Clinical trials: Group A Streptococcus
Group A Streptococcus
Strep A FIA Field Study, Sofia
To demonstrate the clinical performance of the Strep A FIA and Sofia, using throat swabs collected from symptomatic subjects.
- Trial name
- NCT02153008
- Where
- 7 sites in United States
- Volunteers
- 1,708 people
- Sponsor
- Quidel Corporation
Streptococcal Pharyngitis
GRoup A StrePtococcus
The purpose of the research is to help understand why some children become carriers of strep and whether children who are carriers need to be treated with antibiotics.
- Trial name
- GRASP (NCT01558804)
- Testing
- Identifying group A strep carriers
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Wisconsin, Madison
Dental Caries, Streptococcal Infections
Evaluation of Efficacy of Antibacterial Activity of Licorice, Clove, and Chlorohexidine Mouthwashes on Salivary Streptococcus Mutans in a Group of Egyptian Children.
A randomized controlled trial that compares the antibacterial effectiveness of three mouthwashes-licorice, clove, and chlorhexidine-in Egyptian children aged 7-12 years.
- Conditions
- Dental Caries, Streptococcal Infections, Mouthwashes
- Trial name
- NCT07828171
- Testing
- Mouth wash
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- British University In Egypt
Group B Streptococcal Infection
Immunogenicity and Safety of GBS-NN/NN2 in Pregnant Women
This is a phase II, multicentre, multinational, randomized, parallel group, placebo-controlled study of four vaccination regimens in healthy pregnant women.
- Trial name
- NCT05154578
- Testing
- GBS-NN/NN2 Vaccine
- Where
- 10 sites in Denmark, South Africa and 1 more
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- Minervax ApS
Streptococcus Pyogenes Pharyngotonsillitis
Prophylactic Effect of Probiotic Streptococcus Salivarius eK12 Against Recurrent Streptococcus Pyogenes Pharyngotonsillitis Infection in Pediatrics
Recurrent Group A Streptococcus (GAS) infections, primarily presenting as strep throat, are a significant health concern in pediatric populations, leading to symptoms like sore throat, fever, and swollen lymph nodes.
- Trial name
- NCT06370208
- Testing
- Probiotic Bactoblis® EVOL (Streptococcus salivarius eK12), Oral vit D3
- Where
- 4 sites in Pakistan
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Liaquat University of Medical & Health Sciences
Invasive Group A Beta-Haemolytic Streptococcal Disease
Severe Group A Streptococcus Infections in Paris, France, 2018-2023
Streptococcus pyogenes, commonly referred to as Group A Streptococcus (GAS), has the ability to induce a diverse range of illnesses.
- Trial name
- IGASI (NCT06297122)
- Testing
- Collection of data from the patient's medical file
- Where
- France
- Volunteers
- 269 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Streptococcus Pyogenes Infection, Pharyngitis
Clinical Performance of the Checkable Medical At-Home Strep A Test
The Checkable Medical At-Home Strep A Test is a rapid chromatographic immunoassay for the qualitative detection of Group A Strep (GAS) antigens from throat swabs.
- Conditions
- Streptococcus Pyogenes Infection, Pharyngitis, Respiratory Tract Infections
- Trial name
- NCT05107362
- Testing
- untrained lay user performs investigational diagnostic test
- Where
- 22 sites in United States
- Volunteers
- 1,347 people
- Sponsor
- Checkable Medical Inc
Tonsillitis
Study of 5 and 10 Days Treatment With Penicillin Against Sore Throat Caused by Streptococci
The primary objective of the study is to compare the clinical efficacy of 5 days (800 mg x 4) versus 10 days (1000 mg x 3) treatment with phenoxymethylpenicillin (PcV) in adults, adolescents and children with streptococcal…
- Trial name
- NCT02712307
- Testing
- Phenoxymethylpenicillin
- Where
- 17 sites in Sweden
- Volunteers
- 433 people
- Sponsor
- Ass. Prof. Katarina Hedin
Dengue, Chikungunya
Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective
RACSMEI addresses the high burden of infectious diseases in low- and middle-income countries, including Cambodia, where limited surveillance and laboratory capacity often obscure etiologies and transmission dynamics.
- Conditions
- Dengue, Chikungunya, Zika Virus Infection, Japanese Encephalitis
- Trial name
- RACSMEI (NCT07358910)
- Where
- Cambodia
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur du Cambodge
Streptococcus Group A
Incidence of Group A Strep Pharyngitis in School Children in Fiji
The purpose of this study is to find out how often group A Streptococcus (GAS) occurs in school-age children of Central Fiji. This bacterium often causes pharyngitis (sore throat) and can also cause pyoderma (skin infection) or…
- Trial name
- NCT00284882
- Where
- Fiji
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Streptococcus Agalactiae (Streptococcus Group B)
The Clinical and Molecular Epidemiology of Streptococcus Agalactiae Colonisation on the Kenyan Coast
Sub-Saharan Africa (sSA) has the highest regional rates of perinatal mortality worldwide. Group B Streptococcus (GBS) has been identified as a leading cause of early onset neonatal sepsis (EOS, in <7 days of life) in sSA.
- Trial name
- GBS (NCT01757041)
- Where
- 4 sites in Kenya
- Volunteers
- 7,967 people
- Sponsor
- University of Oxford
Streptococcus Agalactiae Infection
Development of a Serocorrelate of Protection Against Invasive Group B Streptococcus Disease
A multicentre study to provide evidence that the relationship between an immune marker value (anti-GBS IgG concentration) and the probability of invasive GBS (iGBS) disease in infants less than 90 days of age is sufficiently…
- Trial name
- iGBS3 (NCT04735419)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 400 people
- Sponsor
- St George's, University of London
Group A Streptococcus, Strep Throat
Sofia Strep A FIA Field Study
The purpose of this study is to demonstrate the ability of the Sofia Strep A FIA test and Sofia Analyzer to accurately detect a throat swab specimen for the presence or absence of Group A Streptococcus when compared to culture.
- Trial name
- NCT01494792
- Testing
- In Vitro Diagnositc aid for diagnosis
- Where
- 8 sites in United States
- Volunteers
- 2,090 people
- Sponsor
- Quidel Corporation
Plaque Score, Gingival Health
Effectiveness of Herbal vs Chlorhexidine Mouthwashes in Improving Oral Health in Schoolchildren
Dental plaque and gingivitis are common oral health problems among school children. Mechanical plaque control, such as tooth brushing, is essential but may be insufficient for maintaining optimal oral hygiene.
- Conditions
- Plaque Score, Gingival Health, Streptococcus Mutans
- Trial name
- NCT07309679
- Testing
- Chlorhexidine Digluconate 0.2% Mouthwash, Pomegranate Peel Extract Mouthwash, Neem Extract Mouthwash
- Where
- Egypt
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Probiotic, Ethyl Lauroyl Arginate
Probiotic-Based Versus Ethyl Lauroyl Arginate-Containing Mouthwashes on Streptococcus Mutans Counts, Dental Plaque Accumulation, and Salivary pH in a Group of Egyptian School Children
This study aims to compare the efficacy of probiotic-based mouthwashes versus ethyl lauroyl arginate-containing mouthwashes in reducing Streptococcus mutans count, dental plaque accumulation, and salivary pH among a group of…
- Conditions
- Probiotic, Ethyl Lauroyl Arginate, Mouthwashes, Streptococcus Mutans
- Trial name
- NCT07356869
- Testing
- Probiotic mouthwash, Ethyl lauroyl arginate mouthwash, Professional prophylaxis (scaling + polishing)
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Al-Azhar University
Group A Streptococcal Infection
Performance of Ellume·Lab Group A Strep Test Versus Culture for the Rapid Detection of Group A Streptococcus in Participants With Acute Pharyngitis
Participants who meet the eligibility criteria and who consent to participation or whose parents/legal guardian consent to their participation, will be enrolled in the study for a period of up to 14 days.
- Trial name
- NCT03693495
- Testing
- ellume·lab Group A Streptococcus Test, Bacterial Culture, Polymerase Chain Reaction (PCR)
- Where
- 4 sites in New Zealand
- Sponsor
- Ellume Pty Ltd
Group A Streptococcal Infection, Scabies
Streptococcus Pyogenes Carriage Acquisition and Transmission Study
Group A Streptococcus (GAS) is a bacteria which causes severe infections and leads to deadly diseases such as rheumatic heart disease which kills over 300,000 people a year globally, particularly in low-income countries.
- Conditions
- Group A Streptococcal Infection, Scabies, Microbial Colonization
- Trial name
- SpyCATS (NCT05117528)
- Where
- The Gambia
- Volunteers
- 441 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Pregnancy, GBS
Clinical Evaluation of the ARIES Group B Streptococcus (GBS) Assay
The ARIES GBS Assay is a real-time PCR based qualitative test designed to detect Group B Streptococcus (GBS) nucleic acid from Lim Broth enriched vaginal-rectal specimen swabs obtained from pregnant women between 35 - 37 weeks…
- Trial name
- NCT02497430
- Where
- 5 sites in United States
- Volunteers
- 918 people, healthy volunteers welcome
- Sponsor
- Luminex Corporation
Streptococcus Group A
Mol Epi GrAS in Nicaragua
The purpose of this study is to determine the epidemiology of throat isolates of group A streptococci among 3-15 year-old children with pharyngitis (sore throat) living in Leon, Nicaragua.
- Trial name
- NCT00170521
- Where
- Nicaragua
- Volunteers
- 13,000 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Group B Streptococcus Infections
Trial To Evaluate The Safety, Tolerability, And Immunogenicity Of A Multivalent Group B Streptococcus Vaccine In Healthy Nonpregnant Women And Pregnant Women And Their Infants
Phase 1/2, randomized, placebo-controlled, observer-blinded study will evaluate the safety, tolerability and immunogenicity of the investigational multivalent group B streptococcus vaccine administered at one dose level (various…
- Trial name
- NCT03765073
- Testing
- Multivalent Group B streptococcus vaccine
- Where
- 35 sites in United States, South Africa and 1 more
- Volunteers
- 1,208 people, healthy volunteers welcome
- Sponsor
- Pfizer