Clinical trials: Generations
Next Generation Sequencing (NGS), Surgical Site Infection (SSI)
Efficacy of Integrating Next Generation Sequencing for Treatment of Surgical Site Infection After Fracture Fixation:
The study focuses on the serious problem of infections and wound-healing issues that can happen after high-energy bone fractures.
- Conditions
- Next Generation Sequencing (NGS), Surgical Site Infection (SSI), Fracture Fixation
- Trial name
- NGS (NCT07458230)
- Testing
- NGS diagnostic findings
- Where
- 18 sites in United States
- Volunteers
- 250 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Microbiome, Metagenomic Next Generation Sequencing
Norovirus Prevalence and Fecal Microbiome Characterization Through Metagenomic and Metatranscriptomic Analyses
The goal of this clinical trial is to characterize the fecal microbiome composition (including bacteria, archaea, viruses, fungi, and parasites) in fecal samples collected from travelers (including occupational travelers, leisure…
- Conditions
- Microbiome, Metagenomic Next Generation Sequencing, Norovirus Infection
- Trial name
- METATRAV (NCT07866469)
- Testing
- Characterization the fecal microbiome composition in travelers
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Sacro Cuore Don Calabria di Negrar
Resilience, Burnout
Effects of a Connection-Enhancement Program for Newly Employed Generation Z Nurses.
The purpose of this randomized controlled trial is to evaluate the effects of a connection-enhancement program on resilience, perceived stress, burnout, and intention to stay among newly employed Generation Z nurses in a military…
- Conditions
- Resilience, Burnout, Occupational Stress, Newly Employed Nurses
- Trial name
- NCT07832357
- Testing
- Connection-Enhancement Program, Conventional Orientation Education
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Defense Medical University, Taiwan
Prebiotics, Metagenomic Next Generation Sequencing
Assessing Changes in the Gut Microbiome of Non-Gastrointestinal Disordered Subjects Before and After Oral Prebiotic Supplementation Using the SIMBA Capsule
This is a randomized, double-blind, placebo-controlled, parallel-group clinical study. The primary objective is to assess the changes in the small intestinal (SI) metagenomic profile of healthy participants without any known…
- Conditions
- Prebiotics, Metagenomic Next Generation Sequencing, Microbiome, Small Intestine
- Trial name
- NCT07788924
- Testing
- FiberSmart
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Anderson Advanced Ingredients
Red Blood Cell Alloimmunization in Pregnancy, HDFN
Prenatal Blood Typing With Next Generation Sequencing (NGS) - an Implementation Study in HDFN (PREFAB)
Determination of Fetal Blood Group by Next-Generation Sequencing - A Clinical Study in Pregnancies with Maternal Alloantibodies Directed Against Fetal Blood Cells (Alloimmunization During Pregnancy) Maternal antibodies can cross…
- Conditions
- Red Blood Cell Alloimmunization in Pregnancy, HDFN, Next Generation Sequencing (NGS)
- Trial name
- PREFAB (NCT07715214)
- Testing
- NGS analysis for fetal red cell blood type in maternal plasma
- Volunteers
- 750 people
- Sponsor
- Karolinska University Hospital
Gonorrhea, Neisseria Gonorrhea
Metagenomic Analysis of the Pharynx in High Risk Partners
The Neisseria gonorrhoea (NG) epidemic in England is at the highest level in one hundred years of public health records. The World Health Organisation has listed NG as one of the top five bacterial infections globally because of…
- Conditions
- Gonorrhea, Neisseria Gonorrhea, Neisseria Meningitidis, Metagenomic Next Generation Sequencing
- Trial name
- NCT07671014
- Volunteers
- 100 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Third-generation TKI, NSCLC (Advanced Non-small Cell Lung Cancer)
Third-generation EGFR-TKI Treatment in Metastatic EGFR-mutant NSCLC
The goal of this observational study is to explore the feasibility of stereotactic radiotherapy (SRT) as consolidation therapy for patients with advanced non-small-cell lung cancer who were treated with third-generation epidermal…
- Trial name
- NCT06613633
- Testing
- third-generation EGFR-TKI (Osimertinib, Almonertinib or Furmonertinib)
- Where
- 3 sites in China
- Volunteers
- 4,000 people
- Sponsor
- Fudan University
Pneumonia, Next-generation Sequencing
Monitoring of Antimicrobial Resistance Based on Metagenomics Analyses in Pneumonia Patients
Monitoring of antimicrobial resistance (AMR) based on metagenomics analyses in pneumonia patients is critical for optimizing clinical diagnosis and treatment and improving clinical prognosis.
- Conditions
- Pneumonia, Next-generation Sequencing, Microbiome, Antimicrobial Resistance
- Trial name
- NCT06566898
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Shanghai General Hospital, China
Gastric Cancer (GC), Next-generation Sequencing
Influence of Age on the Choice of Treatment and Prognosis in Patients With Resectable Gastric Cancer
Next-generation sequencing (NGS) and biomarkers play a key role in the diagnosis and personalized therapy of gastric cancer. These technologies provide a deep understanding of the molecular basis of the disease.
- Conditions
- Gastric Cancer (GC), Next-generation Sequencing, Molecular Analysis
- Trial name
- NCT07403916
- Testing
- Next-generation sequencing
- Where
- Russia
- Volunteers
- 90 people
- Sponsor
- P. Herzen Moscow Oncology Research Institute
Castration-Resistant Prostate Carcinoma, Castration-Resistant Prostate Carcinoma Refractory to Second-Generation Androgen Receptor Axis-Targeted Agents
Erdafitinib for the Treatment of Patients With Castration-Resistant Prostate Cancer
This phase II trial studies the effect of erdafitinib in treating patients with prostate cancer that grows and continues to spread despite the surgical removal of the testes or drugs to block androgen production…
- Conditions
- Castration-Resistant Prostate Carcinoma, Castration-Resistant Prostate Carcinoma Refractory to Second-Generation Androgen Receptor Axis-Targeted Agents, Metastatic Malignant Neoplasm in the Bone, Metastatic Prostate Adenocarcinoma
- Trial name
- NCT04754425
- Testing
- Biopsy, Biospecimen Collection, Erdafitinib
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- M.D. Anderson Cancer Center
Coronary Artery Disease Requiring Coronary Revascularization With Newer Generation DES Implantation
Effect of High-intensity Statin With Ezetimibe COmbination theRapy Versus High-intensity sTatin Monotherapy After Percutaneous Coronary Intervention With Drug-eluting Stents; the ESCORT Trial
This study sought to evaluate whether ezetimibe combination to high-intensity statin therapy will have more prominent beneficial effect compared to high-intensity statin monotherapy in patients who underwent coronary…
- Trial name
- NCT05782777
- Testing
- ezetimibe/high-intensity statin combination therapy (ezetimibe 10mg plus atoravastatin 40mg), high-intensity statin monotherapy (atoravastatin 40mg)
- Where
- South Korea
- Volunteers
- 4,310 people
- Sponsor
- Yonsei University
Cerebral Small Vessel Diseases, Cadasil
Taiwan Associated Genetic and Nongenetic Small Vessel Disease
The TAG-SVD enrolled patients with clinical and neuroimaging features of cerebral small vessel disease (CSVD). All enrolled patients will receive next-generation sequence (NGS) with probes designed to target five candidate CSVD…
- Conditions
- Cerebral Small Vessel Diseases, Cadasil, HTRA1-Related Autosomal Dominant Cerebral Angiopathy, COL4A1-Related Brain Small Vessel Disease With Haemorrhage
- Trial name
- TAG-SVD (NCT05473637)
- Testing
- MRI
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Orofacial Clefts, Next Generation Sequencing (NGS)
Study of Congenital Orofacial Clefts by Implementing Optical Genome Mapping
Orofacial clefts, the most common congenital craniofacial malformations, have a complex etiology involving an interaction between genetic and environmental factors.
- Conditions
- Orofacial Clefts, Next Generation Sequencing (NGS), Optical Genome Mapping
- Trial name
- CARTOFENTE (NCT06880094)
- Testing
- blood withdrawal
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Lymphangioleiomyomatosis (LAM), Extracellular Vesicles; Generation and Function
Role of Extracellular Vesicles as Biomarkers of Pulmonary Involvement in Patients With Lymphangioleiomyomatosis and Tuberous Sclerosis Complex
Lymphangioleiomyomatosis (LAM) is a rare lung disease, linked to Tuberous Sclerosis Complex (TSC) or occurring sporadically, and involves abnormal mTORC1 activation.
- Trial name
- NCT07304856
- Testing
- Pulmonary Function Test, Analysis of Extracellular Vesicles
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Milan
Melanocytic Nevi, Melanoma (Skin Cancer)
Reflectance Confocal Microscopy and Molecular Correlation in Atypical Melanocytic Lesions
This observational, prospective cohort study aims to evaluate the diagnostic relevance of Reflectance Confocal Microscopy (RCM) features in atypical melanocytic lesions scheduled for surgical excision, and to correlate these…
- Conditions
- Melanocytic Nevi, Melanoma (Skin Cancer), Next Generation Sequencing (NGS)
- Trial name
- NCT07277920
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Modena and Reggio Emilia
Treatment With Second-generation Bruton's Tyrosine Kinase Inhibitors (Acalabrutinib, Zanubrutinib)
Innovative Biomarkers of Cardiovascular Complications Associated With Second-generation Bruton Tyrosine Kinase Inhibitor Treatments: a Single-center Cohort Study
Second-generation Bruton's tyrosine kinase inhibitors (BTKIs) (zanubrutinib, acalabrutinib) are recently discovered oral targeted therapies used to treat hematological disorders such as chronic lymphocytic leukemia, mantle cell…
- Trial name
- CACIS II (NCT07174141)
- Testing
- Ophthalmological examination, Blood sample
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Generation Gap
The Correlation Between Psychological Capital, Intention to Leave, Work Job and Environment Satisfaction, and Political Skills Among Different Generations Nurses
Purpose 1. To understand the current status of demographic characteristics, inclination to resign, Psychological Capital, work environment and job satisfaction, and political skills among incumbent clinical nursing staff across…
- Trial name
- NCT06495060
- Testing
- No intervention (Only observation)
- Where
- Taiwan
- Volunteers
- 646 people
- Sponsor
- Mackay Memorial Hospital
Solid Tumor, Adult, Next-generation Sequencing
Study of Pazopanib Combined With Palbociclib for Refractory Solid Tumors With Co-amplified in the 11q13(FGF3/4/19/CCND1)
The efficacy and safety of Pazopanib combined with Palbociclib in the third line and above treatment of refractory solid tumors co amplified in the 11q13 region (FGF3/4/19/CCND1).
- Conditions
- Solid Tumor, Adult, Next-generation Sequencing, Precision Medicine
- Trial name
- NCT06895733
- Testing
- Pazopanib Oral Tablet, Palbociclib
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Tianjin Medical University Second Hospital
B Cell Precursor Acute Lymphoblastic Leukemia, Pediatric
NGS MRD-Guided Blinatumomab Treatment for Pediatric B-ALL
The goal of this clinical trial is to determine whether pediatric B-cell acute lymphoblastic leukemia (B-ALL) patients with negative deep minimal residue disease (MRD) can benefit from blinatumomab treatment.
- Conditions
- B Cell Precursor Acute Lymphoblastic Leukemia, Pediatric, Minimal Residual Disease, Next Generation Sequencing (NGS)
- Trial name
- NCT06763302
- Testing
- Blinatumomab
- Volunteers
- 1,220 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Generation Gap, Generations
Generational Diversity in the Medical Profession
The purpose of this work is to investigate how post-graduate doctors in training (PGDiTs) experience generational diversity with their colleagues in the workplace.
- Conditions
- Generation Gap, Generations, Intergenerational Relations
- Trial name
- NCT06446297
- Testing
- Focus Group.
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital Plymouth NHS Trust