Clinical trials: Gonarthrosis, open to volunteers
Osteoarthritis, Knee
MOTION Clinical Trial
Prospective, multicenter, two-arm, 2:1 randomized controlled trial (RCT) comparing the benefits in subjects with medial knee osteoarthritis who are treated with either the MISHA Knee System or with non-surgical treatment.
- Trial name
- NCT06843980
- Testing
- MISHA Knee System, Non-Surgical Treatment
- Where
- 9 sites in United States
- Volunteers
- 100 people
- Sponsor
- Moximed
Joint Pain
Genicular Nerve Phenol Neurolysis Versus Radiofrequency Ablation for Pain Relief in Grade 4 Knee Osteoarthritis
The goal of this clinical trial is to compare the efficiency and efficacy of genicular nerves blockade by chemical phenol neurolysis versus radiofrequency ablation in managing pain in patients suffering from grade IV KOA in term…
- Trial name
- NCT06864390
- Testing
- genicular nerve neurolysis
- Volunteers
- 114 people
- Sponsor
- Ain Shams University
Meniscus Rupture, Meniscus Injury
Surgical Outcome After Displaced Bucket-handle Meniscal Lesions - Repair Versus Partial Meniscectomy
The menisci of the knee joint are structures composed of cartilage and connective tissue, whose primary functions are to stabilize the joint and distribute weight across joint surfaces.
- Conditions
- Meniscus Rupture, Meniscus Injury, Osteoarthritis of Knee
- Trial name
- NCT07079254
- Testing
- Meniscus suture, Partial meniscectomy
- Where
- 2 sites in Sweden
- Volunteers
- 300 people
- Sponsor
- Region Skane
Knee Osteoarthrosis
Conservative Management vs. Arthroplasty in Knee Osteoarthritis
The goal of this observational study is to learn about the long-term effects of a non-surgical management programme in people with osteoarthritis that are eligible for a knee joint replacement surgery to treat their knee…
- Trial name
- NCT06623149
- Testing
- Non-Surgical Intervention, Current practice
- Where
- 6 sites in Denmark
- Volunteers
- 2,500 people
- Sponsor
- Marius Henriksen
Knee Osteoarthritis
Clinical Cohort Study of Knee Arthroplasty Assisted by Digital Technology
Through this cohort study, previous clinical data can be systematically reviewed and supplemented through clinical follow-up. Prospective enrollment and follow-up observation of subsequent patients can also be carried out to…
- Trial name
- NCT06010979
- Testing
- conventional intrumentation assisted knee arthroplasty, computer navigation assisted knee arthroplasty, robotic system assisted knee arthroplasty
- Where
- China
- Volunteers
- 12,000 people
- Sponsor
- Tian Hua
Knee Osteoarthritis
The Effect of a Group Exercise Intervention on Balance in People With Knee Osteoarthritis: a Pilot Study
In this study, the investigators want to find out if a 12-week exercise program improves balance in people with knee osteoarthritis.
- Trial name
- NCT06807541
- Testing
- Exercise intervention
- Where
- 2 sites in Canada
- Volunteers
- 32 people
- Sponsor
- University of the Fraser Valley
Osteoarthritis, Knee
Standard Versus Novel RFA for Chronic Knee Pain in Osteoarthritis
Brief Summary The goal of this pilot study is to evaluate the feasibility and safety of conducting a randomized comparison of two standard-of-care knee radiofrequency ablation (RFA) techniques in adults with chronic knee pain…
- Trial name
- NCT07674082
- Testing
- Radiofrequency ablation - 3-target technique, Radiofrequency ablation - 6-target technique
- Volunteers
- 24 people
- Sponsor
- Lawson Research Institute of St. Joseph's
Knee Injuries, Anterior Cruciate Ligament Rupture
Stopping OsteoARthritis After an ACL Tear
By 2040, 25% of Canadians will have osteoarthritis, a disabling joint condition. Most people think osteoarthritis only affects older adults, but 50% of the 700,000 Canadian youth who hurt their knee playing sports annually will…
- Conditions
- Knee Injuries, Anterior Cruciate Ligament Rupture, Osteoarthritis, Knee
- Trial name
- SOAR (NCT06195423)
- Testing
- Stop OsteoARthritis (SOAR) program, Living Well after ACLR program
- Where
- 2 sites in Canada
- Volunteers
- 210 people
- Sponsor
- University of British Columbia
Knee Osteoarthristis
Clinical Outcomes of Focused Shockwave Therapy Without Adjunct Rehabilitation Compared to Standard Physical Rehabilitation in Patients With Grade I-III Knee Osteoarthritis: A Single-Blind Randomized Study
Clinical Outcomes of Focused Shockwave Therapy Without Adjunct Rehabilitation Compared to Standard Physical Rehabilitation in Patients with Grade I-III Knee Osteoarthritis: A Single-Blind Randomized Study
- Trial name
- NCT07567365
- Testing
- Physical Rehab, Focused Shockwave Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Pulse Wave USA
Osteoarthritis, Knee, Anterior Cruciate Ligament Injuries
Vibration and Post-traumatic Osteoarthritis Risk Following ACL Injury
The goal of this randomized clinical trial is to evaluate the effects of vibration on factors related to the risks of post-traumatic knee osteoarthritis and secondary anterior cruciate ligament (ACL) injury in individuals who…
- Conditions
- Osteoarthritis, Knee, Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis, Quadriceps Muscle Atrophy
- Trial name
- NCT04875052
- Testing
- Experimental: Whole Body Vibration, Experimental: Local Muscle Vibration, Standard ACL Rehabilitation
- Where
- 2 sites in United States
- Volunteers
- 114 people
- Sponsor
- University of North Carolina, Chapel Hill
Knee Osteoarthritis, Hip Osteoarthritis
Adapting Rehabilitation Delivery for Maximum Impact at Home-2 (ReDI-2)
People who live in rural areas and have hip or knee arthritis can have difficulty receiving physical therapy (PT) close to home.
- Trial name
- ReDI-2 (NCT07055113)
- Testing
- Individual-based Virtual Physical Therapy Program, Group-based Virtual Physical Therapy Program
- Where
- Canada
- Volunteers
- 270 people
- Sponsor
- University of Alberta
Osteoarthritis
Effectiveness of Stromal Vascular Fraction (SVF) and Platelet -Rich Plasma (PRP) in Patients With Knee Osteoarthritis: Study Protocol for a Phase III, Prospective, Randomized, Controlled Multi-center Study.
This multicenter, randomized, triple-blind, controlled trial, will enroll 108 patients who will block-randomized in a 1:1 ratio to either the intervention or control group.
- Trial name
- SPOST (NCT05660824)
- Testing
- Stromal Vascular Fraction infiltration, Plattelet Rich Plasma infiltration
- Volunteers
- 108 people
- Sponsor
- Adrien Schwitzguebel
Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis
Gait Rehabilitation to Treat FastOA
The purpose of this study is to determine the effects of real-time gait biofeedback delivered over a 6-week period on early markers of FastOA and conduct 6-week and 6-month follow-up assessments in anterior cruciate ligament…
- Conditions
- Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis, Knee Osteoarthritis, Osteo Arthritis Knee
- Trial name
- NCT05848622
- Testing
- Real-time gait biofeedback
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of North Carolina, Chapel Hill
Revision Total Knee Arthroplasty, Osteoarthritis, Knee
Gut Microbiome in Orthopaedics: Revision Total Knee Arthroplasty
Many patients who receive knee replacement surgery must return for a revision (or repeat) surgery due to ongoing pain, stiffness, infection, or implant loosening.
- Trial name
- GUMBO (NCT06951477)
- Testing
- Revision Total Knee Arthroplasty
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
LET, ACL Reconstruction
Long-term Follow up of the Stability 1 Trial
From 2014-2017, across 7 Canadian and 2 European sites, we randomized 618 patients at high-risk of re-injury, to anterior cruciate ligament reconstruction (ACLR) with or without a lateral extraarticular tenodesis (LET) and…
- Conditions
- LET, ACL Reconstruction, Osteoarthritis (OA) of the Knee
- Trial name
- STABILITY LTF (NCT06885372)
- Testing
- Lateral Extra-Articular Tenodesis (LET), ACL Reconstruction
- Where
- 8 sites in Canada, United Kingdom
- Volunteers
- 510 people
- Sponsor
- Western University, Canada
Knee Osteoarthritis, Osteoarthritis, Knee
Serum Fetuin-A and COMP Levels in Knee Osteoarthritis
The purpose of this study is to investigate the relationship between the clinical and radiographic severity of knee osteoarthritis (OA) and the serum levels of specific biomarkers, namely Fetuin-A and Cartilage Oligomeric Matrix…
- Trial name
- NCT07706569
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Antalya Training and Research Hospital
Osteoarthritis, Knee
The Safety/Efficacy of hUC Mesenchymal Stem Cells（19#iSCLife®-OA） Therapy for Patients With Osteoarthritis
The purpose of this study is verify the efficacy and safety of Human Umbilical Cord Mesenchymal Stem Cells (UC-MSC) therapy for patients with Osteoarthritis, and in addition, provide basis for exploring the treatment regimen of…
- Trial name
- NCT03383081
- Testing
- Low dose mesenchymal stem cells, High dose mesenchymal stem cells, Intraarticular injection
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sclnow Biotechnology Co., Ltd.
Knee Pathology, Osteoarthritis, Knee
Knee Registry (Knieregister)
Rationale: In view of patient care, patient characteristics and treatment parameters are registered for all patients visiting the Mobility Clinic of the University Medical Center Utrecht for orthopaedic knee treatment.
- Conditions
- Knee Pathology, Osteoarthritis, Knee, Osteochondritis Dissecans, Chondral Defect
- Trial name
- NCT04364334
- Where
- Netherlands
- Volunteers
- 1,000,000 people
- Sponsor
- UMC Utrecht
Knee Osteoarthritis
Implementing a Group Physical Therapy Program for Veterans (GroupPT): Function QUERI 3.0
Implementing Group Physical Therapy for Veterans with Knee Osteoarthritis (Group PT): Function QUERI 3.0 aims to compare two implementation approaches for implementing Group PT in 20 VA facilities using a type III…
- Trial name
- GroupPT (NCT07215572)
- Testing
- Implementation Strategy: Foundational Arm, Implementation Strategy: REACH Arm
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development
Knee Osteoarthritis
Innovations in Genicular Outcomes Registry
The registry will capture prospective data on patients receiving pain management for chronic pain due to knee osteoarthritis (OA) or pain optimization for knee arthroplasty due to knee OA.
- Trial name
- iGOR (NCT05495334)
- Testing
- Treatment for Knee OA
- Where
- 19 sites in United States
- Volunteers
- 10,000 people
- Sponsor
- Pacira Pharmaceuticals, Inc