Clinical trials: Generations
Scoliosis, Adolescent Idiopathic Scoliosis
Validation of a New Generation of Orthopedic Brace for Treating Adolescent Idiopathic Scoliosis by Using Growth Modulation
Adolescent Idiopathic Scoliosis affects 3-4% of the Canadian population, of which about 10% will need a brace treatment during pubertal growth spurt.
- Trial name
- NCT04889339
- Testing
- Test brace versus control brace: Immediate correction, Test brace versus control brace: Long-term correction
- Where
- Canada
- Volunteers
- 58 people
- Sponsor
- St. Justine's Hospital
Genetic Predisposition
Next Generation to Identify Genetic Causes of Disease in Patients Participating in NICHD Clinical Protocols
Background: The purpose of this study is to identify changes in genes that cause human diseases. We would like to obtain some of you or your child s DNA and test for changes in genes that may contribute to a disease in you or…
- Trial name
- NCT01375543
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Myocardial Infarction
Novel Biomarkers of Thrombotic Risk
Treatment of patients who have had a heart attack with drugs that prevent formation of blood clots has been shown to reduce the patient's risk of subsequent cardiovascular events such as heart attack, stroke, and death.
- Trial name
- NCT02505217
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Vermont
Surgery
Learning Curves in Laparoscopic Distal Pancreatectomy: A Different Experience for Each Generation
This study compared the learning curves and outcome of Laparoscopic Distal Pancreatectomy between 'pioneers' and early adopters in terms of feasibility and proficiency using short term outcomes.
- Trial name
- NCT05595343
- Testing
- Laparoscopic distal pancreatectomy
- Volunteers
- 600 people
- Sponsor
- Fondazione Poliambulanza Istituto Ospedaliero
Radiology, Artificial Intellegence
Chest X-Ray Image Diagnosis and Report Generation Dedicated Model Based on Deepseek
The global shortage of radiologists is a pressing issue, particularly in regions with limited medical resources. Against this backdrop, making report generation the core objective of radiology AI systems not only aligns with the…
- Conditions
- Radiology, Artificial Intellegence, Large Language Model, Chest X-ray for Clinical Evaluation
- Trial name
- NCT06874647
- Testing
- AI-generated report for reference
- Where
- 3 sites in China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Albinism, Ocular
NGS Panel of Incomplete Forms of Ocular Albinism
Implementation of a next-generation sequencing panel of genes to identify deleterious variants in patients with incomplete forms of albinism.
- Trial name
- DIA (NCT04495218)
- Testing
- Blood samples
- Where
- France
- Volunteers
- 53 people
- Sponsor
- University Hospital, Bordeaux
Overweight and Obesity, Child Obesity
Fruit and Vegetable Products Enriched With Fibre From Potato Starch With Prebiotic Properties for Children and Youth
The main goal of the project is to test fruit and vegetable mousse, with the addition of a fiber preparation made of potato starch with prebiotic properties, on selected clinical, metabolic and immunological parameters in…
- Conditions
- Overweight and Obesity, Child Obesity, Hypertension, NAFLD
- Trial name
- NCT05140070
- Testing
- Vegetable and fruit mousse enriched with a fiber preparation from potato starch with prebiotic properties, Vegetable and fruit mousse, Dietary and physical activity counselling
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Children's Memorial Health Institute, Poland
Insecticide Resistance
Effectiveness Study of New Generation Bednets in the Context of Conventional Insecticide Resistance in the Democratic Republic of the Congo
Despite the mass distribution of LLINs (long-lasting insecticidal nets) as a Malaria control strategy, populations are still continuously exposed to a high frequency of malarial inoculation in some countries.
- Trial name
- Net-PBO (NCT03289663)
- Testing
- synergistic combination of insecticides, Pyrethroids
- Where
- Democratic Republic of the Congo
- Volunteers
- 1,680 people, healthy volunteers welcome
- Sponsor
- Université de Lubumbashi
B-cell Leukemia, B-Cell Lymphoma
CD19-targeting, 3rd Generation CAR T Cells for Refractory B Cells Malignancy
Treatment of patients with B cell lymphoma or leukemia with two doses of CD19-targeting chimeric antigen receptor (CAR) T cells to evaluate for safety and efficacy.
- Trial name
- NCT03068416
- Testing
- CAR T cells
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Uppsala University
Endodontically Treated Teeth, Primary Teeth
Accuracy of Apex Locators in Primary Teeth
The aim of this study was to evaluate the effectiveness of tactile sense, digital periapical radiograph and two different varieties of electronic apex locators at working length determination in primary molars.
- Conditions
- Endodontically Treated Teeth, Primary Teeth, Pulp Necroses
- Trial name
- NCT04638972
- Testing
- working length determination techniques
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Eskisehir Osmangazi University
Growth Hormone Deficiency
IGF1 Generation Test
To assess the predictive value of the short term IGF-1 stimulation test, based on IGF-1 changes, on the 24 months growth response to 2 different doses of GH in patients with conventional GH deficiency.
- Trial name
- CAREL (NCT00145457)
- Testing
- Blood sample, Radiography
- Where
- 8 sites in France
- Volunteers
- 82 people
- Sponsor
- Pfizer
Septoplasty
Safety and Performance of ENTACT Septal Staple System for Septoplasty
This is a prospective, multi-center, single arm PMCF study to evaluate the safety and performance of the ENTACT (Next Generation) resorbable staple system for septoplasty in 40 subjects.
- Trial name
- NCT04392583
- Testing
- ENTACT Septal Staple system
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Smith & Nephew, Inc.
Pneumonia, Next-generation Sequencing
Monitoring of Antimicrobial Resistance Based on Metagenomics Analyses in Pneumonia Patients
Monitoring of antimicrobial resistance (AMR) based on metagenomics analyses in pneumonia patients is critical for optimizing clinical diagnosis and treatment and improving clinical prognosis.
- Conditions
- Pneumonia, Next-generation Sequencing, Microbiome, Antimicrobial Resistance
- Trial name
- NCT06566898
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Shanghai General Hospital, China
Arterial Calcification Due to Deficiency of CD73
Diagnosis and Treatment of Patients With Inborn Errors of Metabolism
Researchers intend on diagnosing and treating certain inborn errors of metabolism. By doing this researchers hope to expand their knowledge about these disorders and provide access to patients of interest for research, teaching…
- Trial name
- NCT00369421
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Adenovirus Infection
Clinical Grade Adenovirus Specific T Cells for Immunotherapy After Allogeneic Stem Cell Transplantation (CTL-ADV)
Fourteen patients will be included for infusion of adenovirus-specific T-cells generated by a clinical grade IFN-γ based immunomagnetic isolation from a leukapheresis from their original donor or a haploidentical donor, in case…
- Trial name
- CTL-ADV (NCT02851576)
- Testing
- Infusion of ADV specific T cells
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Central Hospital, Nancy, France
Cerebral Palsy, Genetic Disease
Genetic Etiology in Patients With Cerebral Palsy
Cerebral palsy (CP) is a permanent disorder of movement or posture due to non-progressive impairments of the developing brain. Current estimates indicate that as many as 30% of CP cases may be genetic in nature.
- Conditions
- Cerebral Palsy, Genetic Disease, Developmental Delay, Metabolism, Inborn Errors
- Trial name
- GenCP (NCT05123768)
- Testing
- NGS
- Where
- Slovenia
- Volunteers
- 150 people
- Sponsor
- University Medical Centre Ljubljana
Gastrointestinal Cancers, Breast Cancer
Generation of Cancer Antigen-Specific T-cells From Human Induced Pluripotent Stem Cells (iPSC) for Research and Potential FutureTherapy
Background: Researchers want to test if certain cells can be re-programmed into stem cells. Stem cells can keep reproducing for a long time. Cells made by stem cells can be turned into different types of cells.
- Conditions
- Gastrointestinal Cancers, Breast Cancer, Pancreatic Cancer, Melanoma
- Trial name
- NCT03407040
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- National Cancer Institute (NCI)
MDS, Cardiovascular Diseases
Mutational Analysis as a Prognostic and Predictive Marker of Cardiovascular (CVD) Disease in Patients With Myelodysplasia
This study evaluates the relationship between myelodysplastic syndromes (MDS) and cardiovascular disease. MDS patients will be evaluated for the presence of mutations and whether they are associated with an increased risk of…
- Conditions
- MDS, Cardiovascular Diseases, Inflammation
- Trial name
- NCT04110925
- Testing
- Genetic Mutations, Inflammatory and lipid markers, Computed Tomography (CT) of the heart
- Where
- Canada
- Volunteers
- 400 people
- Sponsor
- Sunnybrook Health Sciences Centre
Environmental Awareness, Ecological Footprint
Effect of AI-Based Image Generation on Children's Ecological Footprint Awareness
The aim of this study is to examine the effect of artificial intelligence-based image generation on children's ecological footprint awareness.
- Conditions
- Environmental Awareness, Ecological Footprint, Healthy Children
- Trial name
- NCT07898527
- Testing
- AI-Based Image Generation Activity
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Balikesir University
Genetic Diseases
Mutation Exploration in Non-acquired, Genetic Disorders and Its Impact on Health Economy and Life Quality
The MENDEL-study will investigate whether the use of gene panel or whole genome sequencing (WGS) will: 1. improve the rate of diagnosis and through this compare the performance of the two diagnostic approaches (gene panel vs.
- Trial name
- MENDEL (NCT02380729)
- Testing
- Gene Panel Sequencing, Whole Genome Sequencing (WGS)
- Where
- 3 sites in Germany
- Volunteers
- 200 people
- Sponsor
- Charite University, Berlin, Germany