Clinical trials: Genetic Predisposition
Neurotoxicity Syndrome, Cassava, Neurotoxicity Syndrome, Cyanate
Cassava Intervention Project
Investigators will implement a novel cassava processing method (wetting method, WTM) that safely removes cyanogenic compounds from cassava flour prior to human consumption in a stratified village-cluster randomized…
- Conditions
- Neurotoxicity Syndrome, Cassava, Neurotoxicity Syndrome, Cyanate, Neurotoxicity Syndrome, Cyanide, Neurotoxicity Syndrome, Thiocyanate
- Trial name
- NCT03157336
- Testing
- Non Inferiority WTM Interventional Trial
- Where
- Democratic Republic of the Congo
- Volunteers
- 1,200 people
- Sponsor
- Ministry of Public Health, Democratic Republic of the Congo
Rare Diseases, Genetic Predisposition to Disease
Genetic Causes of Discrepant Clinic in Monogenic Twins
In the DISCO-TWIN study (prospective, open-label molecular-genetic study), twin pairs with one healthy and one affected twin with molecularly undiagnosed diseases will be analysed by means of omics technologies and/ or…
- Trial name
- DISCO-TWIN (NCT04046796)
- Testing
- NGS Diagnostic
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital Tuebingen
Nasopharyngeal Carcinoma
Molecular Genetics Study of Nasopharyngeal Carcinoma: Characterization of NCP Susceptibility Gene(s)
The objective of this study is to characterize genes associated either with susceptibility or resistance to the development nasopharyngeal carcinoma (NPC) in a Chinese population where the incidence of NPC is as high as 50 in…
- Trial name
- NCT00341146
- Where
- China
- Volunteers
- 6,490 people
- Sponsor
- National Cancer Institute (NCI)
Listeriosis
Genetic Susceptibility to Listeriosis
Listeriosis is a rare, severe foodborne infection, responsible for severe invasive infections. It occurs in the great majority of cases in elderly patients and / or patients with comorbidities, with a deficit of innate or…
- Trial name
- Listeria-GEN (NCT03357536)
- Testing
- Human biological samples
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Atypical Femoral Fractures, Osteoporosis
Exome Sequencing for Atypical Femoral Fractures
The purpose of this study is to determine whether women who have atypical subtrochanteric and diaphyseal femoral fractures after treatment with bisphosphonates for osteoporosis, have a genetic predisposition to these unusual…
- Conditions
- Atypical Femoral Fractures, Osteoporosis, Bisphosphonate Therapy
- Trial name
- NCT02731040
- Testing
- Bisphosphonate
- Volunteers
- 38 people
- Sponsor
- Washington University School of Medicine
Nephrolithiasis
Genetic Study of Nephrolithiasis in Gouty Diathesis
Gouty diathesis describes uric acid or calcium oxalate nephrolithiasis and low urinary pH (<5.5). A hereditary component has been outlined for several forms of nephrolithiasis (such as hypercalciuria, hyperoxaluria, cystinuria…
- Trial name
- NCT00149305
- Testing
- Genetic analyses
- Where
- Italy
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Mario Negri Institute for Pharmacological Research
Graves' Disease
Genetic Polymorphisms Associated With Cigarette Smoking and Risk of Graves' Disease
Cigarette smoking is a well-recognized risk factor of Graves' disease and, particularly, Graves' ophthalmopathy. Hence, germline polymorphisms of detoxification genes and genes belonging to the major DNA repair/apoptosis pathways…
- Trial name
- NCT00505011
- Volunteers
- 1,998 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Prostate Cancer
Application of Genetic Polymorphisms of DNA Repair in The Prediction of Prostate Cancer Susceptibility and Its Clinical Outcome
Primary: to investigate the effects of DNA repair gene polymorphisms on prostate cancer susceptibility, pathological grade, disease stage and clinical outcome Secondary: to understand the association between DNA repair gene…
- Trial name
- NCT00167024
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Li-Fraumeni Syndrome
Screening With Whole Body MRI For Detection Of Primary Tumors In Children And Adults With Li-Fraumeni Syndrome (LFS) And Other Cancer Predisposition Syndromes
This study is evaluating Whole Body MRI as a possible screening tool to diagnose cancer for people with LFS and other inherited cancer predisposition syndromes.
- Trial name
- NCT02950987
- Testing
- Whole Body MRI
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- Dana-Farber Cancer Institute
Hereditary Neoplasms, Cancer
Clinical, Laboratory, and Epidemiologic Characterization of Individuals and Families at High Risk of Cancer
This is a clinical, epidemiologic, genetic, and laboratory study of individuals and families at high risk of cancer and selected tumors to investigate the genetic susceptibility and environmental exposures which may alter cancer…
- Conditions
- Hereditary Neoplasms, Cancer, Genetic Predisposition to Cancer, Environment
- Trial name
- NCT00001163
- Where
- United States
- Volunteers
- 5,201 people
- Sponsor
- National Cancer Institute (NCI)
Rare Diseases, Genetic Predisposition
Mitochondrial Diseases - Long-read Genome and Transcriptome Sequencing in Cases Unresolved After Short-read Genomics
The MiDiSeq project will enroll 20 unresolved index patients with suspected mitochondrial disease prioritized for genomic analysis.
- Trial name
- NCT03962452
- Testing
- Next Generation Sequencing (NGS)
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Tuebingen
Predisposition, Genetic, Cancer
Investigating the Role of Genetics in Disease Predisposition
Gametogenesis is the production of sperm and eggs; it takes place through the process of meiosis. Gametogenesis is subject to the acquisition of mutations as with other processes in the body.
- Conditions
- Predisposition, Genetic, Cancer, Mutation, Fertility Disorders
- Trial name
- NCT06584994
- Testing
- sample collection
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The Wellcome Sanger Institute
Asthma in Children, Allergy in Children
Project 500 CHILD Study
This proposal relates to the testing of several specific hypotheses in a subset of 500 participants in the Canadian Healthy Infant Longitudinal Development (CHILD) Study.
- Conditions
- Asthma in Children, Allergy in Children, Environmental Exposure, Genetic Predisposition
- Trial name
- NCT03225534
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- McMaster University
Chronic Lung Disease
Genetic Variants and Susceptibility to Diseases of Prematurity in Very Low Birth-Weight Infants
The purpose of this study is to determine if sequence variations in genes involved in the development and function of vulnerable organs increases susceptibility to chronic lung disease (CLD) and other diseases affecting premature…
- Trial name
- CLD (NCT00710112)
- Testing
- gene variations
- Where
- United States
- Volunteers
- 1,100 people
- Sponsor
- Medical College of Wisconsin
Hepatitis, Viral, Human
Genes Involved in Resistance or Susceptibility to Hepatitis B Virus
This study, conducted by the Beijing University First Hospital of China and the National Cancer (NCI), will try to identify genes associated with either susceptibility or resistance to chronic infection by the hepatitis B virus…
- Trial name
- NCT00342186
- Where
- China
- Volunteers
- 2,303 people
- Sponsor
- National Cancer Institute (NCI)
Listeriosis
Genetic Susceptibility and Biomarkers in Listeriosis
Listeriosis is a rare, severe foodborne infection caused by the bacterium Listeria monocytogenes (Lm). It manifests as septicemia, central nervous system (CNS) infection and maternal-fetal (MF) infection.
- Trial name
- MONALISAGENBIO (NCT02924220)
- Where
- France
- Volunteers
- 1,080 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Physical Inactivity, Obesity, Childhood
Children With High Genetic Susceptibility Benefit More From Short-term Physical Activity Interventions
Sharp increase in childhood obesity has been regarded as one of the most serious but preventable global public health challenges.
- Trial name
- NCT06583421
- Testing
- 4-week MVPA intervention
- Where
- China
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- China Medical University, China
Metabolic Dysfunction-Associated Steatotic Liver Disease, Pediatric Obesity
Non-Invasive Diagnostic Panel for MASLD in Children With Obesity
This prospective, single-center, two-group observational study evaluates a non-invasive multi-parameter diagnostic panel for metabolic dysfunction-associated steatotic liver disease (MASLD) in children with obesity.
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease, Pediatric Obesity, Insulin Resistance Syndrome
- Trial name
- PedMASLD-Pilot (NCT07731360)
- Testing
- Non-Invasive Multi-Parameter Diagnostic Panel
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Kayseri City Hospital
Bladder Cancer
Genetic Susceptibility to Bladder Cancer
This clinical research study will identify biologic and lifestyle factors which increase a person's risk of developing specific cancer.
- Trial name
- NCT00848289
- Testing
- Interviews
- Where
- 2 sites in United States
- Volunteers
- 6,086 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Influenza A Virus/H5N1 Subtype
Host Genetic Susceptibility to Avian Influenza A/H5N1
The identification and characterization of susceptibility loci for H5N1 infection in humans could have profound implications. The detection of host genetic factors may shed light on key pathogenic interactions between H5N1 and…
- Trial name
- NCT01074736
- Where
- Vietnam
- Volunteers
- 500 people
- Sponsor
- South East Asia Infectious Disease Clinical Research Network