Clinical trials: Genetic Factors
Body Mass Index Quantitative Trait Locus 5 Disorder, Tangier Disease
Effect of High Protein Diet on Adiponectin and Inflammation Among Overweight and Obese Children
The investigators aimed to determine the effects of HP diet on adiponectin and inflammatory factors among overweight and obese children.
- Trial name
- NCT01886495
- Testing
- nutrition intervention
- Where
- Iran
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Attention Deficit Disorder With Hyperactivity
Genetic, Brain Structure, and Environmental Effects on ADHD
Background: Attention deficit hyperactivity disorder (ADHD) is one of the most common and inheritable of all neuropsychiatric disorders. It causes problems with attention and impulse control.
- Trial name
- NCT01721720
- Where
- United States
- Volunteers
- 1,091 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Obesity, Childhood
Food Genetics Behavior Study
A genetic risk for obesity does not always translate to the development of obesity among children, which points to the presence of risk-modifying factors that likely relate to energy balance behaviors as key behavioral drivers.
- Trial name
- FOODIE (NCT05783765)
- Testing
- Heightened Drive to Eat
- Where
- United States
- Volunteers
- 317 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Type 1 Diabetes Mellitus
Biomarkers of Type 1 Diabetes in Children and Their Healthy Siblings
This prospective observational cohort study evaluated genetic, immunologic, and environmental factors associated with type 1 diabetes in children.
- Trial name
- NCT07627230
- Where
- Russia
- Volunteers
- 1,034 people, healthy volunteers welcome
- Sponsor
- Privolzhsky Research Medical University
Cystic Fibrosis (CF), Cystic Fibrosis Pulmonary Exacerbation
Identifying the Causes and Risk Factors of Pulmonary Exacerbations in Cystic Fibrosis
The CF-Tracker study is a community surveillance study, designed to understand the causes of exacerbations in people with cystic fibrosis (CF) (pwCF).
- Trial name
- CF-Tracker (NCT06940531)
- Where
- 18 sites in United Kingdom
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Alexander Horsley
Waldenstrom Macroglobulinemia, Chronic Lymphocytic Leukemia
Clinical, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Hematologic Cancer
Background: Individuals may be prone to develop blood or lymph node cancers (leukemia or lymphoma) for a variety of reasons, including genetic predisposition to these cancers, environmental exposures or other medical conditions.
- Conditions
- Waldenstrom Macroglobulinemia, Chronic Lymphocytic Leukemia, Hodgkin Disease, NonHodgkin Lymphoma
- Trial name
- NCT00039676
- Where
- 2 sites in United States
- Volunteers
- 1,836 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Autism, Developmental Disabilities
Childhood Autism Risks From Genetics and the Environment (The CHARGE Study)
The purpose of this study is to understand how genes, environment, and the interplay between the two, influences the development of autism and other neurodevelopmental disorders.
- Trial name
- NCT00106652
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Collection of Clinical Data That Will be Used in This Study and Will Form a Data Bank for Asthma in Saudi Arabia, Identify Known and NOVEL Genetic Risk Factors Contributing to Asthma Susceptibility
Novel Gentic Variations Contributing to Asthma Susceptability in Saudi Arabia
Research Problem Asthma is one of the most common chronic diseases in the world that affects approximately 300 million individuals worldwide.
- Conditions
- Collection of Clinical Data That Will be Used in This Study and Will Form a Data Bank for Asthma in Saudi Arabia, Identify Known and NOVEL Genetic Risk Factors Contributing to Asthma Susceptibility, Study the Mechanistic Roles of the Genetic Variants Within Major Asthma Susceptibility Genes
- Trial name
- NCT01216215
- Where
- Saudi Arabia
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- King Saud University
Cataract
Non-genetic Risk Factors of Congenital Cataracts
Prevention and treatment of the reversible childhood blindness, including congenital cataracts (CC), has been listed as a significant component of the international programme "VISION 2020 - the Right to Sight" launched by WHO in…
- Trial name
- NCT03215186
- Testing
- observational study
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Aortic Aneurysm, Thoracic, Aneurysm, Dissecting
A Registry Study on Genetics and Biomarkers of Thoracic Aortic Aneurysm/Dissection
This is a national registry study to determine genetic risk factor and serial biomarkers of thoracic aortic aneurysm/dissection
- Trial name
- ARSGBTAAD (NCT03010514)
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Beijing Institute of Heart, Lung and Blood Vessel Diseases
PML, AIDS
Genetics of Progressive Multifocal Leukoencephalopathy and Acquired Immunodeficiency Syndrome
This study will identify genetic factors associated with the development of progressive multifocal leukoencephalopathy (PML) in patients with acquired immunodeficiency syndrome (AIDS).
- Trial name
- NCT00342602
- Where
- 6 sites in United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Vaccine-induced Thrombotic Thrombocytopenia Syndrome, Guillain-Barre Syndrome
Gene Sequencing as a Strategy for Identifying Genetic Factors Associated With Serious Adverse Events After Covid-19 Vaccines in Use in Brazil
This protocol proposes to investigate genetic factors that may be involved in the pathogenesis of adverse events of interest with selected covid-19 vaccines: vaccine-induced immune thrombotic thrombocytopenia, and neurological…
- Conditions
- Vaccine-induced Thrombotic Thrombocytopenia Syndrome, Guillain-Barre Syndrome, Acute Disseminated Encephalomyelitis, Transverse Myelitis
- Trial name
- NCT05630313
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Immunobiological Technology Institute (Bio-Manguinhos) / Oswaldo Cruz Foundation (Fiocruz)
Type 1 Diabetes, Stress
The Influence of Psychobiological Adversity to Children and Adolescents With Type 1 Diabetes
The aims of this study are two fold: To show whether there is an increased environmental or genetic susceptibility to stress in patients with T1D and whether it influences diabetes management.
- Trial name
- NCT02575001
- Testing
- Psychological background determinations, Genetic susceptibility determination, Cortisol release test
- Where
- Slovenia
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- University of Ljubljana, Faculty of Medicine
Self-harm, Personality Disorder, Borderline
Self-harm Behaviour Among the Most At-risk Adolescents
In the proposed study, three objectives will be pursued: 1. To develop a method to identify more effectively the acute and long-term risk of adolescents with the most threatening self-harm behaviours. 2.
- Conditions
- Self-harm, Personality Disorder, Borderline, Epigenetic Disorder, Non-Suicidal Self Injury
- Trial name
- SH-MARA (NCT05765864)
- Testing
- Enrollment questionnaire, General questionnaire1, General questionnaire2, General questionnaire3, Columbia Suicide Severity Rating Scale (CSSRS), The Brief Non-Suicidal Self-Injury Assessment Tool (B-NSSI-AT)
- Where
- 2 sites in Slovenia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Ljubljana, Faculty of Medicine
Central Precocious Puberty
Analysis of Genetic and Environmental Parameters Influencing Growth Rate of Precocious Puberty Children
The goal of CPP-EDG 01 study is to assess possible genetic and/or environmental parameters which may influence the growth rate of children affected by precocious puberty.
- Trial name
- CPP-EDG 01 (NCT00438217)
- Testing
- Triptorelin (GnRH agonists), Leuprolide (GnRH agonists)
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pisa
Acquired Immunodeficiency Syndrome, Alcoholism
Genetic Factors and Interrelationships for Cancer Risk-Related Behaviors and Complex Traits
We propose to conduct a multifactorial genetic study of cancer risk-related behaviors and other complex human characteristics. The main areas of interest are tobacco smoking, excess alcohol consumption, psychological traits, and…
- Conditions
- Acquired Immunodeficiency Syndrome, Alcoholism, HIV Infection, Neoplasm
- Trial name
- NCT00001500
- Where
- United States
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Psoriasis, Atopic Dermatitis
Impact of the Severity of Pediatric Psoriasis on Childhood Body Mass Index
The object of this research study is to examine these associations in children as very little is known about psoriasis and cardiovascular risk factors in the pediatric population.
- Trial name
- NCT00879944
- Testing
- Blood pressure, Height, Weight
- Where
- 14 sites in United States, Canada and 4 more
- Volunteers
- 409 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Autism Spectrum Disorder (ASD), Neurodevelopmental Disorders
Multi-observational Study for the Early Identification of Autism Spectrum Disorder (ASD) and Other Neurodevelopmental Disorders (NDD) in At-risk Populations
Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) that affects about 78 million people worldwide. Its prevalence and degree of impact on individuals and families place it among disorders of global importance.
- Trial name
- BABY@NET (NCT06915805)
- Where
- 5 sites in Italy
- Volunteers
- 455 people, healthy volunteers welcome
- Sponsor
- Istituto Superiore di Sanità
Enterovirus 71, Host Genetics, Social, Behavior, Environmental Factors
Children's Susceptibility to Enterovirus 71 in Different Areas of Taiwan
EV71 has caused large epidemics with lots of fatal cases and cases with sequelae. However, the clinical syndromes and severity of the same EV71 strain are very diverse, ranging from asymptomatic (71%) to fatal (0.05%) disease…
- Trial name
- DMR100-IRB-010 (NCT01311921)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Asthma, Allergic Rhinitis
Study on the Influence of Climatic and Environmental Factors on Respiratory Diseases in Sanya, Hainan Province, China.
To investigate the Influence of Climatic and Environmental Factors on Respiratory or Allergic Diseases in Sanya.
- Conditions
- Asthma, Allergic Rhinitis, Chronic Obstructive Pulmonary Disease(COPD), Atopic Dermatitis
- Trial name
- NCT05330637
- Testing
- Climate and environment in Sanya
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine