Clinical trials: Gut Function
Stress, Irritable Bowel Syndrome
Evaluating and Treating Potential Research Participants With Digestive Disorders
Background: Some research studies focus on digestive disorders, such as nutritional, gastrointestinal, and liver disorders. Researchers want to examine and treat people with digestive disorders in order to learn more about these…
- Conditions
- Stress, Irritable Bowel Syndrome, Obesity, Abdominal Pain
- Trial name
- NCT01736280
- Testing
- Standard of Care
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- National Institute of Nursing Research (NINR)
Stress Physiology
Prebiotic and Probiotic Modulation of the Gut Microbiota-gut-brain Axis During Acute Stress
Emerging evidence supports the existence of a microbiota-gut-brain axis through which gut microbes influence cognition, mood and behavior.
- Trial name
- NCT05392556
- Testing
- Probiotic, Prebiotic
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Obesity, Growth
Essential Fatty Acids During Complementary Feeding
The objective of this intervention study is to examine the effect of n-3 LCPUFA on growth and body composition, intestinal health and microbiotic composition, immune function and risk markers for later diseases in 9-18 months old…
- Conditions
- Obesity, Growth, Metabolic Syndrome, Cardiovascular Disease
- Trial name
- EFiON (NCT00631046)
- Testing
- Fish Oil, Sunflower Oil
- Where
- Denmark
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Functional Gastrointestinal Disorders (FGIDs), Cyclic Vomiting Syndrome
Autonomic Reactivity and Personalized Neurostimulation
Disorders of gut-brain interaction (DGBI) affect up to 25% of U.S. children. Patients often suffer from disabling, multisystem comorbidities that suggest a common root (sleep disturbances, fatigue, anxiety, etc).
- Conditions
- Functional Gastrointestinal Disorders (FGIDs), Cyclic Vomiting Syndrome, Functional Dyspepsia, Dysautonomia
- Trial name
- NCT06863207
- Testing
- Percutaneous electrical nerve field stimulation, Hypnotherapy
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Irritable Bowel Syndrome (IBS), Sucrase Isomaltase Deficiency
Genetic Carbohydrate Maldigestion as a Model to Study Food Hypersensitivity
Irritable bowel syndrome (IBS) affects one in seven people with gastrointestinal (GI) symptoms. IBS strongly impacts quality of life, is a leading cause of work absenteeism, and consumes 0.5% of the healthcare annual budget.
- Trial name
- GenMalCarb (NCT05795049)
- Testing
- Stool and saliva sample collection, Questionnaire completion
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
Abdominal Pain, Irritable Bowel Syndrome
Pain Processing and Pain Neuroscience Education in Children With Chronic Abdominal Pain
The primary scientific objective of the study entails examining whether altered endogenous pain inhibition is present in children with functional abdominal pain (FAP) and irritable bowel syndrome (IBS) compared with healthy…
- Trial name
- NCT02880332
- Testing
- Usual care, Pain Neuroscience education, Extra care
- Where
- Belgium
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Constipation, Fecal Incontinence
Diagnosis of Functional Defecation Disorders in Childhood
Purpose To compare different kinds of diagnostic investigations in order to identify the most sensitive and least invasive when diagnosing constipation.
- Trial name
- NCT00230360
- Where
- Denmark
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Irritable Bowel Syndrome
Randomised Double-blind Active vs. Placebo Clinical Trial on the Effect of a Food Supplement on IBS in Children
The goal of this clinical trial is to test a food supplement in children of 3-17 years with IBS. The main questions it aims to answer are: Is the tested supplement able to improve and/or reduce IBS-related symptoms? After…
- Trial name
- NCT06123234
- Testing
- Verum
- Where
- Italy
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico "G. Martino"
COVID-19-Associated Encephalitis, Long COVID
Longterm Influence of Pediatric Long COVID Syndrome
We enroll pediatric patients who were diagnosed COVID-19 for main observation target. We will perform brain MRI and neuropsychiatric evaluation 4-6 months after COVID-19 diagnosed.
- Trial name
- NCT05566392
- Testing
- Brain MRI
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Effects of Coffee Ingestion on Recovery of Bowel Function
>The Purpose of This Study Was to Determine Whether Consuming a 100-mL Cup of Coffee is Effective in Preventing or Reducing Postoperative Ileus After Laparotomy of Benign Gynecological Patients
Comparison of the effectiveness coffee (with or without caffeine) ingestion and water for reducing the duration of Postoperative ileus after Laparotomy of Benign Gynecological Patients
- Trial name
- NCT03660267
- Testing
- caffeine coffee, decaffiene coffee, still water
- Where
- Thailand
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Constipation, Children
Comparison of Anorectal Manometry and 3D Manometry in Diagnosis of Functional Disorders in Children
Pressures measured by manometric solid-state catheters may differ according to the type of the catheter and specific anatomy and physiology of anorectum.
- Conditions
- Constipation, Children, Fecal Incontinence
- Trial name
- NCT02812823
- Testing
- High-resolution anorectal manometry
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Irritable Bowel Syndrome
Prevalence of Intestinal Parasitic Infections in Patients With Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is common medical disorder and represent a group of diseases of the gastrointestinal tract that is characterized by chronic abdominal pain , bloating , passage of mucus or straining with bowel…
- Trial name
- NCT05830370
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sohag University
Microbial Colonization, Gut Microbiota
Diet Supplementation With Prebiotics to Improve Gut Health in Egyptian Children
The study described herein seeks to assess the extent to which diet supplementation of young Egyptian children, one of the most vulnerable groups to the risk of diarrhea, with prebiotic fiber can improve their gut health.
- Trial name
- NCT06561724
- Testing
- Biscuits maltodextrin, Biscuits includes prebiotics tartoufa inulin, Biscuits includes prebiotics chicory inulin
- Where
- Egypt
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Research Centre, Egypt
Irritable Bowel Syndrome
The FAIS-Trial: Faecal Microbiota Transplantation (FMT) in Adolescents With Refractory Irritable Bowel Syndrome (IBS)
A Double-blind randomised placebo-controlled pilot study as well as a reversed translational part To investigate whether two faecal transplantations from either allogeneic (healthy) or autologous (own) donor, administered through…
- Trial name
- FAIS (NCT03074227)
- Testing
- Allogeneic faecal transplantation, Autologous faecal transplantation
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Postoperative Ileus
RCT Gum Chewing on Bowel Function After Abdominal Surgery in Children
Traditional postoperative care has been challenged recently to improve and speedup recovery (including the return of bowel function) such that patients can be discharged to home more quickly.
- Trial name
- GUM_RCT (NCT02261454)
- Testing
- Gum chewing
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Alberta Children's Hospital
Constipation - Functional
Breath Gases, Gut Flora, and Immunity in Children With Constipation
Constipation is a common problem in children that can affect their daily life, school performance, and social activities. Researchers have found that the bacteria living in our intestines (called "gut microbiome") may play an…
- Trial name
- NCT07797491
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Chronic Pancreatitis, Inflammatory Bowel Diseases
Genomic Resources for Enhancing Available Therapies (GREAT1.0) Study
This is a prospective, descriptive, observational research study designed to observe and document the clinical practice by domain experts, and how the knowledge of new findings that are published in the medical literature affect…
- Conditions
- Chronic Pancreatitis, Inflammatory Bowel Diseases, Hepatitis, NASH - Nonalcoholic Steatohepatitis
- Trial name
- GREAT1 (NCT04306939)
- Testing
- venipuncture, Questionnaires, Additional Sample Collections
- Where
- United States
- Volunteers
- 120,000 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Lupus Erythematosus, Systemic, Gastrointestinal Microbiome
Assessment of Cognitive Function and Gut Microbiota Analysis in Real World Patients With Lupus Cerebrovascular Disease
Based on clinical manifestations, laboratory data and intestinal microflora detection, the cognitive function characteristics of patients with systemic lupus erythematosus and cerebrovascular disease and its relationship with…
- Trial name
- NCT05636670
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Healthy, Healthy Nutrition
The BEGIN Study Bifidobacterium Infantis to Newborns: Effects of Modulating the Gut Microbial Composition on Growth, Immune Function and Inflammatory Conditions - a Randomized Placebo-controlled Double-blinded Intervention Trial
The goal of The BEGIN Study, a randomized controlled double-blinded intervention trial, is to learn if probiotics, with Bifidobacterium longum subspecies infantis Bifin02 (B.
- Trial name
- BEGIN (NCT06452199)
- Testing
- B. infantis
- Where
- 2 sites in Denmark
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
IBS - Irritable Bowel Syndrome
The Prevalence of Irritable Bowel Syndrome Using Rome IV Criteria in Medical Student and The Related Factors
A cross-sectional study of 350 medical student Universitas Indonesia from first grade until fifth grade was done during November-December 2016. This study used stratified randomized sampling.
- Trial name
- IBS (NCT03178877)
- Testing
- No intervention
- Where
- Indonesia
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia