Clinical trials: Gut
Crohn's Disease, Prenatal Exposure
Pregnancy Exposure Registry for Tysabri®
The primary objective of the Registry was to evaluate the outcomes of pregnancy in women with Multiple Sclerosis (MS) or Crohn's Disease (CD) who were exposed to TYSABRI® at any time within 90 days prior to first day of Last…
- Conditions
- Crohn's Disease, Prenatal Exposure, Multiple Sclerosis, Pregnancy
- Trial name
- NCT00472992
- Where
- United States
- Volunteers
- 376 people
- Sponsor
- Biogen
Adenoma, Colo-rectal Cancer
Clinical Value of G-EYE Colonoscopy in Daily Practice for Adenoma Detection and Time for Polyp Removal
Colonoscopy parameters will be compared before the introduction of the G-EYE endoscope and after the introduction of the G-EYE endoscope
- Trial name
- NCT04767971
- Testing
- Standard Colonoscopy, G-EYE Colonoscopy
- Where
- Germany
- Volunteers
- 2,795 people, healthy volunteers welcome
- Sponsor
- Dr. Horst Schmidt Klinik GmbH
Obesity
Probiotics Effect on Glucose and Lipid Metabolism and Gut Microbiota in Patients With Obesity
The purpose of this study is to determine whether the probiotics will be effective in the treatment of obesity
- Trial name
- NCT02733484
- Testing
- Probiotics
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai 10th People's Hospital
Late-Onset Neonatal Sepsis, Necrotising Enterocolitis
Markers of Platelet Activation foR Identification of Late Onset Sepsis in Preterm Infants
The PARENT study will examine platelet and endothelial associated proteins in preterm infants being investigated for late onset sepsis (LOS) to see if infants with fulminant sepsis can be prospectively identified using these…
- Conditions
- Late-Onset Neonatal Sepsis, Necrotising Enterocolitis, Culture Negative Neonatal Sepsis
- Trial name
- PARENT (NCT05530330)
- Testing
- Platelet/Endothelial proteomics
- Where
- 2 sites in Ireland
- Volunteers
- 268 people
- Sponsor
- University College Dublin
Short Bowel Syndrome
Short Bowel Syndrome Research Study for Children Up To 17 Years of Age on Parenteral Nutrition
Teduglutide is approved for treatment of adults with short bowel syndrome (SBS). The purpose of this study is to evaluate the safety and efficacy of teduglutide in children up to the age of 17 with SBS who are dependent on…
- Trial name
- NCT02682381
- Testing
- Teduglutide 0.05mg/kg, Teduglutide 0.025 mg/kg, Standard of Care
- Where
- 27 sites in United States, Belgium and 5 more
- Volunteers
- 59 people
- Sponsor
- Shire
Fecal Incontinence, Constipation - Functional
Examination of a New Irrigation System for Transanal Irrigation in Children With Fecal Incontinence
The aim of this study is to investigate if a new irrigation system for transanal irrigation (TAI) is effective and more tolerable than the currently used system at the Pediatric Ward at Aarhus University Hospital.
- Trial name
- NCT05032534
- Testing
- Cone Small, Qufora A/S, Colotip, Coloplast A/S
- Where
- 2 sites in Denmark
- Volunteers
- 14 people
- Sponsor
- University of Aarhus
Fontan Operation, Protein-Losing Enteropathy
Camostat Mesylate for Protein-losing Enteropathy After Fontan Operation
This study is phase 2 open-label, single-arm, multi-center clinical trial to evaluate the efficacy and safety of Camostat mesylate in patients with Protein-losing enteropathy after Fontan operation.
- Conditions
- Fontan Operation, Protein-Losing Enteropathy, Camostat Mesylate
- Trial name
- NCT05474664
- Testing
- Camostat mesylate
- Where
- South Korea
- Volunteers
- 19 people
- Sponsor
- Seoul National University Hospital
Inflammatory Bowel Diseases, Crohn Disease
De-escalation of Anti-TNF Therapy in Inflammatory Bowel Disease
BACKGROUND/RATIONALE: Treatment outcomes of patients with inflammatory bowel disease (IBD) have improved enormously during the past decade due to the use of anti-tumour necrosis factor (anti-TNF) therapy.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Colitis, Ulcerative
- Trial name
- FREE (NCT04646187)
- Testing
- Infliximab, Adalimumab
- Where
- 7 sites in Belgium, Netherlands and 1 more
- Volunteers
- 148 people
- Sponsor
- University Medical Center Groningen
Gut Microbiota, Skin Microbiota
Lactobacillus Rhamnosus GG: Interaction With Human Microbiota and Immunity
Hypothesis: Probiotics have been used as novel adjunct therapeutic approach in atopic dermatitis. In addition to balancing the gut microecology and promoting host immune defences, specific probiotics might further aid in…
- Conditions
- Gut Microbiota, Skin Microbiota, Humoral Immune Responses, Severity of Atopic Dermatitis
- Trial name
- NCT01148667
- Testing
- Casein hydrolysate added with LGG, Infants drink casein hydrolysate without LGG
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- Turku University Hospital
Cystocele, Vaginal Vault Prolapse
Laser Therapy in Managing Vaginal Prolapse
Efficacy of laser therapy in postmenopausal women with symptomatic prolapse stage >1. Assessment tools will include prolapse stage quantification system (POP-Q) and validated condition related questionnaires.
- Conditions
- Cystocele, Vaginal Vault Prolapse, Rectocele, Enterocele
- Trial name
- NCT03714607
- Testing
- Erbium Yttrium Aluminum Garnet (Er:YAG) laser
- Where
- Greece
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Health Behavior, Child Development
Dietary Modulation of Gut Microbiota in Overweight/Obese Adolescents and COVID-19 Infection
Probiotic intervention has been currently suggested to provide supportive benefits in promoting health, including alleviating disease symptoms, protecting against diarrhea and respiratory infection, affecting growth and…
- Conditions
- Health Behavior, Child Development, Adolescent Obesity
- Trial name
- DIVINE (NCT05623007)
- Testing
- Probiotics, Counselling on healthy eating, physical activity, and psychosocial stimulation
- Where
- Indonesia
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Acute Appendicitis, Acute Appendicitis With Rupture
Prostaglandin-E Urinary Metabolite (PGE-M) as a Predictor of Acute Appendicitis in Children
Diagnosing acute appendicitis in children remains a clinical challenge, with delayed or incorrect diagnosis potentially leading to serious complications or unnecessary surgery.
- Conditions
- Acute Appendicitis, Acute Appendicitis With Rupture, Abdominal Pain (AP)
- Trial name
- NCT07008092
- Testing
- Blood specimen collection, Urine collection
- Where
- Croatia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- KBC Split
Infectious Gastroenteritis
Probiotics for Infectious Diarrhea in Children in South India
The overall goal of this study is to investigate whether the modulatory effects of probiotics, which are used as food supplements (Lactobacillus GG marketed as Culturelle or yoghurt) in the gastrointestinal tract promote…
- Trial name
- NCT01130792
- Testing
- Lactobacillus GG, Inulin
- Where
- India
- Volunteers
- 124 people
- Sponsor
- Christian Medical College, Vellore, India
Anal Fissure, Microbial Colonization
Microbiota in Chronic Anal Fissure and Its Association With Prognosis
In this study, we will try to answer the following questions: 1. What are the salient features of the microbiota in chronic anal fissure? 2. Are these features associated with prognosis and response to therapy? 3.
- Trial name
- NCT05405634
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lasse Krogsbøll
Ulcerative Colitis, Crohn's Disease
A Long-Term Extension Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis (UC) or Crohn's Disease (CD)
The main aim of this study is to learn about medical problems (adverse events) if vedolizumab subcutaneously (SC) is given to a child or teenager with UC or CD for a long time.
- Trial name
- NCT06405087
- Testing
- Vedolizumab SC, No Intervention
- Where
- 47 sites in United States, Belgium and 12 more
- Volunteers
- 70 people
- Sponsor
- Takeda
Obesity, Overweight
The Effects of Type 1 Diabetes Mellitus and Increased Weight on Gut Microbiome and Urine Metabolome Profiles in Children
This study employs a cross-sectional design to profile the gut microbiome and urine metabolome in overweight/obese children with type 1 diabetes (T1D).
- Conditions
- Obesity, Overweight, Type 1 Diabetes Mellitus
- Trial name
- NCT02938806
- Testing
- No intervention
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Colonoscopy Preparation
Colon Cleansing Quality of Polyethylene Glycol Compared With Polyethylene Glycol Plus Ascorbic Acid.
The purpose of the study is to assess whether a low volume polyethylene glycol (PEG) plus ascorbic acid based bowel preparation for colonoscopy is not inferior to a large volume polyethylene glycol preparation in subjects with…
- Trial name
- REPREP1 (NCT02073552)
- Testing
- Polyethylene glycol 4000, Macrogol 3350 plus ascorbic acid
- Where
- Spain
- Volunteers
- 472 people
- Sponsor
- Fundación Canaria Rafael Clavijo para la Investigación Biomédica
Growth
BIG Study (Brain, Immune, and Gut Health Evaluation of Infants/Young Children Fed Infant Formula, and Later Supplemental Toddler Nutrition, With 5 Specific HMOs)
The purpose of this study is to evaluate the growth and development outcomes of infants fed a new infant formula and toddler drink through 24 months of age.
- Trial name
- NCT04957992
- Testing
- Control Infant Formula, Control Toddler Drink, Experimental Infant Formula
- Where
- 42 sites in United States
- Volunteers
- 607 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Preterm Birth
Impact of Dietary Sodium Supplementation on Growth & Intestinal Microbiome
The purpose of this project is to determine the direct impact of sodium supplementation in preterm infants and to see the overall improvement of their growth and health status.
- Trial name
- NCT05546814
- Testing
- Sodium algorithm
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Enterocolitis, Necrotizing
Probiotics Reduce Incidence of Necrotizing Enterocolitis for Very Low Birth Weight Infants
We investigate the efficacy of probiotics in reducing the incidence and severity of necrotizing enterocolitis (NEC) for very low birth weight (VLBW) infants.A prospective, masked, multi-center randomized control trial will be…
- Trial name
- NCT00540033
- Testing
- infloran
- Where
- Taiwan
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
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