE & CONNECT: Impact Study of the BPC
The PRESERVE \& CONNECT project is a multi-site randomized control trial of the Breakthrough Parenting Curriculum: Navigating Trauma Across Generations (BPC) in rural and racially and ethnically diverse communities in Vermont and…
- Trial name
- (BPC) (NCT06160050)
- Testing
- Breakthrough Parenting Curriculum: Transforming trauma across generations
- Where
- 2 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Phenylketonurias
A 16 Week Study Evaluating the Introduction of a GMP Based Protein Substitute in Participants With PKU
This study aims to measure changes in participants' blood phenylalanine (Phe) levels in participants with PKU when switching from a conventional amino acid based protein substitute to a GMP based protein substitute (PKU Sphere)…
- Trial name
- GMP In PKU (NCT03771391)
- Testing
- PKU Sphere
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Vitaflo International, Ltd
Power PATH, Head Start as Usual
Improving Family Well-Being and Child School Readiness: Power PATH Dual Generation Intervention
This project will test the proximal and distal effects of an integrated dual-generation intervention, Power PATH, in Head Start preschoolers and their parents in Alabama.
- Trial name
- NCT02176590
- Testing
- Power PATH, Head Start as usual
- Where
- United States
- Volunteers
- 540 people
- Sponsor
- University of Alabama, Tuscaloosa
Idiopathic Short Stature
Predictive Value of the Insulin-like Growth Factor-1 (IGF-1) Generation Test for the Growth Response to Growth Hormone Treatment (PRED-IGF)
The evaluation of a standardized diagnostic test to predict the growth response in a 1 year trial with Growth Hormone (GH) treatment (carried out in the context of regular patient care) in non GH deficient short children with low…
- Trial name
- NCT01438801
- Testing
- Nutropin [Somatropin (rDNA origin) for injection]
- Sponsor
- Ipsen
Pediatric Population on Second Generation Antipsychotics
Beta-carotene and Oxidative Stress in Pediatric Second Generation Antipsychotic Use
Weight gain, hypertension, high cholesterol and sugar abnormalities in childhood are strongly linked and predict the risk of further complications and early death in adulthood.
- Trial name
- NCT02363816
- Sponsor
- Wayne State University